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MNJ (Malang Neurology Journal)
Published by Universitas Brawijaya
ISSN : 24076724     EISSN : 24425001     DOI : -
Core Subject : Science,
Neuroscience
Malang Neurology Journal is a peer-reviewed and open access journal that focuses on promoting neurological sciences generated from basic neurosciences and clinical neurology. This journal publishes original articles, reviews, and also interesting case reports. Brief communications containing short features of medicine, latest developments in diagnostic procedures of neurology disease, treatment, or other health issues related to neurology that is important also acceptable. Letters and commentaries of our published articles are welcome.
Arjuna Subject : -
Articles 25 Documents
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Search results for , issue "Vol. 11 No. 1 (2025): January" : 25 Documents clear
THE CORRELATION BETWEEN SLEEP QUALITY AND MEMORY FUNCTION IN MEDICAL STUDENTS Setyo Pambudi , Arif; Sahidu, Muhammad Ghalvan; Hunaifi, Ilsa
MNJ (Malang Neurology Journal) Vol. 11 No. 1 (2025): January
Publisher : PERDOSSI (Perhimpunan Dokter Spesialis Saraf Indonesia Cabang Malang) - Indonesian Neurological Association Branch of Malang cooperated with Neurology Residency Program, Faculty of Medicine Brawijaya University, Malang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.mnj.2025.011.01.10

Abstract

Background: sleep is a physiological need for every human, including medical students. Studies have shown that poor sleep quality can lead to a decline in learning and memory abilities in medical students. The dual process theory explains that certain types of memory depend on common sleep conditions. This study aims to determine the association between sleep quality and short-term memory function, as measured by the digit span test, among medical students at the University of Mataram Objective: To determine the association between sleep quality and short-term memory function as measured by the digit span test among Medical Students at the University of Mataram. Methods: Observational analytic study with a cross-sectional design. The primary data included sociodemographic characteristics, Pittsburgh Sleep Quality Index, and the Digit Span Test. Data were analyzed using chi-square test and Fisher's exact test. Results: 62 participants were observed. Participants ranged from 18 to 23 years, with 42 students (67.7%) identified as female. 71% of the participants experienced poor sleep quality, while 29% reported good sleep quality. All 62 students showed normal performance in the forward digit span test. In the backward digit span test, 79% obtained normal results, while 21% performed abnormally. There is no relationship between sleep quality and short-term memory (p=0,739). Conclusion: sleep quality doesn’t influence memory function among medical students at the University of Mataram.
DIFFERENCES IN THE AMPLITUDE OF ACCOMMODATION BETWEEN CHILDREN WITHOUT DEVELOPMENTAL DISABILITIES AND CHILDREN WITH DEVELOPMENTAL DISABILITIES Karim, Muhammad Rico Abdul; Wulandari, Lely Retno; Dewi, Nadia Artha; Anandita, Nanda Wahyu
MNJ (Malang Neurology Journal) Vol. 11 No. 1 (2025): January
Publisher : PERDOSSI (Perhimpunan Dokter Spesialis Saraf Indonesia Cabang Malang) - Indonesian Neurological Association Branch of Malang cooperated with Neurology Residency Program, Faculty of Medicine Brawijaya University, Malang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.mnj.2025.011.01.11

