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Jurnal Ilmiah Farmasi
Published by Universitas Islam Indonesia
ISSN : 16938666     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
JIF merupakan jurnal yang dikelola oleh Prodi Farmasi Universitas Islam Indonesia, dan diterbitkan dua kali dalam setahun. Jurnal ini dirancang sebagai sarana publikasi penelitian yang mencakup secara rinci sejumlah topik dalam bidang farmasi yang berkaitan dengan farmasi sains dan teknologi serta klinik dan komunitas. Jurnal ini menyediakan sebuah forum sebagai sarana pertukaran gagasan dan dan informasi antar peneliti, akademisi dan praktisi sehingga diharapkan mampu mendukung dan menginisiasi berbagai penelitian terkini yang terkait dengan ilmu kefarmasian. Hasil penelitian yang disajikan dalam jurnal ini diharapkan dapat memberikan kontribusi bagi perkembangan ilmu di bidang farmasi dan kesehatan.
Arjuna Subject : -
Articles 269 Documents
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Phenolic content, flavonoid, and antioxidant activity of Etlingera comosa Ardiyani and Ardi leaf extract endemic to Central Sulawesi Rasida; Anugraini, Annisa Putri; Satriani; Maskur, Risda; Widodo, Agustinus; Yuyun, Yonelian
Jurnal Ilmiah Farmasi Vol. 21 No. 2 (2025): Jurnal Ilmiah Farmasi
Publisher : Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/jif.vol21.iss2.art3

Abstract

Background: The recently identified plant species Etlingera comosa Ardiyani & Ardi is endemic to Tentena, Central Sulawesi, where it thrives both terrestrially and as an epiphyte. Nevertheless, the antioxidant activities of E. comosa have yet to be investigated, although other Etlingera species are recognized for their antioxidant components. Objective: This work aims to evaluate the antioxidant capabilities of E. comosa leaf extract using the Ferric Reducing Antioxidant Power (FRAP) assay, subsequently determining the total phenolic and flavonoid content. Method: The leaf extract was prepared through maceration with 96% ethanol. The FRAP method was employed to assess antioxidant activity, whereas the Folin-Ciocalteu method was utilized to quantify total phenolic content. The aluminum chloride colorimetric technique was employed to determine the total flavonoid content. Result: The results indicated that the extract exhibited robust antioxidant activities, with an EC₅₀ value of 9.94 µg/mL, whereas vitamin C, serving as the positive control, demonstrated an EC₅₀ value of 3.50 µg/mL. The extract comprised 18.86 mg GAE per 100 mg of extract for total phenolics and 3.31 mg QE per 100 mg of extract for total flavonoids. Conclusion: The antioxidant capacity of E. comosa leaf extract is significant, rendering it a promising subject for further pharmacological investigation.
Perbedaan Efektivitas Terapi Antihipertensi Nifedipin dan Metildopa Pada pasien preeklamsia di RSUD Dr. H. Moch. Ansari Saleh Kurniawan, Guntur; Wati, Helmina; Annisa, Rezka
Jurnal Ilmiah Farmasi Vol. 19 No. 2 (2023): Jurnal Ilmiah Farmasi
Publisher : Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/jif.vol19.iss2.art14

