Articles
334 Documents
<![CDATA[Perbedaan Pemberian Asam Valproat dan Fenobarbital terhadap Kadar Kalsium Darah Pasien Epilepsi Anak di RSUD Dr. Moewardi ]]>
<![CDATA[Kusumaningtyas, Friska]]>;
<![CDATA[Tia Nur, Fadhilah]]>;
<![CDATA[Ratna Budiani, Dyah]]>
<![CDATA[ Nexus Kedokteran Klinik Vol 2, No 3 (2013): Nexus Kedokteran Klinik ]]>
Publisher : <![CDATA[Fakultas Kedokteran Universitas Sebelas Maret Surakarta ]]>
Show Abstract
|
Download Original
|
Original Source
|
Check in Google Scholar
|
Full PDF (14.046 KB)
<![CDATA[Background : Antiepileptic drugs have different mechanisms. Meanwhile valproate acid and phenobarbital have similar mechanism, inactivation of voltage gated Ca2+ channels, Na+ channels, and increased activity of GABAergic inhibitory. However, the mechanism of phenobarbital also induces cytochrome P450 (CYP450) enzymes that affect the metabolism of vitamin D. The aim of this study was to examine the differences between valproic acid and phenobarbital on blood calcium levels of pediatric epilepsy. Methods : The cross sectional study was conducted by 24 pediatric epilepsy in the pediatric neurology clinic of RSUD Dr. Moewardi who met the inclusion criteria. Calcium ion levels in blood serum obtained from the medical records of pediatric patients who had been done routine laboratory tests about the side effects of antiepileptic drugs. Data normality was tested by Shapiro-Wilk. The differences of giving valproic acid and phenobarbital on calcium ion level of blood serum were analyzed by the Mann-Whitney test. The correlation between long term drug use and calcium ion levels in blood serum were analyzed by Spearman test. Results : The analysis results show that there is no difference between calcium ion levels in blood serum of valproic acid and phenobarbital of pediatric epilepsy in RSUD Dr. Moewardi with p = 0.881 (p > 0.05). Correlation analyze show that there is no correlation between duration of drug intake and calcium ion levels in blood serum levels with p = 0.191 (p > 0.05), 35.7% of subjects had a negative correlation for valproic acid and p = 0.548 (p > 0.05), 23.2% of subjects had a negative correlation for phenobarbital. Conclusion : There is no significant difference between calcium ion levels in blood serum of valproic acid and phenobarbital in pediatric epilepsy in RSUD Dr. Moewardi. As well as, there is a weak correlation between duration of drug intake and calcium ion in blood serum. Keywords : epilepsy, antiepileptic drug, valproic acid, phenobarbital, calcium ion ]]>
<![CDATA[Hubungan antara Kadar Feritin dengan Kreatinin Serum pada Pasien Thalassemia di RSUD Dr. Moewardi ]]>
<![CDATA[Utami, Eko Dewi Ratna]]>;
<![CDATA[Salimo, Harsono]]>;
<![CDATA[Budiani, Dyah Ratna]]>
<![CDATA[ Nexus Kedokteran Klinik Vol 2, No 3 (2013): Nexus Kedokteran Klinik ]]>
Publisher : <![CDATA[Fakultas Kedokteran Universitas Sebelas Maret Surakarta ]]>
Show Abstract
|
Download Original
|
Original Source
|
Check in Google Scholar
|
Full PDF (14.046 KB)
<![CDATA[Background : Patients with thalassemia that underwent routine blood transfusion are developing iron overload. In the state of excess iron, ferritin levels increase. When iron storage capacity has been depleted, free iron will cause tissue damage. One of that damaged organ is kidney. One of parameter used to know the function of kidney is GFR (Glomerular Filtration Rate). A simple way to estimate GFR is serum creatinine. Increased 1-2 mg/dL of creatinine serum showed decrease ±50% of GFR. This research was aimed to determine the correlation between ferritin levels and serum creatinine of patients with thalassemia. Methods : A cross-sectional study which the subjects were 30 patients with thalassemia in the pediatric ward RSUD Dr. Moewardi who met the inclusion criteria. Ferritin levels and serum creatinine obtained from medical records or patient report book. Data normality was tested with Shapiro-Wilk normality test. Correlation between ferritin levels and serum creatinine were analyzed with non-parametric correlation test Spearman using Statistical Product and Service Solutions (SPSS) 20.0 for Windows. Results : Ferritin levels ranged from 1004.2 to 9600 ng/mL. Creatinine serum were 0.2 mg/dL; 0.3 mg/dL; 0.4 mg/dL; 0.5 mg/dL with almost equal distribution. Results of the analysis with non-parametric correlation test Spearman obtained R = 0.044 and p = 0.816. Conclusion : There was no correlation between ferritin levels and serum creatinine of patients with thalassemia. Keywords : thalassemia, ferritin, creatinine]]>
