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All Journal Jurnal Kedokteran dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Universitas Sriwijaya Majalah Kedokteran Sriwijaya Biomedical Journal of Indonesia SRIWIJAYA JOURNAL OF MEDICINE JPP Jurnal Kesehatan Poltekkes Palembang Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML) Jurnal Ners Abdimas Galuh: Jurnal Pengabdian Kepada Masyarakat Jurnal Pengabdian Masyarakat: Humanity and Medicine Jurnal Kesehatan Gigi dan Mulut (JKGM) International Journal of Islamic and Complementary Medicine Jurnal RSMH Palembang eJournal Kedokteran Indonesia JMLS: Journal of Medical Laboratory and Science Faedah: Jurnal Hasil Kegiatan Pengabdian Masyarakat Indonesia
Oktariana, Desi
Universitas Sriwijaya
Religion Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemistry Dentistry Economics, Econometrics & Finance Education Engineering Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Neuroscience Nursing Physics Public Health

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SIDE EFFECTS OF SECOND-LINE ANTITUBERCULOSIS DRUGS IN MULTI-DRUG RESISTANCE (MDR) TUBERCULOSIS PATIENTS Tamzil, Nia Savitri; Lorenza, Geofanny; Andriani, R.A. Linda; Theodorus, Theodorus; Sudarto, Sudarto; Lusiana, Evi; Harahap, Debby Handayati; Oktariana, Desi; Prasasty, Gita Dwi
Jurnal Kedokteran dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Universitas Sriwijaya Vol. 12 No. 2 (2025): Jurnal Kedokteran dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Univers
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/jkk.v12i2.483

Abstract

Multidrug-resistant tuberculosis (MDR TB) is caused by Mycobacterium tuberculosis strains resistant to isoniazid and rifampicin—the most potent anti-TB drugs. Prolonged treatment duration and complex drug regimens often lead to poor adherence, contributing to high MDR TB incidence and low treatment success rates, particularly in Indonesia. This study analyzed drug utilization patterns in 52 MDR TB patients at Dr. Mohammad Hoesin Hospital Palembang, using total sampling based on medical records from October 2018 to December 2019. Data were analyzed descriptively with SPSS v25. The most common side effects reported were weakness, nausea, and vomiting (84.6%), followed by arthralgia, hyperuricemia, and hearing loss (42.3%). Severe side effects were more prevalent in the short-term regimen group (40.4%) compared to the long-term group (7.7%). Weakness, nausea, and vomiting were the most frequently observed side effects in MDR TB patients.
The Role of Innate and Adaptive Immune Responses in The Pathogenesis of Periodontitis: A Narrative Review Yunita, Rahma; Oktariana, Desi
Sriwijaya Journal of Medicine Vol. 8 No. 1 (2025): Vol 8, No 1, 2025
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/sjm.v8i1.307

Abstract

Periodontitis is a complex disease that attacks periodontal tissue by progressive damage caused by various factors lead to inflammatory process. The progression of periodontitis is associated with bacterial activity that induces an inflammatory response in the host. Changes in the composition of bacteria within dental plaque leading to increased inflammation of the periodontal tissue which triggers the activation of inflammatory mediators from the host. Relative studies were identified and collected through case report and review article in Medline/Pubmed, Sciencedirect, Wiley Online Library and Google Scholar websites from 2011 until 2024. In addition to producing a chronic inflammatory process, periodontitis induces immune system dysregulation, which leads to microbial dysbiosis in the subgingival and submarginal locations. Both the humoral and cellular components of the innate and adaptive immune systems are plays crucial role for periodontitis. Periodontitis is a chronic disease and an advanced stage of gingivitis, when the immune system fails to counter bacterial invasion, the inflammatory process persists, and leading to extensive damage to periodontal tissues.
POTENTIAL OF DUTCH TEAK LEAVES (Guazuma ulmifolia) AS ANTIOXIDANTS AND ANTI-INFLAMMATORIES AGENT Smaradhna, Safira; Az Zahra, Zaviera; Maria Sidabutar, Carolina; Eskalatin, Khaira; Tamzil, Nia Savitri; Lusiana, Evi; Oktariana, Desi; Dwi Prasasty, Gita; Parisa, Nita
International Journal of Islamic and Complementary Medicine Vol. 4 No. 1 (2023): International Journal of Islamic and Complementary Medicine
Publisher : International Islamic Medicine Forum

