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Majalah Obat Tradisional

TradMedJ
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Published by Universitas Gadjah Mada

ISSN : 14105918 EISSN : 24069086 DOI : -

Core Subject : Health,

Health Professions Medicine & Pharmacology Public Health

raditional Medicine Journal (Majalah Obat Tradisional), or Trad. Med. J. (ISSN 1410-5918 (print) and ISSN 2406-9086 (online)), is an international scientific journal published by Faculty of Pharmacy, Universitas Gadjah Mada, three times annually. Collaborating with Indonesian Pharmacist Association, Daerah Istimewa Yogyakarta, and we dedicate our journal to researches and development in traditional medicine. The journal receives papers on research laboratory, field research, and case studies of traditional medicine and its constituent, covering research topics including raw materials, cultivation, phytochemical, pharmacological effects and toxicology, formulation, and biotechnology.

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Articles 564 Documents

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Optimization Formula Tablet Extract of Bengkuang (Pachyrrhizus erosus) Variation Avicel® Ph 101 and Crospovidone Rizki Kharisma; Ika Puspita Sari; Angi Nadya Bestari
Majalah Obat Tradisional Vol 23, No 1 (2018)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Bengkuang (Pachyrrhizus erosus) contains daidzein which is pro-estrogenic compound, suppressing bone restoration by directing mechanism in bone estrogen receptor. Bengkuang can be developed into a useful source of phytoestrogens as a supplement in menopausal women. This study aims to determine the stability and influence of Avicel® PH 101 and crospovidone on granular flow properties and physical properties of Bengkuang tuber extract. Bengkuang tuber extracts were made into tablet preparations by wet granulation method. Variation of crospovidone composition was between 2-5%, while Avicel® PH 101 was between 38.86 to 41.86%. The tablet formulation is optimized using the Simplex Lattice Design method. The results show that the addition of Avicel® PH 101 can improve the index of determination, water absorption, moisture content, hardness, time of disintegration, and friability of the tablet, as well as crospovidone addition. Avicel® PH 101 and crospovidone interactions increase water content, decrease hardness, and tablet friability. The optimum tablet formula consists of composition of 293 mg of Avicel® PH 101 and 14 mg of crospovidone per tablet. Testing of optimum formula results with SLD method did not differ significantly to the response of the compression index, hardness and friability of the tablet. The tablet was stable at room temperature (30ºC ± 2 ºC) for four weeks.

EFEK MUTAGENIK EKSTRAK METANOL AMPAS BIJI JARAK (Jatropha curcas L.) SISA PENGOLAHAN BAHAN BAKAR NABATI (BIOFUEL) Retno Wahyuningrum; Komar Ruslan Wirasutisna; Elfahmi Elfahmi; Marlia Singgih Wibowo
Majalah Obat Tradisional Vol 15, No 3 (2010)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Jatropha curcas seed contains viscous oil that can be used for soap making, cosmetic and as biofuel. It contains phorbol ester that was toxic. Biofuel production of Jatropha curcas seed left seedcake from mechanical press process. For safety evaluation, mutagenicity test was carried out. The seedcake was extracted by maceration method at room temperature with methanol and the mutagenic effect was evaluated by Ames test against Salmonella typhimurium TA 1535 with or without S9 metabolic activator. Methanolic extract of Jatropha curcas seedcake had no mutagenicity effect against S. typhimurium TA 1535.

AKTIVITAS ANTIOKSIDAN DAUN KESEMEK (Diospyros kaki L.F) DENGAN METODE DPPH (2,2-DIFENIL-1 PIKRILHIDRAZIN) Isnindar Isnindar; Erna Prawita Setyowati; Subagus Wahyuono
Majalah Obat Tradisional Vol 16, No 2 (2011)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