<![CDATA[Hubungan Pernikahan Usia Dini dengan Kejadian Kanker Serviks di RSUD Dr. Moewardi ]]>
<![CDATA[Gayatri, Anindita Ratna]]>;
<![CDATA[Angelia, Affi]]>;
<![CDATA[Primadewi, Novi]]>
<![CDATA[ Nexus Kedokteran Klinik Vol 2, No 3 (2013): Nexus Kedokteran Klinik ]]>
Publisher : <![CDATA[Fakultas Kedokteran Universitas Sebelas Maret Surakarta ]]>
Show Abstract
|
Download Original
|
Original Source
|
Check in Google Scholar
|
Full PDF (14.046 KB)
<![CDATA[Background:Every year the incidence of cervical cancer is increase and the risk of death from cervical cancer is also increased. One of the risk factor of cervical cancer is a history of early marriage. In Indonesia,there are many womenwho married in early age. The purpose of this study is to detemine whether early marriage may increase the risk of cervical cancer. Methods:This research is a case control based study. The sample consist of 30 cervical cancer patients and 30 normal women with total sample of 60 women. The data was collected from medical record and validated questionnaire. The data was analyzed with multiple logistic regression analysis. Results:There is a statistically significant relationship between early marriage and the incidence of cervical cancer. Women who had history of early marriage have risk to get cervical cancer 8,4 times bigger than women who didnât have history of early marriage (p = 0.002; OR = 8,442). Conclusions:Based on this research women who had history of early marriage have risk to get cervical cancer 8,4 times bigger than women who didnât have history of early marriage. Keywords:Early marriage, cervical cancer.]]>
<![CDATA[Kehamilan pada Usia Remaja Sebagai Faktor Risiko Terjadinya Ketuban Pecah Dini ]]>
<![CDATA[Prasetyo, Kevin Wahyudy]]>;
<![CDATA[Angelia, Affi]]>;
<![CDATA[Primadewi, Novi]]>
<![CDATA[ Nexus Kedokteran Klinik Vol 2, No 3 (2013): Nexus Kedokteran Klinik ]]>
Publisher : <![CDATA[Fakultas Kedokteran Universitas Sebelas Maret Surakarta ]]>
Show Abstract
|
Download Original
|
Original Source
|
Check in Google Scholar
|
Full PDF (14.046 KB)
<![CDATA[Background: Premature Rupture of Membranes (PROM) is a complication that happens in 10% of pregnancy and it increases the risk of fetal death. Teenagers who get pregnant have risk for having PROM. This condition is related to nutrition factor that changes the immunity of mother. The goal of this research is to acknowledge teenage pregnancy as risk factor of PROM. Methods: This research is a case control based study. The sample used by researcher is term pregnant women with and without PROM complication with a total sample of 30 people. The data is collected from medical record and questionnaire. The data, afterwards, analyzed with multiple logistic regression analysis. Result: There is a statistically significant relationship between teenage pregnancy and PROM. Pregnant teenagers have risk to get PROM 11,808 times bigger than those of adult (p = 0,021; OR = 11,808). Conclusion: Based on the result, it can be concluded that teenage pregnancy has risk to get PROM 11,808 times bigger than those of adult. Keyword: teenage pregnancy, Premature Rupture of Membranes ]]>
<![CDATA[Hubungan Antara Stres Psikologis Dan Olahraga Terhadap Terjadinya Dismenore Primer Pada Mahasiswi Fakultas Kedokteran Universitas Sebelas Maret ]]>
<![CDATA[Ananda, Mutiara Rizky]]>;
<![CDATA[Y, Eric Edwin]]>;
<![CDATA[Wijayanti, Lilik]]>
<![CDATA[ Nexus Kedokteran Klinik Vol 3, No 1 (2014): Nexus Kedokteran Klinik ]]>
Publisher : <![CDATA[Fakultas Kedokteran Universitas Sebelas Maret Surakarta ]]>
Show Abstract
|
Download Original
|
Original Source
|
Check in Google Scholar
