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Althea Medical Journal
Published by Universitas Padjadjaran
ISSN : -     EISSN : 23374330     DOI : 10.15850/amj
Core Subject : Health,
Medicine & Pharmacology
Althea Medical Journal (AMJ) is a peer reviewed electronic scientific publication journal which is published every 3 months (March, June, September, and December). Althea Medical Journal publishes articles related to research in biomedical sciences, clinical medicine, family-community medicine, and public health.
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Articles 11 Documents
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Search results for , issue "Vol 10, No 3 (2023)" : 11 Documents clear
Penile Length of Prepubertal Children in Surabaya Susiana, Okta Margarita; Yuliawati, Tri Hartini; Purwanto, Bambang; Rezano, Andri; I’tishom, Reny
Althea Medical Journal Vol 10, No 3 (2023)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15850/amj.v10n3.3094

Abstract

Background: Early recognition of phallic size abnormalities is essential to identify underlying endocrine and genetic disorders. Parents are concerned regarding their son’s penis length, especially obese and short-stature boys. This study aimed to investigate the factors of penile length in prepubertal boys aged 9-11 in Surabaya.Methods: A cross-sectional analytic observational study was conducted between October and November 2021 during the community services program of the Andrology Study Program, Universitas Airlangga. One hundred forty-eight healthy boys aged 9-11 years were enrolled in this study. Penile parameters and anthropometric measures were recorded. Data were analyzed with Spearman Rho’s formula to correlate the variables studied.Results: The average penile lengths and penile circumference of the penis were 6.3±1.4 and 5.2±1.0 cm, respectively. This study found two boys with micropenis (1.35%) with normal and overweight body mass index (BMI). The penile length was positively correlated with height but not with BMI.Conclusion: Androgen and growth hormones significantly influence penile length. Children with abnormal BMI tend to have smaller penile sizes, associated with increasing androgen aromatization.
Relationship between Knowledge, Attitude and Practice of the Use of Face Mask with Acne among Health Workers at General Hospitals in Mataram City, West Nusa Tenggara, Indonesia Rifdayani, Dinda; Hidajat, Dedianto; Istikharoh, Umu
Althea Medical Journal Vol 10, No 3 (2023)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15850/amj.v10n3.2918

Abstract

Background: The World Health Organization (WHO) has declared the coronavirus a global emergency transmitted by droplets. Personal protective equipment (PPE) such as masks can help lower the  viral infection risk. However, prolonged use of PPE can cause skin lesions and aggravate acne. Acne that develops because of the usage of masks is called mask acne (maskne). Knowledge, attitudes, and practices of health workers regarding the use of face masks can help minimize the occurrence of maskne. This study aimed to assess the relationship between knowledge, attitude ,and practices of the use of face masks with  mask acne among health workers in general hospitals in Mataram City, Indonesia.Methods: This study was a cross-sectional analytic observational study involving health workers from type b and c general hospitals in the city of Mataram, specifically the West Nusa Tenggara Provincial Hospital and the Mataram University Hospital. Primary data were collected using a questionnaire consisting of demographic characteristics, knowledge, attitude, and practice of using masks, then analyzed using Lambda test.Results: In total, 104 respondents were included, of whom 39.4% (n=41) had good knowledge, 35.6% (n=37) had a good attitude towards the use of masks, and 25.0% (n=26) had good practice. Interestingly, 42.3% (n=44) had experienced maskne. Lambda test showed that a relationship between knowledge, attitude, and practices towards the usage of masks and the incidence of maskne (p = 0.014; p = 0.000; p = 0.006).Conclusion: There is a relationship between knowledge, attitudes, and practice of health workers regarding the usage of masks with the prevalence of mask acne at the general hospitals type b and c in the Mataram City. This study implies  is that health workers can prevent the occurrence of mask acne, which can make the work of health workers more difficult.
Diagnostic Value of Coproantigen for Detection of Giardia Infection in Stunted Children Octoviani, Fanny Anggraeni; Kurniawan, Agnes; Sari, Ika Puspa; Fauziah, Nisa; Faridah, Lia; Adrizain, Riyadi
Althea Medical Journal Vol 10, No 3 (2023)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15850/amj.v10n3.2860

