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Jurnal Ilmiah Farmasi
Published by Universitas Islam Indonesia
ISSN : 16938666     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
JIF merupakan jurnal yang dikelola oleh Prodi Farmasi Universitas Islam Indonesia, dan diterbitkan dua kali dalam setahun. Jurnal ini dirancang sebagai sarana publikasi penelitian yang mencakup secara rinci sejumlah topik dalam bidang farmasi yang berkaitan dengan farmasi sains dan teknologi serta klinik dan komunitas. Jurnal ini menyediakan sebuah forum sebagai sarana pertukaran gagasan dan dan informasi antar peneliti, akademisi dan praktisi sehingga diharapkan mampu mendukung dan menginisiasi berbagai penelitian terkini yang terkait dengan ilmu kefarmasian. Hasil penelitian yang disajikan dalam jurnal ini diharapkan dapat memberikan kontribusi bagi perkembangan ilmu di bidang farmasi dan kesehatan.
Arjuna Subject : -
Articles 269 Documents
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α-AMYLASE INHIBITION TEST OF ETHANOL EXTRACT OF MIANA RED TONGUE LEAVES (Solenostemon scutellarioides (L.) Codd) IN VITRO Hartono, Dimas Rahmatullah Tri; Rukmi, MG. Isworo; Wulandari, Fitri
Jurnal Ilmiah Farmasi Vol. 21 No. 1 (2025): Jurnal Ilmiah Farmasi
Publisher : Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/jif.vol21.iss1.art9

Abstract

Background: Hyperglycemia occurs due to an increase in blood glucose levels, making them higher than the normal range, which is a sign of diabetes mellitus. One therapeutic approach for DM is inhibiting enzymes that convert carbohydrates into glucose. Coleus (S. scutellarioides (L.) Codd), an ornamental plant, is believed to have antihyperglycemic effects due to its phenolic phytochemicals.Objective: To determine the phytochemical content and antihyperglycemic activity of 70% ethanol extract of coleus leaves through α-amylase enzyme inhibition.Method: The leaves were characterized and tested qualitatively for phytochemical content using the test tube method. The extract was prepared using maceration with 70% ethanol, followed by thin-layer chromatography (TLC). The 200-ppm extract was tested for α-amylase enzyme inhibition, with acarbose as a positive control. Statistical differences were analyzed using the t-test method.Results: The herbarium specimen of coleus leaf was shown to contain flavonoids, tannins, saponins, and steroids. The 200-ppm extract reduced the activity of the α-amylase enzyme by 61.03%, while the positive control (acarbose) reduced it by 92.16%.Conclusion: The coleus leaf extract contains active phytochemicals that may help lower blood glucose levels. At 200 ppm, the extract demonstrates potential as an antihyperglycemic agent through α-amylase inhibition.
Integritas Tablet Ekstrak Daun Sirsak dengan Crospovidone Handayani, Fajar; Kurniasari, Devita; Indrati, Oktavia; Perdana Kusuma, Aris
Jurnal Ilmiah Farmasi Vol. 21 No. 1 (2025): Jurnal Ilmiah Farmasi
Publisher : Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/jif.vol21.iss1.art2

Abstract

Background: Annona muricata L. (A. muricata) leaf contains several active compounds, including flavonoids, which are known to have antioxidant properties. People only use A. muricata leaves as antioxidants by boiling them in water. Therefore, the development of tablet potential is necessary to enhance user comfort and storage stability.Objective: The aim of this research was to determine the disintegration time of A. muricata leaf extract tablets with varying levels of the disintegrating agent crospovidone and to determine the best disintegrating level according to the results of evaluating the physical properties of the tablets.Methods: Tablets are made using the wet granulation method with a composition of 2-5% crospovidone. The resulting granules are tested for water content, flow time, angle of repose, and tapping. The resulting tablets were tested for hardness, friability, and disintegration time.Results: The test results show that crospovidone and lactose can produce excellent A. muricata leaf extract tablets.Conclusion: Crospovidone 3.5% produces optimum A. muricata leaf extract tablets with a friability of 0.36% and a disintegration time of 7.82 minutes.  
Analisis Biaya dan Kualitas Hidup Pasien Kanker Paru Non-Small Cell Lung Cancer (NSCLC) Mutasi Epidermal Growth Factor Receptor (EGFR) Eliyanti, Uzma; Tyas, Rafi Setyoning; Hapsari, Indri; Setiawan, Didik
Jurnal Ilmiah Farmasi Vol. 21 No. 1 (2025): Jurnal Ilmiah Farmasi
Publisher : Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/jif.vol21.iss1.art3