Abstract

Background: Preeclampsia in pregnant women can occur with elevated blood pressure >140/90 mmHg. Nifedipine and methyldopa can be used as antihypertensive therapy in pre-eclampsia patients. These two drugs have differences in their mechanisms of action to decrease blood pressure. Objective: To evaluate the effects of nifedipine and methyldopa in hospitalized pregnant female patients at RSUD Dr. H. Moch. Ansari Saleh from January to December 2018.Method: This research method was descriptive-observational, obtaining data retrospectively. This research included 30 hypertensive pregnant women who were divided into the nifedipine group or the methyldopa group. The blood pressure measurements of the patients were documented before and after therapy. The data was evaluated with an independent sample t-test.Result: The outcomes of this research indicated that nifedipine reduced the systolic blood pressure from the average of 159.33 to 127.66 mmHg and in the methyldopa group from the average of 162.67 to 137.33 mmHg (p < 0.05). The mean arterial pressure (MAP) after using nifedipine was 99.44 ± 10.15 mmHg, and after using methyldopa, it was 106.22 ± 7.65 mmHg (p <0.05).Conclusion: Nifedipine was more effective than methyldopa in lowering blood pressure in pre-eclampsia subjects.Keywords: Nifedipine, methyldopa, hypertension, blood pressure Intisari Latar belakang: Ciri-ciri hipertensi pada ibu hamil ditandai dengan peningkatan tensi darah diatas 140/90 mmHg yang dapat menyebabkan terjadinya preeklampsia. Nifedipin dan metildopa digunakan sebagai terapi antihipertensi khususnya pada pasien preeklampsia. Kedua obat tersebut memiliki perbedaan pada mekanisme kerja untuk mengurangi tekanan pada pembuluh arteri.Tujuan: Menganalisa efek pemakaian obat nifedipin dan metildopa pada subyek wanita hamil dan dirawat inap di RSUD Dr. H. Moch. Ansari Saleh di tahun 2018.Metode: Jenis penelitian ini adalah observasional deskriptif dengan memperoleh data secara retrospektif. Jumlah subyek sebanyak 30 pasien ibu hamil dengan kondisi hipertensi dibagi menjadi kelompok nifedipin atau kelompok metildopa. Data tekanan darah diambil sebelum dan sesudah pengobatan yang diperoleh dari rekam medis pasien yang kemudian diuji dengan independent sample t-test.Hasil: Nifedipin dapat mengurangi tekanan darah sistolik dari rerata 159,33 mmHg ke 127,66 mmHg dan pada grup metildopa dari rerata 162,67 mmHg ke 137,33 mmHg (p <0,05). Hasil rerata tekanan arteri (MAP) subyek setelah menggunakan nifedipin yaitu 99,44 ± 10,15 mmHg dan pada metildopa yaitu 106,22 ± 7,65 mmHg (p <0,05). Kesimpulan: Nifedipin lebih efektif dibandingkan dengan metildopa dalam menurunkan tensi darah pada wanita hamil dengan preeklampsia. Kata kunci: Nifedipin, metildopa, hipertensi, tekanan darah
Senyawa aktif monoterpenoid dan sesquiterpenoid dari minyak atsiri rimpang suku Zingiberaceae Shifa, Hasna Nur; Marliani, Lia; Suhardiman, Aris
Jurnal Ilmiah Farmasi Vol. 19 No. 2 (2023): Jurnal Ilmiah Farmasi
Publisher : Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/jif.vol19.iss2.art17

Abstract

Background: Plants of the Zingiberaceae family are widely grown and cultivated in Indonesia. One of the uses of these plants by the community is as traditional medicine. The part of the plant that is often used as a traditional medicine in the Zingiberaceae family is the rhizome. The potential of Zingiberaceae as a drug is closely related to its pharmacological activity and the active compounds it contains. Essential oils are materials contained in the Zingiberaceae family and have the potential to be active compounds.Objective: This review article was compiled to study the compounds contained in the essential oil of the Zingiberaceae family and the biological activities of these compounds.Method: Article reviews were conducted using an electronic literature search method through journal portals such as Google Scholar, Science Direct, and Research Gate using keywords, namely identification of the chemical content of essential oils, rhizomes, Zingiberaceae, biological activity, and pharmacological activity.Results: This study found that the main terpenoid compounds in the essential oil from the rhizome of the Zingiberaceae family are α-cineol, β-pinene, β-sesquiphellandrene, and α-Zingiberene. Each of them has a different pharmacological activity, such as antibacterial, antiviral, or cytotoxic.Conclusion: The essential oil from the rhizomes of the Zingiberaceae family has great potential to be developed as a medicinal ingredient with antibacterial, antiviral, and anticancer properties. Before being used as a drug, it is necessary to carry out further research on toxicity, biopharmaceutical, and clinical research.Keywords: Essential oil, rhizome, Zingiberaceae, terpenoid Intisari Latar belakang: Tumbuhan suku Zingiberaceae banyak tumbuh dan dibudidayakan di Indonesia. Salah satu pemanfaatan tumbuhan tersebut oleh masyarakat adalah sebagai obat tradisional. Bagian tumbuhan yang sering dimanfaatkan sebagai obat tradisioal dari suku Zingiberaceae adalah rimpang. Potensi suku Zingiberaceae sebagai obat berhubungan erat dengan aktivitas farmakologi dan senyawa aktif yang dikandungnya. Minyak atsiri merupakan zat yang terkandung dalam suku Zingiberaceae dan berpotensi sebagai senyawa aktif. Tujuan: Review artikel ini disusun untuk mengkaji senyawa yang terkandung pada minyak atsiri rimpang tanaman suku Zingiberaceae dan aktivitas biologi dari senyawa tersebut. Metode: Review artikel dilakukan menggunakan metode pencarian literatur secara elektronik melalui portal jurnal seperti Google Scholar, Science Direct, dan Research Gate dengan menggunakan kata kunci yaitu identifikasi kandungan kimia minyak atsiri, rimpang, Zingiberaceae, aktivitas biologi, aktivitas farmakologi.Hasil: Senyawa terpenoid yang banyak terkandung dalam minyak atsiri rimpang suku Zingiberaceae, yaitu 1,8-cineol, α-pinene, β–pinene, β-sesquiphellandrene dan α-Zingiberene. Masing-masing memiliki aktivitas farmakologi berbeda seperti antibakteri, antivirus, dan sitotoksik.Kesimpulan: Minyak atsiri dari rimpang suku Zingiberaceae berpotensi besar untuk dikembangkan sebagai bahan obat seperti antibakteri, antivirus dan antikanker. Sebelum digunakan sebagai obat ,perlu dilakukan penelitian lebih lanjut mengenai toksisitas, biofarmasetika, dan penelitian secara klinis.Kata kunci: Minyak atsiri; rimpang; Zingiberaceae, terpenoid
Aktivitas Antioksidan Masker Gel Peel-Off dari Fraksi Etil Asetat Daun Salam (Zyzygium polyanthum (Wight.) Walp.) dengan Metode ABTS Lukita, Marie Eksanti; Dhurhania, Crescentiana Emy; Andriani, Disa
Jurnal Ilmiah Farmasi Vol. 20 No. 1 (2024): Jurnal Ilmiah Farmasi
Publisher : Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/jif.vol20.iss1.art1

