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INDONESIA
Jurnal Farmasi Udayana
Published by Universitas Udayana
ISSN : 23017716     EISSN : 26224607     DOI : -
Core Subject : Health,
Medicine & Pharmacology
Jurnal Farmasi Udayana merupakan jurnal elektronik yang dikelola oleh jurusan Farmasi FMIPA Udayana. Jurnal ini yang merupakan media publikasi penelitian dan review article pada semua aspek ilmu farmasi yang bersifat inovatif , kreatif, original dan didasarkan pada scientific. Artikel yang dimuat dalam jurnal ini meliputi penemuan obat, sistem penghantaran obat serta pengembangan obat. Jurnal ini memuat bidang khusus di farmasi seperti kimia medisinal, farmakologi, farmakokinetika, farmakodinamika, analisis farmasi, sistem penghantaran obat, teknologi farmasi, bioteknolofi farmasi, obat herbal dan komponen aktif tanaman serta evaluasi klinik obat
Arjuna Subject : -
Articles 322 Documents
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Studi Penggunaan Obat Golongan Beta-Blocker Pada Pasien Rawat Inap Rumah Sakit Ansari Saleh Banjarmasin Okta Muthia Sari
Jurnal Farmasi Udayana Vol. 9, No. 2, Tahun 2020
Publisher : Departement of Pharmacy, Faculty of Mathematics and Natural Science, Udayana University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/JFU.2020.v09.i02.p07

Abstract

Beta-blockers have a role in cardiovascular and non-cardiovascular therapy. Many beta-blockers are now available and in general they are all equally effective. There are, however, differences between them, which may affect choice in treating particular diseases or individual patients. Research related to the profile of beta-blocker drug use in cardiovascular and non-cardiovascular therapy is still limited. This study aims to describe the use of beta-blockers in inpatients at Ansari Saleh Hospital, Banjarmasin. This retrospective descriptive study was conducted from April to May 2019 at the Anshari Saleh Hospital, Banjarmasin. The beta-blocker drugs used were bisoprolol and propranolol which were administered in cardiovascular medications such as angina (3.7%); arrhythmia (3%); Congestive Heart Failure (20%); hypertension (3%); myocardial infarction (54.8%); non hemorrhagic stroke (9.6%); and non-cardiovascular including hepatic cirrhosis (1.5%); hyperthyroidism (4.4%). The bisoprolol dosage used by inpatients at Ansari Saleh Hospital starts from 1.25 to 5 mg per day. Myocardial infarction and non-hemorrhagic stroke patients received bisoprolol dose uptitration. The propranolol dosage is 20-30 mg per day. In cardiovascular patients, bisoprolol is a drug that is often given to patients with comorbids than propranolol. Keywords: Beta-blockers, cardiovascular, non-cardiovascular, therapy
Hubungan Pemberian Ekstrak Cordyline fruticosa L.A Cheval Terhadap Penurunan Kolesterol Tikus Putih Dian Rahmawati
Jurnal Farmasi Udayana Spesial Issue, Desember 2020
Publisher : Departement of Pharmacy, Faculty of Mathematics and Natural Science, Udayana University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/JFU.2020.v09.i03.p03

