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Indonesian Journal of Pharmaceutical Science and Technology

ijpst
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Published by Universitas Padjadjaran

ISSN : 23561971 EISSN : 2406856X DOI : -

Core Subject : Health, Science,

Computer Science & IT Medicine & Pharmacology

Jurnal Sains dan Teknologi Farmasi Indonesia (IJPST) adalah publikasi ilmiah pada seluruh aspek Sains dan Teknologi Farmasi. Jurnal ini diterbitkan 3 kali setahun untuk menyediakan forum bagi apoteker, dan profesional kesehatan lainnya untuk berbagi praktik terbaik, meningkatkan jaringan kerja dan pendekatan yang lebih kolaboratif dalam Sains dan Teknologi Farmasi.

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Articles 494 Documents

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Optimization of Extraction from Sappan Wood and Its In uence on Food Bacterial Contaminants Adirestuti, Putranti; Puspadewi, Ririn; Mardatillah, Athina; Anggita, Dismayana; Helena, Meidy; Octavia, Alfa; Putri, Yosinta
Indonesian Journal of Pharmaceutical Science and Technology Suppl 1, No. 1 (2018)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Sappan wood has already known as an ingredient of jamu, especially in Central Java. If it dissolved in hot water, it will show a red color and has been used as health drink for blood current obstruction, diarrhea, blood cough, dysentry, malaria and tetanus. The red pigment of sappan wood contained avonoid and polyphenol. The two kind of extractions of sappan wood used in this experiment were obtained by boiling water extraction at 90oC in 15 minutes and maceration in ethanol 50% overnight. The aim of this research was to nd the potential of inhibiting sappan wood for presence of bacterial contaminants in food, such as Escherichia coli, Staphylococcus aureus, and Pseudomonas aeruginosa in several time storages. Microbial examination by observing visual characteristics of damage to the food model and the decrease number of food bacterial contaminants. The result showed that ethanol extract 10% of sappan wood inhibited a food bacterial contaminants in three days at cold temperatures storage (8-10OC), and percent decrease population of E. coli, S. aureus and P. aeruginosa were 99.74%, 96.28%, and 99.88%, respectively. Key words : Ethanol extract, food contaminant bacterias, inhibiting, sappan wood, water extract

Antibacterial Activity From Cucumber (Cucumis sativus .L) Ethanol Extract In Deodorant Roll On Dosage Form Susanti, Laila; Widodo, Subur; Aini, Qurrota; Rahmawati, Dyah
Indonesian Journal of Pharmaceutical Science and Technology Supp 1, No 1 (2017)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Body odor of human skin usually occur due to excessive production of sweat glands couples with the presence of bacteria. The active ingredient to prevent body odor are chemicals materials from alum or sodium in order to have negative effects such as skin irritation, Alzheimer disease, prostate and breast cancer. Natural materials technology has been development as an active agent by using cucumber (Cucumis sativus .L). The purpose of this research to conduct a deodorant roll on a stable and qualified physical quality and also develop the use of extract cucumber as an antibacterial Staphylococcus epidermidis. Cucumber extraction has been done by maceration with ethanol 70% for 4 days and then divided into three formulation extract (5%, 10%, and 20% (b/v)). All of the formulations has been tested by zone inhibition, organoleptic, homogenity, pH, viscosity and irritation test. The results given that all of the formulations meet the quality requirements of physical and the best formulation extract 20% able to inhibit bacterial by 26 mm as a largest diameter of the inhibitory zone. In addition the stability of deodorant roll on form were performed accelerated stability test for 35 days at room temperature (28Â°C) and 40Â°C. The test results indicate that the stability of the extract 10% quali ed physical quality during storage at room temperature (28Â°C) and high temperature (40Â°C) for 35 days. While in the extract 20% at high temperature (40oC) physical changes characterized by the deposition. Keyword : cucumber, deodorant roll on, antibacteriaÂ

