cover
Article Per Year (5 Year)
All
Home Page
OAI Link
Editorial Team
Contact
Reviewer
Google Scholar
Contact Name
-
Contact Email
-
Phone
-
Journal Mail Official
-
Editorial Address
-
Location
Kab. sleman,
Daerah istimewa yogyakarta
INDONESIA
Biology, Medicine, & Natural Product Chemistry
Published by Universitas Islam Negeri Sunan Kalijaga Yogyakarta
ISSN : -     EISSN : -     DOI : -
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Medicine & Pharmacology Public Health
BIOLOGY, MEDICINE, & NATURAL PRODUCT CHEMISTRY, this journal is published to attract and disseminate innovative and expert findings in the fields of plant, animal, and microorganism secondary metabolite, and also the effect of natural product on biological system as a reference source for researchers in these fields, and with the aim to set international standards in their methodology.
Arjuna Subject : -
Articles 37 Documents
 1   2   3   4 
Search results for , issue "Vol 13, No 1 (2024)" : 37 Documents clear
Comparative Effects of Ripe and Unripe Lime (Citrus aurantifolia) on Spermatozoa and Gonadosomatic Index in Matured Male Wistar Rats Ogbonnaya, Obioma; Nwankwo, Azubuike; Ifenkwe, Daniel Chidi; Ibe, Chikera Samuel; Ikpegbu, Ekele; Onwuka, Osah Martins
Biology, Medicine, & Natural Product Chemistry Vol 13, No 1 (2024)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2024.131.109-119

Abstract

To ascertain the comparative effects of ripe and unripe Lime (Citrus aurantifolia) on spermatozoa and gonadosomatic index evaluation in matured male Wistar rats; exploring the idea that both ripe and unripe Lime (Citrus aurantifolia) might or might not positively affect semen quality, crucial for male fertility. Twenty-eight (28) sexually mature male Wister rats, aged 9–10 weeks and weighing between 211.50g and 217.00g, were divided equally into seven groups (1 to 7); with Group 1 serving as the control and Groups 2 to 7 receiving 25%, 50%, and 75% concentrations of ripe lime juice (RLJ) and unripe lime juice (ULJ) respectively. The findings indicated that ULJ had a higher concentration (0.1mg/ml) compared to ripe lime RLJ at 0.08mg/ml, although both had approximately the same LD50 value of 1581.138mg/kg. RLJ, at different concentrations, adversely impacted the reproductive performance of rats, leading to decreased progressive motility, livability, sperm count, testicular size, and sexual drive. However, ULJ did not exhibit these effects. A 75% concentration of RLJ showed anti-prostatic activity, causing a reduction in prostate size, which was more pronounced than that of the same ULJ concentration. Importantly, both RLJ and ULJ did not have a significant impact on the sizes of the liver, spleen, heart, kidneys, and lungs, with these visceral organs maintaining normal sizes comparable to the control group (statistically, p>0.05).The findings suggest that RLJ or ULJ consumption, particularly at the highest concentration, may lead to alterations in reproductive performance, hence such consumption should be discouraged.
The Study of Biosurfactant Stability and The Effect on Lipase Activity Alvionita, Mieke; Hertadi, Rukman; Fazli, Rahmat Rizki; Dewi, Andi Alfira Ratna Faradisa; Rose, Tasyang Oktavia
Biology, Medicine, & Natural Product Chemistry Vol 13, No 1 (2024)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2024.131.235-238

