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All Journal Indonesian Journal of Applied Sciences Jurnal Ilmu Kedokteran (Journal of Medical Science) Majalah Kedokteran Bandung Pharmaciana: Jurnal Kefarmasian Jurnal Kesehatan Andalas Jurnal Kesehatan Komunitas Indonesian Journal of Obstetrics & Gynecology Science Indonesian Journal of Obstetrics and Gynecology (Majalah Obstetri dan Ginekologi Indonesia) Jurnal Riset Kesehatan Poltekkes Depkes Bandung Medica Hospitalia Indian Journal of Forensic Medicine & Toxicology MAHESA : Malahayati Health Student Journal Narra J Malahayati International Journal of Nursing and Health Science
Donel S
Universitas Riau
Biochemistry, Genetics & Molecular Biology Dentistry Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health

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Effectiveness of Vitamin D Suplementation in Pregnant Women with Vitamin D Deficiency to Improved Fetal Biometry Donel S.; Ruza Prima Rustam; Inayah Inayah; M. Yulis Hamidy; Ratu Astuti Dwi Putri; Machyuddin T.M Pangaribuan; Ahmad Fahruddin; Maya Savira
Indonesian Journal of Obstetrics & Gynecology Science Volume 6 Nomor 1 Maret 2023
Publisher : Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/obgynia/v6n1.461

Abstract

Objective: The aim of this study was to determine the effect and effectiveness of vitamin D on fetal biometry.Method: This study was a Quantitative Study of two quasi-experimental groups. The research was conducted in Rupat District, Bengkalis Regency, Riau Province from June 2022 to August 2022. The research sample was pregnant women with vitamin D deficiency who were divided into an intervention group of 20 subjects and a control group of 20 subjects.Results: Examination of vitamin D levels in pregnant women and examination of fetal biometry was carried out. Then given a 1000 IU vitamin D supplement to pregnant women with vitamin D deficiency levels, re-evaluated after 3 months vitamin D levels in pregnant women and re-measured fetal biometry. There were significant differences in Fetal Biometrics between the pre-Intervention and post-Intervention studies in the intervention group with p=0.001. The intervention group also showed that there was an increase in the proportion of Normal Biometrics from 8 subjects before the intervention compared to 13 subjects after 3 months of vitamin D supplementation interventionConclusion: Vitamin D supplementation for 3 months in pregnant women with Vitamin D deficiency is proven to improve fetal health through Fetal Biometry examination.Efektivitas Suplemen Vitamin D dalam Meningkatkan Biometri Janin pada Wanita Hamil dengan Defisiensi Vitamin DAbstrakTujuan: Studi ini bertujuan mengetahui dampak dan efektivitas vitamin D terhadap biometri janin.Metode: Studi kuantitatif ini mengunakan dua grup dengan pendekatan kuasi-eksperimental. Penelitian ini dilaksanakan di Rupat, Kabupaten Bengkalis, Provinsi Riau dari Juni 2022 hingga Agustus 2022. Sampel penelitian ini adalah Wanita hamil dengan defisiensi vitamin D yang dibagi menjadi grup intervensi sebanyak 20 orang dan grup kontrol sebanyak 20 orang.Hasil: Dilakukan pengukuran kadar vitamin D pada Wanita hamil dan biometri janin. Pada grup intervensi diberikan suplementasi vitamin D 1000IU dan dievaluasi kembali kadar vitamin D setelah tiga bulan dan dilakukan kembali biometri janin. Terdapat perbedaan signifikan pada biometri janin sebelum dan sesudah intervensi dengan p=0.001. Grup intervensi juga menunjukkan peningkatan proprorsi biometri normal dari 8 orang menjadi 13 orang setelah tiga bulan suplementasi vitamin DKesimpulan: Suplementasi vitamin D selama tiga bulan pada Wanita hamil dengan defisiensi vitamin D terbukti membantu kesehatan janin melalui pemeriksaan biometri janin.Key words: Biometri, Defisiensi Vitamin D, Kehamilan
Repurposing drugs in endometrial cancer using genomic variants database Darmawi Darmawi; Donel S; Wiwin Suhandri; Winarto Winarto; Wirawan Adikusuma; Lalu Muhammad Irham; Wiwit Ade Fidiawati; Renardy Reza Razali; Auren Nathania; Leina Putri Zahra
Pharmaciana Vol 13, No 3 (2023): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/pharmaciana.v13i3.27201

