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Jurnal Ilmiah Farmasi
Published by Universitas Islam Indonesia
ISSN : 16938666     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
JIF merupakan jurnal yang dikelola oleh Prodi Farmasi Universitas Islam Indonesia, dan diterbitkan dua kali dalam setahun. Jurnal ini dirancang sebagai sarana publikasi penelitian yang mencakup secara rinci sejumlah topik dalam bidang farmasi yang berkaitan dengan farmasi sains dan teknologi serta klinik dan komunitas. Jurnal ini menyediakan sebuah forum sebagai sarana pertukaran gagasan dan dan informasi antar peneliti, akademisi dan praktisi sehingga diharapkan mampu mendukung dan menginisiasi berbagai penelitian terkini yang terkait dengan ilmu kefarmasian. Hasil penelitian yang disajikan dalam jurnal ini diharapkan dapat memberikan kontribusi bagi perkembangan ilmu di bidang farmasi dan kesehatan.
Arjuna Subject : -
Articles 269 Documents
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Bioinformatics analysis of radix Angelica dahurica, Chuanxiong rhizoma, and Cyperi rhizoma for COVID-19 treatment Hoang, Thi-Van; Nguyen, Chi-Cong; Nguyen, Thi-Thuy-An; Pham, Thi-Thuy-Linh; Nguyen, Phan-Anh; Nguyen, Trang-Thuy; Ha, Hai-Anh
Jurnal Ilmiah Farmasi Vol. 20 No. 2 (2024): Jurnal Ilmiah Farmasi
Publisher : Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/jif.vol20.iss2.art1

Abstract

Background: The COVID-19 pandemic, which has unfolded over the past years, poses significant threats to global public health and socioeconomic well-being. Three herbs (radix Angelica dahurica, Chuanxiong rhizoma, and Cyperi rhizoma) have been long utilized in combination for treating common colds and flu.Objective: To analyze potential biotargets and explore possible effects of plant-derived compounds from 3 herbs towards COVID-19 treatment.Method: Bioinformatics databases and network pharmacology were employed to identify bioactive compounds and their biotargets with integrated statistical calculation, followed by Gene Ontology enrichment. KEGG pathway analysis was performed to elucidate the involvement of selected bioactive compounds in COVID-19-related processes.Results: Network pharmacology highlighted essential receptors, cytokines, and signaling proteins. Gene Ontology analysis revealed associations with signal transduction, RNA transcription enzymes, and crucial cellular components. Molecular function analysis emphasized interactions related to virus entry. KEGG analysis uncovered 32 potential targets across various pathways, elucidating their role in inflammation and cytokine storms. Conclusion: This study provides new insight for the molecular mechanisms underlying the therapeutic potential of a combination of radix Angelica dahurica, Chuanxiong rhizoma, and Cyperi rhizoma against COVID-19. The identified targets and pathways offer new directions for further experimental validation, paving the way for potential therapeutic interventions for COVID-19.
Prevalensi Problem Depresi pada Pasien Diabetes Mellitus di Puskesmas Puspita, Salma Fajar; Saepudin
Jurnal Ilmiah Farmasi Vol. 20 No. 2 (2024): Jurnal Ilmiah Farmasi
Publisher : Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/jif.vol20.iss2.art3

