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INDONESIA
Jurnal Kesehatan Andalas
Published by Universitas Andalas
ISSN : 23017406     EISSN : 26151138     DOI : -
Core Subject : Health,
Health Professions
Jurnal Kesehatan Andalas merupakan Jurnal yang diterbitkan oleh Fakultas Kedokteran Universitas Andalas.
Arjuna Subject : -
Articles 1,294 Documents
 116   117   118   119   120 
Mantle Cell Lymphoma Payudara, Suatu Kasus Jarang Valencia, Valencia; Asri, Aswiyanti; Novianti, Hera
Jurnal Kesehatan Andalas Vol. 9 No. 4 (2020): Online December 2020
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jka.v9i4.1530

Abstract

Mantle cell lymphoma (MCL) adalah neoplasma sel β-matur yang biasanya terdiri dari sel limfoid monomorf berukuran kecil hingga sedang dengan kontur inti ireguler, pada > 95% kasus, terdapat translokasi  Cyclin D1 (CCND1). Limfoma payudara merupakan suatu kasus yang jarang. Dilaporkan seorang pasien perempuan usia 50 tahun yang datang dengan keluhan massa di payudara kanan sejak satu tahun yang semakin bertambah besar. Pemeriksaan fisik didapatkan tumor ukuran 11x6x5 cm, konsistensi kenyal padat, terfiksir, dan berulkus. Tidak ditemukan Nipple discharge/bleeding dan pembesaran kelenjar getah bening tidak ditemukan. Pasien menjalani mastektomi. Pemeriksaan histopatologi tampak potongan jaringan payudara dengan stroma jaringan ikat dan jaringan lemak mengandung proliferasi sel-sel limfoid berukuran kecil, monoton dan tersebar difus di antara stroma. Sel-sel dengan inti pleomorfik, hiperkromatik, berlekuk, membran inti ireguler, di antaranya tampak beberapa sel plasma. Pemeriksaan imunohistokimia CD-20 dan Cyclin-D1 menunjukkan pulasan positif serta Ki-67 antara 30-40%. Hasil pemeriksaan histopatologi dan imunohistokimia dapat disimpulkan diagnosis mantle cell lymphoma pada payudara.Kata kunci: limfoma, MCL, payudara
Profil Ekspresi MikroRNA Kanker Payudara di Purwokerto Nurasih, Ari Dwi; Sulistiyawati, Indah; Falah, Muhammad
Jurnal Kesehatan Andalas Vol. 9 No. 4 (2020): Online December 2020
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jka.v9i4.1553

Abstract

Penemuan metode deteksi dini kanker payudara secara sensitif, spesifik dan minimal invasif merupakan kunci dalam keberhasilan pengobatan. Hal ini dapat dilakukan menggunakan biomarker yang bersirkulasi dalam plasma darah yaitu mikroRNA. MikroRNA adalah asam ribonukleat yang tidak mengkode protein tetapi memiliki peran dalam menghambat dan mendegradasi mRNA sehingga mempengaruhi perkembangan kanker. Tujuan: Mengetahui profil ekspresi mikroRNA pada pasien kanker payudara di Purwokerto dan mikroRNA yang mengalami disregulasi sebagai kandidat biomarker kanker payudara. Metode: Analisis profil ekspresi mikroRNA pada kanker payudara dilakukan dengan isolasi plasma dari pasien kanker payudara dan individu sehat, sintesis cDNA, dan kuantifikasi mikroRNA dengan quantitative real time PCR (qPCR). Kemudian dilakukan penghitungan dengan metode Livak untuk mengetahui mikroRNA yang mengalami peningkatan dan penurunan ekspresi yang signifikan. Hasil:  Biomarker kanker payudara di Purwokerto adalah MikroRNA yang mengalami upregulation adalah hsa-miR-543 (sebanyak 1612,28 kali), hsa-miR-495-3p (1797,95 kali), hsa-miR-382-5p (8780,32 kali), hsa-miR-155-5p (8552,18 kali) dan hsa-miR-154-5p (2339,41 kali). mikroRNA yang mengalami downregulation adalah hsa-miR-590-5p (sebanyak 4,70 kali), hsa-miR-33a-5p (sebanyak 74,29 kali), hsa-miR-100-5p (sebanyak 23,09 kali), hsa-miR-19b-3p (sebanyak 11,71 kali) dan hsa-miR-144-3p (sebanyak 25,30 kali) (p < 0,05). Simpulan: Biomarker yang dapat digunakan sebagai alat deteksi dan diagnostik dini kanker payudara di Purwokerto adalah miR-382-5p.Kata kunci: biomarker, kanker payudara, mikroRNA, qPCR
Penatalaksanaan Multirinosinusitis Kronis dengan Komplikasi Abses Subperiosteal Sinistra Ambriani, Desy; Irfandy, Dolly; Vitresia, Havriza
Jurnal Kesehatan Andalas Vol. 9 No. 4 (2020): Online December 2020
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jka.v9i4.1562

