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Journal of Islamic Pharmacy
Published by Universitas Islam Negeri Maulana Malik Ibrahim Malang
ISSN : 24605182     EISSN : 25276123     DOI : http://dx.doi.org/10.18860/jip
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Chemistry Immunology & microbiology Medicine & Pharmacology Public Health
Welcome to Journal of Islamic Pharmacy (e-ISSN : 2527-6123) formerly Jurnal Farmasains (p-ISSN : 2460-5182) Department of Pharmacy, Universitas Islam Negeri Maulana Malik Ibrahim Malang, Indonesia. The journal was established in 2015 and online publication was begun in 2016. Since 2016, the journal has been published in English and only receives manuscripts in English.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 8 Documents
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Search results for , issue "Vol 5, No 2 (2020): J. Islamic Pharm." : 8 Documents clear
Glucocorticoid Tapering: a Literature Review Damayanti, Nurul; Sumarno, Sumarno
Journal of Islamic Pharmacy Vol 5, No 2 (2020): J. Islamic Pharm.
Publisher : Universitas Islam Negeri Maulana Malik Ibrahim Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/jip.v5i2.8704

Abstract

Glucocorticoids (GCs), a class of corticosteroids that widely used a variety of diseases, associated physiological processes in the body [1,2]. It has structurally and pharmacologically similar to the endogenous hormone cortisol with various beneficial functions like anti-inflammatory, immunosuppressive, anti-proliferative, and vasoconstrictive effects. As an anti-inflammatory and immunosuppressive effect, corticosteroids through a combination of both inhibition upregulation of gene transcription [3-5]. Despite beneficial effects, they also have side effects that depend on the dose, type of steroid and length of treatments [6]. Short courses of high-dose GCs usually are safe and reasonably well-tolerated, but they do have numerous potential adverse effects [7]. Many of the severe complications occur in long-term use at doses greater than 20 mg of prednisone per day for three weeks or more causes tertiary adrenal insufficiency due to the HPA-axis (Hypothalamic Pituitary Adrenal Axis) suppression by endogenous GCs [8-10]. In this article, we’ll discuss how to manage GCs tapering and when is the right time to use GCs.
A Case Report of Parkinson’s Disease in a 70 year Man With Myasthenia Gravis Ahadi, Muhammad Yanuar; Hadi, Deby Wahyuning; Soemarno, Soemarno; Octavia, Evi
Journal of Islamic Pharmacy Vol 5, No 2 (2020): J. Islamic Pharm.
Publisher : Universitas Islam Negeri Maulana Malik Ibrahim Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/jip.v5i2.8813

Abstract

AbstractBackground:. Neurodegenerative diseases such as Parkinson’s disease (PD) have increasing incidence, due to lifespan expansion. The association between PD and Myasthenia Gravis (MG) is uncommon, and so far, since 1987, 26 cases have been reported.Case presentation: This is a report of a 70-year-old man was referred into the hospital with ptosis, disfagia and dispnea. He was diagnosed with Suspected Myasthenia Gravis, Post Stroke Trombotik, Parkinson’s Disease and Hypertension. The patient was admitted to the outpatient unit, received of treatment Pyridostigmine, Clopidogrel, Trihexylphenidil, Vitamine B1, Vitaminie B6, Vitamine B12 and Levodopa-Benserazide .Discussion: Treatment guidelines by using some guidelines are also drug doses and do not have adverse side reactions during treatment.Conclusion:. PD and MG very rarely occur together. case report or a series of brief cases reported in the literature, it is very important not to miss the diagnosis of MG in patients with PD, because the treatment implications are very important and greatly influence the prognosis. More basic research needs to be done to understand the pathogenesis of both diseases, to provide more therapeutic options and possibly change the approach of the patient, whose quality of life is determined by these two neurological diseases, which have an increased impact on increasing disabilityKey words: Parkinson disease; Myasthenia gravis; co‐occurrence; case report.
Kajian Efek Ekstrak Umbi Bawang Dayak (Eleutherine palmifolia (L.) Merr) sebagai Antikanker Muti'ah, Roihatul; Listiyana, Anik; Nafisa, Belia Bima; Suryadinata, Arief
Journal of Islamic Pharmacy Vol 5, No 2 (2020): J. Islamic Pharm.
Publisher : Universitas Islam Negeri Maulana Malik Ibrahim Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/jip.v5i2.9778

