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INDONESIA
Indonesian Journal of Tropical and Infectious Disease
Published by Universitas Airlangga
ISSN : 20851103     EISSN : 23560991     DOI : -
Core Subject : Health, Science,
Earth & Planetary Sciences Health Professions Medicine & Pharmacology Public Health
This journal is a peer-reviewed journal established to promote the recognition of emerging and reemerging diseases specifically in Indonesia, South East Asia, other tropical countries and around the world, and to improve the understanding of factors involved in disease emergence, prevention, and elimination. The journal is intended for scientists, clinicians, and professionals in infectious diseases and related sciences. We welcome contributions from infectious disease specialists in academia, industry, clinical practice, public health, and pharmacy, as well as from specialists in economics, social sciences and other disciplines.
Arjuna Subject : -
Articles 382 Documents
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The Role of Host Genetics Regulating Proteins in HIV-1 Susceptibility: Epidemiological and Demographic Insights on HIV-1 in Indonesia (2022) Saefudin, Siti Amalia Firdza; Handayani, Niken Satuti Nur
Indonesian Journal of Tropical and Infectious Disease Vol. 12 No. 3 (2024)
Publisher : Institute of Topical Disease Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/ijtid.v12i3.54366

Abstract

Human Immunodeficiency Virus type 1 (HIV-1) remains a global public health concern, marking 52,995 cases in Indonesia alone, dominated with CRF01_AE strain which is classified as an X4 strain or a virus that uses CXCR4 co-receptor. This highlights the urgent needs  to develop therapies that utilize CXCR4 inhibitors to modulate HIV-1 infection and replication. The aims of this study were to assess the epidemiological and demographic insights on HIV-1 in Indonesia in 2022, and connecting it to the dominated strain to further assess various host genetics known to promote HIV-1 infection, focusing on the co-receptors CCR5 and CXCR4. A systematic review was conducted, analyzing published studies and the 2022 HIV/AIDS report from the Ministry of Public Health of Indonesia. Additionally, the study evaluated the therapeutic potential of CXCR4 antagonists, including AMD3100, AMD070, BPRCX807, and MCo-CVX-5c, known for their anti-HIV-1 activity. Among the listed antagonists, AMD070 and MCo-CVX⎯5c are advancing among the others, leading to a potential most advanced combination antiretroviral therapy (cART). This research contributed to the development of personalized treatment strategies for HIV-1 by providing insights into the genetic factors influencing co-receptor regulation and HIV-1 susceptibility.
Description of Mothers' Knowledge, Attitudes, and Behavior Regarding Deworming The Children Against Soil-Transmitted Helminthiasis at The Lampaseh Health Center in Banda Aceh City Suryawati; Putra, Teuku Romi Imansyah; Liansyah, Tita Menawati; Maulina, Novi; Maulidina, Rizka Yuliani; Al-Muchtari, Teuku Az Zikri
Indonesian Journal of Tropical and Infectious Disease Vol. 12 No. 3 (2024)
Publisher : Institute of Topical Disease Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/ijtid.v12i3.54434

Abstract

Helminth infections are a significant public health problem in developing countries, including Indonesia, where the prevalence ranges from 60% to 90%. One common helminth infection is Soil-Transmitted Helminthiasis (STH), which particularly affects children. One of risk factors is children who lack personal hygiene, especially when they are playing with soil. The increased incidence of STH can be prevented by deworming programs, and the role of parents, especially maternal parenting. This study aims to determine the description of the level of knowledge, attitudes and behavior of mothers on deworming the children against STH at the Lampaseh Health Center, Banda Aceh City, Indonesia. This research is descriptive with a cross-sectional design. The sample consists of mothers with children aged 2-12 years, selected using accidental sampling techniques. Data were collected through interviews using structured questionnaires. The results showed that the level of maternal knowledge of deworming the children against STH categorized as good (95.1%), quite good (3.9%), and less good (1.0%) as well as the attitude of mothers was categorized into good (51.5%), quite good (46.6%), and less good (1.9%). However, the mother’s behavior was good (69.9%) and less good (30.1%). The conclusion was that the knowledge, attitudes, and behavior of mothers on deworming the children against STH need to be maintained and improved.
Predation Time for Halfmoon and Multicolor Plakat of Varieties of Betta Fish Against Aedes aegypti Larvae in Different Water Volume Adrianto, Hebert; Ritunga, Imelda; Tabita Hasianna Silitonga, Hanna; Ibrahim, Syahriar Nur Maulana Malik
Indonesian Journal of Tropical and Infectious Disease Vol. 12 No. 3 (2024)
Publisher : Institute of Topical Disease Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/ijtid.v12i3.56498

