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INDONESIA
Indonesian Journal of Pharmaceutical Science and Technology
Published by Universitas Padjadjaran
ISSN : 23561971     EISSN : 2406856X     DOI : -
Core Subject : Health, Science,
Computer Science & IT Medicine & Pharmacology
Jurnal Sains dan Teknologi Farmasi Indonesia (IJPST) adalah publikasi ilmiah pada seluruh aspek Sains dan Teknologi Farmasi. Jurnal ini diterbitkan 3 kali setahun untuk menyediakan forum bagi apoteker, dan profesional kesehatan lainnya untuk berbagi praktik terbaik, meningkatkan jaringan kerja dan pendekatan yang lebih kolaboratif dalam Sains dan Teknologi Farmasi.
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Articles 511 Documents
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Mapping the Anticancer Mechanism of Asiatic Acid : A systematic review of preclinical evidence Sari, Rina Kartika; Dalimunthe, Rahmi Syaflida; Amir, Lisa Rinanda; Wimardhani, Yuniardini Septorini; Musfiroh, Ida; Sastradipura, Dewi Fatma Suniarti
Indonesian Journal of Pharmaceutical Science and Technology Vol 13, No 1 (2026)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v13i1.62028

Abstract

Studies have demonstrated that Asiatic acid (AA) from Centella asiatica has anticancer properties in cancer cell lines, but translating these findings into clinical research remains challenging. This review aims to provide a robust scientific foundation for enhancing the translational potential of AA-based anticancer therapy. The PubMed, Scopus, and ScienceDirect databases were searched electronically using specific keywords and screened in accordance with the PRISMA 2020 guidelines.  Fourteen studies meet the criteria. All research was conducted in vitro; four studies were conducted both in vitro and in vivo, and three were conducted in silico.Asiatic acid (AA) demonstrates potent anticancer activity by modulating key signaling pathways, including PI3K/Akt and NF-κB, thereby inhibiting proliferation, promoting apoptosis, and reducing metastasis. Its cytotoxic effects are time- and dose-dependent (1–50 µM) and minimal in normal cells. While AA and its derivatives consistently outperform controls, limitations such as missing control dose data warrant further investigation. Future studies should focus on in vivo validation, clinical translation, and advanced strategies such as targeted delivery and AI-assisted drug development to fully realize AA’s therapeutic potential.
Formulation and Anti-Hypertensive Activity of Ambon Banana Peel Foam Mat Drying Granules as a Nutraceutical Arifin, Ibrahim; Anwar, Khoirul; Shabrina, Ayu; Wibowo, Danang Novianto; Amirudin, Muhammad Subhan; Kumalasari, Wahyu; Angelita, Anastasya; Mastuti, Sri; Inayati, Dian
Indonesian Journal of Pharmaceutical Science and Technology Vol 13, No 1 (2026)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v13i1.63013

Abstract

Ambon banana peel (ABP) is rich in phenolic compounds yet unstable to light and heat. Foam-mat drying (FMD) protects bioactive components and facilitates the development of nutraceutical products. This study aimed to formulate and evaluate FMD granules containing ABP for their antioxidant and antihypertensive activities. Granules were prepared with ABP at 1% (F1), 2.5% (F2), and 5% (F3) w/w, combined with 6% Tween-80 and 15% maltodextrin, dried at 40 °C for 60 min, and blended with excipients. Physical characteristics, pH, flowability, and antioxidant activity (ABTS assay) were assessed. Antihypertensive effects were tested in Wistar rats induced with 2% NaCl and treated orally for 14 days; captopril (5 mg/kg BW) served as a positive control. Data were analyzed by one-way ANOVA. All formulations produced free-flowing granules with a moisture content <2% and a dissolution time <5 min. Antioxidant inhibition increased with ABP content, with F3 showing the highest activity (71.3 ± 1.4%). F3 also achieved the greatest reductions in systolic (≈31%) and diastolic (≈39%) blood pressure, approaching the effect of captopril. Moreover, F3 exhibits strong antioxidant activity and significant antihypertensive effects, indicating potential as a sustainable nutraceutical for the management of hypertension. Further studies on product stability and clinical efficacy are warranted.
Pengembangan Dispersi Padat Glukosamin-PEG 6000/PVP untuk Meningkatkan Disolusi Celecoxib sebagai Agen Antiinflamasi Wibowo, Danang Novianto; Prihantini, Malinda; Nazilah, Nur Milatin; Novitaningrum, Pramesti Ayu; Fina, Ya’ti Nur
Indonesian Journal of Pharmaceutical Science and Technology Vol 13, No 1 (2026)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v13i1.51711

