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Contact Name
Ghufran Ibnu Yasa
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+6285277813297
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Syeikh Abdur Rauf street, Kopelma Darussalam, Banda Aceh, Aceh, Indonesia
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Kota banda aceh,
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INDONESIA
Elkawnie
ISSN : 24608912     EISSN : 24608920     DOI : -
Elkawnie is a journal of Integration Science and Technology with Islam. It's covering research and technology in the field of study of Architecture, Biology, Chemistry, Environmental Engineering, ICT, Physical Engineering and other science and technology field. In particular, Elkawnie's journal discusses the development of research and technology in contributing to development as part of Muslim scientists in the academic sphere.
Articles 220 Documents
Anticancer Activity of N-Hexane Extract from Sphagneticola trilobata (L.) J.F Pruski Against MCF-7 Breast Cancer Cell Vivi Mardina; Tisna Harmawan; Halimatussakdiah Halimatussakdiah; Syafruddin Ilyas; Masitta Tanjung
Elkawnie: Journal of Islamic Science and Technology Vol 6, No 1 (2020)
Publisher : Universitas Islam Negeri Ar-Raniry Banda Aceh

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22373/ekw.v6i1.6183

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Abstract : Sphagneticola trilobata (L.) J.F. Pruski is one of the perennial herbs that is widely used by the national and international community to treat various diseases including cancer. The objective of this study was to assessment the anticancer activity of n-hexane extract of S. trilobata leaves for inhibiting the growth of MCF-7 breast cancer cells in vitro by MTT (microculture tetrazolium salt) method. The n-hexane extract of sernai leaves was obtained from the maceration process of samples that were collected from the Langsa city, Aceh. The cytotoxicity test was carried out by incubating MCF-7 cells which had been exposed to several series of sample levels, viz. 1000; 500; 100; 50; 25; 10; 5 and 1 µg/mL. LC50 values are calculated using probit analysis. The results revealed that the n-hexane extract of S. trilobata leaves was cytotoxic against breast cancer cells (MCF-7) with an LC50 value of  0.037 μg /mL.Abstrak : Sphagneticola trilobata (L.) J.F. Pruski merupakan salah satu tanaman herbal yang digunakan secara luas oleh masyarakat nasional dan internasional untuk mengobati berbagai penyakit termasuk kanker. Penelitian ini bertujuan untuk mengetahui aktivitas antikanker ekstrak n-heksana daun S. trilobata dalam menghambat pertumbuhan sel kanker payudara MCF-7 secara in vitro dengan metode MTT (microculture tetrazolium salt). Ekstrak n-heksana daun sernai diperoleh dari proses maserasi sampel yang dikoleksi dari kota Langsa, Aceh. Uji sitotoksisitas dilakukan dengan menginkubasi sel MCF-7 yang telah dipaparkan beberapa seri  kadar sampel yaitu 1000, 500, 100, 50, 25, 10, 5 dan 1 µg/mL. Nilai LC50 dihitung dengan menggunakan analisa probit. Hasil penelitian menunjukkan bahwa ekstrak n-heksana daun S. trilobata bersifat sitotoksik terhadap sel kanker payudara (MCF-7) dengan harga LC50 sebesar 0,037 µg/mL. 
The Effect of Applied Voltage in The Electrocoagulation Process of Reducing Pond and River Water Turbidity Masthura Masthura
Elkawnie: Journal of Islamic Science and Technology Vol 6, No 1 (2020)
Publisher : Universitas Islam Negeri Ar-Raniry Banda Aceh

