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INDONESIA
Jurnal Sains dan Teknologi Farmasi
Published by Universitas Andalas
ISSN : -     EISSN : -     DOI : -
Core Subject : Science, Education,
Computer Science & IT Education
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Articles 16 Documents
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Search results for , issue " Vol 16 No 2 (2011)" : 16 Documents clear
Analisa Drug Related Problems pada Pasien Dislipidemia di Bangsal Rawat Inap dan Rawat Jalan Penyakit dalam RSUP Dr. M. Djamil Padang Arsil, Yuliana; Arifin, Helmi; Darwin, Deswinar; Raveinal, Raveinal
Jurnal Sains dan Teknologi Farmasi Vol 16 No 2 (2011)
Publisher : Fakultas Farmasi Universitas Andalas

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Abstract

Dyslipidemia is an abnormality of lipid metabolism, which is characterized by elevated or reduced plasma lipid fractions. Dyslipidemia is a major risk factor of cardiovascular disease. An Improve of lipid profile may reduce the risk of cardiovascular disease. This research was conducted to determine the Drug Related Problems (DRPs) occured in patients with dyslipidemia. This research was a prospective observational study using descriptive cross sectional approach, performed on dyslipidemia patients with or without comorbidities in outpatient and inpatient of Internal Medicine DR. M. Djamil Padang from March to May 2011. Evaluation of the data was carried outdescriptively. Results showed that type of DRPs occurred from 11 dyslipidemia patients with or without comorbidities on inpatient of Internal Medicine were drug interactions in 4 patients, adverse drug reactions in 2 patients, noncompliance in 2 patients, dosage too high in 1 patient, inappropriate drug administration interval in 1 patient while other components of DRPs had no problem. In the outpatient of Internal Medicine, DRPs occured at 98 patients of dyslipidemia with or without accompanying diseases were drug interactions in 26 patients, patient noncompliance in 22 patients, adverse drug reactions in 13 patients, dosage too low in 5 patients, drug therapy without medical indications in 4 patients, inappropriate drug administration interval in 3 patients while other components DRPs had no problem. Drug interactions consisted of pharmacokinetic and pharmacodynamic interactions. In practice, those can be accommodates by separating their administration and monitoring of drug interaction. Meanwhile, toxic drug interactions were not found.
Kajian Toksisitas Ekstrak Tumbuhan Talinum triangulare (Jacq) Willd. Rustam, Erlina; Masri, Machdawaty; Arifin, Helmi
Jurnal Sains dan Teknologi Farmasi Vol 16 No 2 (2011)
Publisher : Fakultas Farmasi Universitas Andalas

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Toxicity studies have been conducted from plant extracts of Talinum triangulare (Jacq) Willd. on male white mice. Toxic effects were observed in the form of liver dysfunction and renal dysfunction of experimental animals that were given orally by the variation extract dose of 150, 300 and 600 mg / kg once daily for 15, 30 and 45 days. As a control group used male white mice which were given only 2.5% Tween 80. Parameters to be measured are the activity of SGPT and SGOT, creatinine clearance, renal function and percentage ratio of kidney weight. From the results of studies it appears that administration of plant extract Talinum triangulare (Jacq) Willd. with a given dose affects liver function and kidney function were significantly (P <0.05)
Perbandingan Sosiodemografi End Stage Renal Failure Yang Disebabkan oleh Diabetes Mellitus dan Hipertensi Fitria, Najmiatul; A, Almahdy; Gillani, Syed Wasif
Jurnal Sains dan Teknologi Farmasi Vol 16 No 2 (2011)
Publisher : Fakultas Farmasi Universitas Andalas

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Our study aimed at evaluating sociodemographic value between diabetes mellitus and hypertension as the main cause of end-stage renal failure. Retrospective cross-sectional study was used as the research method. Two hundred end-stage renal failure patient records at 2010 were used to evaluate this study. Statistical analysis was done using statistical package of social sciences (SPSS 17®). Ethical clearance was issued by respective clinical research committee. Sociodemographic factors included gender, age, race, education and lifestyle. Results showed that from 200 end-stage renal failure patients there were 1% secondary to diabetes mellitus, 26.5% secondary to hypertension and 44% secondary to diabetes mellitus and hypertension. Case of end-stage renal failure in male secondary to diabetes mellitus (39%) was higher than hypertension (23.5%). End-stage renal failure secondary to diabetes mellitus was higher than hypertension (14%) in female. 33.5% patients were smokers, 22% were end-stage renal failure secondary to diabetes mellitus and the rest were secondary to hypertension. Statistical analysis showed no significant correlation (sig.>0.05) between lifestyle and end-stage renal failure secondary to diabetes mellitus and hypertension.
Penetapan Kadar Kumarin dari Kulit Manis (Cinnamomum burmanii Bl.) dengan Metoda Kromatografi Gas Yulianis, Yulianis; Adnan, Adek Zamrud; Putra, Deddi Prima
Jurnal Sains dan Teknologi Farmasi Vol 16 No 2 (2011)
Publisher : Fakultas Farmasi Universitas Andalas