Abstract

ABSTRAK Penelitian ini bertujuan untuk mengetahui efek ekstrak etanol daun andong dengan kontrol normal dalam menurunkan kadar kolesterol total tikus putih jantan. Penelitian ini menggunakan hewan uji tikus putih jantan sebanyak 30 ekor yang dibagi menjadi 6 kelompok perlakuan, tiap kelompok terdiri dari 5 ekor hewan uji. Kelompok I kontrol normal, Kelompok II kontrol negatif (pakan tinggi kolesterol dan streptozotocin 30 mg/kgBB), Kelompok III kontrol positif (suspensi simvastatin), Kelompok IV, V, VI masing-masing diberikan ekstrak etanol daun andong dosis 100 mg/kgBB, dosis 150 mg/kgBB, dan dosis 200 mg/kgBB secara peroral selama 14 hari berturut-turut. Pengukuran Kadar kolesterol total pada hari ke 0, 14, 21, 28, 35. Data yang diperoleh dianalisis menggunakan uji statistik one way (ANOVA) pada taraf kepercayaan 95% dan dilanjutkan dengan uji Least Significant Difference (LSD) untuk melihat perbedaan antar perlakuan. Berdasarkan hasil penelitian menunjukkan bahwa Ekstrak etanol daun andong dosis 300 mg/kgBB mampu menurunkan kadar kolesterol total pada tikus putih dengan kadar kolesterol 39 mg/dL. Kata kunci: Cordyline fruticosa L.A Cheval, Daun Andong,Kolesterol.
Uji Aktivitas Antioksidan Ekstrak etanol Daun Kratom (Mitragyna Speciosa) Dengan Metode 1, 1 Difenil-2-Pikrihidrazil (DPPH) Herni Setyawati
Jurnal Farmasi Udayana Spesial Issue, Desember 2020
Publisher : Departement of Pharmacy, Faculty of Mathematics and Natural Science, Udayana University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/JFU.2020.v09.i03.p09

Abstract

Kratom (Mitragina speciosa) merupakan salah satu tumbuhan herbal berasal dari Indonesia. Tumbuhan kratom memiliki beberapa manfaat empirik diantaranya mengatasi diare, meningkatkan daya tahan tubuh dan mengatasi nyeri. Daun kratom memiliki beberapa efek farmakologi salah satunya antioksidan. Kandungan berbagai senyawa yang memberikan efek farmakologis sebagai antioksidan didalam daun kratom cukup tinggi. Tujuan dilakukannya penelitian adalah mengetahui adanya aktivitas antioksidan ekstrak etanol daun kratom melalui metode 1,1-Difenil-2Pikrilhidrazil (DPPH), berdasarkan nilai nilai IC50. Daun Kratom diekstraksi dengan metode remaserasi 3x24 jam memakai pelarut etanol 70%, lalu dipekatkan dengan Rotary Evaporator pada suhu 40°C, dan dioven pada suhu (40-50)°C hingga menghasilkan ekstrak kental. Ekstrak daun kratom memiliki kandungan senyawa alkaloid, flavonoid, tanin dan saponin. Pengujian aktivitas antioksidan menggunakan analisa kualitatif dan uji kuantitatif. Uji kualitatif antioksidan dilakukan melalui cara Kromatografi Lapis Tipis (KLT) dengan cairan pengelusi n-heksana:etil asetat (7:3), dilanjutkan dengan penyemprotan DPPH menunjukkan hasil positif memberikan aktivitas antioksidan. Uji kuantitatif antioksidan memakai metode 1,1-Difenil-2-Pikrilhidrazil (DPPH) dengan pengukuran kadar menggunakan Spektrofometer UV-Vis, dan vitamin C sebagai pembanding. Hasil pengujian aktivitas antioksidan ekstrak etanol daun kratom menunjukkan nilai IC50 sebesar 91,86 ppm sehingga termasuk golongan antioksidan kuat. Kata kunci: Antioksidan, DPPH, Etanol, IC50, Kratom
Aktivitas Antioksidan Ekstrak Etanol Kayu Manis (Cinnamomum burmani) Secara In Vitro / Antioxidant Activities Of Cinnamon (Cinnamomum burmani) In Vitro Irma Antasionasti; Jayanto I
Jurnal Farmasi Udayana Vol. 10, No 1, Tahun 2021
Publisher : Departement of Pharmacy, Faculty of Mathematics and Natural Science, Udayana University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/JFU.2021.v10.i01.p05