Abstract

Celecoxib memiliki disolusi yang rendah sehingga memengaruhi bioavailabilitas obat. Sistem dispersi padat dapat digunakan sebagai salah satu pendekatan untuk meningkatkan disolusi obat. Glukosamin HCl, PEG 6000, dan PVP merupakan bahan yang dapat digunakan sebagai pembawa dalam sistem dispersi padat. Penelitian ini bertujuan untuk meningkatkan disolusi celecoxib melalui pembentukan dispersi padat, dan mengevaluasi perubahan kristalinitas yang terbentuk. Dispersi padat dan campuran fisik celecoxib dibuat menggunakan pembawa glukosamin HCl dengan rasio (F1) 1:1, (F2) 1:2, dan (F3) 2:1; glukosamin HCl–PEG 6000 dengan rasio (F4) 1:1:1, (F5) 1:2:1, dan (F6) 1:1:2; serta glukosamin HCl–PVP dengan rasio (F7) 1:1:1, (F8) 1:2:1, dan (F9) 1:1:2. Dispersi padat dipreparasi menggunakan metode pelarutan. Celecoxib murni, campuran fisik, dan dispersi padat diuji disolusinya serta dikarakterisasi sifat kristalnya menggunakan x-ray diffraction (XRD). Hasil penelitian menunjukkan bahwa disolusi celecoxib meningkat pada sistem dispersi padat. Nilai Q45 dispersi padat celecoxib memenuhi kriteria karena memiliki nilai lebih dari 45%. Nilai DE60 tertinggi diperoleh pada sistem dispersi padat celecoxib dengan pembawa glukosamin HCl pada rasio 1:2, yaitu 80,28% ± 0,58. Hasil difraktogram menunjukkan bahwa dispersi padat dapat mengubah sifat kristalin celecoxib. Secara keseluruhan, sistem dispersi padat meningkatkan disolusi celecoxib dengan pembawa glukosamin, baik tunggal maupun dikombinasikan dengan PEG 6000 atau PVP.
Pea Seed (Pisum sativum L.) Extract Exhibits Cytotoxic Activity against T47D Cancer Cells Chasani, Failasufia Maulida; Hidayati, Devi Nisa; Hartati, Indah
Indonesian Journal of Pharmaceutical Science and Technology Vol 13, No 1 (2026)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v13i1.62205

Abstract

Pea (Pisum sativum L.) contain flavonoids with potential anticancer activity against breast cancer cells. Yet, the influence of extraction methods and solvent choice on flavonoid yield and bioactivity remains insufficiently studied. This study evaluated the effect of solvent type and extraction method on the flavonoid content and cytotoxic activity of Pisum sativum L. seed extract on T47D breast cancer cells. Extraction was performed using reflux and infusion methods with 96% ethanol, 70% ethanol, and water solvents. Flavonoid content was determined using the AlCl₃ colorimetric test, while cytotoxic activity was tested using the MTT method. The results showed that the 96% ethanol extract had the highest flavonoid content (9.88 ± 0.05 mg QE/g), followed by 70% ethanol (5.91 ± 0.26 mg QE/g) and water extract (2.63 ± 0.06 mg QE/g). Cytotoxic activity was demonstrated by 96% and 70% ethanol extracts with IC₅₀ values of 147.12 ± 8.81 µg/mL and 90.59 ± 5.75 µg/mL, respectively, while the water extract was inactive. These findings confirm that solvent polarity plays an important role in optimizing flavonoid content and cytotoxic potential. However, high flavonoid content does not always correlate with cytotoxic effects, so a comprehensive approach is needed in the development of natural-based anticancer agents.
Rapid and Non-Destructive Analysis of Plant Material Using FTIR and Chemometric Methods Salsabilla, Bunga Indra; Muchtaridi, Muchtaridi; Megantara, Sandra; Novitasari, Dhania; Musfiroh, Ida
Indonesian Journal of Pharmaceutical Science and Technology Vol 13, No 1 (2026)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v13i1.63950

