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Majalah Obstetri dan Ginekologi
Published by Universitas Airlangga
ISSN : 08540381     EISSN : 25981013     DOI : 10.20473/mog.V27I32019.90-93
Core Subject : Health,
Health Professions Medicine & Pharmacology
Majalah Obstetri & Ginekologi (MOG) or the Journal of Obstetrics & Gynecology Science is a scientific journal published by the Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia, in collaboration with the Indonesian Obstetrics and Gynecology Association (POGI) of Surabaya branch.
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Articles 298 Documents
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Ethanol extract of Cyclea barbata Miers induces follicle development through 17ß-estradiol level and LHR expression Noviyanti, Noviyanti; Yueniwati, Yuyun; Rahardjo, Bambang; Permatasari, Galuh W.
Majalah Obstetri & Ginekologi Vol. 33 No. 3 (2025): December
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/mog.V33I32025.195-203

Abstract

HIGHLIGHTS Docking analysis revealed that there are four novel compounds in barbata, including Zearalenone, Bis(2-ethylhexyl) phthalate, Benzanthrone, and Octytldecyl phthalate have stronger affinity -9.7; -9.6; -9,2; and -7.7 kcal/mol, respectively. The extract of barbata leaves increased follicle development (75%) by elevating estrogen levels and LHR expression at all doses.   ABSTRACT Objective: Infertility, often linked to anovulation from impaired follicular maturation, affects millions globally. Cyclea barbata Miers, a plant with estrogen-like properties, may enhance follicle development through hormonal modulation. This study evaluated the ethanol extract of C. barbata leaves for its ability to promote in vitro follicle development by increasing 17ß-estradiol levels and luteinizing hormone receptor (LHR) expression. Materials and Methods: Molecular docking analysis identified four novel compounds in C. barbata, Zearalenone, Bis(2-ethylhexyl) phthalate, Benzanthrone, and Octyl decyl phthalate, with binding affinities of -9.7, -9.6, -9.2, and -7.7 kcal/mol to estrogen receptor alpha (ESRa). Secondary follicles (2-3 mm) from goat ovaries were cultured in vitro using TCM-199 medium supplemented with 10% FBS, PMSG, hCG, and C. barbata extract at 25, 50, or 100 ppm for six days. Follicle maturation was assessed via microscopy for size, cumulus-oocyte complex formation, and polar body extrusion. 17ß-estradiol levels and LHR expression were analyzed using one-way ANOVA and LSD tests. Results: The 100 ppm dose achieved 75% follicle maturation, significantly higher than 25% at lower doses and controls. It increased 17ß-estradiol levels (36.83 ± 2.33 pg/mL, p < 0.000) and LHR expression (261.874 ± 54.606, p < 0.000), with dose-dependent effects confirmed by statistical analysis. Conclusion: C. barbata extract at 100 ppm enhances follicular maturation by elevating 17ß-estradiol and LHR expression, likely due to its estrogenic compounds. Further in vivo and clinical studies are needed to confirm its therapeutic potential for ovulatory disorders.
Maternal profiles and outcome of Placenta Accreta Spectrum (PAS) in a retrospective cohort study in Dr. Saiful Anwar General Hospital, Malang, Indonesia Rahardjo, Bambang; Pratama, Harry Dwi; Purbandari, Rosalia; Alim, Fathi Nabila
Majalah Obstetri & Ginekologi Vol. 33 No. 3 (2025): December
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/mog.V33I32025.204-213

