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INDONESIA
Indonesian Journal of Pharmaceutical Science and Technology
Published by Universitas Padjadjaran
ISSN : 23561971     EISSN : 2406856X     DOI : -
Core Subject : Health, Science,
Computer Science & IT Medicine & Pharmacology
Jurnal Sains dan Teknologi Farmasi Indonesia (IJPST) adalah publikasi ilmiah pada seluruh aspek Sains dan Teknologi Farmasi. Jurnal ini diterbitkan 3 kali setahun untuk menyediakan forum bagi apoteker, dan profesional kesehatan lainnya untuk berbagi praktik terbaik, meningkatkan jaringan kerja dan pendekatan yang lebih kolaboratif dalam Sains dan Teknologi Farmasi.
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Articles 494 Documents
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Cytotoxicity and Antimicrobial Activity of Propolis from Trigona itama Stingless Bees against Staphylococcus aureus and Escherichia coli Yusop, Syed A. T. W.; Asaruddin, Mohd R.; Sukairi, Ahmad H.; Sabri, Wan M. A. W.
Indonesian Journal of Pharmaceutical Science and Technology Suppl 1, No. 1 (2018)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (707.484 KB) | DOI: 10.15416/ijpst.v1i1.16118

Abstract

Trigona itama is a stingless bees that produce honey which has been used widely as a traditional medicine. Due to limited research and knowledge on T. itama propolis, it becomes less popular in industrial production than honeybee propolis. The aim of this study was to identify the antibacterial activity and toxicity level in hexane, ethyl acetate and methanol extracts of T.itama propolis. T.itama propolis crude extract was tested for antibacterial activity by using disk di usion method. The antibacterial activities were assessed according to the inhibitory zone of agar medium with sample concentration of 1000 μg/mL, 750 μg/mL and 500 μg/mL. The result from this study revealed that all T. itama propolis crude extract shows presence of inhibition zone against Staphylococcus aureus ATCC 25923 and Escherichia coli ATCC 25922. The brine shrimp lethality test was used to monitor the toxicity level of T. itama propolis where methanol, ethyl acetate and hexane fraction showed low activity of toxicity where all crude extract LC50 showed above 250 μg/mL. It could be concluded from this study that extract from T. itama propolis possessed antimicrobial activity and low level of toxicity. Key Words: Escherichia coli, propolis, stingless bees, Staphylococcus aureus, Trigona itama
Aktivitas Tabir Surya Formula Bedak Dingin Jawa Kusumanti, Diah Puti; Sayuti, Nutrisia Aquariushinta; AS, Indarto
Indonesian Journal of Pharmaceutical Science and Technology Supp 1, No 1 (2017)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (311.446 KB) | DOI: 10.15416/ijpst.v1i1.12156

Abstract

Sinar matahari mengandung sinar ultraviolet yang mengakibatkan efek negatif pada kulit sehingga sediaan tabir surya dibutuhkan untuk melindungi kulit. Bedak dingin Jawa merupakan salah satu sediaan tabir surya yang telah digunakan secara empiris untuk melindungi kulit dari paparan sinar matahari. Formula bedak dingin Jawa tediri dari tepung beras (Oryza sativa L.), pati bengkoang (Pachyrhizu serorus (L.) Urb), kulit kayu manis jangan (Cinnamomum burmanii (nees) BI), pulasari (Alyxia reinwardtii BI), temugiring (Curcuma heyneana) dan biji pinang (Areca catechu L.). Penelitian ini bertujuan untuk mengetahui aktivitas tabir surya kombinasi tepung beras dan ekstrak sonikasi simplisia lain dalam formula bedak dingin jawa melalui pengujian nilai Sun Protection Factor (SPF), nilai persen transmisi eritema (%Te) dan pigmentasi (%Tp). Simplisia penyusun bedak dingin dibuat ekstrak dengan metode sonikasi dan dikombinasikan dengan tepung beras di dalam larutan dengan perbandingan 1:1 kemudian dilakukan pengujian aktivitas tabir surya dengan menggunakan spektrofotometri UV-Vis. Hasil penelitian ini adalah aktivitas tabir surya formula bedak dingin memiliki nilai SPF 15,6 dinyatakan dalam kategori proteksi maximal, nilai persen transmisi eritema 1,2 dinyatakan dalam kategori proteksi ultra, dan nilai persen transmisi pigmentasi 9,3 dalam kategori sunblock. Suatu sediaan tabir surya dinyatakan efektif dalam melindungi kulit bila memiliki nilai SPF yang tinggi, sedangkan nilai %Te dan %Tp efektif melindungi kulit bila nilainya rendah. Melalui penelitian ini dapat disimpulkan bahwa formula bedak dingin jawa efektif dalam melindungi kulit dari paparan sinar matahari. Kata Kunci : Aktivitas Tabir Surya, Bedak Dingin Jawa, SPF, Transmisi Eritema, Pigmentasi 
Simultaneous Estimation of Ketorolactromethamine and Tiemonium methylsulphate in biofluids by a New Validated UPLC Method Uddin, Mohammad Nasir; Uddin, Monir; Kabir, Md. Touhidul
Indonesian Journal of Pharmaceutical Science and Technology Vol 5, No 1 (2018)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (765.646 KB) | DOI: 10.24198/ijpst.v5i1.14381

