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INDONESIA
Indonesian Journal of Pharmaceutical Science and Technology
Published by Universitas Padjadjaran
ISSN : 23561971     EISSN : 2406856X     DOI : -
Core Subject : Health, Science,
Computer Science & IT Medicine & Pharmacology
Jurnal Sains dan Teknologi Farmasi Indonesia (IJPST) adalah publikasi ilmiah pada seluruh aspek Sains dan Teknologi Farmasi. Jurnal ini diterbitkan 3 kali setahun untuk menyediakan forum bagi apoteker, dan profesional kesehatan lainnya untuk berbagi praktik terbaik, meningkatkan jaringan kerja dan pendekatan yang lebih kolaboratif dalam Sains dan Teknologi Farmasi.
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Articles 535 Documents
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In Silico Screening of Soursop Leaf (Annona muricata L.) Secondary Metabolites as Potential Estrogen Receptor Alpha Inhibitors Kautsar, Fachrizal Dwi; Sianipar, John Ebenezer; Haiba, Ulaya Warda; Fathinabila, Neysa Zahra; Wulandari, Rizky Prasiska; Nurdin, Halwa Aulia; Nuwarda, Rina Fajri
Indonesian Journal of Pharmaceutical Science and Technology Vol 12 (2025): Vol. 12 Suppl. 3
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v12i3.70710

Abstract

Breast cancer is the most prevalent malignancy among women worldwide. Estrogen receptor alpha (ERα) plays a critical role in regulating cancer cell proliferation, differentiation, and survival, making it an important therapeutic target. Annona muricata Linn. has attracted considerable attention because its leaves contain diverse secondary metabolites with reported anticancer activities, making them a promising source of potential ERα inhibitors. Therefore, this study aimed to evaluate the inhibitory potential of ten selected secondary metabolites from A. muricata leaves against ERα using an in silico approach. Drug-likeness and pharmacokinetic properties were assessed using Lipinski’s Rule of Five and ADMET prediction. Ligand-based pharmacophore modeling was performed, followed by pharmacophore-based virtual screening and molecular docking. Four compounds, namely chlorogenic acid, luteolin, quercetin, and daidzein, fulfilled the pharmacophore criteria with fit scores of 47.17; 47.17; 47.17; and 46.97, respectively, and were subsequently evaluated by molecular docking. Among them, daidzein exhibited the strongest inhibitory potential, with a binding free energy of −8.56 kcal/mol and an inhibition constant of 513.26 nM. Overall, these findings suggest that daidzein is the most promising secondary metabolite of A. muricata leaves for ERα inhibition and may serve as a lead compound for further computational and experimental validation.
Aktivitas Antibakteri Ekstrak Daun dan Batang Pidada Merah (Sonneratia caseolaris) terhadap Bakteri Gigi dan Mulut Melinda, Angeline; Bachtiar, Eri; Susilawati, Yasmiwar; Agung, Mochamad Untung Kurnia
Indonesian Journal of Pharmaceutical Science and Technology Vol 13, No 2 (2026)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v13i2.65347

Abstract

Triclosan (TCS) adalah bahan antibakteri yang umum terdapat dalam pasta gigi dan dikaitkan dengan dampak negatif bagi kesehatan, sehingga diperlukan alternatif alami. Penelitian ini mengevaluasi potensi ekstrak daun dan batang Sonneratia caseolaris sebagai pengganti TCS. Ekstrak diperoleh melalui proses maserasi dan dianalisis kandungan fitokimianya. Penyaringan kualitatif menggunakan prosedur Farnsworth yang dimodifikasi mendeteksi adanya polifenol, flavonoid, kuinon, saponin, terpenoid, dan steroid. Kadar fenolik total terukur sebesar 20,964% (daun) dan 8,419% (batang), sedangkan kadar flavonoid mencapai 1,465% (daun) dan 0,326% (batang). Efektivitas antibakteri diuji terhadap Streptococcus mutans, Porphyromonas gingivalis, dan Pseudomonas aeruginosa menggunakan metode difusi sumur pada konsentrasi 5%, 10%, 20%, dan 40%. Hasil menunjukkan bahwa ekstrak daun menunjukkan aktivitas pada konsentrasi 40%, sedangkan ekstrak batang efektif mulai dari konsentrasi 20%. Temuan ini menunjukkan bahwa S. caseolaris merupakan alternatif yang layak untuk TCS berkat sifat antibakterinya pada konsentrasi 20% dan 40%. Namun, kelarutan sampel yang rendah secara signifikan memengaruhi hasil, yang menunjukkan bahwa diperlukan optimasi lebih lanjut untuk aplikasi praktis.
Pharmacogenomics β-Blockers in Cardiovascular Disease: Implications for Blood Pressure and Clinical Outcomes Zulqifli, Iqbal; Malau, Jekmal; Aditya, Fitra Ari; Nursyafillah, Rizki Noval; Harbulcholizi, Luthfi; Rahmasari, Ratika; Raekiansyah, Muhareva; Hermosaningtyas, Anastasia Aliesa
Indonesian Journal of Pharmaceutical Science and Technology Vol 13, No 2 (2026)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v13i2.60681