Abstract

Background: The ethyl acetate fraction of bay leaf contains flavonoids, alkaloids, and tannins. It has the strongest antioxidant activity compared to the n-hexane fraction and aqueous fraction. Antioxidants play a critical role in maintaining skin health, particularly facial skin, by preventing damage from oxidative stress. One of the topical preparations that are considered very practical and effective in facial skin care is a peel-off gel mask.Objective: The aim of the study is to determine the concentration of the ethyl acetate fraction of bay leaf (Zyzygium polyanthum (Wight.) Walp.), which is capable of producing a peel-off gel mask with good physical characteristics and the strongest antioxidant activity.Methods: Extraction was carried out by maceration and fractionation with liquid-liquid partitions to obtain the n-hexane fraction, ethyl acetate fraction, and water fraction. The ethyl acetate fraction of bay leaf was used to make peel-off gel masks with various concentrations of 0.5, 1, and 1.5%, then tested for physical characteristics and antioxidant activity using the ABTS method.Results: All of the peel-off gel mask formula that used different concentrations of bay leaf ethyl acetate fraction met the standards for excellent physical properties, such as organoleptic, pH, spreadability, adhesion, viscosity, folding resistance, and drying time. The peel-off gel mask with a 1.5% bay leaf ethyl acetate fraction exhibited the most effective antioxidant activity, with an IC50 value of 46.6954 ppm, compared to an IC50 value of 17.5809 ppm for quercetin. Conclusion: At a concentration of 1.5%, the ethyl acetate fraction of bay leaf was able to produce a peel-off gel mask with good physical characteristics, accompanied by antioxidant activity in the very strong category.Keywords : Bay leaf, peel-off gel mask, antioxidant IntisariLatar Belakang: Fraksi etil asetat daun salam mengandung senyawa flavonoid, alkaloid, dan tanin, dengan aktivitas antioksidan yang paling kuat daripada fraksi n-heksan dan fraksi airnya. Kandungan antioksidan sangat penting untuk menjaga kesehatan kulit, termasuk kulit wajah, sehingga mampu menghambat terjadinya kerusakan yang disebabkan oleh stres oksidatif. Salah satu sediaan topikal yang dinilai sangat praktis dan efektif dalam perawatan kuit wajah adalah masker gel peel-off. Tujuan: Untuk mengetahui konsentrasi fraksi etil asetat daun salam (Zyzygium polyanthum (Wight.) Walp.) yang mampu menghasilkan masker gel peel-off dengan karakteristik fisik yang baik disertai dengan aktivitas antioksidan yang paling kuat.Metode: Ekstraksi dilakukan secara maserasi, dilanjutkan fraksinasi dengan teknik partisi cair-cair hingga diperoleh fraksi n-heksan, fraksi etil asetat, dan fraksi air. Fraksi etil asetat daun salam digunakan untuk membuat masker gel peel-off dengan variasi konsentrasi 0,5, 1, dan 1,5%, kemudian dilakukan uji karakteristik fisik dan aktivitas antioksidan dengan metode ABTS.Hasil: Seluruh formula masker gel peel-off dengan berbagai variasi konsentrasi fraksi etil asetat daun salam mampu memenuhi persyaratan karakteristik fisik yang baik, meliputi organoleptis, pH, daya sebar, daya lekat, viskositas, ketahanan lipat, dan waktu mengering. Aktivitas antioksidan yang paling efektif diperoleh pada masker gel peel-off dengan fraksi etil asetat daun salam sebesar 1,5% dengan nilai IC50 46,6954 ppm dan kuersetin sebagai pembanding memiliki nilai IC50 17,5809 ppm. Kesimpulan: Fraksi etil asetat daun salam pada konsentrasi 1,5% mampu menghasilkan masker gel peel-off dengan karakteristik fisik yang baik disertai dengan aktivitas antioksidan pada kategori sangat kuat.Kata Kunci : Daun salam, masker gel peel-off, antioksidan
The Perception, Religiosity, Adherence, and Quality of Life of Diabetes Mellitus Patients in Primary Health Center: Persepsi, Religiusitas, kepatuhan dan Kualitas Hidup Pasien Diabetes Mellitus Di Fasilitas Kesehatan Primer Aristia, Bella Fevi; Akrom; Saputri, Ginandjar Zukhruf; Mustofa
Jurnal Ilmiah Farmasi Vol. 20 No. 1 (2024): Jurnal Ilmiah Farmasi
Publisher : Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/jif.vol20.iss1.art10