|
Full PDF (14.046 KB)
<![CDATA[Background: Prevalence of primary dysmenorrhea in the adolescent in Surakarta is 87,7% and 15% of women in Indonesia complained that their activity were interrupted due to dysmenorrhea. Psychological stress and irregular sports allegedly have connection in increase the incidence of primary dysmenorrhea. This research aims to know the relation between psychological stress and exercise against the occurrence of primary dysmenorrhea. Methods: This study is analytical observational with cross sectional approach, and using primary data. This study using medical student of 2010, 2011, 2012 at Sebelas Maret University as sample, taken by simple random sampling methods about 62 samples. Data analysis using Chi Square test and binary logistic regression. Results: Result of data analysis using Chi Square test shows p value for the relationship of psychological stress with primary dysmenorrhea is 0,013 whereas p value of relations sports with primary dysmenorrhea is 0,009. For the results of the analysis data using binary logistic regression found that psychological stress has OR = 0,352 whereas exercise has OR = 3,808. Conclusions: Based on result of the study can be concluded that there is a relationship between psychological stress and exercise against the occurrence of primary dysmenorrhea in the medical student of Sebelas Maret University Surakarta. Keywords: Psychological Stress, Exercise, Primary Dysmenorrhea. ]]>
<![CDATA[Hubungan antara Penggunaan Obat Nyamuk dengan Tingkat Kontrol Asma ]]>
<![CDATA[Astuti, Astari Rindu]]>;
<![CDATA[Aphridasari, Jatu]]>;
<![CDATA[Widardo, .]]>
<![CDATA[ Nexus Kedokteran Klinik Vol 2, No 3 (2013): Nexus Kedokteran Klinik ]]>
Publisher : <![CDATA[Fakultas Kedokteran Universitas Sebelas Maret Surakarta ]]>
Show Abstract
|
Download Original
|
Original Source
|
Check in Google Scholar
|
Full PDF (14.046 KB)
<![CDATA[Background: Asthma is a chronic inflammatory disorder of the airways with episodic symptoms such as cough, shortness of breath, wheezing, and uplifted chest. Mosquito repellent consists of chemical synthetic chemical materials that can prevent mosquitoâs bite towards. This study is to find out if there is or not any correlation between mosquito repellent usage and rate of asthma control. Methods: This study was an analytic observational study using cross sectional approach conducted on May to July 2013. Sixty samples were taken by using purposive sampling from outpatients who visited Pulmonary Clinics of Local Public Hospital Dr. Moewardi and fulfilled the inclusive criteria. The data was collected via interview by using a set of questionnaire. The data was then analyzed using Chi-Square test on Statistical Product and Service Solution (SPSS) 20.00 for Windows. Results: There is no significant correlation between mosquito repellent usage and rate of asthma control. From the Chi-Square test result, it was obtained that the significance value is p = 0,817. Conclusions: Based on this research, it can be concluded that there is no correlation between mosquito repellent usage and rate of asthma control. Keywords: mosquito repellent, rate of asthma control  ]]>
<![CDATA[Perbedaan Aldrete Score Akibat Penggunaan Halotan dan Sevofluran ]]>
<![CDATA[Rinanto, D. Purbo]]>;
<![CDATA[Supraptomo, R.Th]]>;
<![CDATA[Wicaksono, Bagus]]>
<![CDATA[ Nexus Kedokteran Klinik Vol 2, No 3 (2013): Nexus Kedokteran Klinik ]]>
Publisher : <![CDATA[Fakultas Kedokteran Universitas Sebelas Maret Surakarta ]]>
Show Abstract
|
Download Original
|
Original Source
|
Check in Google Scholar
|
Full PDF (14.046 KB)