Abstract

Background: Accommodation is the eye's ability to change the refractive power of the lens, allowing objects to focus on the retina at different distances. The Amplitude of Accommodation (AoA) is the closest point at which the eye can focus and the distance between the far point and near point on the diopter scale. Children with developmental disabilities (CDD) are at a higher risk of encountering vision problems, including accommodation issues. Objective: This study aims to ascertain the disparity in Amplitude of Accommodation (AoA) results between children with developmental disabilities (CDD) and those without developmental disabilities (CWDD) Methods: This research constitutes an observational study with cross-sectional data, involving 44 subjects with developmental disabilities (CDD) and 44 subjects without developmental disabilities (CWDD). The participants were further categorized into 33 deaf children (DC) and 11 children with intellectual disabilities (CID). The data were obtained from eye examinations conducted at several special schools and orphanages in the city of Malang. The examinations covered the right eye (OD), left eye (OS), and binocular vision (ODS). Results: Significant differences were identified among groups in OD (P<0.001), OS (P<0.001), and ODS (P<0.001). To assess the specific variations between groups, a Bonferroni post-hoc test was conducted. The results indicated significant differences between CWDD and DC in both OD (P<0.001), OS (P<0.001), and ODS (P<0.001). Additionally, significant differences were observed between CWDD and CID in OD (P=0.002), OS (P=0.005), and ODS (P<0.001). Conclusion: It can be concluded that there is a significant difference in the average AoA value between CWDD and CDD, both CWDD-DC and CWDD-CID.
BENEFICIAL EFFECTS OF ANTHOCYANINS ON NEUROCOGNITIVE FUNCTIONS: A SYSTEMATIC REVIEW Suryantari, Sang Ayu Arta; Masnathasari, NM Ayu; Sugiritama, I Wayan; Linawati, NM; Widianti, IGA
MNJ (Malang Neurology Journal) Vol. 11 No. 1 (2025): January
Publisher : PERDOSSI (Perhimpunan Dokter Spesialis Saraf Indonesia Cabang Malang) - Indonesian Neurological Association Branch of Malang cooperated with Neurology Residency Program, Faculty of Medicine Brawijaya University, Malang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.mnj.2025.011.01.15

Abstract

Background: Increased research interest in natural compounds from plant has been reported to show possible protective effects on neurocognitive function. Anthocyanins, a polyphenol widely present in many red-blue fruits or plants, has received the most attention in this regard. Objective: This study was conducted to reviews published literature of anthocyanins effect on cognitive outcomes according to PRISMA guideline. Methods: We systematically searched relevant data in PubMed, ScienceDirect, and Medline database published in January 2014 to December 2023. Results: Thirteen studies were reviewed consisting of animal studies (n=7) and human studies (n=6). In animal studies, the effects are particularly important for critical signaling pathways involved in the development of Parkinson's and Alzheimer’s disease. Six human studies found that consuming anthocyanins-rich foods improved either one or more cognitive outcomes with the most significant improvement across all tests associated with memory. Conclusion: The impact of anthocyanins on cognitive aspects in both animal and human studies shows substantial potential. Due to the methodological restrictions and variations among the studies, future study is needed to explore the underlying mechanism and validate these discoveries.
RELATIONSHIP BETWEEN HYPOTHALAMUS AND SEXUAL ORIENTATION Checa, Alejandro; Alvear, Mercedes; Navas, Eliana; Córdova, Nathaly; Martínez, Briggitte; Tapia, William; Yánez-Ortiz, Érika
MNJ (Malang Neurology Journal) Vol. 11 No. 1 (2025): January
Publisher : PERDOSSI (Perhimpunan Dokter Spesialis Saraf Indonesia Cabang Malang) - Indonesian Neurological Association Branch of Malang cooperated with Neurology Residency Program, Faculty of Medicine Brawijaya University, Malang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.mnj.2025.011.01.05

Abstract

Background: Research on biological sexual differences in brain function, structure, and sexual orientation suggests links to prenatal androgen exposure, gender traits, and brain patterns, but findings remain inconclusive due to methodological challenges, inconsistent definitions, and societal or sampling biases. Objective: Determine if there is a relationship between the size of the hypothalamus and sexual orientation. Methods: This was a cross-sectional cohort study conducted between January 2022 and January 2023 at the Eugenio Espejo Specialties Hospital in Quito, Ecuador. Male subjects aged between 20 and 40 years participated. They were asked to reveal their sexual orientation and in the case of homosexual men, specify their sexual role as “active” or “passive”, the “versatile” did not participate in the study. The size of the hypothalamus was identified using simple MRI of the brain. Results: A total of 51 subjects were recruited, of which 40 self-identified as homosexual, of which 25 were passive and 15 active, the remaining 11 were defined as heterosexual. It was found that there is a statistically significant relationship between the size of the hypothalamus and sexual orientation with a p = <0.001. Conclusion: In our study, there is a statistically significant relationship between the size of the hypothalamus and sexual orientation. Keywords: Hypothalamus, sexual orientation, MRI, heterosexual, homosexual
THE ASSESSMENT OF SERUM ADROPIN AND CATALASE LEVELS IN PATIENTS WITH ALZHEIMER'S DISEASE: ADROPIN AND CATALASE LEVELS IN PATIENTS WITH ALZHEIMER'S DISEASE Şimşek, Fatma; Aktaş, Yunus Emre; Gündoğdu, Ömer Lütfi; Kızıltunç, Ahmet
MNJ (Malang Neurology Journal) Vol. 11 No. 1 (2025): January
Publisher : PERDOSSI (Perhimpunan Dokter Spesialis Saraf Indonesia Cabang Malang) - Indonesian Neurological Association Branch of Malang cooperated with Neurology Residency Program, Faculty of Medicine Brawijaya University, Malang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.mnj.2025.011.01.07