Abstract

Endometrial cancer (EC) is the fourth most frequent gynecological cancers, and its incidence and mortality rates have increased over the last decade. Cytotoxic therapy with carboplatin and paclitaxel is the recommended first-line treatment for EC patients. However, the options for following therapy are limited. The latest advances in molecular studies have uncovered the nature of genetic alterations in EC, compelling methods for further research into the treatment of EC since they may disclose to tailored pharmacological therapy. The aim of this study to identify novel drug candidates in treating EC using genomics variants and biological pathway. The genomic variants of  EC were downloaded from cBioportal database. We established connection between the biological EC risk genes from cBioportal database and the DrugBank database. Finally, we used Connectivity Map (CMap) analysis to identify possible drugs whose mechanisms coincided with therapeutic targets and rank them based on the scoring system. We identified novel potential candidate drugs for EC, they are Bosutinib and Nilutamide which exhibit robust scores in the CMap analysis compare to paclitaxel. We also discovered BCR-ABL1 and AR as potential biomarker-driven therapy in EC. This study demonstrates the possibility of using genetic network analysis combined with bioinformatics to repurpose drugs for the treatment of EC. Further study will investigate the mechanisms of using BCR-ABL1 and AR targeting in the treatment of EC.
Dandy– Walker Malformation in a Multiparous Woman: A Case Report Afdanil, Fitra; Suhaimi, Donel
Indonesian Journal of Obstetrics & Gynecology Science Volume 7 Nomor 1 Maret 2024
Publisher : Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/obgynia.v7i1.655