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22373/ekw.v6i1.5538

Abstract

Abstract : The study about the effect of the applied voltage to decrease the water turbidity from local pond and river have been conducted. This study aims to investigate the ability of the electrocoagulation process in removing pollutants containing groundwater from the pond and river. The water sample obtained from Dusun I Paya Perupuk Tanjung Pura in Langkat Regency. Indonesia which has been reported having high water turbidity. A copper plate was used as a sacrificial electrode with a specific variation of applied voltage of 6, 9, and 12 Volts. The result showed that applying 9 and 12 volts of voltages were able to reduce 60% and 66% of water turbidity from water pond, respectively. In river water, both optimum applied voltages could reduce approximately 98% of water turbidity. The result indicated that the electrocoagulation process potentially devoted as an alternative way to treat the massive local groundwater.Abstrak : Penelitian mengenai pengaruh tegangan listrik terhadap penurunan kekeruhan air sumur dan air sungai pada proses elektrokoagulasi telah dilakukan. Penelitian ini bertujuan untuk mengetahui kemampuan proses elektrokoagulasi dalam menghilangkan polutan yang berada di air yang diperoleh dari air sumur dan air sungai. Sampel air diperoleh dari Dusun I Desa Paya Perupuk Tanjung Pura Kabupaten Langkat. Lapisan plat tembaga (Cu) digunakan sebagai elektroda dengan variasi spesifik voltase sebesar 6, 9, dan 12 volts. Hasil menunjukkan bahwa pemberian voltase 9 dan 12 dapat menurunkan kekeruhan air sumur sebesar 60 dan 66%. Pada sample air sungai, pemberian kedua voltase optimum dapat menurunkan 98% dari kekeruhan air. Hasil penelitian mengindikasikan proses elektrokoagulasi berpotensi sebagai sebuah cara alternative untuk mengolah air.
Comparison of Nata Quality From Cassava Peels (Manihot esculenta), Ladyfinger Bananas Peels (Musa acuminata Colla), and Durian Peels (Durio zibethinus) Mashuri Masri; Irhamniah Irhamniah; Ulfa Triyani A Latif; Rusny Rusny
Elkawnie: Journal of Islamic Science and Technology Vol 6, No 1 (2020)
Publisher : Universitas Islam Negeri Ar-Raniry Banda Aceh

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22373/ekw.v6i1.6870

Abstract

Abstract : Agricultural waste is composed of carbohydrates which can be be used as a growth medium for bacteria Acetobacter xylinum to produce fermented products in the form of nata.  Producing nata from fruit waste such as Cassava peels (Manihot esculenta), Ladyfinger bananas peels (Musa acuminata Colla) and Durian peels (Durio zibethinus) is one of the efforts to reduce environmental pollution. This study aims to compare the quality of nata from Cassava peels (endodermis), Ladyfinger bananas peels (endodermis) and durian peels (endodermis) based on the gel thickness, nata yield and organoleptic test. From the results of the study concluded that Durian peels and Ladyfinger bananas peels could be used as an essential ingredient in making nata. Nata de durio is the best nata product in terms of thickness, nata yield and organoleptic tests. Meanwhile Cassava peels cannot be used as raw material for making nata.Abstrak : Limbah pertanian terdiri dari karbohidrat, yang dapat digunakan sebagai media pertumbuhan bagi bakteri Acetobacter xylinum untuk menghasilkan produk fermentasi dalam bentuk nata. Memproduksi nata dari limbah buah seperti kulit ubi kayu (Manihot esculenta), kulit pisang Ladyfinger (Musa acuminata Colla), dan kulit Durian (Durio zibethinus) adalah salah satu upaya untuk mengurangi pencemaran lingkungan. Penelitian ini bertujuan untuk membandingkan kualitas nata dari kulit ubi kayu (endodermis), kulit pisang emas (endodermis), dan kulit durian (endodermis) berdasarkan ketebalan gel, rendemen nata, dan uji organoleptik. Hasil penelitian menyimpulkan bahwa kulit Durian dan kulit pisang emas dapat digunakan sebagai bahan penting dalam membuat nata. Nata de durio adalah produk nata terbaik dari segi ketebalan, rendeman, dan uji organoleptik, sedangkan kulit ubi kayu tidak dapat digunakan sebagai bahan baku pembuatan nata.
Al-Qur’an and Modern Geoscience: Part I Muhammad Zaini; Mulyadi Abdul Wahid; Abd Mujahid Hamdan
Elkawnie: Journal of Islamic Science and Technology Vol 6, No 1 (2020)
Publisher : Universitas Islam Negeri Ar-Raniry Banda Aceh