Abstract

Introduction: Lung cancer remains a leading cause of death worldwide, with non-small cell lung cancer (NSCLC) carrying the highest incidence among lung cancer types, particularly in patients with epidermal growth factor receptor (EGFR) mutations. The first-line therapy for NSCLC lung cancer patients with EGFR mutations typically involves the tyrosine kinase inhibitor (TKI) group.Objective: The study aimed to compare the cost utility of the two TKI groups (afatinib and erlotinib) for NSCLC patients with EGFR mutations.Methods: This pharmacoeconomic study was conducted using the Cost Utility Analysis (CUA) method from the patient’s perspective. The study included 33 patients receiving afatinib and 12 patients receiving erlotinib, conducted in 2022-2023 at Kariadi Hospital, Semarang, and Prof. Dr. Margono Soekarjo Hospital, Purwokerto. Therapeutic outcomes were measured using Quality Adjusted Life Year (QALY), and cost components included actual costs and estimated costs based on clinical pathways. CUA was presented in the form of an Incremental Cost Effectiveness Ratio (ICER).Results: The cost of afatinib was greater than that of erlotinib (IDR 174.395.847 vs. IDR 138.672.688). The quality of life of afatinib was better than that of erlotinib (0.397 vs. 0.161, p-value 0.016). The ICER of afatinib was IDR 151.369.318 per QALY when compared to erlotinib.Conclusion: This study demonstrates that afatinib is a cost-effective treatment option for NSCLC patients with EGFR mutations.
Forced Degradation and Stability Testing of Chloramphenicol Ear Drops Using Derivative Spectrophotometry Combining with Chemometrics Rahmah, Annisa; Wijaya, Triyadi Hendra; Wasito, Hendri
Jurnal Ilmiah Farmasi Vol. 21 No. 1 (2025): Jurnal Ilmiah Farmasi
Publisher : Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/jif.vol21.iss1.art5

Abstract

Background: Chloramphenicol eye drops have a lower stability than solid dosage forms. Hence, it is necessary to assess their stability. One stability test that can be conducted is the forced degradation approach, which involves applying stress conditions that are more severe than those used in accelerated stability testing.Objective: This study used forced degradation to explore the stability profile of chloramphenicol ear drops.Methods: Stability analysis was carried out using a derivative spectrophotometric instrument combined with chemometric analysis. The forced degradation study was conducted by exposing the sample to three conditions: acidic (0.1 N HCl at 80°C for 2 hours), alkaline (0.1 N NaOH at 80°C for 2 hours), and heat (90°C for 4 hours). Principal Component Analysis (PCA) and Partial Least Squares–Discriminant Analysis (PLS-DA) were utilized for the chemometric analysis. Results: Sequential chloramphenicol observations with a zero to third derivative show a maximum wavelength of 278, 260, 234, and 292 nm. According to stability studies with forced degradation, chloramphenicol tended to degrade under alkaline and thermal conditions compared to acidic conditions. A typical grouping pattern amongst forced degradation treatments is revealed by chemometric analysis, which characterizes chloramphenicol's stability profile under different experimental settings.Conclusion: The UV-Vis spectrophotometric approach, both non-derivative and derivative, can describe changes in chloramphenicol degradation profiles, although the specific degradation products generated remain unknown.
Update on pharmacist role in sterile compounding in hospital Albesht, Hanan; Hanifah, Suci; Abukres, Salem
Jurnal Ilmiah Farmasi Vol. 21 No. 1 (2025): Jurnal Ilmiah Farmasi
Publisher : Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/jif.vol21.iss1.art8

Abstract

Background: Sterile compounding, a critical aspect of pharmaceutical practice, involves the preparation of customized medications in a sterile environment. Pharmacists play a pivotal role in ensuring the safety and efficacy of compounded sterile products (CSPs), making their involvement integral to the healthcare system. Objective: This article aims to describe the role of pharmacists in sterile compounding based on literature. Method: Articles from Medline/PubMed, guidelines, reports, and databases related to sterile compounding have been searched and compiled. This review collected the qualitative data and identified the critical point for continuous quality improvement initiatives in sterile compounding.Results: This comprehensive narrative review explores the multifaceted responsibilities of pharmacists in sterile compounding, drawing insights from various studies and databases. However, the study related to the pharmacist's role in sterile compounding practices is very limited. Recent articles that mention the pharmacist's role in sterile compounding commonly come from the guidelines or government documents. In general, CSP needs a commitment to comply with regulatory standards for achieving patient safety using the integration of technology and healthcare collaboration. Continuous professional development is a crucial contributor to keeping the quality of compounded sterile products. Conclusion: The findings from various journals underscore the complexity of their responsibilities and emphasize the need for a holistic approach to ensure the integrity and safety of compounded sterile products in diverse healthcare settings.
Analysis of protein, fat, and iron in catfish and green spinach biscuits Mahalia, Lamia Diang; Harlyanti Muthma’innah Mashar; Sukmawati A. Damiti
Jurnal Ilmiah Farmasi Vol. 21 No. 1 (2025): Jurnal Ilmiah Farmasi
Publisher : Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/jif.vol21.iss1.art6