Abstract

Dayak onion (Eleutherine palmifolia (L.) Merr) is a typical plant in Central Kalimantan. This plant has been passed down for generations by Indonesian people for various treatments. The potential of dayak onions that have various pharmacological activities needs to be increased in their use as modern medicinal ingredients. The purpose of this literature study is to review the various uses, the secondary metabolites content, and the action mechanism as an anticancer both in vitro, in vivo, and in silico. The results of this literature study show that traditionally the Indonesian people use the bulbs for the treatment of breast cancer, colon cancer, hypertension, diabetes mellitus, stroke, fever, dysuria, intestinal inflammation, dysentery, boils, cysts, prostate, lowering cholesterol and triglycerides, breastfeeding and sexual disorders. In the empiric treatment of cancer, this plant is used by drying the bulbs and chewing it. Dayak onion bulbs (Eleutherine palmifolia (L.) Merr) are known to contain flavonoid compounds wich isoliquiritigenin, polyphenols group wich oxyresveratrol and naphtoquinon group, and its derivatives such as elecanacine, eleutherine, eleutherol, eleutherinol, eleutherinon, eleuthoside B, eletherinoside A which has anti-cancer activity. Pre-clinical studies with in vitro and in vivo mechanism showed that dayak onion bulbs (Eleutherine palmifolia (L.) Merr) extracts have pharmacological activities, which are anti-cancer that can inhibit cell signaling through apoptosis and cell cycle arrest. Also, the mechanism of in silico showed anti-cancer activity from the inhibition of VHR receptors, BCL-2 receptors, VEGFR-2 receptors and alpha estrogen receptors (ERα).
Management Therapy of ST-Segment Elevation Myocardial Infarction: A Literature Review Novrianti, Irma; Wijaya, Dhani; Mustamin, Faizal; Wijayanti, Sari
Journal of Islamic Pharmacy Vol 5, No 2 (2020): J. Islamic Pharm.
Publisher : Universitas Islam Negeri Maulana Malik Ibrahim Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/jip.v5i2.8989

Abstract

Coronary Heart Disease (CHD) is the cardiovascular disease due to plaque build-up in the coronary artery, reducing the blood follow to the heart. STEMI (ST-segment elevation myocardial infarction) is the CHD due to the ST-segment elevation in 12 and the cardiac marker elevation as Troponin I. The elevation is due to a blockage in the coronary artery, causing the blood perfusion and oxygen supply for the heart to decrease. The objective of the article review is to describe the correct STEMI therapy based on the research findings and references listed in the literary review. This review was made with the study of literature published in 1993-2019. Conclusion: STEMI therapy management is discomfort management and reperfusion therapy. The reperfusion therapy is aimed to recover the myocardial blood flow, to heal the heart, and to reduce the mortality level. The primary coronary artery reperfusion can be administered with the primary percutaneous coronary intervention (PCI). PCI can open a blockage in the coronary artery and has a good effect on the short-term and long-term clinical results. Besides, it reduces the death risk, myocardial infarction, or repetitive stroke. Meanwhile, reperfusion using fibrinolytics is conducted when PCI is unavailable. Moreover, anticoagulant, antithrombotic, and vasodilators are supporting therapies for STEMI patients to reduce chest pain and prevent reinfarction
Evaluasi Pelayanan Kefarmasian di Puskesmas Kabupaten Ponorogo Norcahyanti, Ika; Hakimah, Farda; Christianty, Fransiska Maria
Journal of Islamic Pharmacy Vol 5, No 2 (2020): J. Islamic Pharm.
Publisher : Universitas Islam Negeri Maulana Malik Ibrahim Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/jip.v5i2.10525