Abstract

One biological strategy for controlling mosquito vectors is using larvivorous fish as larvae predators. Larvivorous fish are an alternative to overcome the problem of larval resistance to temephos.  Among the many varieties of Betta fish, the specific predation rates associated with each variety and their behavior in different water volumes remain unclear. This study aims to analyze the differences in predation time for halfmoon and a  multicolor plakatof varieties of Betta fish against Aedes aegypti larvae in different water volumes.. The research was conducted as a laboratory experiment using a post-test-only design with five replications. Four treatment groups were established, each consisting of one aquarium filled with a specific water volume, one fish, and 25 Ae. aegypti larvae. The tests began at 12:00 WIB, and the predation time was recorded until all larvae were consumed. The findings showed that all All varieties of Betta fish can typically predate Ae. aegypti larvae. Halfmoon and multicolor plakat have the same predation ability against Ae. aegypti larvae (p > 0.05). The Mann Whitney's results indicated that Betta fish placed in water with a water volume of 1 and 3 liters had no significantly different predation against Ae. aegypti larvae (p > 0.05). However, the Kruskall-Wallis test results showed a significant difference in predation abilities between the two varieties when exposed to different water volumes (p < 0.05) . The multicolor plakat variety displayed the fastest predation time in 1 liter of water, whereas the halfmoon variety predated more quickly in 3 liters of water.
Mebendazole treatment in ascariasis re-infection of two-year-old boy in rural Ambon: a case report and literature review Thiono, Marischa Tita; Sutjonong, Tioky; Polanunu, Masayu Ramadhani; Husada, Dominicus
Indonesian Journal of Tropical and Infectious Disease Vol. 12 No. 3 (2024)
Publisher : Institute of Topical Disease Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/ijtid.v12i3.57195

Abstract

Ascariasis is currently a health problem in developing countries, especially in rural areas. Successful control of ascariasis is highly dependent on therapeutic interventions, environmental, and individual hygiene practices. Ascariasis is generally asymptomatic but can cause severe problems if treated improperly. Treatment is available, but reinfection may occur. This case aims to emphasize the usage of mebendazole treatment in ascariasis reinfection. A two-year-old boy came to the hospital with mucus diarrhea and worms in the stool. Two months ago, he had the same symptoms and experienced improvement after taking pyrantel pamoate at the previous hospital. The patient was diagnosed with acute diarrhea with mild to moderate dehydration, re-infection ascariasis, and malnutrition. Mebendazole 100 mg was administered twice daily for 3 days. Treatment with mebendazole was repeated twice with an interval of one month after the previous therapy due to the presence of Ascaris lumbricoides eggs in fecal examination. Fecal examination in the third month revealed the absence of Ascaris lumbricoides egg. Mebendazole can be used as therapy for ascariasis reinfections. However, repeated therapy is required in some cases. By integrating repeated therapy with comprehensive control measures, including health education and improved sanitation infrastructure, sustainable progress in combating ascariasis can be achieved.
Red Laser-Activated Silver Nanoparticles from Green Synthesis Extract of Butterfly Pea for Antimicrobial Photodynamic Therapy Against Staphylococcus aureus Astuti, Suryani Dyah; Farhah, Ghinaa Rihadatul Aisy; Salwa, Umaimah Mitsalia Ummi; Aisya, Rohadatul; Zaidan, Andi Hamim; Yaqubi, Ahmad Khalil
Indonesian Journal of Tropical and Infectious Disease Vol. 12 No. 3 (2024)
Publisher : Institute of Topical Disease Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/ijtid.v12i3.62884

Abstract

This study investigated the potential of photodynamic therapy (PDT) using green-synthesized silver nanoparticles (AgNPs) derived from butterfly pea extract (Clitoria ternatea L.) to combat Staphylococcus aureus (S. aureus). The use of a red diode laser as a method for enhancing the antimicrobial activity of AgNPs presents a novel approach to treating bacterial infections.  The red diode laser is crucial, as it activates the AgNPs, enhancing their antimicrobial properties. This combination of light, natural extract, and nanoparticles underscores the innovative approach of using PDT in treating bacterial infections. By integrating these elements, the study aims to provide insights into effective, biocompatible treatments for antibiotic-resistant bacteria.  The primary objective of this study is to synthesize and characterize AgNPs using butterfly pea extract and evaluate their effectiveness against S. aureus when combined with red laser irradiation.  Silver nanoparticles were synthesized using an environmentally friendly method that processes butterfly pea extract as the reducing agent for the synthesis of the nanoparticles.  Using UV-Vis spectrophotometry to track the creation of silver nanoparticles (AgNPs), it was determined that the butterfly pea extract was an effective source of nanoparticles. The particle size distribution and peak absorbance wavelength were determined by characterization utilizing a Particle Size Analyzer (PSA). Tryptic soy agar (TSA) plates were used to investigate the antibacterial activity of AgNPs against Staphylococcus aureus (S. aureus). The effectiveness of photoinactivation against S. aureus was evaluated by exposing AgNPs at a concentration of 1 mM to a red diode laser for 90 seconds. The results showed that the produced AgNPs had potential antibacterial capabilities when combined with red light therapy. The results demonstrated that the synthesized silver nanoparticles can effectively kill or inhibit the growth of Staphylococcus aureus (S. aureus) when exposed to a red diode laser for 90 seconds. The findings suggest that photodynamic therapy using green-synthesized AgNPs and red laser irradiation could be a promising approach to controlling bacterial infections like S. aureus. Further research is recommended to explore the underlying mechanisms of photoinactivation and to optimize treatment parameters for in vivo applications on experimental animals.
Clinical Patterns and Demographic Characteristics of Dermatophytosis in Surabaya Azzahra, Safira; Ervianti, Evy; Setiabudi, Rebekah
Indonesian Journal of Tropical and Infectious Disease Vol. 12 No. 3 (2024)
Publisher : Institute of Topical Disease Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/ijtid.v12i3.66511