Abstract

Background: Dandy-Walker malformation (DWM) or syndrome is a posterior fossa anomaly characterized by agenesis or hypoplasia of the vermis and cystic enlargement of the fourth ventricle causing upward displacement of the tentorium and torcula characterized by dilated posterior fossa, cystic enlargement of the fourth ventricle, hypoplasia of cerebellar vermis and its upward rotation. Most patients have hydrocephalus at the time of diagnosis.Case presentation: A 36-years-old multiparous woman with 39 weeks’ gestation from obstetrics polyclinic with plan for induction of labor. During an ultrasound examination, the fetomaternal department found congenital abnormalities in the fetus, namely the presence of hydrocephalus accompanied by Dandy-Walker syndrome. The patient denied the consumption of alcohol, usage of cosmetic drugs such as isotretinoin or blood thinning drugs. The patient previously had a sudden fever without reddish rash for 7 days at 6 months of gestation which healed on its own. The patient admitted to keeping a cat at her house since last year. The patient admitted that she had never had her blood checked for TORCH screening. After being done of Cervical ripening with Misoprostol according to FIGO 25 mcg/PV/6 hours, born a live baby girl, BW 2440 gr, BL 46 cm, A/S: 6/8.Conclusions: The patient was admitted to the hospital with the main complaint of G4P3A0L3 Gestational age 39-40 weeks, not in labor and a live single fetus in the womb, the patient’s head presentation from the obstetrics clinic with intermittent episodes of vomiting, headache with plans for induction of labor with ultrasound results of Dandy-Walker Syndrome. Pregnant women with DWS in foetal ultrasonic examination should be offered a careful and comprehensive foetal ultrasound scan and further prenatal genetic testing.Malformasi Dandy-Walker pada Wanita Multipara: Laporan KasusAbstrakLatar Belakang: Malformasi atau sindrom Dandy-Walker (DWM) merupakan anomali fosa posterior yang ditandai dengan agenesis atau hipoplasia vermis dan pembesaran kistik ventrikel keempat yang menyebabkan perpindahan tentorium dan torkula ke atas  yang ditandai dengan melebarnya fosa posterior, pembesaran kistik ventrikel keempat, hipoplasia vermis serebelar, dan rotasinya ke atas. Kebanyakan pasien menderita hidrosefalus pada saat diagnosis.Presentasi kasus: Seorang wanita multipara berusia 36 tahun dengan usia kehamilan 39 minggu, pasien dari poliklinik kebidanan dengan rencana induksi persalinan. Pada pemeriksaan USG oleh bagian fetomaternal ditemukan kelainan kongenital pada janin yaitu adanya hidrosefalus disertai Dandy-Walker syndrome. Pasien menyangkal konsumsi alkohol, penggunaan obat-obatan kosmetik seperti isotretinoin atau obat pengencer darah. Pasien sebelumnya mengalami demam mendadak tanpa ruam kemerahan selama 7 hari pada usia kehamilan 6 bulan dan sembuh dengan sendirinya. Pasien mengaku memelihara kucing di rumahnya sejak tahun lalu. Pasien mengaku belum pernah memeriksakan darahnya untuk pemeriksaan TORCH. Setelah pematangan serviks dengan Misoprostol sesuai FIGO 25 mcg/PV/6 jam. Bayi perempuan lahir hidup, BW 2440 gr, BL 46 cm, A/S : 6/8.Kesimpulan: Pasien masuk RS dengan keluhan utama G4P3A0L3 Usia kehamilan 39-40 minggu, tidak bersalin dan janin hidup tunggal dalam kandungan, presentasi kepala pasien dari klinik kebidanan dengan episode muntah intermiten, sakit kepala dengan rencana induksi persalinan dengan hasil USG Sindrom Dandy-Walker. Keahlian yang cukup diperlukan dalam mendiagnosis dan mengobati malformasi yang disebabkan oleh Dandy Walker. Wanita hamil dengan DWS dalam pemeriksaan USG janin harus ditawarkan pemindaian USG janin yang cermat dan komprehensif serta pengujian genetik prenatal lebih lanjut.Kata kunci: Malformasi Dandy-Walker, kelainan kongenital, kehamilan, diagnosis prenatal
A Clinical Dilemma Of Bilateral Hematosalpinx In Ectopic Pregnancy: Case Report Putri, Ratu Astuti Dwi; Hidayat, Fadler; Suhaimi, Donel; Rhomdaniwahid, Tubagus Odih
Medica Hospitalia : Journal of Clinical Medicine Vol. 11 No. 3 (2024): Med Hosp
Publisher : RSUP Dr. Kariadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36408/mhjcm.v11i3.1052

Abstract

Background: Blastocyst implantation outside the uterine cavity leads to ectopic pregnancy. About 96% of ectopic pregnancies occur in the fallopian tubes, where it most frequently occurs; the fimbrial end accounts for 11% of all ectopic pregnancies. There was an uncommon type of ectopic pregnancy called bilateral tubal ectopic pregnancy. Bilateral tubal ectopic pregnancy is estimated to affect 1 out of 725 - 1580 ectopic pregnancies or 1 out of 200,000 live births. However, the villi quickly penetrate the endosalpinx once the implantation of the ectopic pregnancy has occurred before reaching the tubal wall and peritoneum. Vascular growth and a peritubal hematoma or hematosalpinx, which frequently involves the contralateral tubal section, are also present with this penetration. The purpose of this article is to report on the dilemmas that often occur in the case of bilateral hematosalpinx in ectopic pregnancy. Case Description: In this report, we discuss a 33-year-old woman with a positive pregnancy test and transvaginal ultrasound result that was suggestive of ectopic pregnancy in a stable hemodynamic state. The patient underwent an exploratory laparotomy, which showed bilateral hematosalpinx with right ectopic pregnancy with damaged fimbria. The left fallopian tube had a blue-purple bulge that suggested hematosalpinx secondary to ectopic pregnancy rather than bilateral ectopic pregnancy condition. The decision for definitive management was made, right salpingectomy puncture and drainage of the hematosalpinx were performed without complication. The final diagnosis was confirmed on pathology examination that showing chorionic villi within the right damaged fimbria, focal decidua, a few trophoblast-like cells that indicated ectopic pregnancy in the left tubal cavity. Conclusion: This approach encourages both shared decision-making and preparedness, both of which are required to provide patient-centered and comprehensive caremanagement such as bilateral hematosalpinx in ectopic pregnancy case, that must always be individualized, and patient's desire for future conception must be taken into account.
LAPORAN KASUS: KEMBAR SIAM TIPE HETEROPAGUS (PARASIT) Fahruddin, Ahmad; Suhaimi, Donel
JURNAL RISET KESEHATAN POLTEKKES DEPKES BANDUNG, Online ISSN 2579-8103 Vol 16 No 1 (2024): Jurnal Riset Kesehatan Poltekkes Depkes Bandung
Publisher : Poltekkes Kemenkes Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34011/juriskesbdg.v16i1.2521

