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Folia Medica Indonesiana

FMI
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Published by Universitas Airlangga

ISSN : 23558393 EISSN : 2599056X DOI : -

Core Subject : Education,

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Folia Medica Indonesiana publishes articles in the field of medical science in particular and health sciences in general, as well as a variety of other fields related to those two disciplines. Most of the articles are research article, and others are articles on case reports and literature review. In their presentation in the journal, the articles have passed meticulous editing process by the editors and review process and by competent peer reviewers, with national and international reputation, making the articles presented in this journal qualified, updated, and informative.

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Articles 547 Documents

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PLASMA LACTATE VERSUS C-REACTIVE PROTEIN AS PROGNOSITIC INDICATOR IN UROSEPSIS Prilistiyo, Dwimantoro Iman; Santoso, A; Anniwati, L; Pudjirahardjo, W J
Folia Medica Indonesiana Vol. 53 No. 2 (2017): JUNE 2017
Publisher : Universitas Airlangga

Urosepsis occurs in 20-30 % of septic case. Early diagnosis were undoubtfully important to improve the results of sepsis management. Bacteriological confirmation may be difficult to obtain and negative cultures do not exclude the presence of infection. Increased understanding of inflammatory cascade mechanisms provided several indicator of infection and prognosis. Lactate measurement in patients with infection and possibly severe sepsis to help identify patients at high risk of death in order to apply aggressively therapy. Elevation in serum C-reactive protein (CRP) is also associated with an increasing risk of death in patients with infection. This study was to determine the plasma lactate and CRP levels of patients with urosepsis as a prognostic indicator. This is an analytic observational study to compare the correlation and significance of plasma lactate and CRP with prognosis of urosepsis. Each subject was measured for plasma lactate and serum CRP at time of admission. All subjects were managed according to standard protocol. At the 14th day of treatment, patients were evaluated with a clinical severity score. The outcome was classified as follows: 1=good condition/improved, 2=morbid/worsened and 3=death. The statistical analysis used Spearman's rho test, Ï<0.05 was considerated to indicate significance. We enrolled 25 subjects with urosepsis. 14 patients who were septic, nine patients had severe sepsis and 2 patients had septic shock. Mean plasma lactate level in patients based on outcome (improved/worsened/death) was 2.08 mmol/L; 4.16 mmol/L and 5.27 mmol/L. The mean value of CRP was 13.41 mg/L; 22.28 mg/L and 24.62 mg/L. These were statistically significant (p 0.008 vs 0.016) in determining the outcome of the urosepsis patient. The coefficient correlation is better with plasma lactate than CRP (0.517 vs 0.475). In conclusion, the measurement of plasma lactate and CRP level can be used as a prognostic marker for the outcome of patient with urosepsis. Plasma lactate showed higher correlation with outcome of urosepsis than CRP.

DIABETES RISK FACTOR SCREENING IN ADULTS USING PERKENI QUESTIONNAIRE AND ORAL GLUCOSE TOLERANCE TEST IN SOCAH COUNTY, BANGKALAN Kamal, Radin H; Novendrianto, Dwiki; Chadijah, Faizah; Prasetya, Galan Budi; Pratama, Gilang Satria; Ariadnya, Mentari Octarina; Larasati, Nikita Gladys; Darain, Nur Lia F; Nanda, Ovitrani; Mavita, Silvi; Usamah, Usamah; Prajitno, Jongky Hendro
Folia Medica Indonesiana Vol. 53 No. 3 (2017): September 2017
Publisher : Universitas Airlangga

There are 8.4 million diabetes adult patients in Indonesia and most remained undiagnosed. Screening process for diabetes is very important. PERKENI has recommended the use of questionnaire and Oral Glucose Tolerance Test (OGTT) as risk factor screening tools. This study aimed to find out the use of PERKENI questionnaire and OGTT in adults as diabetes risk factor screening tools. This was a descriptive cross sectional study conducted in 2015 in Socah County Bangkalan. Participants (n=91) were interviewed regarding diabetes risk factor using PERKENI questionnaire. Anthropometric (height, weight, and abdominal circumference) measurements were also taken. The results were categorized into: very low risk, increased risk, moderate risk and high risk. Only those categorized as high risk were asked to take OGTT. Exclusion criteria were participants who had been diagnosed with diabetes by a physician and/or routinely taking anti diabetic medication, consumed drugs during the previous two weeks and does not finish the required procedures. From 91 eligible participants, only 9 (9.89%) were categorized as high risk. The result of OGTT were: 4 were within normal limit, 1 had impaired glucose tolerance (IGT) and 4 were newly diagnosed with diabetes. The use of PERKENI questionnaire and OGTT in high risk adult population as a diabetes risk factor screening tool increased new findings of diabetes cases. Our analysis may support the adoption of diabetes risk factor screening methods through questionnaires and OGTT in high risk adult population, especially in low resource setting.