Abstract

HIGHLIGHTS This study compared maternal characteristics and outcomes between PAS and non-PAS patients, including analysis using the Placenta Accreta Index. PAS is associated with significantly higher intraoperative blood loss and postoperative ICU admission rates. Findings underscored the importance of early identification and PAI-based risk stratification to optimize surgical planning and maternal outcomes.   ABSTRACT Objective: This study aimed to investigate maternal risk factors associated with PAS among patients at Dr. Saiful Anwar Regional General Hospital in Malang, Indonesia. Materials and Methods: This retrospective cohort study was conducted at Dr. Saiful Anwar General Hospital, Malang, analyzing medical records of patients diagnosed with Placenta Accreta Spectrum (PAS) from January 2023 to August 2024. Patients were categorized into PAS and non-PAS groups, with further classification of PAS patients based on their Placenta Accreta Index (PAI) score (<5 and ≥5) to compare clinical outcomes. A total of 47 eligible patients were included based on gestational age ≥28 weeks, clinical suspicion of PAS, and histopathological confirmation. Demographic, clinical, intraoperative, and postoperative data were collected and analyzed. Data were analyzed using SPSS 27.0. Ethical approval was obtained from the Dr. Saiful Anwar General Hospital Ethics Committee. Results: Patients with PAI scores ≥5 had higher intraoperative blood loss (3467.50 ± 2520.35 mL) compared to those with PAI scores <5 (2212.50 ± 1055.32 mL, p=0.764). Hysterectomy was the primary surgical approach in both groups (PAI <5: 88.88%, PAI <5: 92.75%, p=0.667). Bladder trauma (AAST grade IV) occurred in 100% of patients with PAI <5, whereas bladder infiltration was observed only in the PAI ≥5 group (p=0.117). NICU admission was more frequent in the PAI ≥5 group (31.25% vs. 0%, p=0.061). ICU admission was required in all PAI <5 patients (100%) and 75% of PAI <5 patients (p=0.102). No statistically significant associations were found. Conclusion: Higher PAI score may indicate a more complex clinical course, further research with larger sample sizes is necessary to validate its predictive value.
Exploring the role of healthcare providers in supporting women after pregnancy loss: A scoping review Rosyidah, Rafhani; Azizah, Nurul; Jayanti, Ratna Dwi; Prisusanti, Retno Dewi
Majalah Obstetri & Ginekologi Vol. 33 No. 3 (2025): December
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/mog.V33I32025.228-235

Abstract

HIGHLIGHTS The study examines healthcare providers’ roles in delivering holistic physical, emotional, and psychosocial support to women after pregnancy loss. The findings identify major provider barriers—limited training, institutional constraints, and emotional burden—and recommend improved training, clearer guidelines, and stronger support systems.   ABSTRACT Objective: Pregnancy loss is a complex emotional experience with a significant impact on women's physical and psychosocial health. This study aimed to explore the role of health workers in supporting women after pregnancy loss, focusing on their physical, emotional, and psychosocial needs, as well as the barriers faced by health workers. Materials and Methods: A systematic search was conducted on six electronic databases, namely PubMed, Science Direct, Springer, ProQuest, Sage Journals, and EBSCOhost, using keywords related to pregnancy support, pregnancy loss, and challenges faced by health workers. Articles published within the last 10 years (2014-2024) were selected for this review. The selection process followed PRISMA guidelines, starting with the identification of 383 articles, followed by the removal of duplicates and screening of titles and abstracts. After the eligibility assessment stage, five articles were selected that met the inclusion criteria. Data were systematically extracted using tables that included study purpose, design, participants, type of pregnancy loss, and key findings. The results of the analysis mapped the physical, emotional, and psychosocial support provided by health workers and the barriers affecting the quality of that support. Results: Integrating physical, emotional, and psychosocial care is crucial to improve outcomes for women experiencing pregnancy loss. Addressing challenges faced by healthcare providers will enhance service quality and patient support. Conclusions: Holistic support that includes physical, emotional and psychosocial aspects is essential in helping women to cope with pregnancy loss. However, barriers such as lack of training and institutional support affect the effectiveness of care. This review recommends strengthening formal training, developing structured guidelines, and improving support systems for health workers to enhance the quality of care and professional well-being.
Gestational weight gain as a factor associated with urinary incontinence and quality of life Aulia, Rizka; Sukarsa, M. Rizkar Arev; Prasetyo, Dwi; Hilmanto, Danny; Sasotya, R.M. Sonny; Susiarno, Hadi
Majalah Obstetri & Ginekologi Vol. 33 No. 3 (2025): December
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/mog.V33I32025.214-220