Abstract

Background: Depression is a common psychological disorder in diabetic patients that potentially causes non-adherence and complications. However, information regarding the prevalence and risk factor of depression in diabetic patients in Indonesia remains inconsistent.Objective: This study is aimed to determine the prevalence of depression and its associated factors among patients with type II diabetes mellitus (T2DM) in primary public health centers.Method: This cross-sectional study involved adult patients with T2DM in primary health centers in Sleman, Indonesia. Subjects were recruited using the purposive sampling method, and depression was assessed using the PHQ-9 questionnaire. The association between subject characteristics and depression was determined using the chi-square of Fisher’s exact test. Results: Among 268 subjects, most of them were women, aged <60 years old, had at least 1 comorbidity, and were taking a combination of oral antidiabetics. More than half of subjects had T2DM for <5 years. The prevalence of depression among T2DM was 36.6%. Being aged ≥60 years old, having a low education level, being a provider of family, and having T2DM for 5-10 years (p<0.05) were significantly associated with depression.Conclusion: T2DM patients aged ≥60 years old, who have a low education level, are providers of family, and have had T2DM for 5-10 years are more vulnerable to depression, thus needing more attention from healthcare providers to achieve diabetes goal therapy.
Stability and beyond-use date of anesthetic agents used in surgical procedures: a review: Stability and Beyond-Use Data of Anesthesia Wijayanti, Shofia; Hanifah, Suci; Fudholi, Dhomas Hatta
Jurnal Ilmiah Farmasi Vol. 20 No. 2 (2024): Jurnal Ilmiah Farmasi
Publisher : Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/jif.vol20.iss2.art4

Abstract

Background: Anaesthesia drugs are often divided into other syringes to be soluted or mixed with other medications to share with other patients for the sake of efficiency. Objectives: This study aims to know the stability of anesthetic agents and the compatibility with co-simultaneous drugs used. Methods: This review was conducted by searching literature through the following databases: PubMed, Science Direct, and Google Scholar. The keywords used in the search for articles were "stability," "beyond use date," "anesthetic drug," and "intravenous."Results: The data showed that mixing fentanyl with levo-bupivakain or epinefrin is relatively stable up to one month, but it decreases only for 72 hours in dextrose 5% or normal saline (NS). Pethidin can be mixed with acetaminophen and metoclopramide using dextrose, NS, or water and stored up to 24 hours. Midazolam diluted in dextrose 5% (D5) or mixed with other medications maintains stability for up to 14 days or more. Stability of ketamine is 24 hours longer whether it is mixed in solvent or acetaminophen. Mixing with propofol induces instability because of the emulsion form of propofol. Conclusion: In general, the anesthetic drugs of fentanyl, pethidine, midazolam, and ketamine are stable and safe for preparation and administration in more than 24 hours. These four medications are compatible with NS and D5 and all tested medications during 24 hours.
PERBANDINGAN EFEKTIVITAS TERAPI DAN BIAYA FILGRASTIM DAN LENOGRASTIM PADA PASIEN KANKER KOLOREKTAL DENGAN REGIMEN KEMOTERAPI FOLFOX Pratama, Jainuri Erik; Ramadhan, Viren; Saharuddin; Pahlavi, Ridlo
Jurnal Ilmiah Farmasi Vol. 20 No. 2 (2024): Jurnal Ilmiah Farmasi
Publisher : Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/jif.vol20.iss2.art10

Abstract

Background: Granulocyte colony-stimulating factor (GCSF) is a primary regulator of the granulopoiesis process, which mobilizes stem cells from the bone marrow to the blood vessels. Filgrastim and lenograstim are the types of GCSF that have been widely used. Objective: This research aims to study the comparative therapeutic outcomes and cost-effectiveness of filgrastim and lenograstim therapies in colorectal cancer patients undergoing chemotherapy with the FOLFOX regimen.Method: This research was conducted at the pharmacy installation of the Dr. Kariadi Central General Hospital (RSUP Dr. Kariadi) from December 2023 to January 2024. It is observational research with a retrospective pre-posttest cohort study design that evaluates the comparative effectiveness and costs of filgrastim and lenograstim therapies in patients with neutropenia based on an increase in white blood cells (WBC) and absolute neutrophil count (ANC) scores of patients. The data was analyzed using the unpaired comparative analysis method and using the cost-effectiveness analysis (CEA) method to determine the cost-effectiveness. The observations were carried out twice, before and after administering the GCSF therapy. The samples consisted of 25 patients divided into two treatment groups. Results: The average scores of WBC and ANC levels in 15 patients who received filgrastim therapy were 2000 cells/mm3 and 666 cells/mm3. At the same time, the WBC and ANC levels in 10 patients who received lenograstim therapy were 1980 cells/mm3 and 449 cells/mm3. After administering the GCSF therapy, there was a significant increase in WBC and ANC levels (p<0.05) in each group. Still, there was no significant difference in the increase in WBC and ANC between the groups receiving filgrastim and lenograstim (p>0.05). The CEA analysis results showed that an increase of 1 cell/ml of WBC score cost Rp24.2 for filgrastim and Rp347 for lenograstim. In contrast, an increase of 1 cell/ml of ANC score cost Rp111.8 for filgrastim and Rp1572.5 for lenograstim.Conclusion: This research concludes that filgrastim is as effective as lenograstim, yet filgrastim is considered more cost-effective than lenograstim.
Potential advancement utilizing nanotechnology-based delivery system to enhance the therapeutic properties of lavender essential oil: a review article Trianloka, A. M. Bagas; Chabib, Lutfi; Ramadani, Arba Pramundita
Jurnal Ilmiah Farmasi Vol. 20 No. 2 (2024): Jurnal Ilmiah Farmasi
Publisher : Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/jif.vol20.iss2.art6