PHYSICAL ACTIVITY PROFILE OF THE PROFESSORS OF PADJADJARAN UNIVERSITY BASED ON GLOBAL PHYSICAL ACTIVITY QUESTIONNAIRE Mutia Nur Maulida; Leonardo Lubis; Dian Marta Sari
Folia Medica Indonesiana Vol. 53 No. 4 (2017): December 2017
Publisher : Faculty of Medicine, Universitas Airlangga

Physical activity is one of the factors which determines one’s health and fitness, including the professors of Padjadjaran University, as it might support their academic performances. Global Physical Activity Questionnaire (GPAQ) may describe physical activity. The purpose of this study was to describe physical activity profile of the professors of Padjadjaran University based on GPAQ. Physical activity profile which was classified as gender, age group, recommendation fulfillment, and intensity variables by present-ing quantity (n) and percentage (%) was obtained from 141 professors who fulfilled the inclusion criteria. The result of this des-criptive-quantitative study showed that 109 of the respondents were male, and 32 were female. According to WHO age group cate-gories, 35 respondents were middle aged, 78 were elderly, and 28 were late elderly. Fifty-eight respondents (41.1%) did not fulfill minimal recommendation for physical activity, 114 respondents (80.8%) underwent moderate activity and 29 respondents (20.6%) underwent vigorous activity. Therefore, it can be concluded that professors of Padjadjaran University, which were mostly middle-aged men, did not fulfill minimal recommendation for physical activities, although many of them underwent moderate activities in their daily routines.

EFFECT OF Cayratia trifolia L (Domin) EXTRACT ON REDUCED EXPRESSION OF MATRIX METALLOPROTEINASE-9 (MMP–9) AND VASCULAR ENDOTHELIAL GROWTH FACTOR –A (VEGF-A) IN WHITE RATS WITH BREAST CANCER Dewi, Devi Cynthia; Sudiana, I Ketut
Folia Medica Indonesiana Vol. 52 No. 1 (2016): JANUARY - MARCH 2016
Publisher : Universitas Airlangga

The number of cancer cases in every year has increased. One effort in reducing breast cancer cases is by using anti-angiogenesis which could prevent the growth and metastasis of cancer cells. Xxx the process of angiogenesis and metastasis in cancer cells are associated with the expression of Matrixmetalloproteinase- 9 (MMP-9) and Vascular Endothelial Growth Factor (VEGF). To reduce metastasis in cancer cells, it can be performed by giving plant extracts Cayratiatrifolia L (Domin), containing the active compound Resveratrol, delphinidin/malvidin and Quercetin. The content of the chemical compound of these herbs has immunomodulatory effects, which could potentially prevent angiopoitin, FGF and decrease angiogenesis and neovascularization. So, the metastatic cancer cells can be inhibited. Objective to analyze the effect of the ethanol plant extract Cayratiatrifolia L (Domin) toward the reduction of Matrixmetalloproteinase Expression.-9 (MMP-9) and Vascular Endothelial Growth Factor (VEGF) on white rat of breast cancer models. This study used pure experiment laboratory (True Experimental) with Randomized design study. Post Test was only applied on Control Group Design. This research used experimental female animal Sprague Dawley Rattus which consisted of 30 individuals divided into three groups, from aged 30-40 days. In this research the number of K0 consisted of 5 individual, 6 Kl and 8 KP. KP is a group of experimental animals with breast cancer who were given Cayratiatrifolia extract as much as 300 mg/kg for four weeks. To create animal cancer models, the researcher used DMBA a dose of 10 mg/kg given orally. The measured variables were cells expressing Matrixmetalloproteinase-9 (MMP-9) and Vascular Endothelial Growth Factor (VEGF), differential test applied in this study is Manova. Results based on the statistical analysis of MMP-9 and VEGF-A, between the KI to KP showed a significant difference (p <0.05). Cayratiatrifolia plant extract orally can decrease the number of cells that express MMP-9 and the number of cells that express VEGF-A. The ethanol extract of plants Cayratiatrifolia L (Domain) can reduce the expression Matrixmetalloproteinase-9 (MMP-9) and Vascular endothelial growth factor (VEGF) on white rat of breast cancer models.