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55116/IJICM.V4I1.57

Abstract

Oxidative stress is an imbalance in the quantity of reactive species and antioxidant activity that is often associated with inflammatory diseases. Inflammation is the main cause of morbidity in most of the world's population. Inflammation occurs when there is an invasion of foreign bodies and pathogenic agents such as bacteria, parasites, and viruses that cause activation of the immune system. The protective effect of the inflammatory process is actually very good under normal circumstances. However, in chronic inflammation, tissue damage becomes uncontrollable and can lead to various diseases such as rheumatoid arthritis, multiple sclerosis, inflammatory bowel disease, psoriasis and neoplastic transformation. For inflammatory therapy, steroids and non-steroidal drugs (NSAIDs) are usually used, but the use of these drugs can have serious long-term effects. Therefore, the development of anti-inflammatory agents from natural sources such as certain plant species that are safe, efficacious, biocompatible and cost-effective is a rational strategy that can be used to treat inflammatory diseases. One of its species, Guazuma ulmifolia or Dutch teak plant, is widely used in traditional medicine because it contains bioactive compounds, especially proanthocyanidins and flavonoids which have anti-oxidant and anti- microbial properties. The leaves and flowers of Guazuma ulmifolia can be used in fever, gastrointestinal disease, kidney disease and diabetes. Guazuma ulmifolia can protect the gastric mucosa against the harmful effects of NSAIDs through anti-inflammatory and anti-oxidant mechanisms. The extract of Dutch teak leaves (Guazuma ulmifolia) was also effective in reducing the expression of myeloperoxidase in the pulmonary tissue of Wistar white rats with pulmonary contusions .
THE AUTOANTIBODY AND ITS DETECTION IN MYASTENIA GRAVIS: LITERATURE REVIEW Wulandari, Septi; Oktariana, Desi
Journal of Medical Laboratory and Science Vol 4 No 1 (2024): JMLS: Journal of Medical Laboratory and Science
Publisher : Jurusan Teknologi Laboratorium Medis, Poltekkes Kemenkes Palembang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36086/medlabscience.v4i1.2163

Abstract

Latar Belakang: Miastenia Gravis (MG) adalah penyakit autoimun yang terbatas pada organ tertentu di mana autoantibodi menyerang reseptor asetilkolin nikotinat di sambungan neuromuskular (NMJ). Gangguan fungsi reseptor ini menyebabkan kerusakan pada transmisi neuromuskular, menyebabkan kelelahan dan peradangan otot rangka, serta produksi antibodi serum terhadap antigen otot. Kelelahan pada otot, seperti pada mata, tenggorokan, bola mata, dan otot ekstremitas lainnya, memburuk saat beraktivitas namun bisa membaik dengan istirahat. MG merupakan penyakit langka dengan insiden 5,3 per juta orang per tahun dan prevalensi 77,7 per juta orang per tahun. MG bisa disebabkan karena kelainan bawaan neuromuscular maupun karena adanya autoantibodi. Patofisiologi miastenia gravis ditentukan oleh jenis autoantibodi pada penderita. Diagnosis MG terutama didasarkan pada penilaian klinis dan pengujian antibodi serum terhadap reseptor asetilkolin (AChR), tirosin kinase spesifik otot (MusK), dan lipoprotein densitas rendah 4 (LPR4) dan autoantibodi lain seperti agrin, titin, Kv14. Ryonadine yang dianggap memiliki keterlibatan dalam pathogenesis MG. Beberapa metode pengujian yan digunakan untuk mendeteksi autontibodi pada penderita MG yaitu RIPA, ELISA, FIPA dan CBA.
POTENSI BONE GRAFT DARI CANGKANG TELUR AYAM TERHADAP PEMBENTUKKAN TULANG PASCAEKSTRAKSI GIGI Yunita, Rahma; Liana, Phey; Oktariana, Desi
Jurnal Kesehatan Gigi dan Mulut (JKGM) Vol 7 No 2 (2025): Jurnal Kesehatan Gigi dan Mulut (JKGM)
Publisher : Jurusan Kesehatan Gigi, Poltekkes Kemenkes Palembang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36086/jkgm.v7i2.2997

