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INDONESIA
Indonesian Journal of Pharmaceutical Science and Technology
Published by Universitas Padjadjaran
ISSN : 23561971     EISSN : 2406856X     DOI : -
Core Subject : Health, Science,
Computer Science & IT Medicine & Pharmacology
Jurnal Sains dan Teknologi Farmasi Indonesia (IJPST) adalah publikasi ilmiah pada seluruh aspek Sains dan Teknologi Farmasi. Jurnal ini diterbitkan 3 kali setahun untuk menyediakan forum bagi apoteker, dan profesional kesehatan lainnya untuk berbagi praktik terbaik, meningkatkan jaringan kerja dan pendekatan yang lebih kolaboratif dalam Sains dan Teknologi Farmasi.
Arjuna Subject : -
Articles 518 Documents
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Effects of Mesenchymal Stem Cell Secretome on Cardiac Histopathological Changes in Doxorubicin-Induced Rats Putri, Liza Aulia; Syahrizal, Dedy; Husna, Fauzul; Ridwan, Muhammad; Fitriyani, Sri
Indonesian Journal of Pharmaceutical Science and Technology Vol 13, No 1 (2026)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v13i1.69258

Abstract

Doxorubicin is an anthracycline chemotherapeutic agent widely used in clinical practice, but its application is limited by cardiotoxicity that damages myocardial structure and function. Mesenchymal stem cell secretome contains diverse bioactive molecules, including cytokines, growth factors, and extracellular vesicles, which contribute to tissue protection and cellular repair. This study aimed to evaluate the preventive and curative effects of secretome administration on histopathological changes in the hearts of doxorubicin-induced rats. Twenty-four rats were divided into four groups: without treatment (KS), cardiotoxicity group (KK), preventive secretome (P1), and curative secretome (P2). Histopathological assessment included degeneration, inflammatory infiltration, congestion, and necrosis using semi-quantitative scoring. Results showed no significant differences in degeneration, inflammatory infiltration, or congestion among groups. In contrast, necrosis scores differed significantly (p = 0.002), with the highest values observed in the KK group. Secretome administration in the P2 group demonstrated the most pronounced improvement, reflected by a greater reduction in necrosis scores compared to other groups. In conclusion, curative-phase secretome treatment provided the most effective histological improvement by reducing myocardial necrosis, indicating a stronger tissue repair response than preventive administration.
OPTIMASI DAN VALIDASI PENETAPAN KADAR BORAKS PADA SOSIS DENGAN METODE SPEKTROFOMETRI UV-VIS MENGGUNAKAN PEREAKSI BUNGA ROSELLA (Hibiscus sabdariffa L.) Kusuma Pramushinta, Intan Ayu; Purbosari, Ira; Rusinta, Rusinta
Indonesian Journal of Pharmaceutical Science and Technology Vol 13, No 1 (2026)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v13i1.49656

Abstract

Boraks sering disalahgunakan sebagai bahan tambahan pangan, khususnya sebagai pengawet dan pengenyal. Penelitian ini bertujuan untuk mengoptimasi dan memvalidasi metode kuantitatif penetapan kadar boraks menggunakan ekstrak bunga rosella (Hibiscus sabdariffa L.) serta menentukan kadar boraks pada sampel sosis menggunakan spektrofotometri UV-Vis. Metode yang digunakan adalah eksperimental kuantitatif. Panjang gelombang maksimum diperoleh pada 518,4 nm. Kondisi optimum dicapai pada campuran 1 mL larutan boraks dan 3 mL ekstrak rosella pada pH 2. Intensitas warna meningkat seiring dengan peningkatan konsentrasi boraks (10–50 ppm). Validasi metode menunjukkan linearitas yang baik dengan persamaan regresi y = 0,006x + 0,3538 dan koefisien korelasi (R²) sebesar 0,9959. Nilai limit deteksi (LOD) sebesar 18,8 ppb, akurasi 99,42%, dan presisi (%RSD) 0,736%. Hasil analisis sampel sosis menunjukkan adanya kandungan boraks sebesar 60,41 ppm. Hasil ini menunjukkan bahwa ekstrak bunga rosella dapat digunakan sebagai indikator alami dalam analisis boraks pada sampel pangan.
Optimasi Granul Effervescent Kombinasi Ekstrak Daun Kepel, Kulit Manggis dan Rimpang Kunyit Husein, Zulaikhah; diniatik, diniatik; Astuti, Ika Yuni
Indonesian Journal of Pharmaceutical Science and Technology Vol 13, No 1 (2026)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v13i1.48085