Abstract

HIGHLIGHTS There is a correlation between maternal weight gain and urinary incontinence, an increase in weight during pregnancy may raise the risk of urinary incontinence. Urinary incontinence correlates with poorer quality of life in pregnant women and has the potential to affect their well-being negatively.   ABSTRACT Objective: Urinary incontinence (UI) frequently occurs in pregnancy, primarily caused by increased intra-abdominal pressure. If left unmanaged, UI can lead to both physical and psychological discomfort, potentially reducing a pregnant woman’s quality of life. This research aimed to examine the relationship between gestational weight gain and the occurrence of urinary incontinence, along with its effects on quality of life. Materials and Methods: A cross-sectional study was carried out among 50 pregnant women in their third trimester residing within the working area of Lebaksiu Primary Health Care, Tegal Regency, Central Java, Indonesia. Pre-pregnancy weight was extracted from the Handbook of Maternal and Child Health (MCH), while current weight was measured directly using the validated Indonesian version of the ICIQ-UI SF questionnaire, while quality of life was assessed with the Indonesian version of the WHOQOL-BREF. Both instruments were administered through face-to-face interviews. Correlation was tested using Spearman’s rank correlation, with statistical significance set at p<0.05. Results: The results showed a statistically significant positive correlation between maternal weight gain and the incidence of urinary incontinence (p=0.001; r=0.462), and a significant negative correlation between urinary incontinence and quality of life (p=0.000; r=-0.614). Seventy percent of the pregnant women experienced urinary incontinence, and 46% reported decreased quality of life. Conclusion: These findings suggest that greater maternal weight gain is associated with a higher risk of UI, and that UI negatively affects pregnant women’s quality of life. Integrating educational programs and policies that emphasize the importance of maintaining an ideal body weight during pregnancy may help prevent UI and improve the overall quality of life for pregnant women.
Perinatal exposure to ultraprocessed foods and its impact on maternal gut dysbiosis, placental inflammation, and neonatal immune programming: A systematic review Sanjaya, I Nyoman Hariyasa; Andonotopo, Wiku; Bachnas, Muhammad Adrianes; Dewantiningrum, Julian; Pramono, Mochammad Besari Adi; Mulyana, Ryan Saktika; Pangkahila, Evert Solomon; Akbar, Muhammad Ilham Aldika; Yeni, Cut Meurah; Aldiansyah, Dudy; Bernolian, Nuswil; Wiradnyana, Anak Agung Gede Putra; Pribadi, Adhi; Sulistyowati, Sri; Stanojevic, Milan; Kurjak, Asim
Majalah Obstetri & Ginekologi Vol. 33 No. 3 (2025): December
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/mog.V33I32025.236-248

Abstract

HIGHLIGHTS Perinatal ultraprocessed food (UPF) exposure disrupts maternal gut microbiota composition, increasing pro‑inflammatory taxa and systemic endotoxemia. Placental immune activation and oxidative stress represent key mediators linking maternal diet to fetal immune and metabolic programming. Neonatal outcomes include altered regulatory T‑cell development, Th2 immune skewing, allergic sensitization, and early metabolic risk. Integrated dietary counseling, microbiota‑targeted interventions, and public health policies are urgently needed to mitigate transgenerational immune health risks.   ABSTRACT Objective: To synthesize and critically evaluate evidence linking perinatal exposure to ultraprocessed foods (UPFs) with maternal gut dysbiosis, placental inflammation, and neonatal immune programming, and to identify translational implications for perinatal care. Materials and Methods: A systematic narrative review was conducted following PRISMA 2020 guidelines, without PROSPERO registration. Literature searches of major databases (2000–March 2025) identified 1,845 records. After screening and eligibility assessment, 20 studies were included. Study quality was appraised using validated tools, and data were synthesized thematically into evidence domains covering maternal microbiota, inflammatory pathways, placental changes, and neonatal immune outcomes. Results: Maternal UPF consumption was associated with gut dysbiosis characterized by reduced microbial diversity, increased pro-inflammatory taxa, and systemic endotoxemia. Elevated inflammatory biomarkers including lipopolysaccharide, interleukin‑6, tumor necrosis factor‑a, and C‑reactive protein were frequently reported. Limited placental studies revealed increased innate immune activation and oxidative stress. Neonatal immune alterations included regulatory T cell suppression, T helper 2 skewing, increased allergic sensitization, and metabolic programming changes. Evidence strength was highest for maternal gut dysbiosis and immune programming but limited for direct placental mechanisms. Translational opportunities include dietary counseling, microbiota-targeted interventions, and public health strategies aimed at improving maternal diet quality. Conclusion: Perinatal exposure to UPFs adversely impacts the maternal gut–placenta–fetal immune axis. Integrated dietary interventions and population-level nutrition policies are urgently needed to mitigate downstream transgenerational immune risk.
Reinterpreting potential biomarker in umbilical cord as a marker of chorioamnionitis and funisitis in prelabor ROM Dewantiningrum, Julian; Pramono, Besari Adi; Poerwoko, Agoes Oerip; Irawan, Budi; Bachrudin, Rizky Aditya; Kristanto, Herman
Majalah Obstetri & Ginekologi Vol. 33 No. 3 (2025): December
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/mog.V33I32025.221-227

