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INDONESIA
Indonesian Journal of Tropical and Infectious Disease
Published by Universitas Airlangga
ISSN : 20851103     EISSN : 23560991     DOI : -
Core Subject : Health, Science,
Earth & Planetary Sciences Health Professions Medicine & Pharmacology Public Health
This journal is a peer-reviewed journal established to promote the recognition of emerging and reemerging diseases specifically in Indonesia, South East Asia, other tropical countries and around the world, and to improve the understanding of factors involved in disease emergence, prevention, and elimination. The journal is intended for scientists, clinicians, and professionals in infectious diseases and related sciences. We welcome contributions from infectious disease specialists in academia, industry, clinical practice, public health, and pharmacy, as well as from specialists in economics, social sciences and other disciplines.
Arjuna Subject : -
Articles 8 Documents
 1 
Search results for , issue "Vol. 12 No. 1 (2024)" : 8 Documents clear
Relationship between Knowledge and Stigma with Attitude Towards People with Leprosy in Professional Nursing Students Ishomatul Faizah; Laily Hidayati; Ika Nur Pratiwi
Indonesian Journal of Tropical and Infectious Disease Vol. 12 No. 1 (2024)
Publisher : Institute of Topical Disease Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/ijtid.v12i1.39109

Abstract

The bacteria Mycobacterium leprae is the source of the chronic infectious illness leprosy (M. leprae). In society, leprosy still carries a shame. The erroneous impression of leprosy gives birth to stigma. Leprosy is thought to be brought on by curses, witchcraft, divine retribution, sin, or genetics. A person's perception of leprosy and lack of understanding about it might have an impact on how they feel about those who have it. Even among health students, information alone will not be sufficient to end the stigma against those who have leprosy; also, students need to learn how to develop greater empathy for those who have the disease. This study sought to ascertain the association between leprosy knowledge and stigma and attitudes among nursing students at the professional level. In this study, a cross-sectional methodology is used with a descriptive correlational design. A total 320 professional nursing students participated in the survey. Total sampling was used to select respondents based on inclusion and exclusion criteria. Utilizing the SPSS version 21, data were gathered by questionnaire and analyzed using the Spearman's rho test at a significance level of 0.05. The Spearman's rho test results revealed a positive link between attitude and knowledge (p=0.001), but a negative relationship between attitude and stigma (p=0.000). It was determined that attitudes toward people with leprosy were significantly influenced by information, stigma, and those attitudes. The better the mindset, the more one knows about leprosy. Leprosy patients are treated better when there is less stigma associated with their condition.
Purple Urine Bag Syndrome: a Rare Manifestation of Urinary Tract Infection Toyyibah, Ilma; Fajariya, Rosida; Keswardiono, Catur Budi; Lucas Teixeira Campos Queiroz; Tarissa Diandra Putri Wibowo
Indonesian Journal of Tropical and Infectious Disease Vol. 12 No. 1 (2024)
Publisher : Institute of Topical Disease Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/ijtid.v12i1.42151

Abstract

Purple urine bag syndrome (PUBS) is rare manifestation of urinary tract infection (UTI). Epidemiological study showed the prevalence of purple urine bag syndrome about 8.3%-16.7% worldwide. There are some factors which lead to the disease including female, long-term urinary catheter, bedridden or immobile for long time, constipation, and urinary tract infection. The mechanism of this condition involves the tryptophan in intestine that is degraded into indole. In the liver, indole is conjugated into indoxyl sulphate. This conjugate product then is excreted into urine by the kidney. In the infected urinary tract, some  gram-negative bacteria produce enzymes called sulphatase and phosphatase. It converts the conjugated product, indoxyl sulphate into pigments, red indirubin and blue indigo. The two pigments-combination produces purple pigment which appears in urine. We present a-61-year-old female who has history of cerebrovascular accident who came to our emergency room with purple urine over the previous seven days.
Re-Emergence of Ampicillin Sensitive Salmonella Typhi and the Increase of Ciprofloxacin Resistance in Typhoid Fever Treatment in Asia: A Systematic Review Tanjaya, Felicity; Nathan, Johan; Nainggolan, Ita Margaretha; Moehario, Lucky; Thantry, Anita Devi Krishnan; Tunru, Andi Miyanza Lakipadada; Sean, Sherlyn
Indonesian Journal of Tropical and Infectious Disease Vol. 12 No. 1 (2024)
Publisher : Institute of Topical Disease Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/ijtid.v12i1.42305