Abstract

Background: Essential oils (EO), such as lavender (Lavandula spp.), which are derived from its flower, have become a growing trend in recent years as an alternative medicine in therapy. However, the poor physicochemical properties of EOs have several disadvantages for their application. Integrating nanotechnology into the formulation of medicinal dosage forms may provide a viable way to mitigate these limitations and improve the effectiveness of EO utilization.Objective: This literature review aims to gather information on the medicinal benefits of lavender EO and the prospective applications of nanotechnology-based delivery systems for EOs.Method: Online databases such as PubMed, Science Direct, Research Gate, Google Scholar, and other reliable sources were used to find 65 publications between 1991 and 2021, which are assessed in this review.Results: It is revealed that the main constituents of lavender EO are linalool, linalyl acetate, and lavandulyl acetate. Its effectiveness as an antibacterial, antioxidant, anticancer, anti-anxiety, and having effects on the central nervous system, along with other qualities including pain relief, has been demonstrated via numerous studies. Additionally, it was demonstrated to have dermatological properties that helped treat dermatitis and encouraged both hair growth and wound healing. Furthermore, it was also found that the application of nanotechnology in EOs has improved the concentration of active compounds in the blood and produced a stable dosage form while also increasing its efficacy.Conclusion: It is feasible to create nanoparticle dosage forms from lavender EO that can improve the substance's solubility, stability, and pharmacological effects. More research is necessary to formulate lavender EO by applying nanotechnology.
Analysis of active compounds in kawista leaf (Limonia acidissima L.) fraction and its antioxidant activity using DPPH method Azizah, Tri Nur; Harmastuti, Nuraini; Wijayanti, Tri
Jurnal Ilmiah Farmasi Vol. 20 No. 2 (2024): Jurnal Ilmiah Farmasi
Publisher : Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/jif.vol20.iss2.art9

Abstract

Background: Kawista (Limonia acidissima L.) is a plant that has been studied for its potential as a natural antioxidant. Research regarding kawista leaves has not been carried out to a more specific stage, so further fraction separation is carried out to determine compounds that have potential as antioxidant agents.Objective: This study aimed to determine the antioxidant activity of kawista leaf fractions using the DPPH method and to determine the active compounds in the highest antioxidant agents of kawista leaf fracton.Method: Kawista leaves were extracted by re-maceration using methanol, which was then purified by the liquid-liquid extraction method with the solvents n-hexane, ethyl acetate, and water. Phytochemical studies were carried out on the fractions using TLC on flavonoids, steroids, tannins, saponins, and alkaloids. The fraction was separated by the vacuum liquid chromatography method with 11 eluents, which were then tested for antioxidants and characterization of the most active compounds in the kawista leaf fraction. Then the highest results as antioxidant agents from the fraction were characterized for their active compounds using a spectrophotometer and FTIR.Results: The results of the study showed that the most active purified extract in antioxidant activity was ethyl acetate, which indicates strong antioxidant activity. The combined fraction 2 (F2) indicates flavonoid compounds that played an active role as very strong antioxidants with an AAI value of 3.3808, which is not significantly different from the vitamin C as standard. Flavonoid compounds that have been characterized using a spectrophotometer interpret the wavelength shift data that possible F2 belongs to the flavanon group.Conclusion: Active compounds from kawista leaf fraction (F2) have the highest antioxidant agent, with the possibility that flavonoid compounds from F2 belong to the flavanon group.
The potential of coconut oil as an anti-obesity agent: a scoping review Duvadilan, Sakti Pratami; Rahmawati, Riana
Jurnal Ilmiah Farmasi Vol. 20 No. 2 (2024): Jurnal Ilmiah Farmasi
Publisher : Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/jif.vol20.iss2.art7