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22373/ekw.v6i1.6828

Abstract

Abstract : Islamic tradition and science have been going through a long history. The Islamic world centred in the Middle East was once a centre of knowledge that was marked by the birth of prominent Islamic scientists and the development of knowledge and technology. Islamic tradition and science are naturally integrated. For instance, it can be seen from the necessity of Earth science knowledge in Islamic ritual practising. However, the decline of Muslim civilization also had an impact on science, including in the field of geoscience. This paper seeks to explain the relationship between the Tafsir al-Qur’an and geoscience, among of them are about the creation of the earth, the structure of the earth, as well as tectonic and volcanism, wherein al-Qur’an they are delivered in many parts.Abstrak : Tradisi Islam dan sains mengalami sejarah yang panjang. Dunia Islam yang berpusat di Timur Tengah pernah menjadi pusat pengetahuan yang ditandai dengan lahirnya ilmuan Islam terkemuka dan pengembangan pengetahuan dan teknologi. Tradisi Islam dan sains terintegrasi secara alamiah termasuk integrasi antara ilmu kebumian dan peribadatan ummat Islam. Namun, kemunduran Islam juga berdampak pada kemunduran di bidang sains, termasuk pada bidang kebumian. Makalah ini berupaya memaparkan hubungan antara tafsir-tafsir Al-Quran dengan ilmu kebumian, diantaranya penciptaan bumi, struktur bumi, serta tetonika dan vulkanisme, dimana hal tersebut telah disebutkan di beberapa bagian di dalam Al-Quran.
Usability Evaluation of Islamic Learning Mobile Applications Syeda Hamna Bibi; Rumsha Muhammad Munaf; Narmeen Zakaria Bawany; Arifa Shamim; Zara Saleem
Elkawnie: Journal of Islamic Science and Technology Vol 6, No 1 (2020)
Publisher : Universitas Islam Negeri Ar-Raniry Banda Aceh

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22373/ekw.v6i1.5920

Abstract

Abstract : The trend of using mobile devices for the purpose of learning is gaining momentum. Apart from traditional education, various applications are being developed for religious learning. Pakistan is inhabited by around 98% of Muslims.  Hence, the informal learning of Islam is essential for Muslim child development. This research presents a usability study of different Islamic learning mobile applications available on the android platform for children. The purpose of this research is to evaluate the usability of different Islamic learning mobile applications for children of diverse age groups in order to understand what design principles must be followed that increase the usability of the application. The main focus of this research is to observe and evaluate how easily children of different age groups respond to different applications, how effectively the children understand the core features of the applications and how easily they are able to use the application by themselves. 
The Effect of Chemical Activation Using Base Solution With Various Concentrations Towards Sarulla Natural Zeolite Saharman Gea; Agus Haryono; Andriayani Andriayani; Junifa Layla Sihombing; Ahmad Nasir Pulungan; Tiamina Nasution; Rahayu Rahayu; Yasir Arafat Hutapea
Elkawnie: Journal of Islamic Science and Technology Vol 6, No 1 (2020)
Publisher : Universitas Islam Negeri Ar-Raniry Banda Aceh

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22373/ekw.v6i1.6913

Abstract

Abstract : Material characteristics analysis of Sarulla natural zeolite (SNZ) with base activation has been carried out. The base used was NaOH at various concentrations; 0.2 M, 0.5 M, and 2 M. Base activated catalysts were characterized by X-ray Fluorescence (XRF), X-ray diffractometer (XRD), Fourier-transform Infrared (FTIR) Spectroscopy, Scanning Electron Microscopy (SEM) and gas adsorption analysis using BET method. The procedures applied have caused differences in adsorption and desorption rates as well as the crystallinity values of the catalytic materials. Moreover, the ratio of Si/Al contents has also changed at the lowest concentration. On the other hand, the crystallinity of catalysts has decreased at the highest concentration of base applied. The results are reinforced in FTIR characterization which shows the changes of silanol bonds to become silicate and aluminate. Furthermore, morphological analysis of the catalysts shows that homogenous surface was obtained at low concentration, while rough/lumpy surfaces was obtained at higher concentration.Abstrak : Analisis terhadap karakteristik material dari zeolit alam Sarulla (SNZ) dengan metode aktivasi basa telah dilakukan. Basa yang digunakan ialah NaOH dengan berbagai konsentrasi; 0,2 M; 0,5 M, dan 2 M. Katalis yang telah diaktivasi dengan basa kemudian dikarakterisasi dengan Analisis X-ray Fluorescence (XRF), X-ray diffractometer (XRD), Fourier-transform Infrared (FTIR) Spectroscopy, Scanning Electron Microscopy (SEM) dan Gas Adsorption menggunakan metode BET. Dari hasil penelitian, ditemukan perbedaan pada tingkat adsorpsi dan desorpsi, begitu juga dengan kristalinitas pada material katalis. Lebih jauh, rasio konten Si/Al juga berubah pada basa dengan konsentrasi terendah. Di sisi lain, tingkat kristalinitas dari katalis mengalami penurunan pada basa dengan konsentrasi tertinggi. Hasil ini diperkuat dengan data FTIR yang menunjukkan perubahan ikatan silanol menjadi silikat dan aluminat. Lebih jauh, analisis morfologi pada katalis menunjukkan bahwa permukaan yang homogen didapatkan dari penggunaan basa dengan konsentrasi rendah. Sebaliknya, basa dengan konsentrasi tinggi memberikan bentuk permukaan katalis yang tidak homogen serta kasar.
An Assessment of Room Acoustics Performance of Baiturrahman Grand Mosque Laina Hilma Sari; Zulfian Zulfian
Elkawnie: Journal of Islamic Science and Technology Vol 6, No 1 (2020)
Publisher : Universitas Islam Negeri Ar-Raniry Banda Aceh