Abstract

Typhoid fever is a disease caused by Salmonella Typhi infection. In 2000, 2.16 million people were affected worldwide, with more than 90% morbidity and mortality in Asia. Ampicillin is the first-line antibiotic used for typhoid management. However, the rise in resistance to first-line antibiotics has shifted ciprofloxacin as an alternative.  This study aimed to describe the trends in ciprofloxacin- and ampicillin-resistant Salmonella Typhi in Asia. This study was a systematic review that conformed to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses criteria. Search was indicated toward studies on Salmonella Typhi susceptibility toward ciprofloxacin and ampicillin were identified using PubMed, Cochrane Library, and ProQuest. Of the 1542 studies found, only 16 fulfilled the criteria. In 1996, Salmonella Typhi was not found to be resistant to ciprofloxacin, whereas 3.5% was resistant to ampicillin. In 2005, ciprofloxacin resistance increased to 19.3%, whereas ampicillin resistance decreased to 13.3%. In 2005-2014, a larger number of Salmonella Typhi isolates resistant to ciprofloxacin than to ampicillin. Furthermore, during 2016-2019, resistance to ciprofloxacin increased from 8.1% to 95%, while ampicillin resistance increased from 27.5% to 85.2%. This the high ampicillin resistance in South and East Asia. In Asia, there was an increase in ciprofloxacin-resistant Salmonella typhi from 1996 to 2019, whereas ampicillin-resistant Salmonella Typhi decreased from 1996 to 2015.  Between 2016 and 2019, contrasting evidence was found in East Asia and South Asia, where resistance toward ampicillin increased.
Occupational and Return-To-Work Characteristics of Covid-19 Patients After Treated in Udayana University Hospital Karya, I Kadek Jony Dwi; Wirawan, I Made Ady; Purnamasidhi, Cokorda Agung Wahyu; Florensia, Maria; Akatsu, Haruko
Indonesian Journal of Tropical and Infectious Disease Vol. 12 No. 1 (2024)
Publisher : Institute of Topical Disease Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/ijtid.v12i1.45414

Abstract

Corona virus disease 2019 (COVID-19) is a new disease caused by severe acute respiratory syndrome corona virus 2 (SARS-COV-2). The COVID-19's symptoms are fatigue, muscle pain, and psychological disorders. The purpose of this study was to describe the occupational characteristics and health conditions of COVID-19 patients who had recovered after being treated at Udayana University Hospital. This study is a descriptive study with a quantitative method and cross-sectional design. The research samples were 110 COVID-19 patients treated at Udayana University Hospital from June to August 2020 and taken using random sampling. The results showed that the highest proportion of respondents were aged between 24-44 years (44.5%), with almost equal proportions of women (50.1%) and men (49.09%). Most of them lived in Denpasar (46.36%). Most respondents work as private sector employees (24.55%), and 70% of them were using personal protective equipment (PPE) while working. Most respondents needed less than seven days to return to work after being declared "in recovery state” (60%), with the remaining 55.5% having a decreased work duration to be less than 8 hours per day. The proportion of respondents with comorbidities was 30.91%. As many as 27.27% were experiencing previously similar symptoms (fever, fatigue, cough) 4 to 5 months after being declared "cured.” COVID-19 patients who have recovered should be monitored for a longer period of time to evaluate the symptom reoccurrence and its impact on their occupational and health conditions.
The Effect of C-Reactive Protein Levels, Neutrophil, and Lymphocyte Count to Mortality of COVID-19 Patients with Sepsis in Referral Hospital Malikhah, Avina Norma; Dhani Redhono Harioputro; Agung Susanto; Evi Nurhayatun
Indonesian Journal of Tropical and Infectious Disease Vol. 12 No. 1 (2024)
Publisher : Institute of Topical Disease Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/ijtid.v12i1.48634

Abstract

Coronavirus disease 2019 (COVID-19) is an infectious disease caused by infection of Severe Acute RespiratoryDistress Syndrom Coronavirus-2 (SARS CoV-2). COVID-19 patients may develop sepsis, the disregulation ofthe immune system that causes organ dysfunction and life-threatening situations. High mortality of COVID-19and sepsis make it important to study. The purpose of this study is to analyze the effect of CRP levels, neutrophil,and lymphocyte count to mortality of COVID-19 patients with sepsis. This study is an analytic observational studywith a cross-sectional approach. Samples were randomly retrieved of COVID-19 patients with sepsis admittedin referral hospital. Univariate, bivariate, and multivariate analysis used SPSS 26th version of Windows. Theresults of this study indicate a significant effect of CRP levels and neutrophil count on mortality of COVID-19patients with sepsis. Meanwhile, lymphocyte count had no significant effects. The multivariate analysis showedits significance value. Partially, the effect of neutrophils on the patient's mortality has a significant value. Theconclusion of this study is CRP levels and neutrophil count simultaneously have an effect on higher mortality ofCOVID-19 patients with sepsis.
Exploring the Therapeutic Potential of Glycyrrhizic Acid in Liver Implication in Dengue Infection: A Case Report Putri, Indah Sagitaisna; Pipik Ripa'i; Donghwa Na; Herry Wibowo
Indonesian Journal of Tropical and Infectious Disease Vol. 12 No. 1 (2024)
Publisher : Institute of Topical Disease Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/ijtid.v12i1.49833

