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INDONESIA
Indonesian Journal of Pharmaceutical Science and Technology
Published by Universitas Padjadjaran
ISSN : 23561971     EISSN : 2406856X     DOI : -
Core Subject : Health, Science,
Computer Science & IT Medicine & Pharmacology
Jurnal Sains dan Teknologi Farmasi Indonesia (IJPST) adalah publikasi ilmiah pada seluruh aspek Sains dan Teknologi Farmasi. Jurnal ini diterbitkan 3 kali setahun untuk menyediakan forum bagi apoteker, dan profesional kesehatan lainnya untuk berbagi praktik terbaik, meningkatkan jaringan kerja dan pendekatan yang lebih kolaboratif dalam Sains dan Teknologi Farmasi.
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Articles 494 Documents
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The Prediction of Curcumin Content in the Turmeric Rhizome with Raman Handheld Spectroscopy Wirasuta, I Made Agus Gelgel; Dewi, Cokorda Istri Tirta Rusmala; Laksmiani, Ni Putu Linda; Srinadi, I Gusti Ayu Made; Putra, Deddi Prima
Indonesian Journal of Pharmaceutical Science and Technology Vol 5, No 3 (2018)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (412.832 KB) | DOI: 10.15416/ijpst.v5i3.16315

Abstract

The quality control of herbal medicine should be started from the determination of the active substance at harvest time. The Raman spectrometry has been used for this propose. The aim of this study is to determine the quantification of curcumin in turmeric rhizome (Curcuma longa Linn.) using Raman spectroscopy combined with multivariate analysis of PLS-R that are expected to provide reference method for quality control in turmeric rhizome, especially for raw materials of Herbal drugs. Parameters that can be used for analysis of curcumin levels on turmeric rhizome obtained using intensity of data Raman and the data obtained from the standard method will be processed with multivariate analysis methods PLS-R. The validation value of quantification result using Raman-PLSR is seen from R2 value of 0.957, RMSEC value of 0,199 and p-value of 0.00. The study showed the developed method could be implemented on to determine the prediction quantification of raw material herbal medicine.Keyword : Curcumin,  PLS-R, Turmeric, Raman Spectroscopy
Isolation and Activity Assay of Secondary Metabolites of Aspergillus niger in-Habiting in Termite’s Queen Nest Macrotermes gilvus Hagen., on Enriched Media Alen, Yohannes; Guslianti, Evi; Suharti, Netty
Indonesian Journal of Pharmaceutical Science and Technology Vol 6, No 1 (2019 In Press)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (514.342 KB) | DOI: 10.15416/ijpst.v5i3.15735

Abstract

The Fungus is a group of the microorganisms that produce secondary metabolites. Secondary metabolites of fungus may be changed in different media. Secondary metabolites from Aspergillus niger in habiting in termite’s queen nest Macrotermes gilvus Hagen are disappeared gradually in artificial media. It was the reason to enrich the media with termite’s queen nest. The purpose of this research was to obtain the similar secondary metabolites of Aspergillus niger as it grows in their habitat. Enrichment was done with the experimental method. It used three concentrations of nest 0.25; 0.75 and 1 g/mL Sabouraud Dextrose Agar (SDA) media. Isolation was done use chromatography method. The antibiotic activities against Pseudomonas aeruginosa ATCC 27853 and Enterococcus faecalis ATCC 10541 were performed by the diffusion method. Results showed that enrichment of nest 1 g/mL media gave the best growth of fungus and it obtain the similar secondary metabolites as it grows in their habitat. Three pure compounds, EG-13-31-2, EG-13-34-9, and EG-13-44-2 were obtained. Based on physicochemical data, all compounds were terpenoid class and one of them (EG-13-34-9) contain the phenolic group. All compounds have activity against Pseudomonas aeruginosa ATCC 27853 and Enterococcus faecalis ATCC 10541 the bacteriostatic category.Key words: Aspergillus niger; Macrotermes gilvus Hagen; Sabouraud Dextrose Agar (SDA); Isolation; Enrich Media; Diffusion Method
Synthesis N1-Tersier-Butilteobromin from Teobromin and Tersier-Butylbromides Husein, Sri Gustini; Zainuddin, Achmad; Hoeruman, Sani
Indonesian Journal of Pharmaceutical Science and Technology Vol 5, No 3 (2018)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (368.687 KB) | DOI: 10.15416/ijpst.v5i3.17931