Abstract

Background: Dementia is a disease that renders performing activities of daily living difficult and has a high cost of treatment. Objective: In this context, this study was conducted to assess the adropin and catalase levels, the relationship between adropin and catalase levels, and the roles of adropin and catalase in treatment in patients diagnosed with Alzheimer's type dementia. Methods: This observational analytical study's sample consisted of 30 patients with Alzheimer’s disease (AD). Thirty individuals without dementia whose age and gender characteristics matched those with AD were included in the control group. The adropin and catalase levels in the serum samples collected from both patient and control groups were analyzed. Results: Adropin and low-density lipoprotein cholesterol (LDLC) levels were notably elevated in patients with Alzheimer's disease (AD). In contrast, levels of vitamin D, albumin, and catalase were significantly reduced in these patients. Additionally, there was no meaningful correlation between the mini-mental state examination (MMSE) scores and the results of laboratory tests in individuals with AD. Additionally, it was determined that MMSE scores were positively correlated with adropin levels and negatively correlated with catalase levels. However, both correlations were statistically insignificant. Conclusion: The low levels of catalase in patients with AD support the important role of oxidative stress in the disease. The high levels of adropin in these patients suggest that adropin acts as a defense mechanism for the body. Catalase and adropin can be used as biomarkers in the diagnosis of AD, but they are not suitable biomarkers for assessing cognitive functions.
THE ASSOCIATION BETWEEN STROKE DETERMINANT FACTORS AND SLEEP QUALITY IN POST-STROKE PATIENTS Afif, Zamroni; Arisetijono, Eko; Setijowati, Nanik; Sitompul, Boyke
MNJ (Malang Neurology Journal) Vol. 11 No. 1 (2025): January
Publisher : PERDOSSI (Perhimpunan Dokter Spesialis Saraf Indonesia Cabang Malang) - Indonesian Neurological Association Branch of Malang cooperated with Neurology Residency Program, Faculty of Medicine Brawijaya University, Malang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.mnj.2025.011.01.09

Abstract

Background: Stroke is a serious condition can cause sudden loss of neurological function. Sleep disorders, such as insomnia, hypersomnia, sleep apnea, and restless leg syndrome, often occur in stroke patients and can worsen the post-stroke rehabilitation process, especially who have a history of diabetes mellitus (DM), hypertension, and heavy smoker. Effective management of post-stroke patients requires identifying and treating sleep quality disorders and associated risk factors to improve quality of life. Objective: This study aims to explore the association between DM, hypertension, and smoking in post-stroke patients and sleep quality. Methods: A cross-sectional study was conducted on post-stroke control patients at the Neurology Clinic at Dr. Saiful Anwar Hospital, East Java, from December 2023 to February 2024. Sleep quality disorder were measured using the Pittsburgh Sleep Quality Index (PSQI) within one month after outpatient treatment. Additional data were analyzed using the chi-square test and binary logistic regression. Results: Among the 74 participants, 25 patients (25.7%) had a history of DM, 68 (91.9%) with hypertension, and 20 (27%) were heavy smokers. There were 34 patients (45.9%) who experienced sleep quality disorders. There was a significant association between DM and sleep disorders (p=0.005), while hypertension and smoking did not show a significant correlation. History of DM was a significant predictor of sleep disorders (p=0.09 | OR 4.782, 95% CI 1.483–15.421). Conclusion: This study shows a significant association between history of DM in post-stroke patients and sleep quality based on PSQI.
OPTIC NEURITIS AND SEIZURES IN A PEDIATRIC PATIENT: IS IT RELATED TO NEUROMYELITIS OPTICA SPECTRUM DISORDER? Wulandari, Lely Retno; Vierlia, Wino Vrieda
MNJ (Malang Neurology Journal) Vol. 11 No. 1 (2025): January
Publisher : PERDOSSI (Perhimpunan Dokter Spesialis Saraf Indonesia Cabang Malang) - Indonesian Neurological Association Branch of Malang cooperated with Neurology Residency Program, Faculty of Medicine Brawijaya University, Malang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.mnj.2025.011.01.18