Abstract

HIGHLIGHTS HsCRP and IL-6 levels in umbilical cord blood serve as reliable early biomarkers of chorioamnionitis and funisitis in prelabor ROM, enabling more accurate neonatal sepsis risk assessment and targeted clinical intervention. Early identification of amnionitis and funisitis through hsCRP and IL-6 measurements guides timely clinical decisions, including prompt antibiotics or intensified monitoring, thereby reducing severe neonatal complications.   ABSTRACT Objective: Prelabor rupture of membranes (ROM) occurs in approximately 1% of all pregnancies and 30% of all preterm births, and the etiology remains unclear. Prelabor ROM is associated with a high incidence of funisitis and chorio-amnionitis leading to neonatal sepsis. This study aimed to assess whether hsCRP, procalcitonin, and IL-6 level in umbilical cord as indicators for identifying pregnancies at risk for these complications. Materials and Methods: This research used cross sectional design conducted in dr. Kariadi Hospital. Inclusion criteria were pregnant woman with 28-42 weeks of gestational age, singleton and prelabor ROM. Exclusion criteria included other comorbidities. The participants were divided into two groups: with and without funisitis-chorioamnionitis, which were detected using histopathologic examination. Statistical analysis was performed using the chi-square, t-test/Mann-Whitney between two group, wit statistically significant set at p<0.05. Results: A total of 88 pregnant women were included in the study, consisting of 23 pregnant women with chorioamnionitis-funisitis and 65 pregnant women without funisitis-chorioamnionitis. Procalcitonin levels in the group with and without chorioamnionitis-funisitis were 0.88±0.6 vs 1.06±0.46 ug/mL (p=0.07). IL-6 levels in the chorioamnionitis-funisitis were 54.41(9.34-445.9) vs 2.83(0.09-454.82) pg/mL in without chorioamnionitis-funisitis (p<0.001). HsCRP levels in the funisitis-chorioamnionitis compared to those without chorioamnionitis-funisitis group were 1.39(0.07-10.5) vs 0.17(0.03-10.5) mg/L (p<0.001). Conclusion: Elevated levels of hsCRP and IL-6 in the umbilical cord were found to be significant biomarkers for chorioamnionitis and funisitis in prelabor rupture of membranes. These biomarkers could be useful in identifying pregnant women at high risk for these complications, enabling better clinical management.
Front Matter Vol. 33 No. 3 December 2025 Obstetri & Ginekologi, Majalah
Majalah Obstetri & Ginekologi Vol. 33 No. 3 (2025): December
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/mog.V33I32025.%p

Abstract

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Back Matter Vol. 33 No. 3 December 2025 Obstetri & Ginekologi, Majalah
Majalah Obstetri & Ginekologi Vol. 33 No. 3 (2025): December
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/mog.V33I32025.%p

Abstract

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