There are two groups of antioxidant resources, these are synthetic and natural antioxidants. The most important natural antioxidant is phenolic compounds that are produced naturally from plants. Phenolic Antioxidants are potent antiradical, biologically active as they are able to donate hydrogens to free radicals and break the chain of lipid oxidation reactions in the early stages. This study is aimed to search natural antioxidant compounds from the leaves persimmon (Diospyros kaki L.F) that have been utilized traditionally to prevent from sickness. In order to detect the presence of antioxidant compounds in the leaves extract, a reagent of DPPH (2,2-diphenyl-1-pykrilhidrazine) in methanol was used. Initially, powder of persimmon leaves (115 g) is macerated 3 times with methanol, 24 hours each time at room temperature. The liquid extract obtained is evaporated by rotavapor till residue (methanol extract) (phase I) is obtained. The residue was then extracted with CHCl3 to give CHCl3 soluble (phase II) and insoluble fractions. The later is then extracted with water to give water soluble (phase III) and insoluble fractions. These fractions (phase I-III) are chromatophed by TLC and sprayed by DPPH. Phase II contains antiradical compounds as shown by yellow color on the violet background. By preparative TLC [SiO2, CHCl3-EtOAc (1-4 v/v)], antiradical substance is isolated and identified tentatively as substituted phenolic compounds. Antiradical potential is measured spectrophotometrically, the isolat shows IC50 at 107.7 μg/mL that is lower than that of vitamin C (3.04 μg/mL).

KAPASITAS ANTIOKSIDAN DAN ANTIBAKTERI LOLOH SEMBUNG (Blumea balsamifera) BERDASARKAN METODE EKSTRAKSI IGA. Wita Kusumawati; IBA. Yogeswara
Majalah Obat Tradisional Vol 21, No 3 (2016)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Loloh sembung (Blumea balsamifera) is a traditional herbal drink which of the extraction methods can be done by boiling and brewing. Loloh sembung was prepared from fresh and dried leaves. Loloh sembung extracted by different methods producing phenolic content, tannin content, antioxidant capacity, are different. Dried leaves were extracted by brewing have high content of total phenolic was at 13.15±0.11 mg GAE/g sample, while dried leaves were extracted by boiling have high content of tannin and antioxidant capacity were at 1.65±0.01 mg TAE/g sample and 5.55±0.01 mg GAE/g sample respectiveliy. Both of fresh and dried leaves were extracted by boiling and brewing were not show inhibition against Escherichia coli and Staphylococcus aureus bacteria.

SELEKTIVITAS EKSTRAK TERPURIFIKASI DAUN Tithonia diversifolia (Hemsley) A.Gray TERHADAP SEL HELA M. Sri Hartati Wahyuningsih; Rul Afiyah Syarif; Sri Suharmi; Tri Murini; Firandi Saputra; Adiguno Suryo W
Majalah Obat Tradisional Vol 18, No 1 (2013)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Tanaman kembang bulan [Tithonia diversifolia (Hemsley) A.Gray] merupakan salah satu tanaman yang digunakan dalam pengobatan tradisional untuk berbagai penyakit. Penelitian sebelumnya menyebutkan bahwa kembang bulan memiliki efek antiproliferasi pada sel kanker kolon (Col2). Ekstraksi dan partisi termonitor dengan uji aktivitas merupakan metode untuk mengambil senyawa aktif yang terkandung dalam ekstrak. Penelitian tentang selektivitas ekstrak terpurifikasi dari ekstrak aktif daun Kembang bulan terhadap sel HeLa belum pernah diteliti sebelumnya. Tujuan penelitian ini untuk mengetahui selektivitas ekstrak terpurifikasi daun Kembang Bulan pada sel HeLa dibandingkan dengan sel Vero dan menentukan nilai IC50 serta indeks selektivitasnya. Daun kembang bulan diekstraksi menggunakan pelarut Kloroform dan Metanol. Kedua ekstrak diuji efek sitotoksiknya pada sel Hela dengan beberapa konsentrasi (0,12 s/d 250μg/mL) menggunakan metode MTT (Mosmann, 1983). Pembacaan densitas optik dengan ELISA plate reader. Persentase kematian sel dihitung dan dianalisis dengan menggunakan regresi probit pada program SPSS 15 for Windows. Setelah diketahui nilai IC50 kedua ekstrak tersebut, dipilih salah satu yang memiliki IC50 lebih kecil kemudian dipurifikasi dengan Petroleum Eter (PE) dan diuji kembali pada sel HeLa, sari yang aktif diuji juga selektivitasnya dengan sel Vero, kemudian dihitung nilai IC50 nya. Nilai IC50 ekstrak metanol sebesar 1006,99μg/mL, ekstrak Kloroform sebesar 16,61μg/mL. Nilai IC50 sari larut PE sebesar 325,331μg/mL dan IC50 sari tidak larut PE sebesar 3,078μg/mL dan nilai IC50 pada sel vero adalah 80,30μg/mL. Nilai indeks selektivitas ekstrak terpurifikasi (sari tidak larut PE) adalah 26.09.