Abstract

Xantine derivatives are known to have some pharmacological activity, such as a bronchodilator. The substitution on atoms N1 xantine can improve the activity and selectivity as a tracheaspasm. The purpose of this research was to investigate the influence of concentration sodium hydroxide in sodium acetate as solvent used on the production yield of N1-tert-butilteobromin. The result of the synthesis was isolated using chloroform and purified with the preparative thin layer chromatography. The molecule structure of N1-tert-butilteobromin was confirmed using ultraviolet and infrared spectrophotometry. The result showed that sodium hydroxide concentration could effect the results of yield. The yields of 4%, 8%, and 12% sodium hydroxide concentration were 3.7% (0.074 g), 7.2% (0.144 g), and 1.3% (0.026 g), respectively.Keywords: N1-tert-butylteobromin, sodium hydroxide, tert-butylbromide, theobromine
Isolation And Characterization of Physicochemical Properties of Mucilago Gedi Leaf (Abelmoschus manihot L. Medik) Rindengan, Elvie Rifke; Abdassah, Marline; Chaerunisaa, Anis Yohana
Indonesian Journal of Pharmaceutical Science and Technology Vol 5, No 3 (2018)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (444.952 KB) | DOI: 10.15416/ijpst.v5i3.16744

Abstract

The aim of this research was to isolation of mucilage from gedi leaf (Abelmoschus manihot L. Medik) and characterized physicochemical properties. The isolation result was yellowish brown powder that swelling and dissolves slowly in water, but does not dissolve in ethanol, methanol, acetone and ether. The yield is 1.33%. Swelling index value 100% and viscosity 28 ± 2.65 mpas, pH 7.1. Proximate analysis showed 10.46% water content, 38.80% ash, 14.66% protein, 0.69% fat, 35.38% carbohydrate Water holding capacity (WHC) and  oil holding capacity (OHC) of musilago are respectively 4.23 ± 0.18 and 0.65 ± 0.14. Viscosity, Swelling index, WHC and OHC mucilage gedi leaf  may be considered as pharmaceutical excipients.Keywords: Mucilage, Abelmoschus manihot, swelling, viscosity
Antibacterial Activity of Extract and Fraction From Shitake Mushroom (Lentinula edodes) Against Acne Bacteria Sukmawati, Ika Kurnia; Yuniarto, Ari; Alighita, Widhya; Zam-zam J, Ade
Indonesian Journal of Pharmaceutical Science and Technology Vol 6, No 1 (2019 In Press)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (522.261 KB) | DOI: 10.15416/ijpst.v6i1.14732

Abstract

Acne is an inflammatory disease that occurs in the skin triggered by the bacteria acne treatment can be done by using natural materials that shiitake mushrooms (Lentinus edodes). This aims of this study were to determining the antibacterial activity of extracts and fractions shiitake mushrooms with broth microdilution method, determining the value of equality shiitake mushrooms with antibacterial comparison and determining the morphological changes of bacteria after exposure to the test sample with a Scanning Electron Microscope (SEM). Tests conducted antibacterial activity against Propionibacterium acnes, Staphylococcus epidermidis and Staphylococcus aureus at concentrations used is 1 ppm, 2 ppm, 4 ppm, 8 ppm, 16 ppm, 32 ppm, 64 ppm, 128 ppm, 256 ppm, 512 ppm. Best MIC value obtained in fraction of ethyl acetate and n-hexane fraction of the bacterium Propionibacterium acnes, Staphylococcus epidermidis and Staphylococcus aureus at a concentration of 256 ppm. KBM value of the n-hexane fraction against Staphylococus aureus bacteria at concentrations of 512 ppm and ethyl acetate fraction against bacteria Staphylococus aureus and epidermidis at a concentration of 512 ppm. Value equality is obtained 1 mg of ethyl acetate fraction of shiitake mushrooms equivalent to 5.346 x 10-2 mg of tetracycline. SEM test results showed the presence of antibacterial activity which is indicated by a change in cell morphology, their lumps and their cell wall frown on Propionibacterium acnes were exposed to ethyl acetate fraction.Key words: Acne, Lentinus edodes, antibacterials, microdilution, SEM
Degradation Study of Ketorolactromethamine by a Validated UPLC Method Uddin, Mohammad Nasir; Al-Amin, Md.; Haque Mijan, Md. Nazmul; Das, Suman
Indonesian Journal of Pharmaceutical Science and Technology Vol 6, No 1 (2019 In Press)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (577.906 KB) | DOI: 10.15416/ijpst.v6i1.16508