Abstract

Background: The rising global prevalence of obesity and its related health issues make it crucial to explore all potential therapeutic options. Coconut oil (CNO) has been extensively studied for its health benefits, yet no scoping review has specifically assessed its potential as an anti-obesity agent, particularly among obese subjects. Objective: This review aims to outline the characteristics and findings regarding the use of coconut oil as an anti-obesity agent in both experimental animal and human studies. Method: The review included original studies on the potential of coconut oil as an anti-obesity agent, published in English or Indonesian between 2011 and 2022. A comprehensive search was performed across databases such as PubMed, ScienceDirect, Google Scholar, SpringerLink, and Portal Garuda. Articles were selected following the PRISMA-ScR flow diagram, with subsequent data extraction, analysis, and synthesis conducted.Results: Eight articles met the inclusion criteria, comprising four preclinical trials (involving obese animal models) and four human studies that recruited obese people. The preclinical trials used virgin coconut oil (VCO), while the human studies utilized both VCO and coconut oil (CNO). In preclinical trials, VCO administration was associated with reductions in low-density lipoprotein cholesterol (LDL-C), total cholesterol (TC), and triglyceride (TG) levels. In clinical trials, consumption of VCO and CNO was linked to increased high-density lipoprotein cholesterol (HDL-C) levels and reductions in LDL-C, TC, TG, and anthropometric measures (body weight, body mass index, waist circumference, waist-to-hip ratio, and body fat mass). However, the effects of VCO and CNO on LDL-C, TC, and TG were inconsistent.Conclusion: Coconut oil, particularly in the form of VCO, has shown potential as a supplement for managing obesity. However, this scoping review highlights inconsistencies in the effects of coconut oil on lipid profiles (LDL-C, TC, TG), indicating the need for further research to clarify these outcomes.
The role of pharmacists at the implementation of transformational leadership in the hospital central sterilization Nugroho, Dwi Agung Nugroho; Kusuma, Aris Perdana
Jurnal Ilmiah Farmasi Vol. 20 No. 2 (2024): Jurnal Ilmiah Farmasi
Publisher : Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/jif.vol20.iss2.art8

Abstract

Background: Pharmacists in hospitals have a role that is not only limited to the pharmacy installation and management but also contributes to the Central Sterile Supply Department (CSSD) installation. The issue of sterilization and cleanliness of instruments and linen in hospitals is the responsibility of the CSSD to support the sustainability of quality services in hospitals. Although related to sterility, most of the staff of the installation CSSD in Indonesia are high school graduates with minimal health knowledge and are often transferred from other installations due to problems. Some hospitals combine CSSD with laundry; in contrast to the pharmacy installation, which actively involves pharmacists and pharmaceutical technical personnel, compliance with regulations and provisions is more highly respected compared to personnel in the CSSD installation.Objective: This study aims to analyze the application of transformational leadership style in CSSD installation in hospitals while highlighting the lack of leadership studies in pharmacy and the effectiveness of leadership in managing installation performance in hospitals with non-health personnel.Methods: The methods used include direct observation, interviews, and questionnaires with samples consisting of installation leaders and staff CSSD in hospitals. We explore the factors influencing and challenges faced in implementing transformational leadership in a hospital CSSD environment.Results: The questionnaire results showed that the transformational leadership scores of the leaders were high, and most employees were satisfied with the implementation of transformational leadership. Some management concepts have been applied to improve performance, but many have not been able to provide change due to a lack of response from employees.Conclusion: A leader in CSSD installation must be flexible in adopting a leadership style that suits the situation and conditions; the application of leadership style must consider internal factors such as human resources quality and organizational structure as well as external factors that are hospital management and budget support.
Review: Isolasi, Peningkatan Kadar, dan Analisis Calophyllolide dalam Minyak Calophyllum inophyllum Linn. serta Potensinya untuk Terapi Luka Bakar Herawati, Zainab; Rakhmawati, Rita
Jurnal Ilmiah Farmasi Vol. 21 No. 1 (2025): Jurnal Ilmiah Farmasi
Publisher : Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/jif.vol21.iss1.art10