Abstract

Background: Giardiasis is a protozoa infection caused by Giardia intestinalis, which commonly infects children, impairing children’s growth, development, and cognitive function. Standard diagnosis is carried out by microscopic examination of stool. This study aimed to evaluate coproantigen examination in stunted children compared to microscopic examination.Methods: A cross-sectional study was performed on stools collected from a survey among stunted children in Bandung in 2019. Stools were preserved in 10% formaldehyde and kept at -20oC until used. Direct microscopy examination with 2% lugol solution and coproantigen ELISA test using Giardia Cryptosporidium (combo test) coproantigen test kit were performed in Parasitology Laboratory Faculty of Medicine, Universitas Indonesia.Result: A total of 99 stools originated from stunted children aged 2-6 years. with boys predominant (52.5%). Microscopic examination showed that 12.1% (12/99) of the children were harboring intestinal parasites, such as the protozoa Giardia intestinalis, Blastocystis spp, and Entamoeba coli (E. coli). Giardia was the primary infection (9.1%), of which single Giardia infection (n = 8) and mixed infection of Giardia and Blastocystis spp (n = 1).  Interestingly, coproantigen examination resulted in 6 positive samples, and 4 samples agreed with the microscopy result. With a sensitivity of 44.4% and a specificity of 97.7%. The positive and negative predictive values were 66.7% and 94.7%, respectively.Conclusion: A moderate prevalence of Giardia in stunted children in Bandung regency has been observed. The combo coproantigen test method has high specificity and is suitable for use as a confirmation test to exclude Giardia infection.
Presence of Multidrug Resistance (MDR) Escherichia coli in the Citarum River located in Greater Bandung Area, Indonesia Megantara, Imam; Muhtado, Azmi Raffi; Pradini, Gita Widya; Goenawan, Hanna; Sylviana, Nova
Althea Medical Journal Vol 10, No 3 (2023)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15850/amj.v10n3.2765

Abstract

Background: One of the main problems of the Citarum River is the contamination of E. coli due to livestock activities, washing toilets, and industry. In addition, irrational use of antibiotics in the community and livestock can increase E. coli resistant strains to antibiotics. This study aimed to identify the presence of multidrug resistance (MDR) and extended-spectrum β-lactamase (ESBL) E. coli strains in Citarum river clusters, namely industrial, livestock, and residential clusters.Methods: This was a descriptive study. A sample of 100 mL surface water from each Citarum cluster. Culture, antibiotic sensitivity test, and PCR to identify blaCTX-M-15 gene carriers of ESBL E. coli were carried out in the sample.Results: There were 37 isolates of E. coli, with 24% of these isolates showing MDR properties, which can be found in industrial, livestock, and residential clusters at 13%, 8%, and 3% respectively. The most E. coli-resistant antibiotics found in these samples were ampicillin (45%), followed by tetracycline (37%), and azithromycin (29%). The PCR examination did not find the blaCTX-M-15 gene carrying ESBL properties in all three Citarum river clusters.Conclusion: The presence of E. coli isolates in each Citarum river cluster suggests the occurrence of river pollution due to animal, human or industrial waste.  Therefore, it is necessary to make better government regulations regarding sanitation and education for the surrounding community regarding the importance of keeping the river clean.
Pregnant Human Myometrial 1-41 Cell Viability Test on Vitamin D Administration Aziz, Muhammad Alamsyah; Krisnadi, Sofie Rifayani; Handono, Budi; Setiabudiawan, Budi
Althea Medical Journal Vol 10, No 3 (2023)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15850/amj.v10n3.2750

Abstract

Background: Preterm labor is one of the universal causes of perinatal mortality worldwide. One of the causes of preterm labor is uterine muscle integrity problems. Some mechanistic studies show insight into vitamin D activity’s possible role in the injured muscle. This study aimed to determine whether vitamin D can increase muscle cell viability.Methods: This experimental research used human smooth muscle uterine myometrium cell line pregnant human myometrial (PHM) 1-41. The cells were cultured for 24 hours in hypoxia condition, then incubated with several doses of vitamin D. The PHM1-41 cell viability was measured using spectrophotometry. Data analysis was conducted using IBM SPSS 24.0. A p-value <0.05 was considered statistically significant. Results: The result showed that the minimum level of muscle cell viability after vitamin D incubation was with 300 nM administration, and the maximum level was after 10nM (88.57%+4.48 and 96.21%+2.13 respectively).Conclusions: Vitamin D at a specific dose can improve cell availability. The optimal dose to improve cell viability is 10 nM. 
Thawing Time Difference between Fresh Frozen Plasma Using Ziplock Plastic and non-Ziplock Plastic in Blood Transfusion Unit Dr. Hasan Sadikin General Hospital Bandung, Indonesia Rinanty, Rima; Lismayanti, Leni; Harahap, Raja Iqbal Mulya
Althea Medical Journal Vol 10, No 3 (2023)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15850/amj.v10n3.2795