Abstract

Latar Belakang: Ekstraksi gigi atau pencabutan gigi merupakan salah satu prosedur bedah minor pada kedokteran gigi yang dilakukan untuk mengeluarkan gigi dari soketnya dan berpotensi menyebabkan perlukaan pada jaringan Selama proses penyembuhan, volume tulang alveolar dapat berkurang hingga 40–60%, yang dapat berdampak signifikan pada pasien yang memerlukan terapi implan gigi. Pengurangan volume tulang alveolar dalam prosedur implan dapat diatasi dengan pemberian bone graft. Salah satu bahan bone graft yang paling banyak dikembangkan saat ini adalah hidroksiapatit (HA). Hidroksiapatit adalah komponen mineral utama dari tulang kortikal dan kanselus dewasa. Dikarenakan meningkatnya penggunaan HA sebagai bahan bone graft telah menyebabkan harganya menjadi mahal. Cangkang telur merupakan salah satu sumber alternatif HA yang banyak dikembangkan saat ini. Metode: Artikle dikumpulkan dengan mencari artikel penelitian eksperimental secara in vivo yang diterbitkan antara tahun 2014 dan Desember 2024. Artikel yang dikumpulkan diterbitkan dalam bahasa Inggris di database PubMed, ScienceDirect, dan Wiley menggunakan kata kunci “eggshells” yang dikombinasikan dengan istilah “bone graft” dan “bone formation”. Kesimpulan: Bone graft yang berasal dari cangkang telur dapat dimanfaatkan dalam perawatan pascaekstraksi gigi untuk kondisi infeksi dan non-infeksi.
Kajian Sistematik mengenai Dampak Hipertiroidisme Autoimun pada Kehamilan Hafizzanovian Hafizzanovian; Desi Oktariana
Jurnal Ners Vol. 10 No. 3 (2026): JULI 2026
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jn.v10i3.61287

Abstract

Hipertiroidisme autoimun merupakan gangguan yang ditemukan pada sekitar 0,2% kehamilan. Walaupun prevalensinya tergolong rendah, kondisi ini berhubungan dengan peningkatan risiko berbagai komplikasi yang dapat memengaruhi kesehatan ibu maupun janin. Oleh sebab itu, diperlukan kajian yang komprehensif untuk menelaah bukti ilmiah terkini mengenai konsekuensi hipertiroidisme autoimun selama masa kehamilan. Tinjauan sistematik ini disusun dengan tujuan mengintegrasikan hasil penelitian yang telah dipublikasikan untuk memberikan gambaran mengenai hubungan antara hipertiroidisme autoimun pada ibu hamil dengan luaran maternal serta perkembangan dan luaran janin. Proses penelusuran literatur dilakukan secara sistematis melalui berbagai basis data daring, meliputi ScienceDirect, Elsevier, PubMed, MEDLINE, EBSCO, ProQuest, Wiley, dan Google Scholar. Setelah melalui proses seleksi berdasarkan kriteria inklusi dan eksklusi, diperoleh delapan artikel yang memenuhi syarat untuk dianalisis. Hasil sintesis menunjukkan bahwa hipertiroidisme autoimun selama kehamilan berkaitan dengan peningkatan risiko komplikasi maternal, seperti preeklampsia, diabetes melitus gestasional, dan abruptio plasenta, serta komplikasi fetal berupa abortus, persalinan prematur, hambatan pertumbuhan janin, berat badan lahir rendah (BBLR), dan gangguan fungsi tiroid pada neonatus. Secara keseluruhan, bukti yang tersedia mengindikasikan bahwa hipertiroidisme autoimun memberikan dampak yang bermakna terhadap luaran kehamilan baik pada ibu maupun bayi.
Co-Authors Adil, Mahvira Chow Liana Herman Afifah, Salwa Nur Nur Agustine, Vania Andriani, R.A. Linda Ardesy Melizah Kurniati Arina P Jatmiko Aseptianova Aseptianova Athiah, Medina Az Zahra, Zaviera Banun, Syahri Bella Puspita Aziatri Bintang Fajarullah Dalilah Dalilah Debby Handayati Harahap Dwi Handayani Eny Rahmawati, Eny Eskalatin, Khaira Evi Lusiana Fifa Argentina Gita D. Prasasty Gita Dwi Prasasty Hafizzanovian Hafizzanovian Hafizzanovian Hafizzanovian Hafizzanovian Hafizzanovian, Hafizzanovian Indri Seta Septadina Jayawarsa, A.A. Ketut Kemas Y. Rahadiyanto Khairani, Attina Kristalia, Mareska Reggina Legiran Legiran Lorenza, Geofanny Lusia Hayati Luthfiah, Qonita Mahvira Chow Liana Herman Adil Maria Sidabutar, Carolina Mastiar Endang Frida Siahaan Muhammad Ali Apriansyah Muhammad Irsan Saleh Muhammad Reagan Mutiara Budi Azhar Nia S. Tamzil Nita Parisa Nopriyati Nopriyati, Nopriyati Phey Liana Rachmatunisa, Anita Radiyati Umi Partan, Radiyati Umi Rahadiyanto, Kemas Ya’kub Rahardiyanto, Kemas Ya’kub Rahma Yunita, Rahma SEPTI WULANDARI Smaradhna, Safira Sudarto Sudarto Theodorus Theodorus Vena Sabputri Sutrisno Yuli Kurniawati Yuli Kurniawati, Yuli Yuniza Yuniza