Abstract

Lipase is one of hydrolase enzyme that catalyzed hydrolysis reaction of triacylglycerols into free fatty acids and monoglycerides or glycerol. These biocatalysts are widely used in several industries, namely food and pharmaceutical industry. The activity of lipase can increase significantly if the substrate forms an emulsion. Since biosurfactant has been known to have emulsification characteristic, the effect of biosurfactant addition into lipase is necessary to be investigated. It is the first report that evaluate the effect of microbial surfactant on lipase activity. The purpose of this research is to analyze the stability of biosurfactant emulsion under various conditions, such as salinity and pH as well as their potential to enhance lipase activity. Biosurfactant used was Halomonas elongata BK-AG18 from the collection of Biochemistry Research Group ITB, Bandung, Indonesia. It was found that after the addition of NaCl, there was no significant decrease in the emulsification activity of the biosurfactant. The emulsification index (IE24) of biosurfactant with several NaCl concentrations (2, 5, 10, 15, 20, and 25%) was obtained around 50%. Stability test of biosurfactant at pH range 4-10 showed the highest IE24 of biosurfactant was obtained at pH 6. The effect of biosurfactants on lipase hydrolysis activity is also discussed in this article. Lipase hydrolysis activity was tested using p-nitrophenyl palmitate substrate. The highest lipase activity was obtained after the addition of 70% biosurfactant (v/v) at 0.026 units. This study shows that biosurfactant from H. elongata BK-AG18 has the potential to increase lipase activity.
Effects of Processing on the Proximate Composition, Mineral Content and the Phytochemical Analysis of Groundnut Seeds (Arachis hypogeae) Sanni, Joseph Adaviruku; Sanni, Grace Omayoza; Awoniyi, Rufus Ranmilowo; Osanyinlusi, Remi; Richards, Yvonne Ego; Adesina, Goodness Inioluwa; Adenuga, Ore-ofe Oluwatoyin; Apata, Stella Ayomikun; Ekun, Oluwafemi Emmanuel
Biology, Medicine, & Natural Product Chemistry Vol 13, No 1 (2024)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2024.131.63-71

Abstract

Effect of processing on the nutritional composition of groundnut seeds were carried out using standard analytical methods. Raw, boiled and fried groundnut seeds were analyzed for proximate composition, mineral contents, and phytochemical screening. The result reported that the raw, boiled, and fried contains (5.357±0.190%, 4.545±0.050% and 3.896±0.015%, moisture contents), (2.401±0.011%, 3.225±0.004% and 2.816±0.001%, ash contents), (46.591±0.001%, 25.333±0.003% and 48.012±0.953%, crude fat), (4.126±0.887%, 15.001±0.030% and 7.692±0.002%, crude fibre), (19.520±0.040%, 21.580±0.040% and 23.540±0.000%, crude protein), (22.005±0.587%, 30.316±0.056% and 14.044±0.939%, carbohydrate) respectively. A significant difference was observed. Processing has significant effects on the mineral components of the seeds. The results revealed that raw, boiled and fried contains (56.900mg/100g, 48.400mg/100g and 35.00mg/100g Sodium), (0.215mg/100g, 0.185mg/100g and 0.540mg/100g Zinc), (65.500mg/100g, 42.700mg/100g and 25.500mg/100g Magnesium), (0.218mg/100g, 0.230mg/100g and 0.230mg/100g Iron), (0.250mg/100g, 0.110mg/100g and 0.100mg/100g Manganese). The phytochemical screening shows the presence of alkaloids, carbohydrates and proteins in all the samples and the result reveals that processing does not really have effect on phytochemical constituents. The investigation shows that fresh groundnut is a good source of mineral content, while raw and processed groundnut is a good source of some phytochemical constituents and processed groundnut is a good source of protein, fat, and carbohydrate with high nutritional value.
The Comparison of Long-term Effect Between Intermittent Fasting and Calorie Restriction on Neurological Parameters of Mice Ni'ma, Neli Syahida; Anggadiredja, Kusnandar
Biology, Medicine, & Natural Product Chemistry Vol 13, No 1 (2024)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2024.131.199-204

Abstract

Intermittent fasting (IF) and calorie restriction (CR) were purported to have health benefits. This research aimed to determine the long-term effect of IF and CR on selected neurological parameters in mice. Swiss Webster male mice were divided into 3 groups: ad libitum feeding (AL), IF, and CR. Mice in each group received the treatment for 16 weeks. They were then tested for anhedonia, depression, aggressiveness, and social approach. They were also subjected to contextual fear conditioning tests to model PTSD. Compared to AL, sucrose intake in the IF group was lower, while the CR group showed higher intake (p<0.01). This anhedonia characteristic shown in the IF group was confirmed not related to depression, as shown by significantly lower immobility time in the forced swimming test compared to AL (p<0.05). In the resident-intruder test, attack numbers in the IF group were fewer than in the AL group (p<0.05). As demonstrated by the results of the three-chamber test, the reduced aggressiveness in IF mice was unrelated to a deficit in sociability. In the fear extinction test (PTSD model), mice in the IF group showed lower freezing compared to those in AL (p<0.001). Although both IF and CR caused a reduction in total food intake, in the mice model tested, IF was shown to have favorable impacts on neurological parameters.
Potential Effects of Myrmecodia Pendants (Ant Nests) on Healing Bone Injuries Najah, Adilla Syahsiyatun; Kilo, Akram La; Kadir, Ahmad
Biology, Medicine, & Natural Product Chemistry Vol 13, No 1 (2024)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2024.131.311-319