HIGH BLOOD GLUCOSE LEVEL INCREASE CARDIOVASCULAR DISEASE RISK IN TYPE 2 DIABETES MELLITUS Marchelia, Laili Zahrina; Purwati, Purwati; Wironegoro, Rio
Folia Medica Indonesiana Vol. 52 No. 2 (2016): APRIL - JUNE 2016
Publisher : Universitas Airlangga

Type 2 diabetes mellitus (DM) is the 10th leading cause of death in the world and had a risk 4.06 times greater to have cardiovascular disease (CVD). Fasting plasma glucose and 2-hours postprandial glucose level as diagnostic tests to evaluate DM and also as a predictive factors to CVD. This research uses descriptive analytic research with cross sectional design. The subject of this study is Type 2 DM patients came to Dr Soetomo hospital from January-October 2014. Data was recorded from medical records of patients and was analyzed with Chi Square test with p<0.05. As result, there is 102 Type 2 DM patients with 36 patients have CVD manifestation and 66 patients without complication. There is a significant association between fasting plasma glucose (FPG), 2-hours postprandial glucose (2hPPG) level, and CVD manifestation (p=0.00). So FPG and 2hPPG have a significant association with CVD manifestation. There are other factors that influencing the formation of CVD, hence, further research is needed.

MODIFIED VAC DRESSING IN STERNAL WOUND INFECTION MANAGEMENT. CHEAP AND FEASIBLE TECHNIQUE IN DEVELOPING COUNTRY Sembiring, Yan Efrata
Folia Medica Indonesiana Vol. 52 No. 3 (2016): JULY - SEPTEMBER 2016
Publisher : Universitas Airlangga

Sternal wound infection is a rare but serious complication of cardiac surgery leading to prolonged hospital stay and higher mortality. In the last decades several treatment modalities have been described, of which vacuum-assisted closure (VAC) shows the most promising results. However, the VAC therapy system is expensive, requires extensive amounts of product and needs a power source at all times. Modified VAC dressing to treat sternal wound infection is cheap and feasible technique to use in develop country. This technique can be use as an alternative to the original vacuum-assisted closure and hadshown to serve its function in providing adequatevacuum pressure for wounds.

POTENCY OF CV12 ACUPUNCTURE AS OBESITY PREVENTION THROUGH MODULATION OF ï¡ AND ï¢ ESTROGEN RECEPTORS EXPRESSION ON THE ADIPOSE TISSUE OF OVARIECTOMIZED MICE Rejeki, Purwo Sri; Wiyasihati, Sundari Indah; Atika, Atika
Folia Medica Indonesiana Vol. 53 No. 1 (2017): JANUARY - MARCH 2017
Publisher : Universitas Airlangga

This study aims to determine the potency of CV 12 acupuncture as prevention of weight gain in ovariectomizedmice (OVX). Female mice strain BALB/c, 28 mice, 3-4 weeks, 25-35 grams were divided into four groups; namely K1 (n = 8, sham and vehiculum injection), K2 (n = 8, OVX and vehiculum injection), K3 (n = 7, OVX and injection of estrogen intraperitoneal 10 mg/kg/day) and K4 (n = 6, OVX and CV12 acupuncture with a frequency of 2 Hz in 10 mA of continuous spike current wave).Injection and acupuncture given every day for four weeks. Weight change in K1 (0.75 ± 2.8) grams, K2 (2.71 ± 2.4) grams, K3 (0.71 ± 0.95) g and K4 (0.93 ± 2.40) gram with a significant difference in the K2 and K4 (p = 0.011). a receptor expression in K1 (12.25 ± 2.96), K2 (5.43 ± 2.64), K3 (18.86 ± 1.57), K4 (17 ± 2.00) with a significant difference to the K2 K1, K3 and K4 with p<0.05. b receptor expression in K1 (11.38 ± 1.92), K2 (4 ± 1.41), K3 (16.86 ± 1.86), K4 (14.17 ± 5.24) with significantly different a receptor expression in visceral fat mass on the group K2 to K1, K3 and K4 with p<0.05. CV 12 acupuncture increases the expression of a and b estrogen receptor in visceral adipose tissue of OVX mice equivalently and able to prevent the increase of weight due to the estrogen withdrawal. This point could potentially be used as one of the management ofobesity prevention in menopause.