Antiinflammatory Activity Test of Aqueous Extracts Herb of Ciplukan (Physalis angulata L.) in Caragenan Inducted Wistar Rat (Rattus norvegicus L.) Sri Luliana; Ressi Susanti; Ellya Agustina
Majalah Obat Tradisional Vol 22, No 3 (2017)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Ciplukan (Physalis angulata L.) empirically has been used to treat sore throat, inflammatory of the airways, gingivitis, and other diseases. This research was to determine the inflammatory activity of water herb extract of P. angulata L. on white male rats edema Wistar strain induced carragenan. P. angulata L. herbs were extracted using infundation method and were dried with frezee drying. Parameter that would be observed of this research was the inhibition foot edema of rat after induction of 0.1 mL of λ-carragenan 2% for 360 minutes. Measurement of edema volume was using pletismometer. The results of this research showed water herb extract of P. angulata L. in dose 100, 200, and 400 mg/kgBW has potensial as an antiinflammatory drug by percent respectively were 20.13; 28.93; and 34.70%. The three doses hasn’t showed any significant difference (p>0.05) with the positive control of diclofenac sodium dose 4.5 mg/kgBW was 33.90%. Conclusion of this research states water herb extract of P. angulata L. has antiinflammatory activity with effective dose of 400 mg/kgBW.

INSENCE COMBUSTIBLE SEREH, CENGKEH DAN JERUK SEBAGAI PENOLAK NYAMUK AEDES AEGYPTI Sri Mulyani; Budi Mulyaningsih; Anindita Winda Lestari; Fitri Ana Munawaroh; Diescendy Selly Anna
Majalah Obat Tradisional Vol 18, No 3 (2013)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Mosquitoes are one of the insect vector-borne diseases such as dengue, malaria, filariasis, etc. The use of materials whose got repellent activity such as lemongrass, cloves, and orange leaves are one of the best way to be protected from mosquito bites. Combustible insence known as aromatherapy preparations that can be used at any time, which is commonly used in religious events. This research is intended to make preparations of combustible insence which has dual functions, serve as room fresheners and also as repellent against Aedes aegypti. The research is conducted by making preparations of the active ingredient of lemongrass, cloves, and orange leaves, each with 5 different concentrations. Those preparats are tested on 25 mosquitoes contained in double trap mosquito cages. The number of mosquitoes in box A and B will be calculated at 5, 10, 15, 30, 45, and 60 minutes respectively. Thus, the repellent activity can be determined. Chromatogram profile testing is also being conducted using TAS microdestilation metode with several reagents for identification. Result shown that all preparations have mosquito repellent activity with 40% of effective concentration for lemongrass, 20% for orange leaves, 10% for cloves leaves. Chromatogram profile test shows orange leaves have the most spots for terpenoid and fenolic compound, followed by cloves and lemongrass. Spots as compounds with carbonyl groups (aldehydes and ketones) is only found in lemongrass.