Abstract

Hypertension is a chronic condition that increases the risk of cardiovascular disease and death. β-blockers, including atenolol, metoprolol, bisoprolol, and carvedilol, lower blood pressure by blocking adrenergic receptors. However, variations in response and side effects are often influenced by genetic differences that affect drug metabolism and action. This narrative review analyzes studies published between 2014 and 2024 in PubMed, ScienceDirect, and Google Scholar using keywords related to genetic variation, β-blockers, hypertension, pharmacogenetics, and polymorphisms. Original studies in English, clinical trials on genetic polymorphisms and β-blocker response were included; reviews and incomplete studies were excluded. Clinical outcomes included changes in systolic and diastolic blood pressure, heart rate, hypotension, aortic root z-score, LVOT gradient, NT-proBNP, and premature ventricular contractions, which were associated with polymorphisms in the ADRB1, ADRB2, ACY3, FGD5, SLC4A1, and SLC25A31 genes. Metabolic outcomes, impaired fasting glucose, new-onset diabetes, and melatonin metabolite changes were associated with variants in PRKCB, DPYS, PAH, and PLEKHH2. Most data came from European and North American populations, with limited representation from Asia, limiting generalizability. These findings support the use of pharmacogenomics to personalize β-blocker therapy and improve hypertension management, despite challenges related to high costs, limited infrastructure, the lack of clinical guidelines, and population heterogeneity.
Ekstraksi Hijau Daun Senduduk (Melastoma malabathricum) Menggunakan NaDES: Formulasi Toner dan Evaluasi Antioksidan Putra, Rizky Yulion; Mariska, Ruri Putri; Permatasari, Jelly; Marisanti, Debi Putri; Meliani, Meliani
Indonesian Journal of Pharmaceutical Science and Technology Vol 13, No 2 (2026)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v13i2.66702

Abstract

Daun senduduk (Melastoma malabathricum) mengandung senyawa bioaktif, salah satunya berperan sebagai antioksidan, tetapi pemanfaatannya sebagai kosmetik, khususnya toner, masih terbatas. Tingginya paparan radikal bebas menuntut hadirnya kosmetik alami, sehingga penggunaan pelarut ramah lingkungan seperti NaDES (Natural Deep Eutectic Solvent) menjadi solusi tepat. Penelitian ini bertujuan untuk mengarakterisasi sediaan toner ekstrak daun senduduk dengan NaDES (kolin klorida : asam laktat, 1:1) melalui metode sonikasi pada suhu 30°C dan 70°C selama 15 menit. Ekstrak diformulasikan menjadi enam variasi konsentrasi toner. Evaluasi meliputi uji organoleptik, homogenitas, pH, viskositas, stabilitas, iritasi, hedonik, serta karakterisasi partikel. Karakterisasi kimia dilakukan dengan LC-MS/MS serta uji antioksidan menggunakan metode DPPH dan FRAP. Hasil menunjukkan seluruh formula stabil dan memenuhi standar sediaan kosmetik. Uji iritasi menyatakan semua formula aman, dengan formula mengandung ekstrak NaDES 1% banyak disukai berdasarkan uji hedonik. Nilai IC50 terbaik diperoleh pada formula 5%, menunjukkan aktivitas antioksidan kuat sebesar 88,47 µg/mL (DPPH, 30°C) dan 95,50 µg/mL (FRAP, 70°C). Analisis LC-MS/MS formula 5% (30°C) mengidentifikasi senyawa terpenoid dan alkaloid. Pada uji partikel formula 5% (70°C) dengan ukuran partikel 35,6 nm dan nilai zeta potensial +161,1 mV.  Secara keseluruhan, toner ekstrak NaDES daun senduduk berpotensi dikembangkan sebagai kosmetik alami dengan aktivitas antioksidan kuat.
Effect of Curcumin Nanoliposomal Formulation on Cyclin E1 Expression and Cell Migration in HeLa Cells Subandi, Subandi; Zulhaijah, Resti; Fitri, Loeki Enggar
Indonesian Journal of Pharmaceutical Science and Technology Vol 13, No 2 (2026)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v13i2.71044

Abstract

Cervical cancer remains a major cause of female mortality worldwide and ranks as the second-leading cause of cancer-related death among women in Indonesia, associated with Human Papillomavirus infection. HPV-driven oncogenesis disrupts cell-cycle regulation through Cyclin E1 upregulation and promotes cell migration, thereby accelerating tumor progression. Curcumin exhibits antitumor activity, but poor solubility and bioavailability limit its clinical use. Curcumin nanoliposomal formulations have been investigated to address these limitations. This in vitro study used a post-test-only control group design to evaluate a curcumin nanoliposomal formulation in HeLa cervical cancer cells. Cells received the formulations at 100, 150, and 200 μg/mL, while cisplatin 5 μg/mL served as the positive control. Cyclin E1 expression was assessed by indirect immunofluorescence and quantified using ImageJ, whereas cell migration was evaluated by scratch wound healing assay at 0 and 24 hours. Curcumin nanoliposomal formulations significantly reduced Cyclin E1 expression (p=0.006), particularly at 150 μg/mL (p=0.016) and 200 μg/mL (p=0.034). Wound closure decreased from 19.28% in the negative control to 3.42% at 200 μg/mL, although post hoc analysis showed no significant difference between treatment groups and negative control. These findings suggest that the curcumin nanoliposomal formulation warrants further validation as a potential adjunctive therapy.

Page 54 of 54 | Total Record : 535

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