Abstract

Hiperurisemia adalah suatu keadaan dimana kadar asam urat dalam tubuh lebih dari 7,0 mg/dL. Daun Stelechocarpus burahol, kulit Garcinia mangostana, dan rimpang temulawak memiliki aktivitas antihiperurisemia. Obat herbal yang mengandung ekstrak tumbuhan biasanya memiliki rasa pahit, sehingga dibuat butiran effervescent yang dapat meningkatkan rasa tidak enak dan memiliki efek menyegarkan. Penelitian ini bertujuan untuk menentukan formula optimum kombinasi ekstrak granul effervescent daun kepel, kulit manggis dan rimpang kunyit. Optimasi Metode Faktorial 22 (Design Expert 13) dengan variabel bebas asam sitrat dan natrium bikarbonat. Kelembaban, waktu larut dan kecepatan alir sebagai variabel terikat. Hasil penelitian menunjukkan bahwa granul dengan komposisi asam sitrat 1800 mg dan natrium bikarbonat 2160 mg merupakan formula optimum dengan nilai prediksi kelembaban 1,435%, waktu larut 90,8 detik dan laju alir 12,64 g/detik dengan nilai desirability. dari 0,859. Formula optimum grnul effervescent memiliki nilai kadar air 1,21%, waktu larut 99,92 detik dan laju alir 11,69 g/detik.
Assessing Service Quality of Inpatient Community Health Center and Its Impact on Patient Satisfaction: A SERVQUAL and Zone of Tolerance Approach Kuncoro, Shienny; Fristiohady, Adryan; Wahyuni, Wahyuni; Ruslin, Ruslin; Amran, Mulyaty
Indonesian Journal of Pharmaceutical Science and Technology Vol 12 (2025): Vol. 12 Suppl. 3
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v12i3.62821

Abstract

Community Health Center Poasia, as a public service, aims to provide quality health services. The existence of complaints from patients related to the services received can have an impact on patient visits, which in 2023 decreased by around 21%. One of the causes of decreased patient visits is that patients are not satisfied with the services at the Poasia Health Center. The quality of health services can be measured using the Servqual and ZoT methods. The Servqual method measures the GAP value between the performance value and the expected value, followed by ZoT to see whether the tolerance limit range of patient dissatisfaction is still acceptable. Respondents will be interviewed using a questionnaire. The results of this study showed that the GAP value in the responsiveness dimension is still negative (-0.04), indicating that some patients are dissatisfied with the services received. The GAP value for the other four dimensions is positive, indicating that patients are satisfied with the services received at the health center. The ZoT value in the tolerance limit range is -0.01-2.24. The negative ZoT value indicates that some patients are dissatisfied, and the positive ZoT value of the patient is still within the tolerance limit for receiving minimum service. This study concludes that quality health services will provide satisfaction to patients.
Piper betle Leaf Extract Spray Gel for Diabetic Wound Causes by Bacterial Infections Wulandari, Ririn Lispita; Aljufri, Achmad Quraisy; Chafiffa, Safira; Andani, Geges Arstri
Indonesian Journal of Pharmaceutical Science and Technology Vol 12 (2025): Vol. 12 Suppl. 3
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v12i3.63060

Abstract

Antibiotic resistance in the treatment of diabetic wound infections is common. Piper betle leaf extract has antibacterial, anti-inflammatory, and antioxidant activities. This study aims to formulate a spray gel from Piper betle leaf extract and test its effect on diabetic wounds infected with Methicillin-Resistant Staphylococcus aureus (MRSA) and Pseudomonas aeruginosa. The gel was made with 10% (F1), 15% (F2), and 20% (F3) extracts. The organoleptic physical characteristics, pH, homogeneity, viscosity, spray pattern, adhesive spreadability, drying time, and physical stability were tested. All rats were given alloxan 170 mg/kgBW, fasting glucose levels were measured, and then grouped into control, MRSA-exposed, and P. aeruginosa-exposed groups. The negative and positive controls were also included in the test. A 2 cm wound with a depth of 0.3 cm was given bacteria, except for the normal control. The length of the wound was measured, and the wound reduction was calculated as a percentage of wound closure and statistically analyzed. All the formulas met the physical criteria, significantly closing MRSA wounds by 100%. F2 and F3 significantly closed P. aeruginosa wounds by 89.88% and 93.13%, respectively. Collectively, the Piper betle leaf extract spray gel had an effect that could relieve diabetic wound infections.
Cost-Effectiveness Analysis of Oral Antidiabetic Monotherapy with Metformin and Glimepiride in Diabetes Mellitus at Bahteramas Hospital Pusmarani, Jastria; Apriani, Rini; Himaniarwati, Himaniarwati; Baco, Julianas; Azlimin, Azlimin
Indonesian Journal of Pharmaceutical Science and Technology Vol 12 (2025): Vol. 12 Suppl. 3
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v12i3.63022