Abstract

Dengue is one of the most common infectious diseases affecting humans. The virus is transmitted between humans by the Aedes mosquito. It occurs hyperendemically in tropical and subtropical climates worldwide. Dengue infection can affect numerous organs, with the liver being the most frequently affected organ. The clinical spectrum of liver disorders ranges from mild elevation of transaminase enzymes to severe conditions such as acute liver failure. Several mechanisms have been proposed to describe hepatic dysfunction observed in dengue fever and dengue hemorrhagic fever, such as immunological injury, hypoxic injury, and direct viral damage due to reduced hepatic perfusion during shock. Glycyrrhizic acid, extracted in the form of glycyrrhizin from the root of the licorice plant Glycyrrhiza glabra, is referred to as Stronger Neo-Minophagen-C (SNMC®). It has shown effectiveness in reducing serum aminotransferase and bilirubin levels, attenuating hepatocyte apoptosis, and producing endogenous interferon. The following is a case report of a 23-year-old woman with dengue fever and elevated liver enzyme level. The patient's vital signs were stable. A physical examination revealed no abnormalities. A complete blood count test showed thrombocytopenia without an elevation of the hematocrit. AST level was 901"‰U/L after admission. Causes of other hepatitis infections, such as hepatitis A, B, and C, were excluded. The dengue IgM and IgG antibody levels were reactive. After several days of hospitalization, the patient experienced clinical improvement after supportive therapy and the administration of glicyrrhizic acid or SNMC®.
Neutrophil-to-lymphocyte and Platelet-to-lymphocyte Ratio as Predictors of CD4 Count among People Living with HIV Hasna, Zahra Roidah Amalia; Sunggoro, Agus Jati; Sri Marwanta; Harioputro, Dhani Redhono; Yimam Getaneh Misganie; Siti Qamariyah Khairunisa
Indonesian Journal of Tropical and Infectious Disease Vol. 12 No. 1 (2024)
Publisher : Institute of Topical Disease Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/ijtid.v12i1.49929

Abstract

Human Immunodeficiency Virus (HIV) infection remains a global health concern characterized by the reduction of CD4 lymphocyte cells and weakened immune systems. Knowing the CD4 count and the factors affecting it is crucial for assessing the immune status of HIV patients. Hematological markers, including neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR), have been recognized as prognostic tools that were associated with CD4 Count. The goal of this study was to determine the impact of NLR and PLR on CD4 count among people living with HIV (PLHIV). This study used analytic observational method with a cross-sectional on HIV-positive individuals who were treated at Moewardi Hospital, Surakarta, Indonesia. The Chi-Square and Pearson correlation tests were performed to identify the correlation between variables and the linear regression test was done to investigate the association between NLR and PLR with CD4 count. A total of 80 PLHIV were identified for this study, with the median CD4 count of 103 cells/mm3. NLR and PLR were found to be 3.06 and 181.03, respectively. This study found that opportunistic infection, duration on ARV treatment, body mass index, total lymphocyte count, and hemoglobin were significantly associated with CD4 count. The Pearson correlation test revealed a strong correlation between NLR and PLR to CD4 count. Linear regression analyses showed that NLR and PLR could predict the CD4 count. These findings indicate that NLR and PLR could serve as alternative prognostic parameters for monitoring treatment outcomes in PLHIV, particularly in health facilities where access to CD4 count testing is limited.
In Silico Analysis of Inhibitor Potential of Punicalagin Compound in Pomegranate (Punica granatum) Against NS5 DENV-3 Protein Kautsar, Radinal; Rachmawati, Yuanita; Rokhim, Saiku; Sucipto, Teguh Hari; Damayanti, Mamik; Ramadhani, Aisyah Hadi
Indonesian Journal of Tropical and Infectious Disease Vol. 12 No. 1 (2024)
Publisher : Institute of Topical Disease Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/ijtid.v12i1.52320

Abstract

Indonesia is one of the Dengue Virus (DENV) endemic areas which are dominated by DENV-2 and DENV-3. Until now, no specific drug therapy has been found to cure Dengue Virus Infection (DVI). Punicalagin is one of the active compounds that have the potential to be used as an antiviral. Unfortunately, not many studies have used punicalagin as a DENV antivirus. This study aims to determine the inhibitory potential of punicalagin compounds against NS5 DENV-3 protein through molecular docking. Molecular docking was performed using AutoDock Tools, ChemDraw, and Discovery Studio Visualizer. The target protein used is NS5 DENV-3 protein with PDB ID code: 4V0Q. The ribavirin compound was used as a positive control. The results obtained show that the punicalagin compound has the ability to attach to target receptors in the C-Terminal domain complex. This docking produces a bond free energy (ΔG) of -6.39 kcal/mol. This result is better than the ΔG of the control compound. Punicalagin's Inhibition Constant (Ki) value also showed better results than ribavirin. So it can be seen that the compound punicalagin effectively inhibits DENV replication and has the potential as a DENV drug candidate. 

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