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22373/ekw.v6i1.5420

Abstract

Abstract : Acoustical design as part of the audio comfort influences the architectural design strategy of a mosque significantly. As belonging to the speech room criteria, a mosque should meet some acoustic room requirements to deliver the solemnness to the worshipper during the prayer. Concerning this, the study aims to assess the indoor acoustics performance of Baiturrahman Grand Mosque, Banda Aceh. Baiturrahman grand mosque is an important place of worship for Acehnese and becoming a landmark of Banda Aceh City. The mosque which contains a lot of history of Aceh was built in heavy construction, i.e. concrete wall, marble coated floor, and concrete dome ceiling. Due to its significance, the room acoustics of the mosque as the primary design considerations in a speech room type is evaluated. The acoustics parameters estimated are Noise Criteria (NC), Sound Pressure Level (SPL), Reverberation Time (RT), and Rapid Speech Transmission Index (RASTI). The background noise was recorded for delivering the noise criteria and being the primary data carried out in the acoustic simulation. The study utilised CATT-Acoustic v7.2 software for simulating predicting SPL, RT, and RASTI.Abstrak : Desain akustik merupakan bagian dari parameter audio yang mempengaruhi desain arsitektur masjid secara signifikan. Masjid termasuk dalam kategori speech room yang harus memenuhi beberapa persyaratan akustik ruang untuk dapat menghadirkan kekhusyukan kepada jamaah selama sholat. Penelitian ini bertujuan untuk menilai kinerja akustik dalam ruangan Masjid Raya Baiturrahman, Banda Aceh. Masjid Raya Baiturrahman adalah tempat ibadah yang penting bagi orang Aceh dan menjadi simbol Kota Banda Aceh. Masjid yang memuat banyak sejarah Aceh ini terbuat dari dinding beton, lantai berlapis marmer, dan langit-langit kubah beton. Pada studi ini, parameter akustik ruang yang dievaluasi adalah Kriteria Kebisingan (NC), Tingkat Tekanan Suara (SPL), Waktu Gema (RT), dan Indeks Transmisi kecepatan Bicara (RASTI). Kebisingan latar belakang direkam untuk memberikan kriteria kebisingan dan menjadi data primer yang dilakukan dalam simulasi akustik. Studi ini menggunakan perangkat lunak CATT-Acoustic v7.2 untuk mensimulasikan prediksi SPL, RT, dan RASTI.
Application of Gost Algorithm For The Safety of Data Sending of General Election Novan Wijaya
Elkawnie: Journal of Islamic Science and Technology Vol 6, No 1 (2020)
Publisher : Universitas Islam Negeri Ar-Raniry Banda Aceh