Abstract

Healthcare expenditure due to diabetes mellitus in Indonesia reaches approximately US$143 per person. The largest portion of this cost is attributed to medications. Therefore, ensuring the cost-efficiency and effectiveness of drug use is critically important. This study aims to determine and analyze the cost-effectiveness of antidiabetic drug therapy in patients with type 2 diabetes mellitus in the outpatient department of Bahteramas Hospital in Southeast Sulawesi Province. Descriptive methods and quantitative analysis of medical record data from Type 2 diabetes mellitus (DM) patients and treatment costs at Bahteramas Hospital in 2023. A total of 61 patients were included in the study based on the inclusion criteria. Based on the average cost-effectiveness ratio (ACER), glimepiride was more efficient, with a value of IDR 18,389, compared to metformin, which had an ACER of IDR 25,405. However, based on the incremental cost-effectiveness ratio (ICER), metformin was more cost-effective, with a value of IDR 50,070. While the biguanide group (metformin) appears more cost-effective than the sulfonylurea group (glimepiride) based on ICER, the overall findings indicate that, based on ACER, glimepiride (sulfonylurea) is more cost-effective. Therefore, glimepiride can be recommended as a single oral antidiabetic therapy at Bahteramas Hospital.
Inhibitory Activity of Polypodium feei Root Extracts on Nitric Oxide and TNF-α Synthesis in LPS‐activated RAW264.7 Cell Line Suwandi, Deden Winda; Hamdani, Siva; Ruchiyat, Ruchiyat
Indonesian Journal of Pharmaceutical Science and Technology Vol 12 (2025): Vol. 12 Suppl. 2 (2025)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v12i0.59351

Abstract

Polypodium feei (P. feei) roots have been reported to contain sellegueain A, a compound with analgesic and anti-inflammatory properties demonstrated in experimental animals. However, the anti-inflammatory activity of extracts, which represent the form most used in traditional medicine, has not been scientifically validated. This study aims to test the anti-inflammatory activity of P. feei root extract in inhibiting the synthesis of inflammatory mediators such as NO, iNOS, and TNF-α in RAW264.7 macrophage cells stimulated by lipopolysaccharide (LPS). RAW264.7 cells were used to evaluate the inhibitory activity of test compounds on the production of inflammatory mediators NO, iNOS, and TNF-α. Research parameters included cell viability testing with MTS, colorimetric test to determine the concentration of nitric oxide (NO), ELISA test to measure protein levels of the iNOS and TNF-α. P. feei root extract at concentrations of 10, 50, 100, and 150 µg/mL inhibited the production of inflammatory mediators with the best activity in inhibiting NO and iNOS with IC50 values of 87.22 and 99.99 µg/mL, respectively. This study shows that P. feei root extract has anti-inflammatory activity through inhibiting the production of NO, iNOS and TNF-α mediators in LPS-stimulated RAW264.7 macrophage cells.
Identification of Bioactive Constituents in Forest Honey Using GC-MS and Anti-Inflammatory Activity Through Protein Denaturation Hariana, Hariana; Fristiohady, Adryan; Purnama, La Ode Muhammad Julian; Yodha, Agung Wibawa Mahatva; Irnawati, Irnawati; Wahyuni, Wahyuni; Jumriani, Jumriani
Indonesian Journal of Pharmaceutical Science and Technology Vol 12 (2025): Vol. 12 Suppl. 3
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v12i3.62972

Abstract

Honey is a natural product rich in bioactive compounds with various pharmacological and anti-inflammatory effects. Bee species and nectar sources influence the composition of bioactive compounds in honey. This study aimed to identify bioactive compounds and evaluate the anti-inflammatory activity of honey from Apis mellifera and Apis dorsata. Compound identification from both honey types was performed using Gas Chromatography-Mass Spectrometry (GC-MS). At the same time, anti-inflammatory activity was assessed through the human red blood cell (HRBC) membrane stabilization method and protein denaturation inhibition assay, with sodium diclofenac as a positive control. GC-MS analysis revealed various bioactive compounds, notably 2-Propenoic acid, 3-(4-methoxyphenyl)-2-ethylhexyl ester, consistently present in both honey types. In the HRBC assay, Apis mellifera honey showed the highest stabilization value of 94.14% at a concentration of 6.25 mg/L honey solution, surpassing sodium diclofenac (87.96%), while Apis dorsata honey reached 85.21%. All samples achieved over 95% stabilization at 100 mg/L. In the protein denaturation assay, Apis dorsata honey exhibited stronger anti-inflammatory potential with an IC₅₀ of 12.85 ± 1.477 mg/L compared to Apis mellifera (25.35 ± 0.024 mg/L). In conclusion, both types of honey possess promising natural anti-inflammatory potential through membrane stabilization and protein protection mechanisms.

Page 52 of 52 | Total Record : 518

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