Abstract

An UPLC method has been developed for the simultaneous determination of ketorolac Tromethamine and tiemonium methylsulphate in pharmaceutical and biosamples. Calibration curves were linear with correlation coefficient 0.9997 over a studied concentration range of (01-10μg m ) for both drugs. Method was found to be reproducible with relative standard deviation (RSD) for intra to be 0.32-0.99% for KTR and 0.40-1.01% for TMS and inter day precision to be 0.51-2.77% for KTR and 0.41-2.26% for TMS over the said concentration range. The mean recovery of the drug obtained from the intraday assay was 99.18-103.34% for KTR, 99.14-101.76% for TMS and inter-day assay at six different days was 99.39-102.04% for KTR and 98.08-103.78% for TMS. The LOD and LOQ were found to be 0.125 and 0.41μg mL-1, respectively for KTR  and 0.150 and 0.50 μg mL-1, respectively for TMS. Method was successfully validated as per ICH guidelines can be conveniently employed for routine quality control analysis of ketorolac tromithamine and tiemonium methylsulphate in pharmaceutical formulations and biological samples without any interference.
Uji Cemaran Air Minum Masyarakat Sekitar Margahayu Raya Bandung Dengan Identifikasi Bakteri Escherichia coli Afrianti Rahayu, Susi; Muhammad Hidayat Gumilar, Muhammad
Indonesian Journal of Pharmaceutical Science and Technology Vol 4, No 2 (2017)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (255.33 KB) | DOI: 10.15416/ijpst.v4i2.13112

Abstract

Air merupakan kebutuhan manusia yang paling penting. Agar tetap sehat, air minum harus memenuhi persyaratan fisik, kimia maupun bakteriologis. Penelitian ini bertujuan untuk memeriksa cemaran Air Minum Dalam Kemasan (AMDK), Air Minum Isi Ulang (AMIU), dan air dengan alat Pemurnian (Purrified) di masyarakat sekitar jalan Merkuri Timur, Margahayu Raya Bandung. Penelitian ini dilakukan dengan mengidentifikasi bakteri Escherichia coli pada air minum. Metode tersebut menggunakan angka lempengan total (ALT), Pewarnaan Gram, Pewarnaan Kapsul, Pewarnaan Tahan Asam, Uji Indol, Metil Merah, Voges Proskauer, Sitrat (IMViC) dan uji fermentasi gula. Dari 5 sampel yang diuji, ke-5 sampel tersebut tidak memenuhi syarat menurut SNI serta PERMENKES karena mengandung jumlah bakteri yang melebihi batas maksimal yaitu 1,0 x 102 untuk cemaran mikroba dan 0 koloni/g (per 100 ml sampel) untuk bakteri Escherichia coli . Dari 5 sampel tersebut 2 sampel teridentifikasi bakteri Escherichia coli sementara 3 sampel lainnya mengandung bakteri koliform yang lain.
Reversibility Time in Testicular Damage on Male Wistar Rat after Treatment of Averrhoa blimbi L. Fruits Extract as Antifertility Alipin, Kartiawati; Rochman, Indra A.; Malini, Desak M.; Madihah, Madihah
Indonesian Journal of Pharmaceutical Science and Technology Suppl 1, No. 1 (2018)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (561.875 KB) | DOI: 10.15416/ijpst.v1i1.16123