Abstract

Myrmecodia pendens is a medical plant that can have a healing effect on bone injuries. Bone injuries can occur due to many things, including injuries due to infection, non-infection, degeneration and neoplasms. Bones are the most important part of the body for the human body because the decreased bone function will affect human activities. Therefore better bone healing is needed. This review article aims to study and analyze the role of Myrmecodia pendens in the bone wound healing process. Several studies show that Myrmecodia pendens contain flavonoids, vitamins, terpenoid saponins, quones, and glycosides, as well as anti-inflammatory substances. These ingredients are markers in the healing process. Myrmecodia pendens has been proven to speed up the healing process. The conclusion shows that Myrmecodia pendens is a medicinal plant that can speed up the healing process of bone injuries.
The Neuroprotective and Therapeutic Effects of Medicinal Plants and Natural Products against Aluminium Chloride-Induced Alzheimer's Disease: Recent Update Ojetunde, Ayodeji Oluwatobi
Biology, Medicine, & Natural Product Chemistry Vol 13, No 1 (2024)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2024.131.7-33

Abstract

Alzheimer's disease currently affects more than 35 million individuals worldwide. Aluminium has been implicated in the pathogenesis of various cognitive disorders. Meanwhile, aluminium chloride (AlCl3) has a significant impact on the progression of neurodegenerative diseases including Alzheimer's disease. The majority of Alzheimer's disease medications now on the market are cholinesterase inhibitors. However, the effectiveness of these drugs is limited because they can't totally arrest the progression of the disease. The utilization of medicinal plants and natural products may present excellent prospective options for Alzheimer's disease prevention and therapy. This study summarized medicinal plants and natural products for the prevention and treatment of AlCl3-induced Alzheimer's disease as an alternative therapy using published data in the literature from the years 2021-2023. The medicinal plants and natural products help to reduce Alzheimer's disease pathogenesis by controlling different pathways and could be used as a therapeutic agent against the symptoms. The majority of the medicinal plants and natural products discussed in this review have been shown to have neuroprotective, antioxidant, anti-amyloid, anti-inflammatory, anticholinesterase, anti-apoptotic, and therapeutic actions. Therefore, medicinal plants and natural products may offer neuroprotective and therapeutic effects in the treatment of Alzheimer's disease.
The Diversity of Understory (Shrubs and Herbs) in the Kalikuning Area Supriyati, Hikmah; Ariyanti, Nur Aeni
Biology, Medicine, & Natural Product Chemistry Vol 13, No 1 (2024)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2024.131.159-163

Abstract

Kalikuning is one of the areas that has a diversity of flora. Kalikuning's fertile land helps a variety of plants flourish there. Since there are no people living here, a wide variety of unidentified and underexplored plants can be known. Therefore, more research on the plant diversity is required. The research aims to invent, document, and find out the diversity of the understory (shrubs and herbs) in Kalikuning. This research used survey and exploration methods. The researchers documented shrub and herb species. Based on the results, 28 families consist of 65 species of shrubs and herbs. Those species are flora that have specific characteristics.
Testing Antibacterial Activity of Daun Kentut (Paederia foetida L.) Leaf Extract against Escherichia coli in Vitro Savitri, Lisa; Tiyas, Eka Wahyuning; Krissanjaya, Rochmad
Biology, Medicine, & Natural Product Chemistry Vol 13, No 1 (2024)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2024.131.277-283