Abstract

Conjoined twins are a rare form of multiple pregnancy that occurs due to incomplete division of the zygote. In this report, there was a case of heteropagus conjoined twins where the parasite attached to the oropharyngeal autosite area. Considering the fact that multiple pregnancies with parasitic fetuses are very rare, we consider this case report important and useful. This case report aimed to determine the management of heteropagus conjoined twins. The subject of the case study in this case study was a pregnant woman with a heteropagus conjoined twin pregnancy at Arifin Achmad Hospital in 2022. The research method used  the case study method, which is a study that explores a problem in detail, takes in-depth data and includes various sources of information. which will help doctors gain insight into the mystery of parasitic twins. In this case, the patient underwent a planned CS at 35-36 weeks of gestation, according to the findings on physical examination of the patient's baby there was a mass attached to the intraoral area, the mass showed rudimentary, acephalic and acardiac hand and foot shaped tissue. The limbs in parasites do not move and do not feel. There is no skeletal muscle in the legs and this is thought to be due to failure of myoblast differentiation caused by lack of proper innervation. The baby's condition had deteriorated because the baby's airway was disrupted due to a lump entering the stomach. Currently, the baby's condition is improving after surgery to separate the conjoined twins. Next, focus again on recovering the baby's condition.
Use of Antibiotics and Probiotic Lactobacilli in the Treatment of Preterm Premature Rupture of Membranes: a Review Afdanil, Fitra; Suhaimi, Donel; Anggraini, Dewi
MAHESA : Malahayati Health Student Journal Vol 4, No 4 (2024): Volume 4 Nomor 4 (2024)
Publisher : Universitas Malahayati

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/mahesa.v4i4.14159

Abstract

ABSTRACT To review the current evidence of the potential use of antibiotics and probiotics Lactobacillus in preterm premature rupture of membranes cases and to see the effect on microorganism concentrations especially Streptococcus agalatiae and Lactobacillus. This review used several databases (Google Scholar, Pubmed, and Science Direct) and searched for English and Indonesian articles in the last ten years. Articles were received in the form of case reports, observational studies and clinical trials that discussed the use of antibiotics and probiotic Lactobacillus in premature rupture of membranes especially in preterm pregnancy. After searching the database and eliminating duplicates and articles unrelated to the topic, we included some articles in this review. Prophylactic antibiotics are also expected to prolong the latent phase, thereby reducing the risk of fetomaternal morbidity and mortality. Penicillin is often recommended in preterm PROM, because broad-spectrum antibiotics are better as infection prophylaxis. Providing alternative therapy with lactobacillus probiotics is believed to prevent preterm birth and has the benefit of being a safe and effective therapy in restoring normal vaginal microflora and preventing vaginal infections during pregnancy. However, further research is needed to see the effectiveness of lactobacillus probiotics and look at the concentration of microbes, especially Streptococcus agalctiae and Lactobacillus. Keywords: Preterm Premature Rupture of Membranes, Antibiotics, Probiotics  Lactobacillus, Streptococcus Agalactiae
Genetic variations of the L2 gene in human papillomavirus (HPV) type 16 from cervical cancer patients in Sumatra region, Indonesia Savira, Maya; Farniga, Arnaldi; Ilmiah, Zidny; Rachmadina, Rachmadina; Rini, Ika A.; Kemal, Rahmat A.; Mahargyarani, Azza E.; Admiral, Muhammad Z.; Sofian, Amru; Razali, Renardy R.; Suhaimi, Donel; Putra, Andani E.
Narra J Vol. 5 No. 2 (2025): August 2025
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v5i2.1653