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The qualitative and quantitative analysis of coumarin in cinnamon (Cinnamomum burmanii Bl.) which are qualified in to AA, KA and KB has been done by gas chromatography and gas chromatography-mass spectrometry. Extraction of quality KB coumarin was carried out by soxchletation in hexane, dichloromethane and methanol. Meanwhile, quality AA and KA coumarins are soxchletated in methanol. The qualitative analysis using gas chromatography-mass spectrometry with column BP-5 showed that hexane, dichloromethane and methanol extracts of qualified KB coumarin, as well as methanol extracts of qualified AA and KB only contain coumarin compounds, no other coumarin groups were found. From coumarin quantitative analysis by gas chromatography using BP-624 column and FID detector of methanol extracts obtained 1855.51 ppm (0.186%), 1915.75 ppm (0.192%), 9177.36 ppm (0,918%), for qualified KB, AA, and KA respectively.
Efektifitas Antiemetik pada Pasien Yang Menggunakan Sitostatika Pasca Bedah pada Berbagai Jenis Kanker di Rumah Sakit Umum Daerah Dr. Achmad Mochtar Bukittinggi Nasif, Hansen; Junaidi, Junaidi; Muchtar, Husni
Jurnal Sains dan Teknologi Farmasi Vol 16 No 2 (2011)
Publisher : Fakultas Farmasi Universitas Andalas

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Mual dan muntah terjadi pada 70-80% pasien yang mengalami pengobatan kemoterapi kanker. Efek samping tertinggi dari pengobatan kanker dapat menyebabkan kegagalan proses dan hasil dari kemoterapi.Penelitian ini bertujuan melihat efektifitas penggunaan antiemetik pada pasien yang mendapat sitostatika pasca bedah pada berbagai jenis kanker di RSUD Dr. Achmad Mochtar Bukittinggi. Penelitian dilakukan dengan menggunakan metoda observasi prospektif dengan teknik pengambilan porposive sampling dari bulan maret-juni 2009.Hasil penelitian di rumah sakit menunjukkan antiemetik yang banyak digunakan adalah metoklopramid (tunggal) dan dalam bentuk kombinasi adalah metoklopramid-deksametason. Dari 11 orang pasien yang diamati, 1 orang tidak mengalami mual dan muntah, 7 orang mengalami mual dan 3 orang mengalami mual dan muntah. Secara umum antiemetik yang dipakai pada rumah sakit ini belum efektif mengatasi mual dan muntah.
Optimasi Metoda Isolasi Katekin dari Gambir Untuk Sediaan Farmasi dan Senyawa Marker Rahmawati, Noveri; Bakhtiar, Amri; Putra, Deddi Prima
Jurnal Sains dan Teknologi Farmasi Vol 16 No 2 (2011)
Publisher : Fakultas Farmasi Universitas Andalas

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Optimization studies out on isolation of catechin from gambier and pasta for the pharmaceutical and marker compounds have been carried. Gambier gambier and paste were obtained from the Medicinal Plant Garden Andalas University, Siguntur and Lima Puluh Kota. Isolation method used was non-purification method, pre-purification for gambier and fractination for pasta. The analysis performed included catechin solubility, melting point, maximum absorption, thin-layer chromatography, loss on drying, ash content, yield and determination of levels of catechin. Product which has the highest levels of catechins, the determination was continued by analysis of UV spectra and NMR. The best results for pharmaceuticals derived from Siguntur with pre-purification methods which resulted in yield 56.3% with 96.17% catechin content, whereas for a marker compound was obtained from gambier Siguntur pasta with fractionation method which yielded 12.13% with 97.96% of catechin level.
Uji Efek Sitotoksik Ekstrak Etanol Kulit Buah Asam Kandis (Garcinia cowa Roxb.) Terhadap Sel Kanker Payudara T47d dengan Metoda Mtt (Microtetrazolium) Assay Wahyuni, Fatma Sri; Sutma, Suci; Aldi, Yufri
Jurnal Sains dan Teknologi Farmasi Vol 16 No 2 (2011)
Publisher : Fakultas Farmasi Universitas Andalas