Abstract

Belimbing wuluh (Averrhoa blimbi) fruit is commonly used traditionally as antifertility. The bioactive compounds of A. blimbi have been known could inhibit spermatogenesis and development of testes, as well as decrease the quality and quantity of spermatozoa, thus, caused seminiferous tubular atro- phy. This study aimed to determine the reversibility time in testicular damage after the treatment of A. blimbi fruit extract on male Wistar rat. The method employed a completely randomized design (CRD) consists of nine treatments with three replications each. The treatment of the extract at a dose 1140 mg/ kg BW and control group was given the solvent. After 14 days of treatment, the reversibility time was examined in testis histological section by interval of seven days each until 49 days. The results showed that the treatment of A. blimbi fruit extract caused disruptions in seminiferous tubules, i.e. decreased the number of spermatogonium and spermatid, as well as the diameter of lumen and seminiferous tu- bules. The reversibility time was observing at 21 days after the end extract treatments, by increasing the number of of spermatogonium and spermatid, as well as the diameter of lumen and seminiferous tubules that signi cantly different with infertile rat (p<0.05). In conclusion, the reversibility time was 21 days after the treatment of A. blimbi fruit extract as antifertility. Key words: Averrhoa blimbi, rats, reversible time, tubulus seminiferous
Ekspresi Prethrombin-2 Manusia Recombinan dalamPichia pastoris dan Optimasi Kondisi Ekspresinya Gaffar, Shabarni; Upay, Purba; Maksum, Iman Permana; Hasan, Khomaini; Subroto, Toto; Enus, Sutarya; Soemitro, Soetijoso; Pertiwi, Wulan
Indonesian Journal of Pharmaceutical Science and Technology Vol 4, No 1 (2017)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (566.296 KB) | DOI: 10.15416/ijpst.v4i1.9766

Abstract

Pretrombin merupakan prekursor dari trombin yang memiliki aktivitas proteolitik. Trombin merubah fibrinogen menjadi benang fibrin yang salah satu aplikasinya adalah dapat digunakan sebagai lem untuk menggantikan teknik jahitan pasca bedah. Aplikasi trombin untuk pembuatan lem fibrin menuntut diproduksinya trombin rekombinan. Tujuan dari penelitian ini adalah ekspresi gen pretrombin-2 (PT2) manusia rekombinan menggunakan sistem ekspresi Pichia pastoris. Gen pengode PT2 dirancang sesuaidengan kodon preferensi P. pastoris. Fragmen PT2 diamplifikasi dengan metoda PCR dengan penambahan sisi restriksi EcoR1 pada ujung 5’ dan sisi restriksi SacII pada ujung 3’. Produk PCR yang berukuran 924 pb diligasi dengan vektor ekspresi pPICZaB untuk P. pastoris dan disubkloning dalam inang Escherichia coli. Urutan nukleotida dikonfirmasi dengan metoda dideoxy Sanger. Plasmid rekombinan pPICZaB-PT2 kemudian digunakan untuk mentransformasi P. pastoris SMD1168 defisien protease dengan metoda elektroporasi. Hasil penelitian menunjukkan bahwa gen PT2 berhasil diamplifikasi dan dikloning dalam E. coli. Analisis restriksi dan penentuan urutan DNA menunjukkan bahwa PT2 rekombinan 100% homologi dengan hasil rancangan. Hasil ekspresi PT2 oleh P. pastoris menggunakan metanol sebagai inducer memperlihatkan bahwa PT2 dengan berat molekul 35 kDa berhasil diekspresikan. Optimasi kondisi ekspresi melalui variasi konsentrasi metanol sebagai inducer dan sorbitol sebagai sumber karbon tambahan menunjukkan bahwa metanol 2% dan sorbitol 2% merupakan kondisi optimum ekspresi PT2.
Isolation and Phisicochemical Characterization of Microcristalline Cellulose from Ramie (Boehmeria nivea L. Gaud) Based on Pharmaceutical Grade Quality Nawangsari, Desy; Yohana Chaerunisaa, Anis; Abdassah, Marline; Sriwidodo, Sriwidodo; Rusdiana, Taofik; Apriyanti, Linda
Indonesian Journal of Pharmaceutical Science and Technology Vol 5, No 2 (2018)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (425.191 KB) | DOI: 10.24198/ijpst.v5i3.15040

Abstract

Microcrystalline cellulose is the most used material for medicine, which able to be found in fibrous plants. Microcrystal celluloses are being used as filler or binder in dosage formulas in tablets and capsules. This research aimed to produce microcrystalline cellulose from ramie based on pharmaceutical grade parameters. Research method include hemp fiber preparation, α-cellulose isolation, microcrystalline cellulose production, and microcrystalline cellulose characterization which compare with Avicel® PH 102 . Result shown microcrystalline cellulose yield is 57.26%. The result of physicochemical characterization that can comply the specifications of pharmaceutical grade as a pharmaceutical excipient.  Keywods :  Microcrystalline cellulose, Ramie, physicochemical, pharmaceutical grade.
Pengembangan Formula Nano-fitosom Serbuk Liofilisasi Seduhan Teh Hitam (Camellia sinensis L. Kuntze) Husni, Patihul; Puspitaningrum, Kartika
Indonesian Journal of Pharmaceutical Science and Technology Vol 4, No 3 (2017)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (405.435 KB) | DOI: 10.15416/ijpst.v4i2.10916