Abstract

Abses subperiosteal merupakan salah satu komplikasi dari rinosinusitis baik akut ataupun kronis. Beberapa faktor sangat berperan sebagai penyebab penyebaran rinosinusitis ke orbita. Diagnosis rinosinusitis kronik dengan komplikasi abses periorbita ditegakkan berdasarkan anamnesis, pemeriksaan fisik, nasoendoskopi, tomografi komputer serta Magnetic Resonance Imaging (MRI). Penatalaksanaan rinosinusitis kronis dengan komplikasi abses subperiosteal adalah pemberian medikamentosa antibiotik intravena spektrum luas atau kombinasi, dekongestan, kortikosteroid sistemik disertai dengan tindakan operatif yaitu pendekatan Bedah Sinus Endoskopi Fungsional (BSEF). Dilaporkan satu kasus rinosinusitis kronis dengan komplikasi abses subperiosteal kiri pada laki-laki umur 40 tahun dan telah dilakukan perawatan dan dilanjutkan dengan pembedahan melalui pendekatan BSEF. Rinosinusitis kronik dengan komplikasi abses subperiosteal dapat ditatalaksana dengan terapi antibiotik dan pembedahan. Keterlambatan penanganan mempengaruhi tingkat kerusakan. Penanganan dengan antibiotik yang adekuat dan BSEF memberikan prognosis yang baik pada pasien.Kata kunci: abses subperiosteal, BSEF, rinosinusitis kronik                         
Kemampuan Predasi Ikan Kepala Timah Aplocheilus panchax Jantan dan Betina Terhadap Larva Nyamuk Aedes aegypti Lukas, Jonathan Loody; Adrianto, Hebert; Darmanto, Arief Gunawan
Jurnal Kesehatan Andalas Vol. 9 No. 4 (2020): Online December 2020
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jka.v9i4.1564

Abstract

Demam Berdarah Dengue (DBD) masih menjadi masalah utama di Indonesia sampai sekarang. Pemanfaatan ikan kepala timah (Aplocheilus panchax / A. panchax) sebagai pengendali vektor secara biologis bertujuan untuk memutus rantai penularan. Tujuan: Menentukan kemampuan predasi dan keefektifan ikan A. panchax jantan dan betina terhadap larva nyamuk Aedes aegypti. Metode: Penelitian ini menggunakan metode post-test only design. Pengamatan dilakukan dengan menghitung jumlah larva yang dipredasi setiap lima menit hingga 20 larva habis termakan kemudian dianalisis dengan independent sample t-test untuk mengetahui rerata kemampuan predasi kedua kelompok ikan. Hasil: (1) ikan betina  memakan rerata 9.20 larva per lima menit sedangkan ikan jantan 7.40 larva per lima menit. (2) ikan betina paling cepat menghabiskan 20 larva nyamuk dalam waktu 6 menit 44 detik sedangkan ikan jantan 9 menit 8 detik. Simpulan: Ikan A. panchax betina lebih efektif dari yang jantan sehingga berpotensi untuk dimanfaatkan sebagai pengendalian vektor DBD.Kata kunci: aplocheilus panchax, aedes aegypti, DBD, pengendalian vektor
Analisa Kadar Glutamat pada Penderita Fibrilasi Atrium dengan Gangguan Fungsi Kognitif Syafrita, Yuliarni; Andy, Marfri; Rasyid, Hauda El
Jurnal Kesehatan Andalas Vol. 9 No. 4 (2020): Online December 2020
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jka.v9i4.1571