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The evaluation of cytotoxic effect on ethanolic extract from the fruit rinds of asam kandis (Garcinia cowa Roxb.) on T47D human breast cancer cells in vitro had been evaluated. The cytotoxic effect was carried out by using MTT assay. Extraction of dried fruit rinds of G. cowa Roxb. was macerated with ethanol 70%. The extract was prepared into 4 concentration groups, 100, 10, 1, and 0,1 μg/ml. Results showed that the IC50 of G. cowa Roxb. ethanolic extract was 19,33 μg/ml ± 1,15 on breast cancer T47D cells. The percentage of cells viability and concentration were analyzed analyzed by the two-way analysis of variance (ANOVA) followed by Duncan test. Result showed that the ethanolic extract of G. cowa Roxb gave a significant effect on T47D breast cancer cells viability (P<0.05).
Pengaruh Air Perasan Bengkuang (Pachyrhizus Erosus (L.) Urb.) Terhadap Kadar Gula Darah Mencit Putih Jantan Diabetes Arifin, Helmi; Merry C, Ann; Ahmad, Asram
Jurnal Sains dan Teknologi Farmasi Vol 16 No 2 (2011)
Publisher : Fakultas Farmasi Universitas Andalas

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Telah dilakukan penelitian tentang air perasan umbi bengkuang (Pachyrhizus erosus (L.) Urb.) terhadap kadar gula darah mencit putih jantan diabetes yang diinduksi dengan aloksan dosis 200 mg/kg BB. Air perasan umbi bengkuang diberikan secara oral dengan dosis 10, 20 dan 30 ml/kg BB selama 21 hari. Parameter yang diukur adalah kadar glukosa darah, berat badan, volume air minum, dan volume urin. Hasil penelitian menunjukkan bahwa air perasan umbi bengkuang dengan dosis 30 ml/kg BB mampu menurunkan kadar glukosa darah mencit diabetes secara bermakna (P<0.05). Air perasan umbi bengkuang juga dapat memperbaiki konsumsi air minum, tetapi tidak dapat memperbaiki berat badan dan volume urin mencit diabetes.
Preparasi dan Karakterisasi Mikrokristalin Selulosa dari Limbah Serbuk Kayu Penggergajian Gusrianto, Putra; Zulharmita, Zulharmita; Rivai, Harrizul
Jurnal Sains dan Teknologi Farmasi Vol 16 No 2 (2011)
Publisher : Fakultas Farmasi Universitas Andalas

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A study on the preparation and characterization of microcrystalline cellulose from waste of sawdust has been carried out. A total of 300 grams of sawdust made into alpha-cellulose by multistage pulping method and hydrolyzed by using hydrochloric acid to produce microcrystalline cellulose, which was characterized further. Microcrystalline cellulose obtained as much as 99 grams with a yield of 33%. The organoleptic characteristics were fine powder, white, odorless, and tasteless. Identification with a solution of iodinated zinc chloride produced a blue violet and the infrared spectrum produced nearly the same wavenumber with Vivacel PH 102®. Solubility in water was 0.117% and the pH was 5.08, dissolved in a solution of ammonia-copper tetramin. The loss on drying was 5.85 %, the bulk density was 0.329 g/ml and tapped density was 0.542 g/ml. Carrs index value was 39.60%, Hausner ratio was 1.656 and Hydration capacity was 3.191. There was no starch on this microcrystalline cellulose. Microcrystalline cellulose from waste of sawdust generally met the pharmacopoeia requirements and the characteristics were not significantly different from Vivacel PH 102®.
Studi Sistem Dispersi Padat Gliklazid Menggunakan Polivinil Pirolidon K-30 (PVP K-30) dan Tween 80 Halim, Auzal; Shilvi, Aulia; Erizal, Erizal
Jurnal Sains dan Teknologi Farmasi Vol 16 No 2 (2011)
Publisher : Fakultas Farmasi Universitas Andalas

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Solid dispersions of gliclazide were prepared by solvent evaporation method using PVP K-30 and Tween 80 as dispersion carriers. The  physicochemical characteristics of solid dispersions were evaluated using microscopic analysis, X-ray diffraction, differential thermal analysis, determination of recovery, and dissolution rate test. Difractogram X-rays showed the physical interaction between the drug (gliclazide) and carrier (PVP K-30 and Tween 80), and polymorphic transformation occured during the evaporation of solvent in the preparation of solid dispersion. Thermogram DTA showed that the components of PVP K-30 and Tween 80 used affected the position of endothermic peak and peak sharpness. Determination of gliclazide in the recovery of solid dispersion was done using derivative spectrophotometry. Solid dispersion of gliclazide-PVP K-30-Tween 80 prepared in this study were found to have higher dissolution rates than pure gliclazide.

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