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22373/ekw.v6i1.6211

Abstract

Abstract : The rapid development of the internet has an impact on the security of data sent using internet media. One government agency that uses the internet as data transmission includes the KPU. Data transmission becomes very risky especially the data sent is very important and even confidential. In the internet world, there are many threats and ways to change or retrieve data sent via the internet. Indonesia in particular has conducted direct elections but the data that are in the regions which are the results of recapitulation of the elections will be sent via the internet with a system provided by the KPU. Data from the recapitulation of regional elections becomes very important because it can be changed by intruders. Secure the data sent, methods such as cryptographic techniques that can minimize interference from intruders are needed. One algorithm that can be applied as data security is the GOST algorithm. The GOST algorithm is designed to take a balance between data efficiency and security. Cryptographic techniques that use the GOST algorithm are expected to be able to increase the security of sending election results from various threats without reducing the performance of sending data. The rapid development of the internet has the impact of the security of data sent using internet media. One government agency that uses the internet as data transmission includes the KPU. Data transmission becomes very risky especially the data sent is very important and even confidential. In the internet world, there are many threats and ways to change or retrieve data sent through internet media. Indonesia in particular has conducted direct elections but the data that are in the regions which are the results of recapitulation of the elections will be sent via the internet with a system provided by the KPU. Data from the recapitulation of regional elections becomes very important because it can be changed by intruders. Secure the data sent, methods such as cryptographic techniques that can minimize interference from intruders are needed. One algorithm that can be applied as data security is the GOST algorithm. The GOST algorithm is designed to take a balance between data efficiency and security. Cryptographic techniques that use GOST algorithm can improve the security of sending election results from various threats without reducing the performance of sending data. Election result data that was conducted during the testing was the Ogan Ilir regional election recap data. Tests that have been carried out using the GOST algorithm using WireShark produce stream files sent over the network are not easily identified because they are converted into random strings, so it takes a long time to analyze them.Abstrak : Perkembangan internet yang sangat cepat mempunyai dampak diantranya keamanan data yang dikirim menggunakan media internet. Salah satu instansi pemerintahan yang menggunakan internet sebagai pengiriman data diantaranya KPU. Pengiriman data menjadi sangat beresiko terlebih data yang dikirimkan sangat penting bahkan bersifat rahasia. Didunia internet terdapat banyak ancaman serta cara dalam mengubah atau mengambil data yang dikirimkan melalui media internet. Indonesia pada khususnya telah melakukan pemilu secara langsung tetapi data-data yang berada pada daerah yang merupakan hasil rekapitulasi dari pemilu akan dikirimkan melalui internet dengan sistem yang telah disediakan oleh KPU. Data hasil rekapitulasi pemilu suatu daerah menjadi sangat penting dikarenakan bisa diubah oleh intruder. Untuk mengamankan data yang dikirimkan diperlukan metode seperti teknik kriptografi yang bisa meminimalisir gangguan dari para intruder. Salah satu algoritma yang bisa diterapkan sebagai keamanan data yaitu algoritma GOST. Algoritma GOST dirancang agar mengambil keseimbangan antara efisiensi dan keamanan data. Teknik kriptografi yang menggunakan algoritma GOST mampu meningkatkan keamanan pengiriman data hasil pemilu dari berbagai ancaman tanpa mengurangi performansi dari pengiriman data. Data hasil pemilu yang dilakukan saat pengujian ialah data rekap pilkada Ogan Ilir. Pengujian yang telah dilakukan menggunakan algoritma GOST menggunakan wireshark menghasilkan stream file yang dikirim melalui jaringan tidak mudah diidentifikasi dikarenakan diubah menjadi string acak sehingga membutuhkan waktu yang lama untuk menganalisanya.
Effect of Ethanol Extract of Jamblang Aceh (Syzygium cumini) in Diabetic Mice (Mus musculus) and Its Potential As Anti-Diabetic Agent Ayu  Nirmala Sari; Januardi Januardi; Diky Setya Diningrat
Elkawnie: Journal of Islamic Science and Technology Vol 6, No 1 (2020)
Publisher : Universitas Islam Negeri Ar-Raniry Banda Aceh