Abstract

Nano-fitosom merupakan suatu teknologi nano yang digunakan untuk meningkatkan bioavailabilitas bahan aktif yang terkandung dalam tanaman dengan cara mengikat bahan aktif dengan fosfolipid yang memiliki sifat mirip dengan membran sel. Nano-fitosom dibuat dengan mencampurkan fitokonstituen dan fosfatidilkolin dalam perbandingan molar tertentu. Penelitian ini bertujuan untuk mengembangkan formula nano-fitosom serbuk liofilisasi seduhan teh hitam (Camellia sinensis L. Kuntze). Nano-fitosom diformulasikan dengan membuat tiga variasi perbandingan katekin:fosfatidilkolin:kolesterol mulai dari 1:1:0,2 (F1), 1:2:0,2 (F2), dan 1:3:0,2 (F3) dengan menggunakan metode refluks. Evaluasi nano-fitosom meliputi ukuran partikel, indeks polidispersitas, dan efisiensi penjerapan. Hasil evaluasi menunjukkan bahwa ukuran partikel nano-fitosom sekitar 52,1-101,9 nm dengan nilai indeks polidispersitas 0,309-0,404. Efisiensi penjerapan berkisar antara 6,7266%-11,4317%. Formula nano-fitosom dengan efisiensi penjerapan yang paling baik yaitu F3 dengan perbandingan molar katekin:fosfatidilkolin:kolesterol 1:3:0,2 dengan ukuran partikel sebesar 52,1±12,5 nm, indeks polidispersitas 0,320 dan efisiensi penjerapan 11,4317±0,3153%. Analisis data menggunakan One-Way Anova menunjukkan bahwa terdapat pengaruh konsentrasi fosfatidilkolin terhadap efisiensi penjerapan secara signifikan (p < 0,05).Kata kunci: nano-fitosom, fosfatidilkolin, serbuk liofilisasi, teh hitam (Camellia sinensis)
Chondroitin in Transdermal Patch and Its Main Physical Properties Sopyan, Iyan; Tedjasaputra, Moeljadi G; Utami, Saskia Rizky; Abdassah, Marline
Indonesian Journal of Pharmaceutical Science and Technology Supp 1, No 1 (2017)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (349.217 KB) | DOI: 10.15416/ijpst.v1i1.10425

Abstract

Chondroitin sulphate (CS) in oral dosage form has widely used to help manage osteoarthritis, but regret its bioavailability was very low at only 13%, It was due to the first passed effect in the liver and to avoid it CS is needed to be formulated into another forms of preparation like patch. This study was aimed to gure out in-vitro possibility of chondroitin sulphate (CS) to be formulated in a transdermal patch and characterized by its physical properties such as permeation profile through the Franz’s cell and partition coefficient studies. The study showed that 150 mg CS in transdermal patch given the constant permeation within 19 hours with the partition coefficient of 2.22. Based on the permeation profile and the partition coefficient study, the CS patch would become an effective preparation to be considered.Keyword : Chondroitin Sulphate (CS), Transdermal patch, Permeation profile, Partition coefficient 
Antioxidant and Cytotoxicity Studies of Nypa fruticans (Nypa Palm Sugar) Extract Sabri, Wan M. A. W.; Asaruddin, Mohd R. Asaruddin R.; Sukairi, Ahmad H.; Yusop, Syed A. T. W.
Indonesian Journal of Pharmaceutical Science and Technology Suppl 1, No. 1 (2018)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (381.032 KB) | DOI: 10.15416/ijpst.v1i1.17246

Abstract

Nypa fruticans Wurmb which belongs to the family of Arecaceae is one of the most widely distributed and useful palm in the mangrove forests in the Southeast Asia. Nypa palm sugar or commonly known as “Gula Apong” was processed using nypa palm sap as raw material. The nypa palm sugar was expected to benefit wider community as source of alternative sweetener. In this study, 2, 2-diphenyl1-picryhydrazyl (DPPH) scavenging activity and cytotoxicity test of methanol extract of nypa palm sugar were conducted. The antioxidant activity was determined based on DPPH scavenging activity of extract. The cytotoxicity test was conducted against brine shrimp Artemia salina, and the LC50 value of the extract was calculated. The antioxidant activity showed that the EC50 of nypa palm sugar was 1304 mg/mL while the value of EC50 for ascorbic acid was 0.6112 mg/mL. The results of the cytotoxicity showed that the methanol extract of nypa palm sugar was interpreted as non-toxic as the value of LC50 was 184.0 mg/mL.Keywords: 2,2-diphenyl-1-picryhydrazyl, antioxidant, cytotoxicity, Nypa fruticans, nypa palm sugar

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