Abstract

UPLC stability indicating method was developed for determining ketorolac tromethamine in its degradation study at different conditions. An isocratic mobile phase composition of 60:10:30 (v/v) containing CH3OH, CH3CN and 5mM NaH2PO4 and C18 column were used at a flow rate of 0.20 mL min-1. Satisfactory retention time was found 2.13±0.05 min at 320 nm when monitored by DAD detector. Forced degradation studies of ketorolac tromethamine was also performed at the following conditions: acid and basic hydrolysis, heat (50-70°C for 1 hr), photolytic (UV and sunlight for up to 3 hr), oxidation (3% hydrogen peroxide for 1 hr). Forced degradation study revealed that ketorolac degraded significantly under thermal conditions. In 1N acid and base hydrolysis, degradation was moderately significant and comparable. It was degraded marginally in 0.1N acid-base hydrolysis which was comparable to oxidative conditions. But in photolytic condition ketorolac shows insignificant degradation. Method was also applied to pharmaceutical formulation.Keywords: UPLC, Ketorolac tromethamine, pharmaceutical formulation, Forced degradation
Performance Evaluation of Molecularly Imprinted Polymer using Propanol as Porogen for Atenolol Recognition in Human Serum Suherman, Meilia; Susanti, Ike; Rahayu, Driyanti; Pratiwi, Rimadani; Nur Hasanah, Aliya
Indonesian Journal of Pharmaceutical Science and Technology Vol 6, No 1 (2019 In Press)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (532.992 KB) | DOI: 10.15416/ijpst.v6i1.18671

Abstract

Atenolol is a cardiovascular drug that has a narrow therapeutic index with long-term use and it’s often used as doping. Atenolol has a small concentration in human boby and it’s in  biological matrix (serum) so in the testing need a selective extraction so  the analyte can be pra-concentration and removed from matrix. Two molecularly imprinted polymers (MIPs) on propanol as porogen  have been made with two different methods i.e. bulk polymerization and precipitation polymerization. The polymer was made using atenolol as a template, methacrylic acid as a functional monomer, and ethylene glycol dimethacrylate as a crosslinker. Prformance evaluations showed that polymers from bulk polymerization provide better performance than polymers from precipitation polymerization when tested against standard solution. However, this sorbent has low  recovery percentage after applied into serum sample and could not be used as alternative for atenolol extraction in human serum.Key words: Molecularly imprinted polymer, Atenolol, Solid Phase Extraction, Preparation  method, propanol.
Peningkatan Permeasi Mikroemulsi Ketoprofen Dolih Gozali; Fara Warhead; Jutti Levita; Anis Khoirunisa
Indonesian Journal of Pharmaceutical Science and Technology Vol 2, No 2 (2015)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (230.418 KB) | DOI: 10.15416/ijpst.v2i2.7811

Abstract

Penggunaan obat yang sukar larut air tidak efisien apabila kadar penetrasi obat ke dalam tubuh sangat kecil. Mikroemulsi ialah satu sistem dispersi yang dapat meningkatkan kelarutan obat. Pada penelitian ini dilakukan formulasi mikroemulsi ketoprofen menggunakan zat peningkat penetrasi mentol (0%, 1%, 3%, 5%). Asam oleat digunakan sebagai fase minyak, tween 80 sebagai komponen surfaktan, dan propilen glikol sebagai kosurfaktan. Evaluasi sediaan mikroemulsi dilakukan dengan uji permeasi mikroemulsi ketoprofen secara in vitro menggunakan sel difusi Franz terhadap membran kulit ular dengan medium dapar fosfat pH 7,4 selama 90 menit. Formula F4 (mengandung mentol 5%) menunjukkan permeasi tertinggi setelah 90 menit (16,21 ppm) dibandingkan dengan F1 (tidak mengandung mentol). Keempat formula memiliki kestabilan yang baik selama pengamatan. Dapat disimpulkan bahwa mentol meningkatkan permeasi ketoprofen. Kata kunci: Ketoprofen, mentol, mikroemulsi, uji permeasi
Studi Permeabilitas In Vitro Sediaan Gel Natrium Diklofenak dan Dietilamin Diklofenak Yoga Windhu Wardhana; Sriwidodo B; Aliya Nur Hasanah; Priskila O Dwiestri; Anis Khoerunisa
Indonesian Journal of Pharmaceutical Science and Technology Vol 1, No 2 (2014)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (342.372 KB) | DOI: 10.15416/ijpst.v1i2.7514