Abstract

Background: Diabetes mellitus is a chronic disease that can overcome complications and decrease quality of life.Objective: The purpose of this study was to determine the effect of counseling religious nuance and pill box on perception, religiosity, quality of life, and adherence in DM patients who get oral antidiabetic in the outpatient of Jetis 1 Primary Health Center, Bantul Regency.Method: This type of research is quasi-experimental, utilizing a pretest and posttest design with a control group. Recruitment of subjects was done by purposive sampling based on exclusion and inclusion criteria with a simple randomization of allocations in order to obtain a sample of 71 people, divided into control (n = 36) and treatment (n = 35) groups. The instrument to assess the success of counseling is the perception questionnaire (B-IPQ), religiosity, and quality of life (EQ5D-3L) that has been validated, while to measure compliance, it is calculated using the pill count method. Statistical analysis using chi square, t test, independent t-test, Wilcoxon test, and Mann-Whitney test with 95% confidence level.Results: The results showed that the treatment group after being given counseling and pill boxes had a better perception (31.37±6.44) than the control group (34.47±7.16) (p<0,05). The treatment group religiosity score was higher (64.28±3.44) compared to the control group (62.17±4.64) (p<0.05). The adherence value of treatment group (96.28±10.32) is greater than that of the control group (88.37±12.39), p<0.05. The majority of patients are still able to walk, perform self-care independently, and carry out daily activities. The highest mean quality of life score was in the treatment group (0.95±0,08) with a mean VAS (77.40±6.31).Conclusion: Based on the results of this study, it can be concluded that there is an influence of giving counseling religious nuance and pill box, which is marked by an increase in perception, religiosity, quality of life, and adherence.Keywords: Diabetes mellitus, perception, religiosity, adherence, quality of life
PERBANDINGAN EFEKTIVITAS BIAYA TERAPI KOMBINASI OBAT ANTIDIABETIK METFORMIN-GLIMEPIRIDE DAN ACARBOSE-GLIMEPIRIDE Tresnawati, Nden Ajeng; Hany Yusmaini; Mila Citrawati; Erna Harfiani
Jurnal Ilmiah Farmasi Vol. 20 No. 1 (2024): Jurnal Ilmiah Farmasi
Publisher : Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/jif.vol20.iss1.art9