The Purple Sweet Potato Body Scrub Cream Formulation Wirasuta, I Made Agus Gelgel; Triastuti, Ni Komang Dewi; Deviyanthi, Kadek Sintia; Sartika, Dyah Aryani; Utari, Putu Dyah
Indonesian Journal of Pharmaceutical Science and Technology Vol 5, No 1 (2018)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Anthocyanin is active compound of purple sweet potato, has effect as anti-oxidative, anti-inflammatory, and anti-itching, make them interesting ingredients for skin treatment. The body scrub is one of popular cosmetic product in SPA industry. Their stability property is one crucial factor to develop a purple sweet potato body scrub cream. The steam and oven heating of tuber were involved on the scrub powder preparation.The oven and non-heating preparation scrub powder provided fine-sized powder more than 50%, but the steaming produced granular particle distribution. Total anthocyanin content in scrub grains was 326.8 mg/100 g for steam preparation, 103.3 mg/ 100 g for oven, and 34.4 mg/100g for non-heating, respectively. The steamed scrub powder preparation method produced stabile anthocyanin content in body scrub cream for 25 days observation.Â Â

Daya Antioksidan Ekstrak dan Fraksi Daun Kopi Robusta (Coffea Robusta) Terhadap Pereaksi DPPH (2,2-difenil-1-pikrilhidrazil) Hasanah, Mauizatul; Maharani, Bella; Munarsih, Ensiwi
Indonesian Journal of Pharmaceutical Science and Technology Vol 4, No 2 (2017)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Radikal bebas memiliki efek menyebabkan terjadinya kerusakan sel dalam tubuh sebagai pemicu berbagai penyakit. Antioksidan diketahui memiliki kemampuan untuk meredam radikal bebas. Telah dilakukan penelitian potensi aktivitas antioksidan dari ekstrak kental dan fraksi daun kopi robusta (Coffea robusta). Ekstraksi dilakukan dengan metode maserasi menggunakan etanol 70 % selama 3 x 5 hari pada suhu ruangan, diperoleh ekstrak kental dengan rendemen 15,9 % b/b. Fraksinasi dilakukan dengan pelarut berdasarkan perbedaan kepolaran diperoleh fraksi n-heksan, fraksi etil asetat dan fraksi air. Uji antioksidan menggunakan alat Spektrofotometer Uv-Vis dengan metode penghambatan radikal bebas DPPH (2,2-Difenil-1-Pikrilhidrazil) terhadap ekstrak kental dan fraksi n-heksan, etil asetat dan air pada beberapa konsentrasi, yaitu 100 ppm, 80 ppm, 60 ppm, 40 ppm, 20 ppm. Hasil penelitian menunjukkan penghambatan radikal bebas (% Inhibisi) ekstrak dan fraksi meningkat sesuai peningkatan konsentrasi uji. Nilai % Inhibisi ekstrak kental, fraksi n-heksan, fraksi etil asetat dan fraksi air, pada konsentrasi 100 ppm berturut-turut adalah 93,7 %, 95,56 %, 69,54 % dan 61,28 %. Hasil perhitungan IC50 yang diperoleh untuk ekstrak kental adalah 43,83 ppm, fraksi n-heksan adalah 38,32 ppm, fraksi etil asetat adalah 37,07 ppm dan fraksi air adalah 73,62 ppm.

Formulation of Instant Granule Containing Nano Calcium from the Shell of Freshwater Mussels (Anodonta woodiana) for Autism Children Aminingsih, Tri; Srie Rahayu, Sata Yoshida; Yulianita, Yulianita
Indonesian Journal of Pharmaceutical Science and Technology Suppl 1, No. 1 (2018)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

The small particle size of nano calcium from freshwater mussels shell will tend to increase the absorp- tion of calcium by humanâs body and will be very well consumed by children with special needs to suppress hyperactivity disorders that caused by mercury. This study aimed to create and determine the best instant granule formulation containing nano calcium from freshwater mussels shell. The research method began with the manufacture of freshwater mussels shell powder and isolated nano calcium. Nano calcium was tested for its solubility in acid. The granule formula was made with stevia varia- tions. Instant granule evaluation included granule ow test, rest angle, compressibility, water content, solubility, hedonic test, and calcium bioavailability. The results showed that nano calcium was soluble in 1:1 ratio of citric and tartrate acids, so that each formula needs 1.2% citric and 1.2% tartrate acids. Based on the avor, aroma, and texture, the most preferred granule formula contained 600 mg nano calcium, 60 mg citric acid, 60 mg tartaric acid, 400 mg stevia each sachet weighing 5 g. The best in- stant granule evaluation showed that the ow rate was 4.253 g/sec, 33.90 rest angle, 4.65% compress- ibility, 2.21% water content, soluble time 58 second and calcium bioavailability was 100%. Key words: Calcium bioavailability, detoxi cation, freshwater mussels, instant granule, nano cal- cium.