Abstract

ABSTRAK Kayu manis (Cinnamomum burmani) merupakan rempah-rempah yang bisa dijadikan sebagai bahan tambahan dalam makanan dan juga kue serta salah satu bahan farmasi dalam industri farmasi. Oleh karena itu, eksplorasi kayu manis sebagai antioksidan alami sangat diperlukan. Tujuan penelitian ini adalah untuk mengetahui aktivitas antioksidan kayu manis menggunakan uji DPPH, ABTS dan daya aktivitas reduksi besi III serta total fenolik dan total flavonoid. Kayu manis bubuk diekstraksi menggunakan teknik maserasi dengan pelarut etanol 96% dan dilakukan pengujian aktivitas antioksidan. Ekstrak etanol kayu manis menunjukkan nilai aktivitas antioksidan DPPH, ABTS, dan reduksi besi III secara berturut-turut sebesar 1,939 ± 0,055 ?g/mL; 2,235 ± 0,014 ?g/mL; dan 1415,705 ± 38,609 mg asam askorbat/gram ekstrak. Aktivitas antiradikal ekstrak etanol kayu manis lebih rendah dibandingkan dengan vitamin C yaitu 0,554 ± 0,003 ?g/mL (DPPH) dan 0,813 ± 0,028 ?g/mL (ABTS). Aktivitas antioksidan yang diberikan oleh ekstrak etanol kayu manis dipengaruhi oleh kandungan total fenolik dan total flavonoid secara berturut-turut sebesar 75,685 ± 1,408 % EAG dan 60,546 ± 0,670 % EK. Kayu manis memiliki aktivitas antioksidan yang sangat kuat, mengandung total fenolik dan total flavonoid dalam jumlah tinggi sehingga berpotensi sebagai bahan tambahan pangan (antioksidan) dalam industri makanan maupun farmasi.
Analisis Cemaran Kapang/Khamir Pada Serbuk Simplisia Obat Tradisional Resmila Dewi; Nur RM
Jurnal Farmasi Udayana Vol. 10, No 1, Tahun 2021
Publisher : Departement of Pharmacy, Faculty of Mathematics and Natural Science, Udayana University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/JFU.2021.v10.i01.p10

Abstract

Folk remedies are of great benefit to well being and are now being used as they are easier to access. The raw materials used for such products are plant products, animal materials, mineral materials, or mixtures. Parts of plants widely used are roots, rhizomes, branches, fruits, leaves, seeds, and bark. These ingredients are used in both fresh and dry (simplicia) form. Simplicia storage under unregulated conditions will lead to the presence of different types of microorganisms, particularly mold. This research aims at examining the extent of mold/yeast contamination in the simplicity of conventional medicinal plants. The samples used in this analysis were Turmeric rhizome, Curcuma rhizome, ginger rhizome, Sambiloto leaf, and god's crown fruit. Simplicia had been collected from five Aceh Conventional Market traders. Testing sample time bar contamination using cup technique for spreading plate method on PDA media. The results showed that AKK simplicia rhizomes turmeric 46—120 colonies/grams, rhizomes Curcuma 50—96 colonies/grams, ginger rhizomes 23—43 colonies/grams, 46—100 colonies/grams of Sambiloto leaves and 43—83 colonies/grams of god crown berries. This is less than the number of mold/yeast set by BPOM (104 colonies/g).
Pengaruh Variasi Metode Ekstraksi Terhadap Perolehan Senyawa Antioksidan Pada Daun Katuk (Sauropus androgynus (L.) Merr) Ni Putu Ermi Hikmawanti; Sofia Fatmawati; Zainal Arifin; Vindianita .
Jurnal Farmasi Udayana Vol. 10, No 1, Tahun 2021
Publisher : Departement of Pharmacy, Faculty of Mathematics and Natural Science, Udayana University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/JFU.2021.v10.i01.p01