Abstract

Background: Type 2 diabetes mellitus (DM) is one of the cardiometabolic diseases with the highest prevalence worldwide, including Indonesia. The increasing number of type 2 DMs is known to have become an economic burden on Indonesia's health sector. There are several options for treating type 2 DM, either with monotherapy or in combination. At present, metformin, sulfonylurea, and acarbose have become common drugs in the treatment of type 2 DM. Variations in antidiabetic drugs will cause differences in therapy cost and effectiveness.Objective: The purpose of this study is to analyze the cost-effectiveness of the combination therapy of metformin-glimepiride and acarbose-glimepiride antidiabetic drugs in patients with type 2 DM at RSUD Sumedang in 2021 based on the hospital's perspective.Method: This study collected data by documenting medical records and patient costs from January to December 2021 using a cross-sectional design on 60 samples.Results: Findings from the statistical analysis showed that the combination of metformin and glimepiride did not make a difference in GDS (mean difference 10.70 mg/dL-1; p-value = 0.457). The average total direct medical costs of the acarbose-glimepiride group were higher than that of the metformin-glimepiride group, and there was a significant difference between the average costs of the antidiabetic drugs (p-value = 0.000).Conclusion: The combination of metformin-glimepiride therapy is more cost-effective than acarbose-glimepiride, with an ACER value of metformin-glimepiride Rp. 3,037.48.Keywords: Acarbose, cost effectiveness analysis, glimepiride, metformin, type 2 DM Intisari Latar belakang: Diabetes Melitus (DM) tipe 2 merupakan salah satu penyakit kardiometabolik dengan prevalensi tertinggi di seluruh dunia termasuk Indonesia. Peningkatan jumlah DM tipe 2 diketahui telah menjadi beban ekonomi bagi sektor kesehatan di Indonesia. Terdapat beberapa pilihan terapi dalam pengobatan DM tipe 2 baik secara monoterapi maupun kombinasi beberapa obat. Saat ini obat metformin, sulfonilurea, dan acarbose telah menjadi obat umum dalam pengobatan DM tipe 2 di Indonesia. Variasi terapi obat antidiabetik akan menyebabkan adanya perbedaan biaya dan efektivitas terapi. Tujuan: Tujuan penelitian ini untuk menentukan efektivitas biaya terapi kombinasi obat antidiabetik metformin-glimepirid dan acarbose-glimepirid pada pasien DM tipe 2 Instalasi Rawat Jalan di RSUD Sumedang Tahun 2021 berdasarkan perspektif rumah sakit.Metode: Penelitian ini menggunakan desain studi potong-lintang pada 60 sampel dengan pengambilan data dilakukan secara dokumentasi terhadap data rekam medis dan biaya pasien periode Januari-Desember 2021. Hasil: Hasil analisis statistik menunjukkan tidak terdapat perbedaan bermakna selisih GDS pada kombinasi metformin-glimepirid dan acarbose-glimepirid (rata-rata perbedaan 10,70 mg/dL-1; nilai-p=0.457). Rata-rata total biaya langsung medis kelompok acarbose-glimepirid lebih tinggi dibandingkan metformin-glimepirid serta terdapat perbedaan bermakna rata-rata biaya obat antidiabetik (nilai-p=0.000).Kesimpulan: Kombinasi terapi metformin-glimepirid lebih cost-effective dibandingkan acarbose-glimepirid dengan nilai ACER metformin-glimepirid Rp. 3.037,48.Kata Kunci: Acarbose, analisis efektivitas biaya, DM tipe 2, glimepirid, metfotmin
the Antibacterial and antifungi activity of pandan wangi (Pandanus amaryllifolius Roxb)leaf ethanolic extract and its n-heksan and etil acetate fraction Setiyanto, Riyan; Suhesti, Iin; Utami, Annisa Dwi
Jurnal Ilmiah Farmasi Vol. 20 No. 1 (2024): Jurnal Ilmiah Farmasi
Publisher : Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/jif.vol20.iss1.art12