Aktivitas Antioksidan dan Tabir Surya dari Tongkol dan Rambut Jagung (Zea Mays L.) Kusriani, Herni; Marliani, Lia; Apriliani, Erlina
Indonesian Journal of Pharmaceutical Science and Technology Vol 4, No 1 (2017)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Zea mays L. (Jagung) adalah tanaman yang banyak dibudidayakan di Indonesia dan pemanfaatan limbah dari jagung masih sebatas sebagai pakan ternak, sedangkan pemanfaatan kandungan komponen didalamnya masih sangat terbatas. Kandungan kimia yang terdapat pada tanaman jagung antara lain alkaloid, saponin, tanin, flavonoid, fenol, steroid, glikosida, terpenoid, protein, mineral. Senyawa fenol banyak berperan dalam aktivitas antioksidan dan tabir surya. Sampel tongkol dan rambut jagung diduga berpotensi sebagai sumber antioksidan dan tabir surya alami. Penelitian ini bertujuan untuk mengetahui aktivitas antioksidan dan tabir surya dari ekstrak dan fraksi tongkol dan rambut jagung serta kadar fenol totalnya. Uji aktivitas antioksidan dilakukan dengan menggunakan metode peredaman radikal bebas 1,1 Difenil-1-Pikrihidrazil (DPPH) dan uji aktivitas tabir surya dengan penentuan nilai sun protected farctor (SPF) dengan spektrofotometri yang diukur pada Î» 290-320nm. Penetapan kadar fenol total diukur dengan metode kolorimetri menggunakan reagen Folin Ciocalteu dan diukur dengan spektrofotometri pada Î» 765nm. Hasil pengujian aktivitas antioksidan dan tabir surya terbaik ditunjukkan oleh fraksi etil asetat rambut jagung dengan nilai IC50 sebesar 45,18 Î¼g/mLdan nilai SPF sebesar 23,943 serta kadar fenol totalnya sebesar 106,010 mg/G Â± 0,431. Fraksi etil asetat rambut jagung memiliki aktivitas antioksidan, tabir surya, dan kadar fenol yang lebih tinggi dari yang lainnya.

Formation of Andrographlolide-BetaCyclodextrin Inclusion to Increase Solubility and Dissolution Rate Prasetyo, Bayu Febram; Wientarsih, Ietje; Sajuthi, Dondhin; Juniantito, Vetnizah
Indonesian Journal of Pharmaceutical Science and Technology Vol 5, No 2 (2018)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Andrographolide (AG) is a pure isolate of the chemical synthesis of sambiloto (Andrographis paniculata Nees.) which has various pharmacological properties such as anti-inflammatory and antimicrobial. In order to improve the ability of AG to penetrate the membrane in transdermal use, an inclusion complex was formed using beta-cyclodextrin (BCD) by modifying the physical chemistry properties of AG, particularly the solubility in its base, partition, and distribution on the skin, as well as by changing the permeability of the stratum corneum. The inclusion complexes of AG with BCD were prepared by the solvent evaporation method in the mole ratios of 1:1, 1:2, and 2:1. The solid of the yield of AG inclusion complex in BCD has been tested with a solubility test until it reached equilibrium at 37 Â± 5 Â°C for 24 hours and In vitro dissolution rate test using the II USP method (paddle type), then compared to a single AG compound, and a physical mixture of AG-BCD. Based on the solubility and dissolution rate tests, it showed that the formation of AG-BCD inclusion complex was obtained at the mole ratio of 1:2. Moreover, the AG solubility increased 38 timesand the dissolution rate in the 60th minute increased twice Â in the inclusion complex with BCD.Key words: andrographolide, inclusion complex, beta cyclodextrin, solubility, dissolution rateÂ