Abstract

S. androgynus (Phyllanthaceae) contains natural antioxidant compounds such as phenolics and flavonoid derivatives. The successful to obtain the plant metabolite compounds depends on the extraction method. This study aims to determine the total phenolics and flavonoids content of the ethanolic extract of S. androgynus leaves obtained from three types of extraction methods, namely maceration, Soxhletation, and ultrasonic. Determination of total phenolics and flavonoids content was carried out by colorimetric method using Folin-ciocalteu and AlCl3 10% reagents, respectively. The absorbance of the reaction was measured using a UV-Vis spectrophotometer. Total phenolics content is expressed as equivalent to gallic acid, while total flavonoid content is expressed as equivalent to quercetin. Determination of the extract's antioxidant activity was carried out against DPPH free radical and expressed by the IC50 (ppm) value. The results showed that the ultrasonic extraction method produced the best levels of phenolics (42.96 ± 0.51 mgGAE/g), flavonoids (12.05 ± 0.36 mgQE/g) and antioxidant activity (IC50 = 81.43 ± 2.63 ppm) in ethanolic extract of S. androgynus leaves compared to another extraction method (maceration > Soxhletation). Thus, it can be concluded that the ultrasonic extraction method is an efficient and effective extraction method to produce high antioxidant compounds in ethanolic extract of S. androgynus leaves.
Perbandingan Kualitas Layanan Kefarmasian Di Puskesmas Berstandar ISO dan Non-ISO Kota Denpasar Made Krisna Adi Jaya; Ni Luh Santiyani Dewi; I Gusti Lanang Made Rudiartha
Jurnal Farmasi Udayana Vol. 10, No 1, Tahun 2021
Publisher : Departement of Pharmacy, Faculty of Mathematics and Natural Science, Udayana University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/JFU.2021.v10.i01.p06

Abstract

Background: Primary Health Care (puskesmas in Indonesian) is a facilities/infrastructure used to improve health status and health development. Pharmaceutical services at puskesmas are always in the spotlight of the community and tend to be negative in stigma. The community paradigm, especially in Denpasar, tends to state that pharmaceutical services at ISO-standard puskesmas are better than non-ISO. However, this does not mean that non-ISO health centers in Denpasar City do not provide optimal services to the community. Based on this problem, research needs to be conducted to assess the extent of differences in the quality of pharmaceutical services in ISO and non-ISO health centers in Denpasar. Objective: This study aims to compare the quality of pharmaceutical services in ISO and non-ISO puskesmas including the waiting time for drug services, the incidence of Drug Related Problems (DRP), and the level of patient satisfaction. Methods: An analytic observational study was conducted by observing 184 respondents who used the health services at the puskesmas in Denpasar. Waiting time was observed from the patient submitting a prescription until getting the medicine; DRP was observed by the number of drug interactions, patient adherence to therapy and the incidence of Adverse Drug Reaction (ADR); and patient satisfaction using the satisfaction questionnaire. Results: The waiting time for drug services showed that the ISO puskesmas was superior to non-ISO (p <0.05) while the DRP incidence and patient-related satisfaction were not significantly different (p> 0.05). Conclusion: Non-ISO Puskesmas in Denpasar showed the quality of pharmaceutical services that were comparable to Puskesmas with ISO standards. Keywords: Drug Services, Drug Related Problem, Patients Satisfaction, Primary Health Care
Pengaruh Variasi Konsentrasi Natrium Klorida dalam Formulasi Sediaan Facial Wash Kombinasi Ekstrak Spirulina (Spirulina platensis )dan Minyak Nyamplung (Chalophyllum inophyllum) anif nur artanti; Prabawati N; Prihapsara F; Rakhmawati R
Jurnal Farmasi Udayana Vol. 10, No 1, Tahun 2021
Publisher : Departement of Pharmacy, Faculty of Mathematics and Natural Science, Udayana University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/JFU.2021.v10.i01.p11