Abstract

Background: Pandanus amaryllifolius Roxb leaves are commonly used as a food additive, green coloring agent, and flavor enhancer. Additionally, these leaves are renowned in herbal medicine for their potential to inhibit cancer cell growth, relieve diarrhea, and act as antioxidants. The leaves contain alkaloids with promising antibacterial and antifungal properties.Objective: This research aimed to evaluate the inhibitory zone activity of leaf extract (ethanol), n-hexane, and ethyl acetate fractions against methicillin-resistant Staphylococcus aureus (MRSA), Escherichia coli, and Candida albicans.Method: The maceration method was used for extraction, employing a 70% ethanol solution as the solvent. The ethanol extract was then fractionated using n-hexane and ethyl acetate. The Kirby-Bauer disc diffusion method was applied to assess the antibacterial and antifungal activity of the extracts and fractions. The diameter of the inhibition zones was measured and analyzed statistically.Result: The ethanol extract demonstrated the strongest antibacterial activity against MRSA compared to the n-hexane fraction and the ethyl acetate fraction. None of the concentration variations significantly inhibited the growth of Escherichia coli and Candida albicans.Conclusion: The ethanolic extract of Pandanus amaryllifolius Roxb leaves shows potential as an antibacterial agent against methicillin-resistant Staphylococcus aureus.Keywords: Pandanus amaryllifolius Roxb., 70% ethanol extract, fractionation, disc diffusion method, MRSA IntisariLatar belakang: Daun Pandanus amaryllifolius Roxb umumnya digunakan sebagai komponen tambahan makanan zat pewarna hijau dan penambah rasa. Daun ini telah dikenal luas sebagai obat herbal yang mempunyai potensi menghambat pertumbuhan sel kanker, meringankan diare, berkhasiat sebagai antioksidan. Kandungan daunnya mengandung alkaloid yang berpotensi menunjukkan efek antibakteri dan antijamur. Tujuan: Penelitian ini untuk mengukur aktivitas zona hambat dari ekstrak daun (etanol), fraksi n-heksan dan etil asetat terhadap Staphylococcus aureus resisten methicillin, Escherichia coli, dan Candida albicans. Metode: Metode maserasi digunakan untuk mengekstraksi. Pelarut yang digunakan adalah larutan yang terdiri dari 70% etanol. Ekstrak etanol dilakukan fraksinasi n-heksan dan etil asetat. Metode difusi cakram Kirby-Bauer digunakan uji aktivitas diagnostik antibakteri dan antijamur. Diameter zona hambat kemudian diukur dan dilakukan analisis statistik. Hasil: Ekstrak daun (etanol) memperlihatkan daya antibakteri yang paling kuat terhadap MRSA dibandingkan fraksi n-heksana dan fraksi etil asetat. Variasi konsentrasi secara substansial mengurangi pertumbuhan Escherichia coli dan Candida albicans.Kesimpulan: Ekstrak daun Pandanus amaryllifolius Roxb yang dilarutkan dalam pelarut etanol 70% memiliki potensi antibakteri untuk Staphylococcus aureus yang resisten terhadap methicillin. Kata kunci: Pandanus amaryllifolius Roxb, ekstrak etanol 70%, fraksinasi, metode difusi cakram, MRSA  
UJI AKTIVITAS ANTIOKSIDAN FRAKSI ETIL ASETAT BIJI KESUMBA, FRAKSI ETIL ASETAT KUNYIT, DAN KOMBINASINYA Asniati, Asniati; Rahmalia, Winda; Sayekti, Endah
Jurnal Ilmiah Farmasi Vol. 20 No. 1 (2024): Jurnal Ilmiah Farmasi
Publisher : Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/jif.vol20.iss1.art2