Abstract

Background: The quality of fresh frozen plasma (FFP) in a clinical setting depends on thawing time. Thawing using a water bath is often used in blood transfusion units because it is easy to perform, affordable, and easy to look for. Protective plastics (Ziplock and non-Ziplock) are used to reduce the risk of contamination,. This study aimed to determine whether there is a difference in thawing time between FFP using Ziplock plastic and non-Ziplock plastic.Method: This experimental design was conducted in the Blood Bank Unit of Hasan Sadikin Hospital from June-August 2021. Samples were divided into two groups, namely thawing using Ziplock and non-Ziplock. Each group consisted of volume 160-200 ml and 201-240 ml.Results: The total samples were 24 FFP bags. In the group of the bag 160-200 ml, the median thawing time using Ziplock plastic was 8 minutes (8-16 minutes), non-Ziplock was 15 minutes (8-16 minutes) (p value 0,111), whereas in a group of bags with volume 201-240 ml, the median thawing time using Ziplock was 15 minutes (8-28 minutes), non-Ziplock was 20 minutes (14-30 minutes) (p- value 0,332). Although there was a time difference in both groups, the difference was non-significant.Conclusion: The thawing time between the small bag with a volume of 160-200 ml and the larger volume of 201-240 ml shows no difference. Ziplock plastic can be used to reduce the risk of contamination.
Prognostic Nutritional Index and Systemic Immune-inflammation Index: Possible New Parameters for COVID-19 Severity Suyoso, Suyoso; Oehadian, Amaylia; Khotijah, Alfreda Amelia; Marthoenis, Marthoenis
Althea Medical Journal Vol 10, No 3 (2023)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15850/amj.v10n3.3061

Abstract

Background: The prognostic nutritional index (PNI) parameter has been widely used in estimating the severity of COVID-19. In contrast, investigating the role of the systemic immune-inflammation index (SII) in determining the COVID-19 severity is prospective. This study aimed to investigate the potential of PNI and SII parameters to distinguish the severity of symptoms of COVID-19.Methods: A retrospective observational study was conducted among 209 hospitalized patients with COVID-19. Data were collected from August 2021 to February 2022 in Indonesia’s general COVID-19 referral hospital. Demographic and laboratory data, including PNI and SII, were analyzed and compared between the severe and non-severe symptoms of COVID-19 patients. The statistical analysis of the receiver operating characteristic curve (ROC) and area under curve (AUC) was conducted to predict the potential of these parameters in distinguishing the COVID-19 severity. Results: More than half of this study’s patients (54.55%) were non-severe COVID-19. The SII values in patients with severe symptoms were significantly higher than in those with non-severe symptoms (2,445.24 vs. 1,423.28, p=0.005). In contrast, the PNI value in patients with severe COVID-19 symptoms was significantly lower than those with non-severe symptoms (38.04 vs. 33.93, p<0.001). The area under the curve (AUC) value of PNI was 0.694, meanwhile the SII was 0.635. The optimum cut-off for the PNI was <35.407, whereas the SII was >2,212.787. PNI and SII were the potential new diagnostic parameters for COVID-19 severity.Conclusion: PNI and SII parameters can potentially distinguish the severity of symptoms of COVID-19.
Knowledge, Attitude, and Practice Towards Thalassemia Prevention among College Students in Universitas Padjadjaran, Bandung, Indonesia Kusumadewi, Ratu Istihajar; Tansah, Haryono; Widjadjakusumah, Anggraini
Althea Medical Journal Vol 10, No 3 (2023)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Background: Thalassemia is the most common hereditary anemia disease. Sixty thousand thalassemia major patients are born each year and require continuous blood transfusion to survive, meanwhile 12% die in the perinatal period due to anaemic conditions. Specifically in Indonesia, 10% of the societies are deemed to be carriers, but the studies on thalassemia prevention are still limited.. This study aimed to explore the correlations between knowledge, attitude, and practice (KAP) of college students toward thalassemia prevention.Methods: This study was a cross-sectional analytic study conducted in September−October 2015. A total of 536 respondents from various faculties in Universitas Padjadjaran were gathered based on purposive sampling. The data obtained from validated questionnaires were analyzed by Spearman’s Rank correlation test.Results: The correlation between knowledge and attitude was weak, but the p-value was significant (rs= +0.388, ρ= 0.041). Yet, there was no correlation between knowledge and practice (rs= +0.280, ρ= 0.063), nor between attitude and practice (rs = +0.012, ρ= 0.786).Conclusions: Knowledge positively affects college students’ attitude to thalassemia prevention; however, it does not have the same effect on its practice. It is consistent with the attitude, which also does not correlate with the practice of college students toward thalassemia prevention. Therefore, other affirmative actions or direct interventions and programs are still needed to maximize  thalassemia prevention. 
Garcinia Mangostana Pericarp Extract Protection on Reproductive Function of Obese-Diabetic Rats Model Nindita, Yora; Karlowee, Vega; Kesumayadi, Irfan; Istiadi, Hermawan; Muniroh, Muflihatul
Althea Medical Journal Vol 10, No 3 (2023)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15850/amj.v10n3.2905