Abstract

Dermatophytosis, the most common fungal infection in humans, significantly impacts quality of life due to its clinical and cosmetic effects. Its high prevalence underscores the need to evaluate patient profiles to improve management strategies.  This study aim is to identify the most prevalent type of dermatophytosis, patient demographics, clinical characteristics, laboratory investigations, and therapy in dermatophytosis into the clinical and epidemiological characteristics of dermatophytosis in a tropical, high-burden region. This descriptive retrospective study used total sampling of medical records of dermatophytosis patients from January 2017 to December 2022.  Tinea corporis and tinea cruris was the most common, while tinea manuum is the least common dermatophytosis. Female adults were the most affected group. Common clinical features for each type included alopecia for tinea capitis, erythematous macules for other types, and nail dystrophy for tinea unguium. Trichophyton mentagrophytes was the commonest pathogen in 2017. Most of the therapies followed Clinical Practice Guidelines with extensive use of griseofulvin and ketoconazole cream. Further research should explore therapeutic outcomes, preventive measures, and factors influencing recurrence and adherence to treatment.
Factors Analysis That Affecting The Treatment Success In Tb Patients In Situbondo Regency Sasmita, Hasri Yulia; Peristiowati, Yuly; Nurwijayanti
Indonesian Journal of Tropical and Infectious Disease Vol. 13 No. 1 (2025)
Publisher : Institute of Topical Disease Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/ijtid.v13i1.59100

Abstract

Tuberculosis (TB) remains one of the top 10 lethal infectious diseases). In addition, the low case detection rate indicates that the community still has a large number of sources of transmission. Directly Observed Treatment Short-course (DOTS) strategy aims to reduce the new TB cases number by 80% and deaths by up to 90% in 2030. Drug-resistant TB cases especially multidrug resistant TB, exacerbate tuberculosis control because they receive TB treatment irregularly and do not comply to recommended treatment schedules, nonetheless, consistent treatment is critical to successful TB treatment. TB data in Situbondo district show that case detection was 911 out of 1539 cases or 59.14% and treatment success rate was 275 out of 911 cases or 30.2%. This study aims to examine the influence of knowledge, medication supervisors, family support, drug side effects, attitudes, length of treatment, and house physical environment on the treatment success through medication compliance factors. This research is explanatory with 196 respondents while the analysis uses SMART PLS 4.1.0.3. There is a direct influence of medication supervisors, family support, drug side effects, house physical environment and medication compliance and an indirect influence of medication supervisors, family support, drug side effects, and attitudes to TB treatment success. It is hoped that Public Health Centre officers can be more active to educate, detect TB suspect, and also supervise patient so compliance and treatment can be achieved. The patient's family can be more active in providing support during the treatment period for TB sufferers.
Diagnosis Approach of Endobronchial Tuberculosis: Literature Review Ginting, Mario Oktafiendi; Indriani, Sri Indah; Simatupang, Elvando Tunggul Mauliate
Indonesian Journal of Tropical and Infectious Disease Vol. 13 No. 1 (2025)
Publisher : Institute of Topical Disease Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/ijtid.v13i1.60257