Abstract

Salah satu permasalahan neurologi yang ditemukan pada penderita fibrilasi atrium (FA) adalah gangguan kognitif. Silent Brain Infarction (SBI) diyakini menjadi salah satu mekanisme utama yang mendasari terjadinya gangguan ini. Sudah dilaporkan juga bahwa hipoksia serebri akan menimbulkan peningkatan kadar glutamat ektraseluler sehingga bersifat neurotoksisitas dan menimbulkan kematian sel. Tujuan: Menganalisis  kadar serum glutamat pada pasien Fibrilasi Atrial (FA) dengan gangguan kognitif.  Metode: Penelitian dengan disain potong lintang dilakukan di Poliklinik Kardiologi dan Neurologi RS DR M Djamil Padang serta Laboratorium Biomed Fakultas Kedokteran Universitas Andalas. Pemeriksaan kadar glutamat serum dilakukan dengan metode Elisa dan pemeriksaan fungsi kognitif dengan test neuropsikologi Montreal Cognitive Assestment versi Indonesia (MoCA-Ina). Perbedaan kadar glutamat serum pada kelompok FA dengan gangguan kognitif dan kelompok FA tanpa gangguan kognitif diuji dengan t test bila distribusi data normal dan test Mann Whitney bila data tidak terdistribusi normal. Hubungan antara kadar glutamat dengan kejadian gangguan kognitif dilakukan dengan uji Chi-square, setelah dicari dulu nilai cut off point untuk kadar glutamat serum. Uji dikatakan bermakna bila nilai p < 0,05. Hasil: Kadar glutamat serum kelompok FA dengan ganggan kognitif lebih tinggi dari kelompok FA tanpa gangguan kognitif. Pasien FA yang mempunyai kadar glutamat tinggi ( > 29,5µMol/L) beresiko mengalami gangguan kognitif 10,2 kali lebih tinggi dari penderita yang mempunyai kadar glutamat normal (< 29,5 µMol). Simpulan: Ada hubungan antara kadar glutamat serum dengan terjadinya gangguan kognitif pada penderita FA.Kata kunci: fibrilasi atrial, fungsi kognitif, glutamat, silent brain infarction
Uji Daya Hambat Isolat Actinomycetes sebagai Antibakteri terhadap Pertumbuhan Pseudomonas aeruginosa ATCC 27853 secara In Vitro Wahyuningrum, Saskia Arientika; Bahar, Meiskha; Pramono, Andri Pramesyanti
Jurnal Kesehatan Andalas Vol. 10 No. 1 (2021): Online March 2021
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jka.v10i1.1595

Abstract

Pneumonia is a lung parenchymal infection caused by Pseudomonas aeruginosa.It is Gram negative bacteria that have developed antibiotic resistance. Actinomycetes are Gram-positive bacteria that produce secondary metabolites which have the ability as antimicrobial. Objectives: To identified the ability of Actinomycetes isolates to inhibit the growth of the bacterium Pseudomonas aeruginosa ATCC 27853. The samples in this experiment were from Kebun Raya Bogor that had been rejuvenated on Starch Casein Agar (SCA). Methods: Six dilution series 10-1; 10-2; 10-3; 10-4; 10-5; 10-6 Actinomycetes isolates were used to observe the inhibition zone of P.aeruginosa growth on Mueller Hinton Agar (MHA) media by diffusion method. Results: The effective incubation time occurred at 24 hours, and then it resulted in the average clear zone diameter of 14.70 mm, 10.57 mm, 8.53 mm, 8.47 mm, 6.97 mm, and 5.30 mm. The results of the One – Way Anova test with p-value = 0.000 (p < 0.005) showed some differences at each concentration to inhibit the growth of P.aeruginosa ATCC 27853 at 24 hours incubation period. Conclusion: The most effective concentration of Actinomycetes isolates that can potentially be antibacterial was the concentration of 10-1 with potential solid inhibitory power.Keywords: Actinomycetes, antibacterial, Pseudomonas aeruginosa
Perpaduan Isometric Exercise dan Latihan Pernafasan Yoga Terhadap Penurunan Tekanan Darah pada Pasien Hipertensi di Desa Mojojajar Wilayah Kerja Puskesmas Kedungsari Kabupaten Mojokerto Anjarsari, Dinda Risma Putri; Hanan, Abdul; Widiani, Esti
Jurnal Kesehatan Andalas Vol. 10 No. 1 (2021): Online March 2021
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jka.v10i1.1601

Abstract

One of the non-pharmacological treatments that can be done to lower blood pressure is to increase the patient's physical activity, such as Isometric Exercise and Yoga breathing exercises. Objectives: To determined isometric exercise and yoga breathing on reducing blood pressure in hypertension. Methods: This study used a pre-experimental design with a one-group pretest-postest design. The sampling technique was purposive sampling. The number of samples in this study was 25 people. Results: The paired t-test statistical test results were a decrease in blood pressure after being given the intervention of isometric exercise and yoga breathing exercises with a p-value of 0.000 (p<0.05). Conclusion: Isometric exercise and yoga breathing exercises can be an alternative non-pharmacological therapy to reduce blood pressure in hypertension.Keywords:  Isometric Exercise, Yoga Breathing Exercise, Hypertension
Perbandingan Tingkat Keparahan Infeksi Sekunder Virus Dengue pada Keempat Serotipe di Indonesia: Systematic Review Kurniati, Annelin; Fandi, Ahmad; Sariyanti, Mardhatillah; Febrianti, Ety; Rizqoh, Debie
Jurnal Kesehatan Andalas Vol. 10 No. 1 (2021): Online March 2021
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jka.v10i1.1615