Abstract

Background: Antioxidants are compounds that can neutralize free radicals, so they can prevent degenerative diseases such as cardiovascular disease, carcinogenesis, and other diseases. Natural ingredients such as kesumba (Bixa orellana L.) seeds and turmeric (Curcuma longa L.) contain natural pigments that have antioxidant activity. Kesumba seeds contain bixin, and turmeric contains curcumin, each of which is an antioxidant compound that can protect cells in the body and prevent oxidative stress due to free radicals.Objective: To determine the effect of the combination ratio of the ethyl acetate fraction of kesumba seeds and the ethyl acetate fraction of turmeric on antioxidant activity.Method: Extraction was carried out by the maceration method, followed by fractionation. A qualitative test of the content of compounds in each extract and fraction of kesumba seeds and turmeric was carried out using the TLC method. The antioxidant activity test of each ethyl acetate fraction of kesumba seeds (FB) and ethyl acetate fraction of turmeric (FK) and their combination was carried out using the DPPH method.Result: The research showed that the antioxidant activity of the ethyl acetate fraction of kesumba seeds (FB) to the ethyl acetate fraction of turmeric (FK) was 242.95, 65.78, 42.48, 108.81, and 51.46 mg/L for each of the mass ratios (1:0), (3:7), (1:1), (7:3), and (0:1). The combination ratio of FB:FK, which is 1:1, has an effect on increasing antioxidant activity. This combination provides a synergistic effect that can increase antioxidant activity, with an IC50 value of 42.48 mg/L.Conclusion: Based on the results of the study, it can be concluded that the combination of the ethyl acetate fraction of kesumba seeds (FB) and the ethyl acetate fraction of turmeric (FK) has an effect on increasing antioxidant activity in the ratio of FB:FK (1:1) with an IC50 value of 42.48 mg/L, which is included in the very strong antioxidant category.Keywords: Kesumba seeds, turmeric, bixin, curcumin, antioxidant Intisari Latar belakang: Antioksidan adalah senyawa yang dapat menetralisir radikal bebas sehingga mampu mencegah penyakit-penyakit degeneratif seperti kardiovaskuler, karsinogenesis dan penyakit lainnya. Bahan alam seperti biji kesumba (Bixa orellana L.) dan kunyit (Curcuma longa L.) mengandung pigmen alami yang memiliki aktivitas antioksidan. Biji kesumba mengandung bixin dan kunyit mengandung kurkumin yang masing-masing merupakan senyawa antioksidan sehingga mampu melindungi sel-sel dalam tubuh dan mencegah stress oksidatif yang diakibatkan oleh radikal bebas. Tujuan: Untuk mengetahui pengaruh rasio kombinasi fraksi etil asetat biji kesumba dan fraksi etil asetat kunyit terhadap aktivitas antioksidan.Metode: Ekstraksi menggunakan metode maserasi dan dilanjutkan dengan fraksinasi. Uji kualitatif kandungan senyawa dalam masing-masing ekstrak dan fraksi bixin dan kurkumin dilakukan menggunakan metode kromatografi lapis tipis (KLT). Uji aktivitas antioksidan masing-masing fraksi etil asetat biji kesumba dan fraksi etil asetat kunyit serta kombinasinya dilakukan menggunakan metode DPPH.Hasil: Hasil penelitian menunjukkan bahwa tiap kombinasi rasio massa fraksi etil asetat biji kesumba (FB); fraksi etil asetat kunyit (1:0), (3:7), (1:1), (7:3) dan (0:1) memiliki aktivitas antioksidan berturut-turut sebesar 242,95; 65,78; 42,48; 108,81; dan 51,46 mg/L. Kombinasi tersebut memberikan efek sinergis yang dapat meningkatkan aktivitas antioksidan dengan nilai IC50 sebesar 42,48 mg/L. Kesimpulan: Berdasarkan hasil penelitian dapat disimpulkan bahwa pada kombinasi fraksi etil asetat biji kesumba (FB) dan fraksi etil asetat kunyit (FK) dengan rasio FB:FK (1:1) memberikan pengaruh pada peningkatan aktivitas antioksidan dengan nilai IC50 sebesar 42,48 mg/L yang termasuk dalam kategori antioksidan sangat kuat.Kata kunci: Biji kesumba, kunyit, bixin, kurkumin, antioksidan
Peningkatan Pengetahuan dan Sikap Remaja melalui Edukasi Bahan Berbahaya dalam Kosmetika di Kalimanggis Morangan Sleman Purwanto, Purwanto; Munawaroh, Umu Azizah; Aini, Rahma Nur; Burhan, Amelia Handayani; Irianto, Iramie Duma Kencana
Jurnal Ilmiah Farmasi Vol. 20 No. 1 (2024): Jurnal Ilmiah Farmasi
Publisher : Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/jif.vol20.iss1.art11