Abstract

Pulmonary tuberculosis (PTB) remains a global health problem and the leading cause of death from infectious diseases. Indonesia as an endemic country and the second highest contributor of PTB cases in the world provides support and attention to PTB case finding and treatment success. Endobronchial tuberculosis (EBTB) is problematic PTB because the lesions are often not detected by sputum examination and chest X-ray. Clinically, there is no significant difference in symptoms between TB and EBTB. In general, EBTB gives a more severe clinical appearance due to airway stenosis. Bronchoscopy and thoracic computed tomography scan (CT scan), along with microbiological investigations, are the most useful diagnostic tools for confirming and evaluating tracheobronchial stenosis. In addition, bronchoscopy can also be used as a longterm treatment in cases of EBTB due to airway stenosis. The goals of treatment are the eradication of Mycobacterium tuberculosis (Mtb) bacilli with antituberculosis drugs (ATD) and the prevention of airway stenosis. Intervention of bronchoscopic techniques and surgery are required for those patients who develop severe tracheobronchial stenosis that causes significant symptoms, including dyspnea, repeated post-obstructive pneumonia or bronchiectasis. The most common complications of EBTB are airway stenosis, atelectasis, hemoptysis and shortness of breath accompanied by wheezing despite the administration of ATD. Bronchoscopic intervention can support the acceleration of EBTB treatment, prevent repeated hospitalizations and improve the quality of life of patients. Acceleration of diagnosis and administration of ATDs in a complete and routine way is expected to reduce morbidity and even mortality rates in EBTB cases.
Association between Hair Hygiene and Pediculus capitis Infestation among Elementary School Students in Sukorambi District, Jember Regency Ali, Alya Maulidya; Nurdian, Yudha; Rumastika, Nindya Shinta
Indonesian Journal of Tropical and Infectious Disease Vol. 13 No. 1 (2025)
Publisher : Institute of Topical Disease Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/ijtid.v13i1.60916

Abstract

Pediculus humanus capitis (P.h. capitis) is an ectoparasite which inhabits hair and scalp of human, causing a neglected disease called Pediculus humanus capitis infestation or pediculosis capitis. This disease, easily transmitted between people directly or indirect, often affects girls around 3–12 years old in tropical countries with high humidity. This can be avoided with applying personal hygiene focused on hair area (hair hygiene). Hair hygiene in this study was divided into several parameters, such as frequency of hair washing, shampoo usage, hair drying, towel sharing habit, comb and hair accessories sharing habit, head cover sharing habit, and close contact with an infested person. The aim of this study is not only to know the prevalence of P. h. capitis infestation, but also to determine the correlation between hair hygiene and P. h. capitis infestation among elementary school students in Sukorambi District, Jember Regency. This study was held around January to February 2024 using cross-sectional approach with total 83 respondents. Respondents were given several questions about parameters of hair hygiene and their hair was examined using lice comb to find P. h. capitis. Prevalence of Pediculosis capitis infestation among elementary school students in Sukorambi District reached 71.1%. Statistical analysis showed that towel sharing habit and comb and other hair accessories sharing habit had a significant relationship with P. h. capitis infestation (p-value <0.05). Multivariate analysis using logistic regression showed that comb and other hair accessories sharing habit were the most significant hair hygiene parameters.
Correlation Between Complete Blood Count Parameters with Procalcitonin in Immunogenomic Phases of COVID-19 Patients Sellynastiti, Sarah Triwinar; Rusli, Musofa; Hernaningsih, Yetti
Indonesian Journal of Tropical and Infectious Disease Vol. 13 No. 1 (2025)
Publisher : Institute of Topical Disease Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/ijtid.v13i1.63384

Abstract

Coronavirus Disease 2019 (COVID-19), a global pandemic caused by SARSCoV-2, presents varying degrees of severity influenced by different immunogenomic phase. The immunogenomic phase that occurs in patients with COVID-19 is divided into three phases, namely the initial phase, propagating phase, and complicating phase. Severity disease progression can be monitored from the results of complete blood count (CBC) parameters and several inflammatory parameters such as procalcitonin. The purpose of this study was to investigate, during the immunogenomic phase of COVID-19 patients, the correlation between PCT levels and full blood count parameters. Patients treated at Dr. Soetomo General Hospital for COVID-19 were the subjects of this crosssectional study. Data analysis used in this study is Kolmogorov-Smirnov Test for normality, followed by Wilcoxon signed-rank test and bivariate Pearson correlation test to determine the correlation between complete blood count (CBC) parameters and PCT. Our findings reveal that most patients are male, predominantly aged between 50 and 60 years. Distinct variation of CBC parameters and PCT levels were observed in each phase. A significant relationship between these hematological markers, the immunogenomic phase and the progression of the disease. The PCT level of COVID-19 patients was associated with parameters of red blood cells, including hemoglobin, hematocrit, and the width-standard deviation of red blood cell distribution, leukocytes and their differential count, including lymphocytes and neutrophils, and platelets.. This analysis further understanding regarding the hematological dynamics in COVID-19 patients, providing important information about the pathophysiology of the disease and potential biomarkers for monitoring its progression.

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