Abstract

 Akhir-akhir ini di pasaran farmasi beredar produk gel antiinflamasi golongan NSAID diklofenak dengan bahan aktif yang berbeda. Beberapa produk dibuat menggunakan bahan aktif garam natrium diklofenak, sedangkan industri farmasi lainnya menggunakan bahan aktif garam dietilamin diklofenak. Kedua bahan aktif memiliki perbedaan sifat dan karakter terutama dari sifat kelarutannya dalam air. Tujuan dari penelitian ini adalah untuk mempelajari kemampuan penyerapan (permeabilitas) dari kedua zat aktif tersebut. Metode penelitian meliputi pembuatan gel dengan basis gel HPC (Hidroksi Propil Selulosa), evaluasi sediaan yang meliputi: organoleptis, kadar, pH, dan viskositas. Sediaan gel yang telah memenuhi persyaratan kemudian diuji lebih lanjut permeabilitasnya secara in vitro selama 32 jam dengan sel difusi Franz dan sisa kulit ular phyton (Python reticulates) sebagai membrannya. Hasil evaluasi kualitas sediaan gel  menunjukkan bahwa kedua formula gel dari bahan aktif yang berbeda memiliki kualitas yang memenuhi persyaratan sebagai sediaan gel yang baik. Sedangkan hasil uji permeabilitas in vitro memperlihatkan bahwa kedua bahan aktif memberikan profil yang berbeda danjumlah keterserapan bahan yang berbeda. Dimana setelah 32 jam uji difusi diperoleh sebanyak 20% natrium diklofenak dan 15,5% dietilamin diklofenak. Terlihat bahwa profil dari dietilamin diklofenak memiliki efek depo, sehingga dosis yang digunakan lebih efektif untuk jangka waktu lama.  Kata kunci: Gel, dietilamin diklofenak, natrium diklofenak, permeabilitas
Application of Common Greenbottle Fly (Lucilia sericata Meigen, 1826) Larvae Extract for Incision Wound Treatments in Rats Madihah Madihah; Lisda Mawarni Sihotang; Desak Made Malin; Wawan Hermawan
Indonesian Journal of Pharmaceutical Science and Technology Suppl. 2, No. 1 (2019)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (590.33 KB) | DOI: 10.24198/ijpst.v1i1.19144

Abstract

Common green-bottle fly (Lucilia sericata) larvae have been used in maggot debridement therapy to promote wound healing since the 19th century following the emergence of an antibiotic-resistant strain of bacteria. Whole body extracts and hemolymph of L. sericatalarvae shown antibacterial properties. This research aims to examine the ethanol extract from whole body of L. sericatalarvae to accelerate the wound healing on the skin of male Wistar rats (Rattus norvegicus). The method was a completely randomized design with six treatments and four replications each. The incision wound created at the dorsolateral region of shaven skin at ±1.5 cm using sterile scissors. The extract at concentration 5, 10 and 20% in olive oil were applied topically to wounded rats, as well as Betadine® for the reference group. For positive control only olive oil applied to wounded rats, as for negative control was non-treated wounded rats. The treatment was done twice a day for 14 days. At day 15th, the wounded site harvested, fixed in 10% NBF, embedded in paraffin, and sectioned at 5-7 µm, then stained with hematoxylin-eosin or trichrome Heidenhain’s Azan for histological examination. The results showed that topical application of the L. sericata larvae extract at concentration 10% was significantly recover the wounded skin by enhanced re-epithelialization, narrowed granulation tissue, as well as increased capillary number and collagen density than other treatments (p<0.05). Overall, our data support the L. sericatalarva extract as an agent to accelerate the wound healing process on skin.Key words: ethanol extract, green-bottle fly, incision wound, whole body larva, wound healing.

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