Abstract

Public health center is a primary health facility, and pharmacy services support its activities. Periodic monitoring and evaluation of activities are needed to assure the quality of pharmaceutical services. Pharmacy personnels can evaluate pharmaceutical services at the public health center using a guideline published in 2008 by the Directorate of Pharmacy and Community Clinics of the Indonesian Ministry of Health. The purpose of this study was to determine the characteristics, description, and quality of pharmaceutical services at the public health centers in Ponorogo after being evaluated using a list of pharmaceutical services in 2008. This research was an observational survey on all pharmacy personnels and other personnels responsible for the pharmacy room at the public health center in Ponorogo. The analysis of data was using descriptive techniques. The results show that the public health centers were mostly an inpatient center (n=19; 61.3%) and accredited ‘madya’ (n=22; 71%). Morover, the head of a pharmacy room was dominantly a pharmacy technician (n=24; 77.4%). Pharmaceutical services generally fulfilled the supporting for and quality control indicators. However, several indicators did not fully meet the guideline, including clinical judgements, counseling, and home care. Overall, only three public health centers can be rated “good” in delivering quality pharmaceutical services, whilst the other eight and twenty were rated “moderate” and “less”, respectively.
Studi Formulasi Sediaan Lip Balm Ekstrak Kayu Secang (Caesalpinia sappan L.) dengan Variasi Beeswax Ambari, Yani; Hapsari, Fitra Nanda Dwi; Ningsih, Arista Wahyu; Nurrosyidah, Iif Hanifa; Sinaga, Butet
Journal of Islamic Pharmacy Vol 5, No 2 (2020): J. Islamic Pharm.
Publisher : Universitas Islam Negeri Maulana Malik Ibrahim Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/jip.v5i2.10434

Abstract

Bibir merupakan salah satu bagian kulit yang membutuhkan perlindungan agar kelembaban bibir tetap terjaga. Akibat dari fungsi perlindungan yang buruk bibir menjadi kering, pecah-pecah, dan warna bibir menjadi kusam. Lip balm adalah sediaan yang diaplikasikan pada bibir untuk mencegah bibir kering dan melindungi dari efek lingkungan yang buruk. Kualitas fisik lip balm merupakan faktor yang harus dipenuhi sebelum sediaan lip balm dipasarkan ke konsumen. Pemilihan basis yang tepat akan menentukan kualitas kekerasan sehingga dapat diterima oleh masyarakat, karena basis merupakan pembentuk utama dari sediaan lip balm. beeswax mempunyai sifat sebagai pengikat yang baik, dimana membantu untuk menghasilkan massa yang homogen. Pada penelitian ini bahan aktif yang digunakan yaitu kayu secang karena mengandung senyawa brazilein yang bisa sebagai pewarna alami dan antiokasidan.. Penelitian ini merupakan penelitian eksperimental formulasi sediaan lip balm dengan menggunakan beeswax 5%, 10% dan 15%. Tujuan penelitian ini Mengetahui formulasi yang tepat sediaan lip balm dengan bahan aktif ekstrak kayu secang (Caesalpinia sappan L.), mengetahui stabilitas fisik sediaan lip balm dengan bahan aktif ekstrak kayu secang (Caesalpinia sappan L.), mengetahui konsentrasi basis yang sesuai, untuk mendapatkan sediaan lip balm yang berkualitas (sesuai standart farmasi). Hasil penelitian telah didapatkan formula yang bagus dengan karakteristik fisik yang sesuai dengan spesifikasi yang telah ditentukan meliputi pengamatan stabilitas, pengukuran pH, pengujian homogenitas, pengujian iritasi, pengujian kesukaan (Hedonic test) dan pengujian cycling test. formula yang tepat di dapat pada formula 1 dengan konsentrasi beeswax 5% menghasilkan tekstur warna, aroma, memiliki nilai daya lekat dan daya sebar yang baik, pH sesuai terhadap pH bibir, tidak mengiritasi, sediaan homogen, paling banyak disukai oleh responden dan stabil selama penyimpanan. Konsentrasi basis yang baik yaitu basis 5% pada formula 1 karena menghasilkan tekstur lip balm semi padat dan sangat halus.  Kata kunci : Lip balm, Beeswax , Bibir, Caesalpinia sappan
Analisis Kandungan Logam Berat Cd, Hg, dan Pb Daun Semanggi (Marsilea crenata Presl.) di Desa Semen, Kecamatan Pagu, Kabupaten Kediri Ma'arif, Burhan; Muti'ah, Roihatul; Suryadinata, Arief; Nashichuddin, Ach; Karawid, Galih Elsy
Journal of Islamic Pharmacy Vol 5, No 2 (2020): J. Islamic Pharm.
Publisher : Universitas Islam Negeri Maulana Malik Ibrahim Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/jip.v5i2.9356