<![CDATA[Background : Inhaled Anesthesia is anesthesia drugs in the form of gas or volatile liquid that is given through the respiratory patient . This anesthesia has the advantage of high potency and concentration that can be controlled through the engine . Inhaled anesthetics commonly used in surgery are halothane and sevoflurane . The main concern is the safety of anesthesia and patient safety , and one of them includes the recovery of consciousness and regular use Aldrete score . This study aims to determine the effect of the difference Aldrete score inhaled anesthetics halothane and sevoflurane. Methods: This study was an observational analytic study using cross - sectional study with subjects surgery patients with inhalation anesthetics halothane and sevoflurane in the Instalasi Bedah Sentral ( IBS ) RSUD Dr. Moewardi Surakarta . With quota sampling technique, this study obtained 40 sampels, which consisted of 20 patients with halothane anesthesia , and 20 patients with sevoflurane anesthesia . Data were collected by observation in the post-operative and medical records room . Data were analyzed using independent t-test, the homogeneity test and comparison test average. The data were processed with the Statistical Product and Service Solutions ( SPSS )18.00 for Windows. Results : Data were tested by independent t-test , showed average values ââfor halothane group was 9.2 , while the average value for the sevoflurane group was 9.0. However , the value obtained Sig ( 2 - tailed ) ( 0.151 ) > α ( 0.05 ) so that Ho is accepted . Or it can be concluded that there was no significant difference between the average value Aldrete score halothane and sevoflurane groups . Value Std . Error Difference also showed the same value is 0.066 so that there was no significant difference in the two groups . Conclusions : Both groups had an average value of the same or there is no significant difference between the two groups either inhaled anesthetics halothane and sevoflurane Keywords : inhalation anesthetics , halothane , sevoflurane , level of consciousness, Aldrete score  ]]>
<![CDATA[Hubungan Ibu Hamil Perokok Pasif dengan Kejadian Ketuban Pecah Dini ]]>
<![CDATA[Dithyana, Icha]]>;
<![CDATA[Soetrisno, .]]>;
<![CDATA[Dharmawan, Ruben]]>
<![CDATA[ Nexus Kedokteran Klinik Vol 3, No 1 (2014): Nexus Kedokteran Klinik ]]>
Publisher : <![CDATA[Fakultas Kedokteran Universitas Sebelas Maret Surakarta ]]>
Show Abstract
|
Download Original
|
Original Source
|
Check in Google Scholar
|
Full PDF (14.046 KB)
<![CDATA[Background: Premature Rupture of Membranes (PROM) is most important issues commonly encountered. Premature rupture of membranes can cause some complications for both mother and fetus and may increase maternal morbidity and mortality. The prevalence of smoking in Indonesia increase every year and 85.4% current smokers smoke in the home where their family members live with them, thus threatening the health and safety of the environment. This research aimed to analyze the correlation between pregnant passive smoker and premature rupture of membrane. Methode : This research is observational analytic research using case control approach. Total of 60 samples were selected with a fixed - disease sampling, are all expectant mothers and maternity patients at the RSUD Dr. Moewardi. Data were collected by interview and medical record. The data which is got then analyzed by the program Statistic Products and Service Solution (SPSS) for Windows Release 17.0 with the use of statistic test Chi Square. Result: There is a significant correlation between pregnant passive smoker and premature rupture of membrane where the results obtained by using statistical test Chi Square is p = 0.02 and OR= 3.5. Conclusion: Pregnant passive smoker is 3.5 times more risky for experiencing premature rupture of membrane than non-passive smoker. Keywords: Pregnant passive smoker, Premature Rupture of Membrane (PROM)Â ]]>
<![CDATA[Hubungan Pemberian Obat Anti Tuberkulosis (OAT) dengan Kadar Asam Urat ]]>
<![CDATA[Setiawan, Ivan]]>;
<![CDATA[Setijadi, Ana Rima]]>;
<![CDATA[Sari, Yulia]]>
<![CDATA[ Nexus Kedokteran Klinik Vol 3, No 1 (2014): Nexus Kedokteran Klinik ]]>
Publisher : <![CDATA[Fakultas Kedokteran Universitas Sebelas Maret Surakarta ]]>
Show Abstract
|
Download Original
|
Original Source
|
Check in Google Scholar
|
Full PDF (14.046 KB)