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22373/ekw.v6i1.5496

Abstract

Abstract : This study was designed to evaluate the anti-diabetic activity of the ethanol extract of Syzygium cumini leaves in alloxan-induced diabetes mice. The anti-diabetic activity of EDS was investigated in mice (Mus musculus SW.) Alloxan-induced diabetes. The effect of ethanol extract of Syzygium cumini leaves on normal blood glucose levels and oral glucose tolerance tests were studied in normoglycemic mice while the anti-diabetic effect was evaluated in alloxan-induced hyperglycemic mice. Ethanol extract of Syzygium cumini leaves (200 and 400 mg/kg) is given orally for 21 days. Glibenclamide (5 mg/kg, oral for 21 days) is used as a reference standard. Giving ethanol extract of Syzygium leaves causes a significant decrease in blood glucose levels in normoglycemic and hyperglycemic mice and also increases glucose tolerance test. Ethanol extract of Syzygium leaves reduces glycosylated hemoglobin levels, lactate dehydrogenase, and creatinine kinase in alloxan-treated mice. Ethanol extract of Syzygium leaves also improves TBARS oxidative stress parameters, catalase and superoxide dismutase activity and glutathione levels. The ethanol extract of Syzygium cumini leaves shows anti-diabetic activity through increased insulin secretion and this effect can be attributed to the content of flavonoids and phenolic compounds present in the ethanol extract of Syzygium cumini leaves.Abstrak : Penelitian ini dirancang untuk mengevaluasi aktivitas anti-diabetes dari ekstrak etanol daun Syzygium cumini (L) Skeels (EDS) pada mencit diabetes yang diinduksi aloksan. Aktivitas anti-diabetes EDS diselidiki pada mencit (Mus musculus SW.) diabetes yang diinduksi aloksan. Pengaruh ekstrak etanol daun Syzygium cumini (EDS) pada kadar glukosa darah normal dan uji toleransi glukosa oral dipelajari pada mencit normoglikemik sedangkan efek antidiabetik dievaluasi pada mencit hiperglikemik yang diinduksi aloksan. EDS (200 dan 400 mg/kg) diberikan secara oral selama 21 hari. Glibenclamide (5mg/kg, oral selama 21 hari) digunakan sebagai standar referensi. Pemberian EDS menyebabkan penurunan signifikan dalam kadar glukosa darah pada mencit normoglikemik dan hiperglikemik dan juga meningkatkan uji toleransi glukosa. EDS mengurangi kadar hemoglobin glikosilasi, laktat dehidrogenase, dan kreatinin kinase pada mencit yang diberi aloksan. EDS juga memperbaiki parameter stres oksidatif TBARS, aktivitas katalase dan superoksida dismutase dan kadar glutathione. Ekstrak etanol daun Syzygium cumini (EDS) menunjukkan aktivitas antidiabetik melalui peningkatan sekresi insulin dan efek ini dapat dikaitkan dengan kandungan flavonoid dan senyawa fenolik yang ada dalam ekstrak daun.
Inhibition of α-Glucosidase Activity and The Toxicity of Tristaniopsis merguensis Griff. Leaf Extract Robby Gus Mahardika; Occa Roanisca; Fajar Indah Puspita Sari
Elkawnie: Journal of Islamic Science and Technology Vol 6, No 1 (2020)
Publisher : Universitas Islam Negeri Ar-Raniry Banda Aceh

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22373/ekw.v6i1.5732

Abstract

Abstract : This study aims to determine the antidiabetic activity and toxicity of the acetone extract of Tristaniopsis merguensis Griff leaf. The antidiabetic test was the α-glucosidase inhibition method, while the toxicity test used the Brine Shrimp Lethality Test (BSLT) method. The acetone extract possessed antidiabetic activity with an IC50 value of 8.83 ± 0.31 (μg/mL). This value is not much different from the positive control of quercetin which has an IC50 value of 6.04 ± 0.14 (μg/mL). The characteristics of the FT-IR spectrum of acetone extract showed that Tristaniopsis merguensis leaf has the groups Ar-OH (phenolic), -OH (hydroxyl), C=O (ketone) and C=C (aromatic). Based on the toxicity test, the Tristaniopsis merguensis leaf acetone extract has an LC50 value of 959.25 ppm which means that the acetone extract is toxic. Therefore, the acetone extract of Tristaniopsis merguensis might be the potential agent of antidiabetic.Abstrak : Penelitian ini bertujuan untuk mengetahui aktivitas antidiabetes dan toksisitas dari ekstrak aseton daun Tristaniopsis merguensis Griff. Uji aktivitas antidiabetes ditentukan berdasarkan metode inhibisi enzim α-glucosidase, sedangkan toksisitas ditentukan berdasarkan metode Brine Shrimp Lethality Test (BSLT). Ekstrak aseton memiliki aktivitas antidiabetes dengan nilai IC50 8,83 ± 0,31 (μg/mL). Nilai ini tidak jauh berbeda dengan kontrol positif quersetin yang memiliki nilai IC50 6,04 ± 0,14 (μg/mL). Karakteristik spektrum FT-IR ekstrak aseton menunjukkan bahwa daun Tristaniopsis merguensis memiliki gugus fungsi Ar-OH (fenolik), -OH (hidroksil), C=O (keton) dan C=C (aromatik). Berdasarkan uji toksisitas, ekstrak aseton daun Tristaniopsis merguensis memiliki nilai LC50 sebesar 959,25 ppm yang berarti bahwa ekstrak aseton bersifat toksik. Oleh karena itu, ekstrak aseton dari Tristaniopsis merguensis berpotensi untuk dijadikan agen antidiabetes.

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