Abstract

Background: From October to August 2022, BPOM Yogyakarta discovered cosmetic products containing hazardous ingredients, including clindamycin, mercury, betamethasone-17-valerate, clobetasol propionate, o-aminophenol, hydroquinone, arsenic, and retinoic acid. These harmful ingredients are found in cosmetic preparations such as face cream, lipstick, eyebrow pencil, foundation, nail color, masks, soap, lip balm, and eyeshadow. Objective: This study aims to improve the knowledge and attitude of adolescents through education. Method: This type of research is pre-experimental, with a one-group pretest-posttest design. Respondents were adolescents at Kalimanggis Morangan Hamlet who were given educational treatment in the form of direct counseling about hazardous ingredients in cosmetics. The instrument used is a questionnaire that has passed validation and reliability tests.Results: The majority of respondents were in their teens (79.41%) with a high school/vocational school education level (52.94%) and, on average, had not worked (79.42%). A total of 89% of adolescents received their first education during this study, so the material provided was something new to them. Respondents' attitudes and knowledge increased after the counseling was carried out.Conclusion: Direct counseling on hazardous ingredients in cosmetics significantly improved adolescents’s knowledge. However, the education that was given only once did not significantly affect the attitude of adolescents. Keywords: Attitude, harmful cosmetics, knowledge, Sleman IntisariLatar belakang: Dalam bulan Oktober hingga Agustus 2022, BPOM Yogyakarta masih menemukan produk kosmetika yang mengandung bahan berbahaya dalam kosmetika. Bahan berbahaya tersebut diantaranya klindamisin, merkuri, betametason-17-valerate, klobetasol propionat, o-aminofenol, hidrokinon, arsen dan asam retinoat. Bahan berbahaya tersebut terdapat pada sediaan kosmetika berupa krim wajah, lipstick, pensil alis, foundation, pewarna kuku, masker, sabun, lipbalm dan eyeshadow.Tujuan: Penelitian ini bertujuan untuk meningkatkan pengetahuan dan sikap remaja melalui edukasi.Metode: Jenis penelitian ini adalah pre eksperimental dengan rancangan one group pretest posttest design. Responden adalah remaja Dusun Kalimanggis Morangan yang diberi perlakukan edukasi berupa penyuluhan langsung tentang bahan berbahaya dalam kosmetika. Instrumen yang digunakan adalah kuesioner yang telah lolos uji validasi dan realibilitas.Hasil: Mayoritas responden berusia belasan tahun (79,41%) dengan tingkat pendidikan SMA/SMK (52,94%) dan rata-rata belum bekerja (79,42%). Sebanyak 87% remaja mendapatkan edukasi pertama saat penelitian ini sehingga materi yang diberikan merupakan sesuatu yang baru diketahui. Sikap dan pengetahuan responden meningkat setelah dilakukannya penyuluhan.Kesimpulan: Penyuluhan langsung tentang bahan berbahaya dalam kosmetika secara signifikan mampu meningkatkan pengetahuan remaja. Namun edukasi yang diberikan hanya satu waktu tersebut tidak berpengaruh secara signifikan terhadap sikap remaja. Kata kunci: Kosmetika berbahaya, pengetahuan, sikap, Sleman
Pharmacological and molecular mechanism of Syzygium polyanthum leaves as antihypertensive with network pharmacology approach Tirtanirmala, Prisnu; Mun'im, Abdul; Firdayani
Jurnal Ilmiah Farmasi Vol. 20 No. 1 (2024): Jurnal Ilmiah Farmasi
Publisher : Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/jif.vol20.iss1.art5

Abstract

Background: In Central Sulawesi, Indonesia, Syzygium polyanthum leaves (SPL) have been traditionally used by society to reduce high blood pressure. However, the molecular mechanism behind this effect still remains unclear.Objective: This study aims to explore the antihypertensive molecular mechanisms of SPL using a network pharmacology approach.Method: Previous studies have investigated some bioactive compounds contained in SPL. Those studies identified 57 bioactive compounds, of which 31 were filtered for further analysis. Target proteins from SPL and disease were identified using GeneCards. Then, 62 selected target proteins which overlapped through Venn diagrams would be analyzed using Cytoscape software to produce compounds-target proteins’ network. Protein-protein interactions were assessed using STRING and visualized by Cytoscape. GO Function and KEGG Pathways were obtained using ShinyGo.Results: The results of this study revealed pathways associated with hypertension through the cellular senescence pathway with target proteins mTOR, ERK (also known as MAPK), p53, CycD, and IL6. The chemical constituents associated with these target proteins are hydroxychavicol, farnesol, naphthalene, phloretin, pyrogallol, and decanal, which were identified as compounds closely related to the target protein of hypertension.Conclusion: The bioactive compounds in SPL play a significant role in regulating hypertension by influencing various target genes, particularly those associated with cellular senescence. Keywords: Antihypertensive, bay leaf, cellular senescence, network pharmacology, Syzygium polyanthum

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