<![CDATA[Background: Multidrug tuberculosis treatment which is a long term medication often causes various side effects. One of them is an increase of uric acid level. This study aims to determine the correlation between tuberculosis treatment administration and uric acid level. Methods: This study used cohort method with one group before and after intervention design. A total of 30 tuberculosis patients who were admitted to Center of Lung Health Society Surakarta between April and August 2013 were taken as samples by consecutive sampling method. Criteria of sampling are pulmonary tuberculosis patients who is planned to get rifampisin, isoniazid, pirazinamid, and ethambutol for more than 4 weeks, aged over 18 years old, and had given informed consent. In this study we excluded pulmonary tuberculosis patients who also had liver or renal disorders, had suffered from hyperuricemia or took drugs for decreasing uric acid level, or had hypertension. The measurements of uric acid level was collected before the treatment and more than one  month after the treatment. Data were analyzed by paired t test (α = 0,05). Results: The average uric acid level of 30 patients before treatment was 4.68 ± 1.12 mg/dL, while the average uric acid levels after treatment was 8.56 ± 2.21 mg/dL, which was significantly higher than pretreatment (p=0.001). During treatment, hyperuricemia (uric acid level > 7 mg/dL) was reported in 73.33% (22/30) of patients and two patients had arthralgia. Conclusions: Tuberculosis treatment administration may affect uric acid level. Hiperuricemia was reported in 73.33% of patients who receive tuberculosis treatment. Keywords: tuberculosis treatment, uric acid level, tuberculosis ]]>
<![CDATA[Hubungan Diabetes mellitus dengan Hasil Uji Konversi BTA Sputum setelah Pemberian Terapi Tuberkulosis Tahap Inisiasi ]]>
<![CDATA[Pranoto, Avamira Rosita]]>;
<![CDATA[Sutanto, Yusup Subagio]]>;
<![CDATA[Haryati, Sri]]>
<![CDATA[ Nexus Kedokteran Klinik Vol 3, No 1 (2014): Nexus Kedokteran Klinik ]]>
Publisher : <![CDATA[Fakultas Kedokteran Universitas Sebelas Maret Surakarta ]]>
Show Abstract
|
Download Original
|
Original Source
|
Check in Google Scholar
|
Full PDF (14.046 KB)
<![CDATA[Background: Pulmonary tuberculosis (TB) is a chronic infection of lung caused by Mycobacterium tuberculosis. Tuberculosis treatment often gets failure in result because of lack of care in co-morbid disease such as Diabetes mellitus (DM), which can disturb TB patient immunity. The objective of this study was to determine the relation of Diabetes mellitus and result of conversion test of sputum with alcohol-acid resistant bacillus after initiation phase of tuberculosis medication. Methods: This was an observational analytic survey with retrospective cohort study. Using consecutive sampling method, this study took 124 patients from RSUD Dr. Moewardi and BBKPM (Balai Besar Kesehatan Paru Masyarakat) Surakarta, who divided into 2 groups based on the DM status of newly diagnosed pulmonary TB patients. Control group consisted of 86 newly diagnosed pulmonary TB patients without DM; exposure group consisted of 38 newly diagnosed pulmonary TB patients with DM. Patients from both groups were given category-1 tuberculosis treatment during 2 months of initiation phase therapy, then the BTA conversion status of patients was observed. Data collected through the medical record and concurrent data of pulmonary TB patients. Data was analyzed by SPSS using Chi Square test. Probability (p) is < 0.05 with 95% confident interval. Results: There were 14 patients from the control group who failed to undergo conversion after 2 months of initiation phase therapy, whereas from the exposure group, there were 17 patients who got failure in result. Data analysis using Chi Square with significance level p < 0.05 was obtained p = 0.001 and Relative Risk (RR) = 0.66. Conclusions: DM seems to have a negative impact on the outcome of tuberculosis treatment. Pulmonary tuberculosis patients with DM as comorbid disease has probability 0.66 times lower than those without DM to get positive result from BTA sputum conversion test. Screening for DM and subsequent blood glucose control may improve the outcome of tuberculosis treatment. Keywords: Diabetes mellitus, tuberculosis medication, result of conversion test of sputum ]]>