Abstract

Plant material analysis requires efficient, reliable, and sustainable methods for characterization, authentication, and quality control. Fourier Transform Infrared Spectroscopy (FTIR), combined with chemometrics, has emerged as a non-destructive approach that requires minimal sample preparation. This review summarizes developments and applications of FTIR chemometrics in plant analysis from 2015 to 2025, based on more than 32 published studies. The evolution of data analysis is described from classical techniques, including Principal Component Analysis and Partial Least Squares, to machine learning methods such as Support Vector Machines and Random Forests. Various FTIR modes, namely ATR FTIR, DRIFTS, and FTIR PAS, are discussed for analyses of leaves, roots, rhizomes, flowers, fruits, and fossilized plant materials. Reported applications include species identification with accuracies approaching 100%, geographic origin authentication with 77-94% accuracy, detection of adulteration in high-value commodities such as saffron, quantification of bioactive constituents with determination coefficients of 0.96-0.99, and assessment of environmental or agronomic influences on plant composition. Although challenges remain, particularly matrix complexity and calibration transfer, FTIR chemometrics represents a sustainable, rapid, and cost-effective tool for research and industrial quality control. Future directions emphasize the global integration of artificial intelligence and instrument miniaturization.
Standardization, Antioxidant, and Antimicrobial Activity Test of Ethanol Extract from Andiroba Bark (Carapa guianensis) Hasanuddin, Silviana; Isrul, Muhammad; Saafi, La Ode; Dewi, Citra; Yulianingsih, Eka Putri; Dewi, Shafira Endah Amartya; Nita, Waode Adisti Elmira; Zainal, Mardani
Indonesian Journal of Pharmaceutical Science and Technology Vol 13, No 1 (2026)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v13i1.63644

Abstract

Most degenerative diseases are linked to excess free radicals generated by the body's metabolism or exposure to external factors. Antioxidants are used to help neutralize free radicals and treat bacterial infections. Andiroba bark (Carapa guianensis) is one of the plants used empirically by the people of the Province of Jeneponto to treat various diseases. This study aims to determine whether the ethanol extract of andiroba bark meets the standardization requirements and exhibits antioxidant activity, and to identify its ability to inhibit the growth of Staphylococcus aureus, Propionibacterium acnes, Staphylococcus epidermidis, and Escherichia coli. The results of the research showed that the results of specific and non-specific standardization of the ethanol extract from andiroba bark met the specified requirements, the ethanol extract had an antioxidant activity with an IC50 value of 15.985 μg/mL, which was included in the group of very strong antioxidants and could inhibit the growth of Staphylococcus aureus, Propionibacterium acnes, Staphylococcus epidermidis, and Escherichia coli bacteria at concentrations of 0.01 g/mL, 0.05 g/mL, and 0.1 g/mL. Overall, the ethanol extract from andiroba bark meets the standardization requirements and exhibits antibacterial activity.
Ethanolic Extract of Fingerroot (Boesenbergia pandurata Roxb.) Rhizomes exhibits Analgesic and Anti-Inflammatory Activities in Swiss Webster Mice Yuniarto, Ari; Setiawan, Abdul Aziz; Asyila, Nadia Dinda
Indonesian Journal of Pharmaceutical Science and Technology Vol 13, No 1 (2026)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v13i1.66595

Abstract

Pain is a sensory response that indicates tissue damage caused by mechanical, chemical, or physical stimuli. This study aimed to evaluate the analgesic and anti-inflammatory activities of the ethanol extract of fingerroot rhizomes (EEFR) in mice. The extract was prepared by maceration using ethanol and tested in mice divided into five groups: three treatment groups receiving EEFR at doses of 100, 200, and 400 mg/kgBW, a positive control group, and a negative control group. Analgesic activity was assessed by the number of writhing responses induced by 1% acetic acid, while anti-inflammatory activity was evaluated based on paw edema induced by 1% carrageenan. The results showed that EEFR at a dose of 400 mg/kgBW produced the most significant analgesic and anti-inflammatory effects, with pain protection and inflammation inhibition percentages of 69.81% and 58.97%, respectively. These findings indicate that EEFR has potential as a natural analgesic and anti-inflammatory agent.
Potential of avocado seed ethanol extract (Persea americana Mill. var Miki) as an anti-aging Alya, Syadza; Hasballah, Kartini; Fitria, Fitria; Harnelly, Essy; Sary, Nirwana Lazuardi
Indonesian Journal of Pharmaceutical Science and Technology Vol 13, No 1 (2026)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v13i1.69540