Abstract

Background: Optic neuritis is a significant manifestation of central nervous system (CNS) demyelinating disorders, including Neuromyelitis Optica Spectrum Disorder (NMOSD). Pediatric cases are particularly challenging due to overlapping symptoms with other neurological conditions. Objective: This case report discusses a pediatric patient presenting with bilateral optic neuritis and seizures, raising suspicion of NMOSD. Methods: A 12-year-old male presented with acute bilateral vision loss and seizures. Comprehensive ophthalmological examinations, laboratory tests, and neuroimaging such as magnetic resonance imaging (MRI) and optical coherence tomography (OCT ) were performed. Due to financial constraints, specific NMOSD diagnostics, such as AQP4-IgG antibody testing, were not conducted. The patient was treated with high-dose intravenous methylprednisolone (IVMP) following the Optic Neuritis Treatment Trial (ONTT) protocol and valproic acid for seizure control. Results: Significant improvement in visual acuity was observed within five days of IVMP treatment. The right eye (RE) improved from hand motions to 6/48, and the left eye (LE) from hand motions to 6/144. By day eight, further improvement in visual acuity was noted. Seizures were effectively controlled with valproic acid, and no additional neurological symptoms were reported during follow-up. MRI showed no characteristic lesions, and laboratory results were within normal limits. Conclusion: The success of treatment despite diagnostic limitations suggests that with timely intervention, favorable outcomes are possible even in challenging settings. Future research should focus on developing accessible diagnostic tools and protocols that can be implemented in resource-limited environments. Additionally, awareness and training for healthcare providers in such settings are essential to improve early recognition and treatment of NMOSD.
UNRAVELING THE BEST NON-PHARMACOLOGICAL INTERVENTIONS FOR COGNITIVE FUNCTION AND DEPRESSION IN ELDERLY WITH COGNITIVE IMPAIRMENT: A NETWORK META-ANALYSIS Masykur, Umar Jundullah; Janet, Karensa Abby; Putri, Dwi Sandhi Aulia Pramesti; Jatmiko, Sarazata Indi Rozaany; Kurniawan, Shahdevi Nandar
MNJ (Malang Neurology Journal) Vol. 11 No. 1 (2025): January
Publisher : PERDOSSI (Perhimpunan Dokter Spesialis Saraf Indonesia Cabang Malang) - Indonesian Neurological Association Branch of Malang cooperated with Neurology Residency Program, Faculty of Medicine Brawijaya University, Malang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.mnj.2025.011.01.16

Abstract

Background: Emerging evidence suggests that non-pharmacological interventions can improve cognitive function and alleviate depressive symptoms in elderly individuals with cognitive impairment. However, the comparative effectiveness of these interventions remains unclear. Objective: This network meta-analysis (NMA) compares the efficacy of eight non-pharmacological interventions—Virtual Reality (VR) or Exergame, Computerized Cognitive Training (CCT), Mind-Body Exercise (MBE), Physical Exercise, Music or Art Therapy, Health Education, Treatment as Usual (TAU), and a Control group (no intervention, placebo)—on cognitive function and depression in elderly individuals with cognitive impairment. Methods: Randomized controlled trials (RCTs) published up to August 10, 2024, were systematically searched in Web of Science, PubMed, Embase, and Cochrane Library databases. A Frequentist random-effects network meta-analysis was conducted using R. Results: Total 46 RCTs with 3043 participants were included. The pooled results showed that CCT (SMD = 2.33, 95% CI [1.34, 3.32]), Physical Exercise (SMD = 2.24, 95% CI [1.24, 3.23]), and VR or Exergame (SMD = 2.09, 95% CI [1.10, 3.08]) significantly improved global cognition. VR or Exergame was also effective in enhancing attention (SMD = -3.49, 95% CI [-6.85, -0.14]), executive function (SMD = -75.54 (95% CI [-118.24, -33.04]), and reducing depressive symptoms (SMD = -2.62, 95% CI [-4.08, -1.15]). Conclusion: This NMA highlights the superior efficacy of CCT, Physical Exercise, and VR or Exergame in improving global cognition in elderly individuals with cognitive impairment. Additionally, VR or Exergame is particularly effective for enhancing attention, executive function, and reducing depressive symptoms, suggesting it should be integrated into cognitive rehabilitation programs.
THE CORRELATION OF SLEEP QUALITY AND SHORT-TERM MEMORY FUNCTION IN MEDICAL STUDENTS Putu Emilia Dewi; I Made Oka Adnyana; Ketut Widyastuti; I Putu Eka Widyadharma
MNJ (Malang Neurology Journal) Vol. 11 No. 1 (2025): January
Publisher : PERDOSSI (Perhimpunan Dokter Spesialis Saraf Indonesia Cabang Malang) - Indonesian Neurological Association Branch of Malang cooperated with Neurology Residency Program, Faculty of Medicine Brawijaya University, Malang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.mnj.2025.011.01.19