Abstract

Background: Stunting in Indonesia remains a significant health issue that cannot be overlooked. Stunting can be addressed through the consumption of foods derived from both animal and plant sources, which are high in protein and rich in essential amino acids beneficial for preventing stunting. The provision of biscuits fortified with catfish and spinach flour is anticipated to assist the government in reducing the prevalence of stunting.Objective: The aim of this study was to develop a functional food product formula utilizing catfish and spinach flour while also analyzing the nutritional content of the resultant biscuits.Method: This research employed three biscuit formulas with varying ratios of catfish and spinach flour, specifically F1 (15 g : 45 g), F2 (30 g : 30 g), and F3 (45 g : 15 g). Chemical analyses conducted on the biscuits included tests for moisture content and ash content using the gravimetric method, protein analysis utilizing the Kjeldahl method, fat analysis via the Soxhlet extraction method, and carbohydrate analysis employing the titrimetric method.Results: Based on the tests of the three biscuit formulas, it was found that the biscuits with formula F3 meet the minimum requirements outlined by the SNI, except for ash content. The protein content was 11.03%, the fat content was 31.073%, the water content was 2.26%, and the ash content was 2.98%. The protein content in formula F3 was higher than that in formulas F1 and F2 and has a high enough iron content at 5.025 mg/100 g.Conclusion: It can be concluded that biscuits with the F3 formula meet the nutritional values required by SNI regarding protein, fat, and water content. This formula has an opportunity for further development to enhance the carbohydrate, iron, and ash content of the biscuit to comply with SNI standards.
Determination of specific and non-specific parameters of saluang belum (Luvunga sarmentosa (Blume) Kurz.) root extract and quantification of its total flavonoid content Dina Fadhila Zahra; M. Ikhwan Rizki; Wathan, Nashrul
Jurnal Ilmiah Farmasi Vol. 21 No. 1 (2025): Jurnal Ilmiah Farmasi
Publisher : Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/jif.vol21.iss1.art7

Abstract

Background: Saluang belum (Luvunga sarmentosa (Blume) Kurz.) is an endemic plant native to the Kalimantan region. The Dayak people traditionally consume a decoction of L. sarmentosa root to improve stamina. Previous research has confirmed that the roots of L. sarmentosa possess antioxidant properties.Objective: This study aims to determine the characterization values of both specific and nonspecific parameters of the ethanol extract from L. sarmentosa roots, as well as to assess the total flavonoid content.Method: The research samples were collected from Timpah Village, Central Kalimantan. The methods for standardization employed the general standard parameters for Indonesian Herbal Extracts and the Pharmacopoeia. Specific parameters include the characteristics of the extract, phytochemical screening, and thin-layer chromatography profiles, while nonspecific parameters consist of determining water content, total ash, acid-insoluble ash content, and heavy metal contaminants (Pb, Cd, and Hg). The total flavonoid content was determined using a colorimetric method with AlCl₃ and quercetin as the standard.Results: The extract was characterized as a thick, yellowish-brown substance with a strong, distinct odor and a bitter taste. It contains alkaloids, flavonoids, tannins, terpenoids, and steroids. The TLC profile revealed four distinct spots using a non-polar eluent and six spots with a polar eluent. The extract yield was 8.57%, with an average water content of 2.43±0.15%, total ash content of 1.50%, and acid-insoluble ash content of 1.00±0.87%. Heavy metal contamination levels were determined as follows: Pb < 0.001 mg/kg, Cd 0.446 mg/kg, and Hg 2.077 mg/kg. The total flavonoid content of the extract was quantified at 6.9147 ± 0.0083 mg QE/g.Conclusion: All specific and non-specific parameters of the extract meet the requirements except for the heavy metal contaminants of Hg and Cd, which are still within the threshold limits set by BPOM. Meanwhile, the total flavonoid content measured was 6.9147 ± 0.0083 mg QE/g.
Physical stability test of liquid facial soap formulation of citronella extract (Cymbopogon nardus L.) Setyowati, Endang; Nisa, Nur Fadhillah Hidayatul; Nasriyah; Nilawati
Jurnal Ilmiah Farmasi Vol. 21 No. 1 (2025): Jurnal Ilmiah Farmasi
Publisher : Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/jif.vol21.iss1.art1