Abstract

Skin aging, characterized by decreased skin elasticity, is a global concern closely related to elastin degradation caused by oxidative stress and elastase activity. Natural ingredients rich in antioxidants are increasingly explored as potential anti-aging agents. Avocado (Persea americana) seeds contain various bioactive compounds that may protect elastin and slow the skin aging process. This study employed in silico and in vitro approaches to evaluate the antioxidant and anti-elastase activities of ethanol extract of avocado seeds from Bener Meriah, Aceh. Extraction was performed using maceration with 70% ethanol, followed by phytochemical screening. Antioxidant activity was assessed using the DPPH method. Anti-elastase activity was evaluated in silico through molecular docking against porcine pancreatic elastase (PPE) and in vitro using the SANA substrate and PPE enzyme. The avocado seed ethanol extract showed strong antioxidant activity with an IC₅₀ value of 47.31 ppm. It also demonstrated potent anti-elastase activity with an IC₅₀ value of 6.980 ppm. Molecular docking revealed that cholestan-3-ol, 2-methylene-, (3β,5α)- had a binding affinity of −8.0 kcal/mol, comparable to the control. Overall, the ethanol extract of avocado seeds exhibits very strong antioxidant and significant anti-elastase activities both in silico and in vitro, indicating its potential as a natural anti-aging agent.
Analytical Method Validation of High Performance Liquid Chromatography for Ketoconazole Tablets Lumakso, Fajar Aji; Annisa, Viviane; Alviansyah, Muhammad Rizal; Chabib, Lutfi
Indonesian Journal of Pharmaceutical Science and Technology Vol 13, No 1 (2026)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v13i1.69415

Abstract

Ketoconazole is an azole antifungal with low solubility and classified as Biopharmaceutical Classification System (BCS) Class II. A tablet formulation based on an alginate-acacia gum matrix is developed to enhance the solubility of ketoconazole. This study aims to validate the analytical method using High-Performance Liquid Chromatography (HPLC) for the assay of ketoconazole in these tablet formulations. The analysis was performed using a C18 column (250×4.6 mm, 5 μm) with a mobile phase consisting of water for injection (WFI) containing 0.15% TEA (pH 3.3) and acetonitrile (50:50 v/v), flow rate 1.0 mL/min, and detection at 232 nm. Method validation included system suitability testing, linearity, accuracy, precision, specificity, LOD, and LOQ. Specificity testing indicated no interference at the retention time of ketoconazole. Good linearity was achieved over 10–250 ppm (r = 0.9996), with good accuracy (99.8–101.75%) and precision (intraday and interday; %RSD < 2%). LOD and LOQ were 2.357 ppm and 7.142 ppm, respectively. The developed HPLC method was shown to be valid, accurate, precise, selective, and reliable for the assay of ketoconazole in tablets formulated with an alginate-acacia gum matrix. This method can be used for routine quality control.
Effect of Nutmeg on Collagen Remodeling and Epithelialization Using Picrosirius Red and Gold-Orange Staining Fitri, Maisyithoh Rahma; Husna, Fauzul; Suryadi, Taufik; Sary, Nirwana Lazuardi; Fitria, Fitria; Sari, Widya; Maisun, Maisun
Indonesian Journal of Pharmaceutical Science and Technology Vol 13, No 1 (2026)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v13i1.68928

Abstract

Burn injuries, especially second-degree burns, remain a global health concern. Their complex healing mechanisms and socioeconomic burden make them challenging to treat.  This study evaluates the effects of 3% nutmeg (Myristicafragrans) cream on collagen remodeling and epithelial regeneration in grade II burns, using advanced histological techniques.  A post-test-only experimental design was used. Five groups were included: normal control, untreated burn, burn treated with nutmeg cream, burn treated with silver sulfadiazine (SSD), and burn treated with both nutmeg cream and SSD. Collagen subtype distribution was examined using Picrosirius Red–Fast Green staining under polarized light. Epithelialization was assessed using Gold-Orange staining. Results showed that nutmeg cream significantly enhanced the transition from collagen type III to type I. It improved epithelial thickness and promoted keratohyalin granule formation compared to untreated burns. The combination therapy improved some histological features but did not consistently outperform single therapy by day 18. These findings indicate that nutmeg cream supports extracellular matrix remodeling and epithelial maturation. This validates its traditional use and suggests its potential as an accessible adjunctive therapy.  Overall, this study underscores the value of integrating plant-based bioactives with standard treatments to improve burn wound healing.

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