Abstract

Background: Type 2 diabetes mellitus (T2DM) in obese has been considered a risk factor for male infertility. Garcinia mangostana pericarp extract (GMPE) is known to have anti-hyperglycemic, anti-diabetic, and anti-inflammatory effects. This study aimed to evaluate the effect of GMPE therapy on reproductive function in obese T2DM rats by examining testosterone level, testicular histopathological features, and hs-CRP level.Methods: Thirty-six male Wistar rats, aged 2–3 months, were randomly divided into 6 groups and treated with a standard diet (NC), high-fat diet (HFD) with GMPE 200 mg/kgBW (obese GMPE control/OGC200), HFD with 45 mg/kgBW STZ-NA (obese-diabetic control/ODC), obese-diabetic rats with GMPE 100 (DG100); 200 (DG200); and 400 mg/kgBW (DG400). STZ-NA was administered after 8 weeks of HFD treatment and followed by GMPE for 8 weeks after T2DM was confirmed. The level of hs-CRP and testosterone were measured in the serum using an enzyme-linked immunosorbent assay. Testicular histopathological examination was measured after 8 weeks of treatment by using Modified Jonhson Score (MJS) with HE staining. Results: ODC rats significantly showed increased hs-CRP level compared to NC (8.76±0.27 vs 0.30±0.07 ng/mL, p<0.001) and reduced testosterone level and MJS compared to NC (73.69±2.22 vs 170.14±1.34 ng/dL, 4.57±0.93 vs 9.87±0.16 MJS, respectively, P<0.001). Testosterone and hs-CRP levels showed a negative and significant correlation (r=-0.974 and p<0.001). On the treatment group, GMPE significantly reduced hs-CRP and increased testosterone levels in a dose-dependent manner.Conclusion: GMPE effectively protects reproductive function in obese DM rats by increasing testosterone levels and advanced spermatogenesis, as well as decreasing hs-CRP level
Knowledge, Attitudes, and Behavior of E-Cigarette Users in Indonesia Masan, Gracekeren Evalasdhy; Raksanagara, Ardini S.; Rinawam, Fedri Ruluwedrata
Althea Medical Journal Vol 10, No 3 (2023)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15850/amj.v10n3.2731

Abstract

Background: Cigarettes, both traditional and electronic, are widely used. In 2018, 9.1% of Indonesians smoked, up from 8.8% in 2016. In several countries, including Indonesia, e-cigarette use has increased. As a result, regulations to minimize the use of e-cigarettes must be implemented. This study aimed to explore the knowledge, attitudes, and behaviors of e-cigarette users in the Indonesian vaper community.Methods: This study was a quantitative study with a cross-sectional method conducted from September to December 2021. Questionnaires were distributed through social media to 42 randomly selected vaper communities. The minimum sample size was 247 respondents. The analysis used was univariate. Results: Of the 247 respondents, most were aged 17–24 years (78%), mostly male (62.7%), 61.5% were high school graduates or equivalent, and 65.2% had a monthly income of less than 3 million rupiah. A total of 53.1% of respondents had good knowledge scores, and 52.6% had a positive attitude toward e-cigarettes. More than half of the respondents were long-time e-cigarette users (57.9%) and dual users (55.9%). E-cigarettes were used irregularly/occasionally (63.6%). The average number of puffs/days was 50–99 puffs/day. As many as 58.7% of respondents wanted to quit smoking.Conclusions: Slightly more than half of the respondents has good knowledge about e-cigarettes, with a positive attitude towards the use of e-cigarettes. Campaign that e-cigarettes are not a substitute for regular cigarettes and awareness regarding the potential dangers of e-cigarettes need to be increased. Government regulations regarding the control of e-cigarettes need to be considered because underage children are already using them. 

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