Abstract

Secondary infection with the dengue virus causes mild to severe manifestations. The distribution of dengue virus serotypes varies in various areas and can change over time. There are four dengue serotypes, namely DENV-1, DENV-2, DENV-3 and DENV-4. Objectives: To knew the distribution of virus serotypes in an area and determined the pathogenesis of the disease, which can cause severe manifestations in patients with secondary infections. Methods: The data taken is the severity of secondary infections and dengue serotypes. The literature search was performed on PMC and Cochrane. Search criteria were performed using keywords (secondary infection * OR secondary dengue infection *) AND (Dengue Virus * OR Dengue Infection * OR Dengue * OR DENV) AND (Serotype * OR Serogroup) AND (severe dengue * OR severity * OR severity of illness indexs * OR dengue fever * OR dengue haemorrhage fever * OR dengue shock syndrome * OR DF * OR DHF * OR DSS *) AND (Indonesia *). Results: Literature study search found 387 literature with five studies conducted the analysis. From the results of the analysis, it was found that secondary infections were more common in patients with recurrent dengue infection with serotype 2 (DENV-2), serotype 3 (DENV-3) and serotype 4 (DENV-4). Conclusion: Secondary infection of dengue virus serotype 2 (DENV-2) and serotype 3 (DENV-3) can cause severe dengue infection.Keywords:  Dengue Virus, Indonesia, Secondary Infection, Serotype, Severity
Perbandingan Perubahan Luas Luka dan Angiogenesis pada Luka Bakar Derajat IIB Tikus Sprague Dawley yang Diberikan Advanced Platelet-rich Fibrin dan Advanced Platelet-rich Fibrin Plus Stella, Ellia; Wahyuningsih, Komang Ardi
Jurnal Kesehatan Andalas Vol. 10 No. 2 (2021): Online July 2021
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jka.v10i2.1616

Abstract

Platelet-rich fibrin (PRF) has a lot of benefits in the process of healing. The new generation of PRF, namely advanced PRF plus (A-PRF+), has a different fibrin structure and more growth factors compared to Advanced PRF (A-PRF), the generation before A-PRF+. Objectives:To compared the effects of A-PRF and A-PRF+ on the IIB degree burn. Methods: This experimental study used 20 male Sprague Dawley rats. All rats were given IIB degree burn and divided into four groups. Group 1 was treated with saline, Group 2 was treated with silver sulfadiazine 1%, Group 3 was treated with A-PRF, and Group 4 was treated with A-PRF+. Wound size reduction will be calculated every two days and measured with ImageJ and the wound would be made into a histological slide on day 14 to calculate angiogenesis. Results: Changes in the wound surface area for the group that was given A-PRF dan A-PRF+ are 2,333cm and 4,827cm. The wound surface area’s data were analyzed using Kruskal-Wallis and the results are statistically not significant (p>0,05). The number of angiogenesis for the group that was give A-PRF and A-PRF+ as followed are 5,88 and 4,867. The angiogenesis data were analyzed using one-way ANOVA and the results are statistically not significant (p>0,05). Conclusion: There is no difference between the effect of A-PRF and A-PRF+ towards changes in wound surface area and angiogenesis in IIB degrees burn wounds.Keywords:  A-PRF, A-PRF+, burn wound, angiogenesis, wound surface area
Deteksi dan Analisis Faktor Risiko Hipertensi pada Karyawan di Lingkungan Universitas Sriwijaya Utama, Feranita; Sari, Desri Maulina; Ningsih, Windi Indah Fajar
Jurnal Kesehatan Andalas Vol. 10 No. 1 (2021): Online March 2021
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jka.v10i1.1643

Abstract

Office workers are one group with a high proportion of hypertension compared to other types of work. Objectives: To determined the proportion of pre-hypertension, hypertension and risk factors for hypertension among employees in Sriwijaya University. Methods: This study used a cross-sectional design at Sriwijaya University, and samples were taken from 4 faculties totaling 152 respondents. Sampling using cluster random sampling technique. Data were collected from September to October 2020. The analysis was carried out in univariate, bivariate and multivariate analysis with logistic regression tests. Results: There were 13.2% of employees had hypertension, 40.8% had pre-hypertension, and the risk factor for hypertension among employees was age (p-value = 0.01; OR = 4.76; CI 1.50 <OR <15, 10) after controlling for the variables of the length of work, marriage status and cholesterol levels. Conclusion: There are more than 50% of employees are in a condition of pre-hypertension and hypertension, with age as the main risk; for this reason, employees who are 45 years old are expected to carry out routine health checks with the facilitation of the university and be able to implement the Dietary Approach to Stop hypertension in employees with pre-hypertension / hypertension.Keywords:  DASH, hypertension, pre-hypertension, the risk factor

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