Abstract

The L2 protein, a minor capsid component of human papillomavirus (HPV), plays a critical role in the HPV life cycle by packaging the viral genome with the L1 protein and facilitating DNA transport to the nucleus. Identifying genetic variations in the L2 gene is essential for improving vaccine development, diagnostic accuracy, and understanding viral evolution, potentially contributing to more effective HPV vaccines. The aim of this study was to investigate the genetic variation of the L2 gene in cervical cancer specimens collected from patients in Riau Province, Indonesia. A single-center, cross-sectional study was conducted at Arifin Achmad General Hospital, Riau Province, involving cervical cancer patients with confirmed HPV16 infection between January 2018 and August 2020. Demographic, clinical, and risk factor data were collected through structured interviews and direct assessments. Cervical biopsy specimens were collected, and viral DNA was extracted for L2 gene amplification using polymerase chain reaction (PCR). Sequencing was conducted on PCR products, followed by single-nucleotide polymorphism (SNP) identification through alignment with the HPV16 reference genome. The amplification and sequencing of the HPV16 L2 gene from 22 cervical cancer specimens revealed 36 SNPs, including 31 nonsynonymous and five synonymous mutations. High-frequency mutations were observed at nucleotide positions 4,074 and 4,177, each detected in 95.45% of the samples. Notable insertions were found at positions 3,668–3,669 and 4,275–4,276, indicating substantial sequence variation. Phylogenetic analysis grouped the sequences into three clusters, with most belonging to sub-lineage A2 (European), while others aligned with A4 (Asian) and East Asian lineages. The observed genetic diversity in the HPV16 L2 gene may reflect regional viral evolution and has potential implications for future vaccine development.
Maternal Anemia in Patients with Preterm Delivery in Indonesia Mayangsari, Nastiti Hemas; Suhaimi, Donel
Majalah Kedokteran Bandung Vol 57, No 2 (2025)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15395/mkb.v57.3719

Abstract

Preterm delivery remains one of the leading causes of fetomaternal morbidity and mortality worldwide. Anemia during pregnancy is also a significant concern, and may contribute to adverse pregnancy outcomes including preterm birth, intrauterine growth restriction (IUGR), and postpartum hemorrhage (PPH). This study aimed to assess the prevalence of maternal anemia in women with preterm delivery and to evaluate its association with preterm-related complications. A retrospective cross-sectional study was conducted at the Obstetrics and Gynecology Department of Arifin Achmad Hospital, Pekanbaru, Indonesia. Anemia was defined according to the CDC criteria as hemoglobin levels below 11 g/dL in the first and third trimesters or below 10.5 g/dL in the second trimester. Data were collected from medical records of 654 preterm deliveries, of which 359 met the inclusion criteria. Among these, 204 women (56.82%) had anemia, while 155 women (43.18%) had normal hemoglobin levels. A significant association was found between anemia and preterm delivery (p=0.010). Maternal anemia was associated with preterm premature rupture of membranes (PPROM) (p=0.035, contingency coefficient=0.110, 95% CI). These findings suggest that maternal anemia is significantly correlated with preterm birth and its complications, particularly PPROM. Screening and early management of anemia in pregnancy may help reduce the risk of preterm delivery and improve maternal and neonatal outcomes.
Maternal Outcomes with Twelve Hour versus Twenty Four Hour Maintenance Doses Of Magnesium Sulfate in Severe Postpartum Preeclampsia Dwi Putri, Ratu Astuti; Suhaimi, Donel; Hamidy, Yulis; Zulmaeta; Febriani; Yusuf, Muhammad
Indonesian Journal of Obstetrics and Gynecology Volume 13. No. 2 April 2025
Publisher : Indonesian Socety of Obstetrics and Gynecology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32771/inajog.v13i2.2179