AKTIVITAS ANTIRADIKAL DPPH SERTA PENENTUAN KANDUNGAN FENOLIK DAN FLAVONOID TOTAL SARI LARUT AIR DAUN DAN BUAH Ficus carica L. DAN Ficus parietalis Bl. Oktavia Tri Wahyuni; Triana Hertiani
Majalah Obat Tradisional Vol 21, No 2 (2016)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Ficus carica L and Ficus parietalis Bl. (Moraceae) are closely related plants which also known in Indonesia as Figs L. Considering the wide therapeutic value of Figs, this research was aimed to evaluate the DPPH-radical scavenging activity of both plants as well as their total phenolic and flavonoids. Extracts were produced by using boiled water and diluted to gain the desired concentration. Analyses were performed by using UV-vis spectrophotometer. Radical scavenging activity testing was done by using radical of DPPH (2,2-diphenyl-1-pycrylhydrazyl) to determine the IC50s. The determination of total phenolic was conducted by using Folin-Ciocalteau method and calculated as Gallic Acid Equivalence (GAE). The total flavonoid was measured by using AlCl3-reagents, and calculated as Rutin Equivalence (RE). Afterwards, the radical scavenging activity was correlated to the total phenolic and flavonoids contents. The results showed that the water soluble extract of F. carica fruit had the best IC50 value of 33.38 mg/mL, followed successively by the F. parietalis fruit (35.69 mg/mL), F. parietalis leaves (44.01 mg/mL) and the F. carica leaves (76.38 mg/mL). The highest content of total phenolic was shown by the leaves of F. parietalis (1.46% w/w GAE) and the lowest was in the fruit or F. carica (0.36% w/w GAE). The highest flavonoid content was detected in the leaves of F. carica (1.42% w/w RE) and the lowest was in the F. parietalis fruit (0.20% w/w RE). Correlation analyses of the IC50 values vs. the total phenolic and the flavonoids contents resulted in a positive slope having R2 values as 0.5362 and 0.9895, respectively. As a conclusion, the total flavonoid content influenced the DPPH radical scavenging activity by 98.95%, while the total phenolic content influence was only 53.62%.

STABILITAS FISIK DAN AKTIVITAS KRIM W/O EKSTRAK ETANOLIK BUAH MAHKOTA DEWA (Phaleria macrocarph (scheff.) Boerl,) SEBAGAI TABIR SURYA Hidayatu Hana Shovyana; A. Karim Zulkarnain
Majalah Obat Tradisional Vol 18, No 2 (2013)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Cream of Ethanolic extract Mahkota dewa fruit (Phaleria macrocarph (scheff.) Boerl,) has been reported as a sunscreen in in-vivo. The objective of this study is to evaluate the activity of sunscreen and physical stability. Determination of sunscreen was done by defining values of SPF (Sun Protection Factor) using Switzerland Weber strain mice with in vivo method. In this test we used 1 group without treatment, one negative control group (base), and 4 group treatments. Group treatment is a cream w/o ethanolic extract Mahkota dewa fruit. The value of SPF is a comparison of the DEM on the skin which were given sunscreen cream with DEM on the skin without the cream. We also did some physical stability test on the cream such as the viscosity test, spreading power, latched power, and the ratio of segregation. The Data were analyzed using SPSS to find the effect for addition of extract and prolonged storage of stability of cream. The results showed that a cream Mahkota dewa at concentration 4.6, d and 10% have an activity as a sunscreen with an SPF value of 1.25; 1.56; 2.4; and 3.05. In addition the Mahkota dewa have a good physical stability during storage.

Effect of Papaya Seed Extract (Carica papaya Linn.) on Glucose Transporter 4 (GLUT 4) Expression of Skeletal Muscle Tissue in Diabetic Mice Induced by High Fructose Diet Devyani Diah Wulansari; Achmad Basori; Suhartati Suhartati
Majalah Obat Tradisional Vol 22, No 2 (2017)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Ethnobotany surveys show that papaya seeds are widely used as herbs for the management of some diseases such as abdominal discomfort, pain, malaria, diabetes, obesity, and infection. This research was conducted to analyze the effect of papaya seed extract on GLUT4 expression on skeletal muscle tissue of DM type II model induced by high fructose diet. This study used 24 animals, divided into 4 groups of negative control group, treated with papaya seed extract 100 mg / kgBB, 200 mg / kgBW and 300 mg / kgBW, was adapted for 14 days then induced by fructose solution 20% Orally with a dose of 1.86 grams / kgBB for 56 days. The treatment group was given papaya seed extract in accordance with the dose of each group for 14 days. GDP levels was measured using a spectrophotometer. Skeletal muscle tissue is used on the gastrocnemius part. GLUT4 expression was measured through a Immunoreactive Score (IRS) method with immunohistochemical staining using GLUT4 polyclonal antibodies. Comparative test results showed that there were significant differences between groups (p <0.05) in final GDP variables and GLUT4 expression. Pearson correlation test results show that the value p = 0.001, meaning there is a significant relationship between GLUT4 expression with final GDP levels. The result of simple linear regression analysis showed that p = 0,000 (<0,05), meaning that dose of papaya seed extract had a significant influence on GLUT4 expression.

Page 21 of 57 | Total Record : 564

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