Abstract

Spirulina platensis diketahui mengandung fikosianin yang berpotensi sebagai antioksidan dan pewarna alami. Minyak nyamplung merupakan bahan baku kosmetik yang belum banyak digunakan. Minyak nyamplung berkhasiat sebagai antibakteri dan antioksidan, sehingga berpotensi untuk dibuat sediaan kosmetik salah satunya facial wash. Penelitian ini dilakukan untuk mengetahui pengaruh variasi konsentrasi NaCl terhadap sifat fisik sediaan facial wash ekstrak spirulina dan minyak nyamplung. Penelitian dilakukan dengan metode eksperimental laboratorium dengan tahapan pembuatan basis sabun, pembuatan facial wash dengan tiga variasi konsentrasi NaCl 1%; 2%; dan 3%, serta uji sifat fisik dan kimia berupa uji organoleptik, uji viskositas, uji stabilitas busa, dan uji pH. Kemudian hasil pengujian organoleptik, uji pH, uji viskositas, uji stabilitas busa dibandingkan dengan Standar Nasional Indonesia dan literatur lainnya. Hasil penelitian menunjukkan bahwa variasi konsentrasi NaCl memberikan pengaruh signifikan terhadap sifat fisik sediaan, yaitu semakin tinggi konsentrasi NaCl maka viskositas semakin meningkat namun stabilitas busa semakin menurun. Formula 3 dengan konsentrasi NaCl 3% merupakan formula facial wash ekstrak spirulina dan minyak nyamplung yang paling stabil.
Produk Inovasi Aromaterapi Berbasis Minyak Atsiri Kemenyan, Kamfer Sumatera Dan Ekaliptus Cut Rizlani Kholibrina; Aswandi Aswandi
Jurnal Farmasi Udayana Vol. 10, No 1, Tahun 2021
Publisher : Departement of Pharmacy, Faculty of Mathematics and Natural Science, Udayana University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/JFU.2021.v10.i01.p02

Abstract

The global pandemic Covid-19 encourages peoples to improve their immune system. Both healthy food and regular exercise, good immunity can be achieved from healthy and relaxing mind, including through aromatherapy. This is in line with increasing awareness in holistic and organic medicine. The objectives of study are to develop aromatherapy products based-on sumatran camphor, styrax, and eucalypts essential oils; and to identify consumer preferences for innovation products. A conjoint analysis was operated to determine consumer preferences. The active compounds contained in essential oils combination are including a-pinene, 1.8-cineole, limonene, b-caryophyllene and p-cymene. The combination and presence of similar active compound harmonize aroma with minimal contraindications and produce refreshing and relaxing aromas. The 1.8-cineole is known as anti-fungal, antiviral which offer relief to congested respiratory system, thereby boosts immune system. Moreover, p-cymene has been identified to reduce anxiety, nervousness, and relaxing the mind. Based on conjoint analysis, aroma has the greatest influence on consumer preferences. The most preferred profile is aromatherapy product which soft-refreshing aroma, roll-on package, volume 6 ml, at price of Rp 35,000. Aroma is influenced by personal’s perceptions, which related to initial recognition of certain scents as olfactory memory.
Terapi Fibrinolitik Pada Pasien St-Segment Elevation Myocardial Infarction (Stemi) : Review Artikel Irma Novrianti; Heriani .; Mustamin F
Jurnal Farmasi Udayana Vol. 10, No 1, Tahun 2021
Publisher : Departement of Pharmacy, Faculty of Mathematics and Natural Science, Udayana University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/JFU.2021.v10.i01.p07

Abstract

Acute ST-elevation myocardial infarction (STEMI) occurs when there is a blockage caused by sudden atherosclerotic plaque that blocks blood flow to the heart. The goal of STEMI therapy is to restore myocardial blood flow, to save the heart. Coronary arterial reproduction recommended by the American Heart Association (AHA) and the Indonesian Cardiovascular Specialist Association (PERKI) is primary percutaneous coronary intervention (PCI) or fibrinolytic. However, not all hospitals have catheterization laboratory facilities, so they still use fibrinolytic as reperfusion therapy. To provide a review of currently available fibrinolytic therapies that can be used in STEMI patients. Four databases [Pubmed, Libgen, researchgate, and Scopus] were searched from 1987 to 2019. Include original articles including RCT, comparative, literature review, and observational study about fibrinolytics treatment in Acute STEMI. Fibrinolytic was divided into specific fibrin (alteplase, tenecteplase, and reteplase) and non-specific fibrin (streptokinase and urokinase). Fibrinolytic used in STEMI are streptokinase, alteplase, tenecteplase, and reteplase. Fibrinolytic can be given when the patient has no contraindications. Furthermore, the administration must follow protocols to minimize the risk of side effects such as bleeding. Fibrinolytic can be used as reperfusion therapy in STEMI patients when PCI cannot be done promptly.

Page 26 of 33 | Total Record : 322

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