Abstract

Introduction: Severe preeclampsia is a serious emergency that can complicate pregnancy and even lead to maternal death. It contributes to a significant increase in morbidity and mortality rates, affecting over 70,000 mothers. The cause of severe preeclampsia is still uncertain, but its management is continuously being developed to achieve the best possible outcomes for both the mother and baby. Magnesium sulfate (MgSO4) is the preferred treatment for preventing seizures in severe preeclampsia, as it has minimal side effects and is effective. However, there is a need for further research on reducing the duration of MgSO4 administration in Indonesia. Method: A clinical trial was carried out with 80 participants divided into two groups (control and trial), using randomized and double-blind methods. The study was conducted at multiple hospitals including Arifin Achmad Hospital, Tengku Rafian Hospital, Dumai City Hospital, Selasih Hospital, and Bengkalis Hospital from October 2022 to February 2023. The data collected was analyzed to evaluate maternal outcomes for both groups. The study was approved by Ethical Review Board for Medicine and Health and registered with the Thai Clinical Trials Registry (TCTR 20230811008) once the data was assessed. Results: This study examined pregnant women with severe preeclampsia, who were on average 30.98±6.04 years old, with 68.8% having had multiple pregnancies. Their gestational age was 33.37±2.88 weeks and the majority (72.5%) had a cesarean delivery. Their systolic blood pressure was 167.68±14.24mmHg and diastolic was 110.32±18.52mmHg. The study did not report on the incidence of eclampsia or maternal mortality, and there was no significant difference in serum magnesium sulfate levels between the two groups (p>0.005). Conclusions: Administering maintenance doses of MgSO4 for both 12 and 24 hours had similar effectiveness in preventing eclampsia, but the 12-hour group saw better outcomes for the mother. Keywords: Magnesium sulfate, Postpartum, Severe preeclampsia, 12 hours, 24 hours
Congenital Lymphangioma of the Fetal Limb: A Rare Case Riandi, Diki; Suhaimi, Donel
Indonesian Journal of Obstetrics & Gynecology Science Volume 8 Nomor 2 July 2025
Publisher : Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/obgynia.v8i2.851

