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Hasibuan, Poppy Anjelisa Zaitun
Universitas Sumatera Utara
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Antibacterial Activity of Patch Silver Nanoparticles and Chitosan with Cellulose Nanofibers Carriers against Staphylococcus aureus and Escherichia coli Prayoga, Andre; Hasibuan, Poppy Anjelisa Zaitun; Yuandani
Indonesian Journal of Pharmaceutical and Clinical Research Vol. 4 No. 2 (2021): Indonesian Journal of Pharmaceutical and Clinical Research (IDJPCR) Vol. 04, No
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/idjpcr.v4i2.6169

Abstract

One of the medical needs whose demand continues to increase is wound dressings. The wound cover must also be non-toxic, non-allergenic, made of widely available biomaterials, and have antibacterial properties that can prevent infection of the wound. Chitosan is known to have wound healing activity by acting as a blood-clotting agent and stimulating the formation of new tissue, and silver nanoparticles have good antibacterial activity. Silver Nanoparticles and Chitosan with Cellulose Nanofibers carriers (SNCCN) are made in the form of patches with the ratio formula between cellulose nanofibers and chitosan/silver nanoparticles is 1:9, 2:8, 3:8, 4:7, 5:5, 6:4, 7:3, 8:2, 9:1, and 10:0. Then the antibacterial activity was tested against Staphylococcus aureus and Escherichia coli to find the best formula for antibacterial activity. The analysis showed that the SNCCN patch with a ratio of 9:1 had the best antibacterial activity against Staphylococcus aureus (13.8±0.05 mm) and Escherichia coli (12.5±0.05 mm). It can be concluded that patch Silver Nanoparticles and Chitosan with Cellulose Nanofibers carriers (SNCCN) have good antibacterial activity at a concentration of 9:1 in the category of strong inhibition (10-20 mm).
Antifungal Activity of Patch Silver Nanoparticles and Chitosan with Cellulose Nanofibers Carriers against Trichophyton rubrum and Pitysporum ovale Ginting, Junius Gian; Hasibuan, Poppy Anjelisa Zaitun; Yuandani
Indonesian Journal of Pharmaceutical and Clinical Research Vol. 4 No. 2 (2021): Indonesian Journal of Pharmaceutical and Clinical Research (IDJPCR) Vol. 04, No
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/idjpcr.v4i2.6295

Abstract

Abstract. Wounds that are not treated and are kept open will provide an entrance for microorganisms from outside that can cause infection. One of the medical needs whose demand continues to increase is wound dressings. Chitosan is known to have wound healing activity by stimulating the formation of new tissue, and silver nanoparticles have good antimicrobial activity. Silver nanoparticles and chitosan with cellulose nanofibers carrier are made in the form of patches with the ratio formula between cellulose nanofibers and chitosan/silver nanoparticles are 1:9, 2:8, 3:8, 4:7, 5:5, 6:4, 7:3, 8:2, 9:1, and 10:0 then tested the antifungal activity against Trichophyton rubrum and Pitysporum ovale for finding the best formula for antifungal activity. The analysis showed that the patch with a ratio of 6:4 had the best antifungal activity against Trichophyton rubrum (14.7±0.1 mm) and a 9:1 patch on the Pitysporum ovale (6.9±0.05 mm) gave a significant difference to negative control (p<0.05). It can be concluded that the Patches Silver Nanoparticle and Chitosan with Cellulose Nanofibers (SNCCN) carriers have good antifungal activity in the inhibitory category.
Cytotoxic and Apoptotic Activities of Vernonia amygdalina Extract in HepG2 Cell Line Harefa, Herman Syukur; Hasibuan, Poppy Anjelisa Zaitun; Harahap, Urip
Indonesian Journal of Pharmaceutical and Clinical Research Vol. 5 No. 2 (2022): Indonesian Journal of Pharmaceutical and Clinical Research
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/idjpcr.v5i2.6350

Abstract

Liver cancer is a malignant tumor originating from the development of chronic hepatitis or cirrhosis and is responsible for damage to the shape and function of the liver. The loss of the ability of conventional chemotherapy to inhibit the growth of cancer cells is a major focus in the world. Natural ingredients are the solution to this problem, for example the use of Vernonia amygdalina leaves. Vernonia amygdalina contains flavonoids, cardiac glycosides, and steroids/triterpenoids which are reported to have anticancer properties. This study aims to examined the activity of these plants as anticancer liver through cytotocix and apoptotic activity. Vernonia amygdalina ethanol extract (VAEE), Vernonia amygdalina ethyl acetate extract (VAEAE), and Vernonia amygdalina n-hexane extract (VAHE) were obtained from a multistage maceration process. The extracts were tested for cytotoxic activity by the MTT method on HepG2 cells. VAEAE had the best inhibitory concentration 50 (IC50) value of 19.91 ± 0.24 µg/mL. Apoptosis test was performed using double staining method. Subjective observations were made using a fluorescence microscope. It was seen that Vernonia amygdalina ethyl acetate extract was able to trigger apoptosis in HepG2 cells.
Formulation and Evaluation of Body Scrub Cream Containing Ethanol Extract of Black Cumin Seeds (Nigella sativa L.) and Coffee Grounds (Coffea arabica L.) as Anti-aging Hasibuan, Poppy Anjelisa Zaitun; Sumaiyah, Sumaiyah; Siregar, Dedek Harianti
Indonesian Journal of Pharmaceutical and Clinical Research Vol. 5 No. 2 (2022): Indonesian Journal of Pharmaceutical and Clinical Research
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/idjpcr.v5i2.8256

Abstract

Cosmetics are now mandatory for most women. Various natural ingredients have now been used as basic ingredients for beauty treatments. This study aimed to formulate and determine the effectiveness of body scrub cream preparations containing ethanolic extract of N. sativa and coffee grounds as antiaging. The skin antiaging was divided into five formulas: F0 (cream base), F1 (coffee ground 5%), F2 [coffee ground 5% + Ethanol Extract of N. sativa (EENS) 2%], F3 (coffee ground 5% + EENS 3.5%) and F4 (coffee ground 5% + EENS 5%). The body scrub cream preparations were subjected to organoleptic, homogeneity, emulsion type, and pH evaluation. The irritation test and antiaging activity were evaluated by using a skin analyzer. The body scrub was stable in 12-week storage. The result showed that there was no irritation on the volunteers’ skin. The body scrub cream with the highest antiaging activity was the F4 formula. It showed 9.6% for increasing skin moisture, 17.68% for increasing skin smoothness, 11.42% in reducing the size of pores and 12.84% in reducing the number of spots.
Co-Authors . Marianne Angkat, Robbani Syahfitri Bestari, Khansa Candra Denny Satria Denny Satria, Denny Ginting, Junius Gian Hanum, Tengku Ismanelly Harefa, Herman Syukur Haro, Ginda Hasibuan, Wan Fadilla Hendri Asrin Ilyas , Syafruddin Irma Yanti Rangkuti M. Ichwan Mardiana Marianne Marianne Nasution , Pandapotan Nasution, Pandapotan Panal Sitorus Prayoga, Andre Putri Tri Hartini Rizka Damela Sibuea Rosidah Rosidah Rosidah Said Aldi Palevi Siregar, Dedek Harianti Sitanggang, Rosa Gloria Suharyanisa Sumaiyah Sumaiyah, Sumaiyah Tri Widyawati Urip Harahap Yuandani