Abstract

Escherichia coli is a pathogenic bacterium that causes infectious diseases in the digestive tract and can produce Lipopolysaccharide (LPS), including lipid A. Exposure to endotoxins in lipid A, can cause systemic effects, such as sepsis, which can lead to clinical manifestations and even death. Daun Kentut (Paederia foetida L.) is one of the herbal plants containing bioactive compounds that can inhibit the growth of E. coli bacteria. The aim of this research is to determine the effective concentration of daun kentut leaf extract to inhibit E. coli growth. This study is an experimental research using maceration extraction method and antibacterial disc diffusion method with 3 repetitions at concentrations of 10%, 20%, 30%, 40%, 50%, 60%, 70%, 80%, 90%, 100%, negative control (aquadest), and positive control (ciprofloxacin) conducted from March to April 2023 in the Microbiology Laboratory of Kadiri University. The observation results of inhibition zones in each treatment varied. The presence of these inhibition zones is due to the presence of secondary metabolite compounds in daun kentut leaf extract that have antibacterial activity, such as inhibiting protein synthesis mechanisms, causing damage to cell wall permeability, and ultimately leading to bacterial cell lysis and death. The statistical analysis using the One Way Anova test with a P-value of 0.05 shows that each variable has significant differences and effects. Thus, it can be concluded that the effective extract variation is the 100% concentration because, in this study, the 100% concentration has an inhibition zone of 26.72 mm and is classified as very strong in inhibiting E. coli bacteria.
Formulation and Antibacterial Activity Testing of Eco-Soap Based on Sodium Lauryl Sulfate Surfactant Widiani, Nurhaida; Novitasari, Aulia; Winandari, Ovi Prasetya; Saputri, Dwijowati Asih
Biology, Medicine, & Natural Product Chemistry Vol 13, No 1 (2024)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2024.131.121-125

Abstract

Pineapple is a fruit that is often used only for its flesh, while the skin remains waste. As a form of dealing with pineapple waste, one way is to use it as an eco-enzyme. Making soap with added eco-enzyme can be used as an alternative for washing dishes. Therefore, this research aims to determine the formulation and test the antibacterial activity of eco-soap based on the surfactant Sodium Lauryl Sulphate. This research is experimental research, which was carried out in July-October 2023. The research results showed that the pH of eco-Soap was 3.46; foam height 1.5 cm; viscosity testing 14.9 mPas; fatty acids 1.44%; and 6 mm antibacterial activity testing. Based on the research results, it was concluded that the surfactant-based eco-soap formulation had good stability in the eco-soap foam height test. The diameter of the zone of inhibition of eco-soap's antibacterial activity showed that bacterial inhibition was moderate.
Commercial Incense: Compound Analysis and Its Molecular Docking Studies as Anxiolytic Agents Apsari, Cintya Nurul; Ujiantari, Navista Sri Octa; Rohmah, Zuliyati; Utami, Setyowati Triastuti; Suma, Artania Adnin Tri; Gusnaniar, Niar
Biology, Medicine, & Natural Product Chemistry Vol 13, No 1 (2024)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2024.131.239-250

Abstract

In the context of Indonesian culture, incense has been traditionally utilized in various rituals. Incense possesses a calming impact and has the potential to reduce anxiety. This physiological response stems from the interplay of chemical components within incense and receptors associated with relaxation, specifically GABAA. This research aims to explore the interaction between substances found in commercially incenses with the GABAA receptors. The compounds of incense were identified through Gas Chromatography-Mass Spectrometry (GCMS) analysis. And there were 54 compounds identified from the 5 incense samples. Next, the ligands employed for docking studies were compounds predicted to traverse the blood-brain barrier (BBB). There were 31 compounds potential of crossing the blood-brain barrier (BBB). Docking results indicated that the majority of tested compounds exhibited notably lower S-scores during receptor interaction, suggesting their potential as anxiety-relieving agents. Furthermore, molecular docking outcomes highlighted that 9-Octadecenoic acid (Z)-, 2-hydroxy-1-(hydroxymethyl)ethyl ester showed the lowest S-score (-6.573). These findings imply that odorant and other volatile organic compounds (VOCs) present in incenses possess the ability to function as anxiety-reducing (anxiolytic) agents, potentially assisting in anxiety treatment.

Page 2 of 4 | Total Record : 37

 1   2   3   4 

Filter by Year

2024 2024


Reset
Filter By Issues
All Issue Vol 14, No 2 (2025) Vol 14, No 1 (2025) Vol 13, No 2 (2024) Vol 13, No 1 (2024) Vol 12, No 2 (2023) Vol 12, No 1 (2023) Vol 11, No 2 (2022) Vol 11, No 1 (2022) Vol 10, No 2 (2021) Vol 10, No 1 (2021) Vol 9, No 2 (2020) Vol 9, No 1 (2020) Vol 8, No 2 (2019) Vol 8, No 1 (2019) Vol 7, No 2 (2018) Vol 7, No 1 (2018) Vol 6, No 2 (2017) Vol 6, No 1 (2017) Vol 5, No 2 (2016) Vol 5, No 1 (2016) Vol 4, No 2 (2015) Vol 4, No 1 (2015) Vol 3, No 2 (2014) Vol 3, No 1 (2014) More Issue