Abstract

Semanggi (Marsilea crenata Presl.) berpotensi untuk diolah menjadi produk obat herbal karena khasiat yang dimilikinya. Namun, tanaman semanggi (Marsilea crenata Presl.) memiliki kemampuan fitoremediasi sehingga berdampak pada penimbunan logam berat yang berbahaya untuk kesehatan tubuh. Penelitian ini dilakukan untuk mengetahui kandungan logam berat Cd, Hg dan Pb pada daun semanggi di Kabupaten Kediri (Desa Semen, Kecamatan Pagu) untuk dibandingkan dengan Perka BPOM No. 12 tahun 2014 terkait batas logam berat untuk simplisia. Metode yang digunakan yaitu menggunakan Atomic Absorption Spectroscopy (AAS) pada sampel simplisia daun tanaman semanggi dan juga sampel tanah sebagai pembanding. Dari hasil pengujian sampel simplisia daun semanggi di Kabupaten Kediri (Desa Semen, Kecamatan Pagu) terdapat (Cd) dengan kadar 4,16 ppm. Hasil ini menunjukkan tidak memenuhi standar Perka BPOM No. 12 tahun 2014 karena melewati batas minimum Cd sebesar ≤ 0,3 ppm.
Analisis Efektivitas Biaya Seftriakson dan Sefotaksim pada Pasien Demam Tifoid Anak di Instalasi Rawat Inap Shofa dan Marwah PKU Karangasem Muhammadiyah Paciran Tahun 2019 Hidayah, Shofi Nurul; Hakim, Abdul; Syahrir, Ach; Anggraini, Wirda
Journal of Islamic Pharmacy Vol 5, No 2 (2020): J. Islamic Pharm.
Publisher : Universitas Islam Negeri Maulana Malik Ibrahim Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/jip.v5i2.9819

Abstract

Demam tifoid adalah suatu penyakit infeksi yang disebabkan oleh bakteri gram negatif Salmonella typhi. Pengobatan untuk demam tifoid berupa terapi simtomatik dan terapi antibiotik. Cost-effectiveness Analysis (CEA) adalah salah satu pendekatan farmakoekonomi untuk mengetahui perbandingan efektivitas hasil terapi dan biaya dari beberapa alternative terapi yang digunakan. Tujuan dari penelitian ini adalah untuk menganalisis efektivitas biaya terapi penggunaan antibiotik pada pasien demam tifoid anak secara farmakoekonomi dengan pendekatan analisis efektivitas biaya di Instalasi Rawat Inap PKU Karangasem Muhammadiyah Paciran dan untuk mengetahui terapi antibiotik yang paling cost-effective. Penelitian ini merupakan penelitian deskriptif yang bersifat observasional dengan pengambilan data secara retrospektif. Data diambil dari rekam medis pasien rawat inap demam tifoid anak di PKU Karangasem Muhammmadiyah Paciran tahun 2019. Parameter yang digunakan adalah lama rawat inap, waktu bebas demam, dan total biaya medis langsung yang meliputi biaya obat, biaya alat kesehatan, biaya rawat inap, biaya laboratorium, dan biaya dokter. Pasien yang sesuai dengan kriteria inklusi dan eksklusi berjumlah 29 pasien. Antibiotik yang digunakan adalah Seftriakson dan Sefotaksim. Efektivitas biaya dinyatakan dalam ACER (Average Cost Effectiveness Ratio) yang diperoleh dari rerata total biaya medis langsung dibagi dengan rerata outcome klinis. Nilai ACER dari antibiotik Seftriakson Rp.346.357,04/hari untuk lama rawat inap dan Rp.447.853,61/hari untuk lama waktu bebas demam, dan Sefotaksim Rp.390.452,88/hari untuk lama rawat inap dan Rp.489.655,89/hari untuk lama waktu bebas demam. Kesimpulan dari penelitian ini adalah bahwa antibiotik yang paling cost-effective yaitu Seftriakson.

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