Abstract

Background: Study on the correlation of sleep quality with short-term memory function in medical students has a high urgency considering that intelligence and good memory function are essential for their performance and learning ability in the field. There are only a few related studies on medical students in the Faculty of Medicine and Health Sciences of Universitas Udayana. Objective: This study aims to determine the correlation between sleep quality and short-term memory function of medical students in the Faculty of Medicine and Health Sciences of Universitas Udayana. Methods: The sample was determined by the non-probability consecutive sampling method. The Indonesian version of the Pittsburgh Sleep Quality Index (PSQI) questionnaire and the Digit Span Backwards Task assessed sleep quality and short-term memory function respectively. The data was analyzed by Pearson correlative test and logistic regression multivariate analysis. Results: There were 75 subjects in this study. The PSQI average score of the respondents was 9.35 ± 4.45, and the Digit Span Backwards Task average was 3.75 ± 1.77. The Pearson correlative test showed a moderate correlation between sleep quality and short-term memory function (r = -0.44.; p < 0,05). The logistic regression multivariate analysis found that sleep disturbances affect short-term memory function more than other sleep quality components, with a probability value of 98%. Conclusion: There is a correlation between sleep quality and short-term memory function of medical students in the Faculty of Medicine and Health Sciences of Universitas Udayana.
DOSAGES ANALYSIS OF HYPERBARIC OXYGEN THERAPY TO IMPROVING COGNITIVE FUNCTION IN PATIENTS POST-TRAUMATIC BRAIN INJURY: A REVIEW Nuri, Almas; Edi, Djatiwidodo; Anindya, Pramita; Ilmawan, Moh. Fathi
MNJ (Malang Neurology Journal) Vol. 11 No. 1 (2025): January
Publisher : PERDOSSI (Perhimpunan Dokter Spesialis Saraf Indonesia Cabang Malang) - Indonesian Neurological Association Branch of Malang cooperated with Neurology Residency Program, Faculty of Medicine Brawijaya University, Malang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.mnj.2025.011.01.24

Abstract

Background: Traumatic brain injury is a type of intracranial injury caused by a mechanical impact that causes anatomical and physiological damage to the brain. Globally, there are 50 million cases of traumatic brain injury each year that cause 10 million deaths and/or hospitalizations. Hyperbaric oxygen therapy is a therapy that uses 100% oxygen at pressures greater than 1 Atmosphere Absolute  (ATA) to increase tissue oxygenation and repair damaged tissue. This study was made to determine the effect of hyperbaric oxygen therapy on improving cognitive function in post-traumatic brain injury patients and the mechanisms underlying it. Objective: To determine the dose of hyperbaric oxygen therapy that can trigger improved cognitive function in post-traumatic brain injury patients, as well as the side effects. Methods: This research is descriptive research and uses the literature study method. In collecting data, using all journals with the search keywords "hyperbaric oxygen therapy" "traumatic brain injury" "hyperbaric oxygen therapy for TBI" "HBOT and TBI" "oxygen therapy and brain injury" published in 2017 - 2022 and indexed by Scimago Journal & Country Rank (SJR) and/or Science And Technology Index (SINTA) then new conclusions and descriptions are made. Results: After selecting 262 journals, ten journals met the inclusion and exclusion criteria. The ten journals stated that there was an effect of hyperbaric oxygen therapy on improving cognitive function in post-traumatic brain injury patients. assessment of improvement in cognitive function in the attached journal, assessed with different parameters. Conclusion: Hyperbaric oxygen therapy is a potential therapy to accelerate cognitive function improvement in post-traumatic brain injury patients.

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