Abstract

Background: Citronella (Cymbopogon nardus L.) is one of Indonesia’s most fertile herbal plants. It contains antibacterial compounds and can be used as a liquid facial wash. With the correct formulation, citronella extract facial wash can effectively remove dirt and sebum on the face and prevent the growth of acne-causing bacteria.Objective: This research aims to obtain the optimal formula for citronella extract liquid facial wash.Method: Citronella extract was formulated into the liquid facial wash with concentrations of 9, 18, and 24%, and then the physical stability of the preparation was tested for 3 weeks. After that, the results are compared with the standards that have been set.Results: The citronella extract contained saponins, polyphenols, and flavonoids. The three liquid facial wash formulations made from citronella grass extract had a thick, liquid texture, a unique smell, a brown color, a viscosity range of 948-2,506 cPs, a potential hydrogen range of 4.8–5.97, an adhesive test range of 1.2-2.58 seconds, a foam height range of 0-107 mm, and a spreading power of 5–6.4 cm.Conclusion: The conclusion is that all stability tests for citronella extract liquid facial wash formulations meet the requirements except for the foam height test. The formulation that differs in extract concentration by 24% is the most optimal.
Model Hewan Uji Agen Terapeutik Alami pada Stroke Iskemik Botutihe, Lisa Agustina; Safira, Rizka; Kintoko
Jurnal Ilmiah Farmasi Vol. 21 No. 2 (2025): Jurnal Ilmiah Farmasi
Publisher : Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/jif.vol21.iss2.art2

Abstract

Background: Ischemic stroke is an acute neurological injury resulting from focal damage to the central nervous system due to vascular obstruction and subsequent decrease in cerebral blood flow. Numerous animal models of ischemic stroke have been established to investigate its mechanism, pathophysiology, and risk factors. The animal model of ischemic stroke includes a global ischemia model and a focal ischemia model. This article describes various parameters, including hematological, biochemical, cytological, histological, and molecular factors, along with diverse biomarkers, that may support research in the development of novel, safer, and more effective therapeutic agents for ischemic stroke using animal models.Objective: This research seeks to determine the appropriate test animal model and parameters for ischemic stroke experiments.Method: A complete literature search was conducted across multiple databases, including NCBI, PubMed, and additional sources.Results: According to reference studies, the animal model test in the ischemic stroke experiment comprised a focal ischemia model and a global ischemic model. The focal ischemic model is more pertinent to ischemic stroke in humans compared to the global ischemic model. In addition, focal ischemic models, including Middle Cerebral Artery Occlusion (MCAO), have been utilized in over 40% of 2,582 nerve protection trials. The wide variety of test animal models possesses distinct advantages and disadvantages, making it crucial to select the appropriate model. The parameters of ischemic stroke, including hematology, biochemistry, cytology, histology, and molecular analysis, together with their biomarkers, can help in identifying the incidence of ischemic stroke in test animals.Conclusion: The focused ischemia model is a more pertinent animal model for ischemic stroke in relation to humans than the global ischemic model. Parameters utilized for the identification of ischemic stroke encompass hematology, biochemistry, cytology, histology, and molecular biology.
Literatur Review Analisis Dampak Kebijakan E-Catalogue terhadap Pengadaan Obat di Era JKN (Jaminan Kesehatan Nasional) Puspitasari, Mitha
Jurnal Ilmiah Farmasi Vol. 21 No. 2 (2025): Jurnal Ilmiah Farmasi
Publisher : Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/jif.vol21.iss2.art1

Abstract

Background: The influence of the e-catalog policy on medication procurement during the National Health Insurance (JKN) era encompasses critical elements such as the necessity to enhance efficiency, accountability, and transparency within the system. All medical facilities working with BPJS Kesehatan are expected to use the e-purchasing application to purchase drugs in this JKN era.Objective: The focus of this literature review was to present empirical evidence about the influence of the e-catalog strategy on the procurement of pharmaceuticals by healthcare institutions during the JKN era.Method: This literature review involved searching for several papers published online via PubMed and Google Scholar using keywords and MeSH terms. The search terms included BPJS e-purchasing, JKN e-purchasing, referral e-purchasing, JKN e-catalog, BPJS, and insurance e-catalog.Result: The e-catalog policy seeks to establish a more equal, efficient, and responsible pharmaceutical procurement system. This aligns with JKN's objective of maximizing resource utilization to enhance the overall quality of healthcare. The execution of the e-catalog policy is an essential measure in modernizing and enhancing the medication procurement system in the JKN era. Consequently, the e-catalog policy is anticipated to yield substantial enhancements in pharmaceutical management and the execution of the JKN program.Conclusion: The e-catalog technique possesses the capacity to markedly enhance drug procurement in the JKN era by augmenting efficiency, accountability, and transparency. System updates will necessitate concentrated efforts.

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