Peningkatan Kelarutan dan Disolusi Ibuprofen melalui Pembentukan Mikropartikel Metode Emulsification-Ionic-Gelation menggunakan Polivinil Alkohol (PVA) sebagai Polimer Tripolifosfat (TPP) sebagai Agen Crosslink Ferdiansyah, Rival; Putri, Yola Desnera; Hamdani, Syarif; Julianto, Angga
Indonesian Journal of Pharmaceutical Science and Technology Vol 4, No 3 (2017)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Ibuprofen dikenal sebagai obat antiinflamasi nonsteroid yang digunakan untuk analgetik dan antipiretik dan termasuk obat dengan kelarutan rendah, tetapi memiliki permeabilitas yang tinggi. Penelitian ini bertujuan untuk menghasilkan ibuprofen dengan kelarutan dan disolusi yang lebih tinggi dengan membentuk mikropartikel menggunakan metode emulsification-ionic gelation. Partikel ibuprofen dikarakterisasi menggunakan Scanning Elektron Microscopy dan Fourier Transform Infrared Spectroscopy (FTIR). Kemudian dilakukan uji kelarutan dan uji disolusi ibuprofen. Pengujian karakteristik menggunakan SE, mikropartikel pH 2, pH4, pH 6 mengalami penurunan ukuran partikel berturut-turut sebesar 97,48%, 84%, dan 72% dari ukuran ibuprofen. Kelarutan ibuprofen setelah proses emulsification-ionic-gelation dalam air pada pH 6 meningkat delapan kali, sedangkan disolusi ibuprofen tertinggi ditunjukkan oleh partikel ibuprofen pada formula 3 yang dapat mendisolusi ibuprofen lebih dari 44% dalam 30 menit pada media dapar HCl 0,1N dibandingkan dengan formula yang lain. Kesimpulan yang diperoleh adalah partikel ibuprofen setelah proses emulsification-ionicgelation dapat memperkecil ukuran partikel dan meningkatkan kelarutan tetapi tidak dengan disolusinya.Kata kunci: Ibuprofen, emulsification-ionic-gelation, polivinil alkohol, kelarutan, disolusi

Effect of Ethanol Concentration on Antibacterial Activity of Bligo Fruit Extract (Benincasa hispida Thunb) to Salmonella typhi Mubarak, Fhahri; Sartini, Sartini; Purnawanti, Dia
Indonesian Journal of Pharmaceutical Science and Technology Vol 5, No 3 (2018)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Bligo fruit (Benincasa hispida Thunb) is one of medicinal plants that used to cure typhoid fever which caused by Salmonella typhi bacteria. The aim of this research is to find ont the effect of ethanol concentration as a solvent from Bligo fruit (Benincasa hispida Thunb) extracts as an antibacterial, especially to Salmonella typhi. This simplicia was being extracted with 96% ethanol, 70% ethanol, and 50% ethanol by using maceration method for 3x24 hours. The antibacterial activity test was done by diffusion of agar method to the MHA medium by obserring the resistor zone which formed from 96% ethanol, 70% ethanol and 50% ethanol. The diametres that have been obtained are 6,815 mm for 96% ethanol, 25,223 mm for 70% ethanol while for 50% ethanol there is no resisten zone can be seen. From the result canbe conclude that the best concentration of ethanol that has a great potencial as resistor to Salmonella typhi bacteria is the Bligo fruit (Benincasa hispida Thunb) extracts of 70% ethanol.Key words: Bligo fruit (Benincasa hispida Thunb), Antibacterial, Salmonella typhi.

Essential Oil Composition, Antioxidant and Antibacterial Activities of Nutmeg (Myristica fragrans Houtt) from Garut West Java Wibowo, Diki Prayugo; Febriana, Yessi; Riasari, Hesti; Auilifa, Diah Lia
Indonesian Journal of Pharmaceutical Science and Technology Vol 5, No 3 (2018)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

West Java is rich in essential oil-producing plants, essential oilsÂ known to beÂ responsible forÂ someÂ pharmacologicalÂ activitiesÂ amongÂ itsÂ antioxidant andÂ antimicrobial.Â This research aims to know antimicrobial, antioxidant activity and identify the components of a compound essential oil of nutmeg (Myristica fragrans Houtt.). Components chemistry identified with GC-MS (Gas Chromatography-Mass pectrometer). Antioxidant activity measured by using the DPPH method (2 2-diphenyl-1-picrylhydrazyl) at 516Â Î»Â wavelengthÂ absorbance. Antimicrobial activity determined Minimum Inhibitory Concentrations (MIC) and Minimum Bactericidal Concentrations (MBC) using microdilution method. The result of GC-MS showed the highest component on nutmeg containing 22.22% myristicin. The antioxidant test showed nutmeg had IC50 at 3,16%, essential oil showed antibacterial activity against Gram positive and Gram negative bacteria. Minimum inhibitory concentrations of essential oils range from 0.313% to 10%. The content of essential oils of nutmeg plants that grow in the area of West Java Garut can be used to overcome the problems of antioxidants and antimicrobial.Key words: Antioxidant, Antibacterial, Pala (Myristica fragrans Houtt), Chemical Composition.

Page 8 of 50 | Total Record : 494

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Muchtaridi

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