GLUT-1 IS A PROMISING TARGET FOR ATP DEPLETION ON DIABETIC ENERGY DEFICIENCY SYNDROME Purwanto, Bambang; Harjanto, Harjanto; Asnar, Elyana
Folia Medica Indonesiana Vol. 53 No. 3 (2017): September 2017
Publisher : Universitas Airlangga

Diabetes is a metabolic syndrome which characterized with insulin insensitivity, lack of GLUT-4 membrane presentation and ATP deficiency. ATP is needed for substrate phosphorylation, signalling pathways, protein translation and cellular survival. Since GLUT-1 was discovered as alternative glucose transporter on muscle membrane, some studies started to investigate it more. This study aimed to investigate GLUT-1 presentation on diabetes muscle membrane of rat model in time. Diabetes was obtained from a 50 mg/kg B.W of streptozotocin intra peritoneal injection on rat. We found that GLUT-1 presentation increased significantly in time of diabetic stages. It correlated negatively with GLUT-4 presentation and mortality. Eccentric downhill running on diabetic rat model improved GLUT-1 presentation and blood glucose level. It was promising for diabetes management therapy at the future.

PREVALENCE OF HUMAN PAPILLOMAVIRUS GENOTYPES IN LOW AND HIGH GRADE SQUAMOUS INTRAEPITHELIAL LESIONS AT CERVICAL TISSUE Rizki Eko Prasetyo; Gondo Mastutik; Sjahjenny Mustokoweni
Folia Medica Indonesiana Vol. 53 No. 4 (2017): December 2017
Publisher : Faculty of Medicine, Universitas Airlangga

HPV infection is known to cause cervical cancer. This study aimed to identify the variant of HPV genotypes of cervical precancerous lesions from low grade squamous intraepithelial lesion (LSIL) and high grade squamous intraepithelial lesion (HSIL). This was an explorative study using formalin fix paraffin embedded (FFPE) from cervical precancerous lesions at Dr. Soetomo Hospital, Surabaya. DNA was extracted from FFPE and hybridized for HPV genotyping using Ampliquality HPV Type Express kit (AB ANALITICA) by reverse line blot techniques. The results showed that there were variants of HPV genotype in LSIL. The variants were HPV16 (8/15), HPV18 (3/15), HPV52 (1/15), HPV6+31 (1/15), HPV6+18 (1/15), and HPV72+68 (1/15), and in HSIL which were HPV16 (4/10), HPV18 (2/10), HPV59 (1/10), HPV6+45 (1/10), HPV61+26 (1/10), and HPV16+31 (1/10). The characteristics of infection in LSIL were single infection of high-risk (hr) HPV and multiple infection of low-risk (lr)+hr HPV, and in HSIL were single infection of HPVhr, multiple infection of HPVhr+hr and HPVlr+hr. In conclusion, HPV prevalence in cervical precancerous lesions is single infection by HPV16 (48%), HPV18 (20%), HPV52 (4%), HPV59 (4%), and multiple infection by HPV6+31, HPV6+18, HPV6+45, HPV16+31, HPV61+26, HPV72+68 is 4%.

Analysis of Methyldopa Therapy on sFlt-1 Antiangiogenic Levels in Patients with Severe Preeclampsia Teri Wina Herwati; Yulistiani Yulistiani; Eddy Zarkaty M
Folia Medica Indonesiana Vol. 54 No. 1 (2018): March
Publisher : Faculty of Medicine, Universitas Airlangga

Methyldopa is the first-line drugs to treat hypertension in pregnancy. It can decrease blood pressure in preeclampsia by affecting a2-adrenoreceptors in central nervous system. However, it could also act by decreasing production of sFlt-1 antiangiogenic protein levels involved in the pathophysiology of hypertention in preeclampsia. The purpose of this study was to analyze methyldopa therapy on sFlt-1 antiangiogenic levels in the plasma of pregnant women with severe preeclampsia at the Obstetric Departement, Haji Hospital, Surabaya. This was a prospective study with observational cross-section study design. The sFlt-1 angiogenic levels were observed before and after (48 hours) methyldopa administration in severe preeclampsia patient with or without complications in the period of August to October 2016. Patient received methyldopa 250 mg or 500 mg, three times a day for clinical indications according a standard protocol. The study was approved by the ethical committee of Haji Hospital, Surabaya. There were 19 patients with preeclampsia who met the inclusion criteria, showed a decrease in the levels of sFlt-1 before and 48 hours after methyldopa therapy. Levels of sFlt-1 before methyldopa therapy in a dose of 250 mg was 10.15±10.00 (2.55-34.70) ng/ml and after therapy 8,37±9,20 (0.72-9.20) ng/ml, with a percentage decrease 17.54%. sFlt-1 levels before methyldopa therapy in a dose of 500 mg was 8.05±7.07 (2.55-20.76) ng/ml, after therapy 4.50±2.90 (2.19-9.95) ng/ml, with a percentage decrease 44.16%. Methyldopa therapy could decrease sFlt-1 levels of antiangiogenic factor in patients with severe preeclampsia.

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