Abstract

Introduction: Lymphangioma is a rare congenital malformation caused by the failure of primitive lymphatic channels to connect with the venous system. Its incidence is approximately 1 in 6,000 pregnancies, with only 2% affecting the limbs. Prenatal diagnosis remains challenging, requiring advanced imaging techniques for accurate differentiation from other congenital masses.Case Presentation: A 39-year-old woman, G6P4A1L4, was referred to Arifin Achmad Hospital at 25+6 weeks due to fetal lower limb enlargement and ascites. Ultrasound revealed a large multicystic mass on the fetal left thigh and buttock, measuring 10.2 × 7.8 × 6.4 cm. Initially suspected as sacrococcygeal teratoma, further evaluation suggested lymphangioma. The Doppler study indicated reduced vascularity. After thorough counseling and an ethics committee review involving obstetricians, neonatologists, and pediatric surgeons, the parents opted for termination. Labor was induced with misoprostol 50 mcg orally every 4 hours (two doses), leading to the delivery of a 1,400-gram male infant with an APGAR score of 3 and 0. The baby died 15 minutes post-birth. Maternal condition remained stable with normal vital signs and laboratory results post-delivery.Discussion: Prenatal diagnosis of lymphangioma is difficult due to its resemblance to other congenital masses. Regular extremity screening is crucial for early detection. Postnatal histopathology confirmed lymphangioma, showing dilated lymphatic channels without solid components. This case highlights the importance of multidisciplinary management and serial imaging for prognosis refining prognosis. Conclusion: Prenatal diagnosis is crucial for management planning. Serial ultrasound and MRI can refine prognosis. A multidisciplinary approach is essential for optimal care.Limfangioma Kongenital pada Ekstremitas Bawah Janin: Kasus Langka Abstrak Pendahuluan: Limfangioma adalah malformasi kongenital langka yang disebabkan oleh kegagalan saluran limfatik primitif untuk terhubung dengan sistem vena. Insidensinya 1 dalam 6.000 kehamilan, dengan hanya 2% yang mengenai ekstremitas. Diagnosis prenatal tetap menjadi tantangan, memerlukan teknik pencitraan canggih untuk membedakannya secara akurat dari massa kongenital lainnya. Presentasi Kasus: Seorang wanita berusia 39 tahun dengan G6P4A1H4 dirujuk ke Rumah Sakit Arifin Achmad pada usia kehamilan 25+6 minggu karena pembesaran ekstremitas bawah janin dan asites. Ultrasonografi menunjukkan massa multikistik besar pada paha kiri dan bokong janin, berukuran 10,2 × 7,8 × 6,4 cm. Awalnya dicurigai sebagai teratoma sakrokoksigeal, namun evaluasi lebih lanjut mengarah pada dugaan limfangioma. Studi Doppler menunjukkan vaskularisasi yang berkurang. Setelah konseling menyeluruh dan tinjauan oleh komite etik yang melibatkan dokter obstetri, neonatologi, dan bedah anak, orang tua memilih terminasi kehamilan. Persalinan diinduksi dengan misoprostol 50 mcg per oral setiap 4 jam (dua dosis). Induksi ini menghasilkan kelahiran bayi laki-laki seberat 1.400 gram dengan skor APGAR 3 dan 0. Bayi meninggal 15 menit setelah lahir. Kondisi ibu tetap stabil dengan tanda vital dan hasil laboratorium normal pascapersalinan.Diskusi: Diagnosis prenatal limfangioma sulit karena kemiripannya dengan massa kongenital lainnya. Skrining ekstremitas secara rutin sangat penting untuk deteksi dini. Histopatologi pascanatal mengonfirmasi limfangioma dengan menunjukkan saluran limfatik yang melebar tanpa komponen solid. Kasus ini menekankan pentingnya manajemen multidisiplin dan pencitraan serial untuk memperjelas prognosis.Kesimpulan: Diagnosis prenatal sangat penting dalam perencanaan manajemen. Ultrasonografi serial dan MRI dapat membantu memperjelas prognosis. Pendekatan multidisiplin sangat diperlukan untuk perawatan optimal. Kata kunci: Diagnosis prenatal, Limfangioma, Malformasi limfatik, Manajemen perinatal, Massa ekstremitas janin.
Co-Authors Admiral, Muhammad Z. Ahmad Fahruddin Amru Sofian Auren Nathania Darmawi Darmawi Dewi Anggraini Dhini Aiyulie Novri Fahruddin, Ahmad Farniga, Arnaldi Febriani Fitra Afdanil Hidayat, Fadler Ika A. Rini, Ika A. Ilmiah, Zidny Inayah Inayah Irwan Irwan Kemal, Rahmat A. Lalu Muhammad Irham Leina Putri Zahra M. Yulis Hamidy Machyuddin T.M Pangaribuan Mahargyarani, Azza E. Maya Savira Mayangsari, Nastiti Hemas Muhammad Arif Syafei Muhammad Imam Muttaqien Muhammad Yusuf Nurhapipa Nurlisis, Nurlisis Oktavia Dewi Putra, Andani E. Putri, Ratu Astuti Dwi Rachmadina, Rachmadina Rahmat Azhari Kemal Ratu Astuti Dwi Putri Ratu Astuti Dwi Putri, Ratu Astuti Razali, Renardy R. Renardy Reza Razali Resty Yuwandari Riandi, Diki Ruza Prima Rustam satiti rahayu ShintaPuja Tilusari sidri rizqi yuniati Sofie R. Krisnadi Syamsul Bahri Syamsul Bahri Syamsul Bahri Riva'i TB Odih Rhomdani Wahid Winarto Winarto Wirawan Adikusuma Wiwin Suhandri Wiwit Ade Fidiawati Yossi Maryanti Yulis Hamidy Yunita, Jasrida Zainal Abidin Zulmaeta