Abstract

Background: Calophyllolide is a dipyranocoumarin compound found in Calophyllum inophyllum L., known for its antimicrobial and anti-inflammatory properties, which are beneficial for burn wound healing. However, variability in its content and lack of standardized methods remain challenges.Objective: This review aims to present a literature study on calophyllolide, including its sources, isolation techniques, bioactive content optimization, analytical methods, and pharmacological potential in burn wound healing.Method: Data were retrieved from Scopus and PubMed using predefined keywords. Articles published in English between 2001 and 2021 and classified as original research were selected. Relevant studies were assessed for quality using the SYRCLE tool (animal studies) and the Young & Solomon checklist (non-clinical research).Results: Seeds harvested in September had the highest calophyllolide content (0.23%). Enhancement through tissue culture using 2 mg/L IBA yielded up to 45.23 mg/100 g callus. Among analytical techniques, a validated GC-MS method showed high precision and recovery. Pharmacological studies confirmed its activity against Staphylococcus aureus and its ability to modulate inflammatory responses.Conclusion: Calophyllolide shows strong potential as a natural agent for burn wound therapy. Standardized extraction, quantification, and production approaches are essential for further development.
Uji Aktivitas Enzim Superoksida Dismutase (SOD) Ekstrak Daun Jambu Biji (Psidium guajava L.) dengan Metode Water Soluble Tetrazolium Salt-1 Mandasari, Mitha Oktavia; Indrayati, Ana; Purwaningsih, Desi
Jurnal Ilmiah Farmasi Vol. 21 No. 1 (2025): Jurnal Ilmiah Farmasi
Publisher : Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/jif.vol21.iss1.art4

Abstract

Background: Antioxidants are compounds that inhibit cell damage caused by free radicals. Antioxidant enzymes include superoxide dismutase (SOD), glutathione, and catalase. SOD protects cells against free radicals implicated in various diseases. The guava plant (Psidium guajava L.) is known to possess SOD activity.Objective: This research was performed to determine the activity of the superoxide dismutase enzyme in guava leaf extract (Psidium guajava L.) with ammonium sulfate concentrations of 25, 50, and 75%.Methods: Guava leaves were extracted using phosphate buffer and centrifugation. The superoxide dismutase (SOD) enzyme was then purified using ammonium sulfate at concentrations of 25, 50, and 75%. The amount of protein was measured with the Lowry method, and the activity of the SOD enzyme was tested using the WST-1 assay to find out how much it was inhibited. The resulting data were statistically analyzed using one-way ANOVA.Results: Guava leaf extract exhibits SOD enzyme activity. The total protein content of the crude guava leaf extract and the extracts purified with 25, 50, and 75% ammonium sulfate were 9.683, 6.958, 8.842, and 11.269 mg/mL, respectively. The corresponding percent inhibition values were 69.652, 35.323, 61.69, and 79.104%. The 75% ammonium sulfate concentration yielded the highest percent inhibition.Conclusion: Guava leaf extract exhibits SOD enzyme activity, with the highest percent inhibition observed at an ammonium sulfate concentration of 75%.

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