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All Journal Jurnal Kedokteran dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Universitas Sriwijaya Majalah Kedokteran Sriwijaya Biomedical Journal of Indonesia SRIWIJAYA JOURNAL OF MEDICINE JPP Jurnal Kesehatan Poltekkes Palembang Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML) Jurnal Ners Abdimas Galuh: Jurnal Pengabdian Kepada Masyarakat Jurnal Pengabdian Masyarakat: Humanity and Medicine Jurnal Kesehatan Gigi dan Mulut (JKGM) International Journal of Islamic and Complementary Medicine Jurnal RSMH Palembang eJournal Kedokteran Indonesia JMLS: Journal of Medical Laboratory and Science Faedah: Jurnal Hasil Kegiatan Pengabdian Masyarakat Indonesia
Oktariana, Desi
Universitas Sriwijaya
Religion Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemistry Dentistry Economics, Econometrics & Finance Education Engineering Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Neuroscience Nursing Physics Public Health

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Transplantasi Stem Cell untuk Keganasan Hematologi Desi Oktariana; Legiran Legiran; Phey Liana; Kemas Y. Rahadiyanto; Gita D. Prasasty; Evi Lusiana; Nia S. Tamzil
eJournal Kedokteran Indonesia Vol. 10 No. 2 - Agustus 2022
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23886/ejki.10.123.186-93

Abstract

Insiden keganasan hematologi terus bertambah serta memiliki tingkat morbiditas dan mortalitas yang tinggi. Keganasan hematologi adalah kondisi sel-sel hematologi seperti eritrosit, leukosit, dan trombosit, tumbuh tidak terkendali dan tidak mengalami kematian sehingga mendominasi populasinya dan tidak dapat berfungsi normal. Terapi stem cell pada keganasan hematologi yang disebut juga terapi transplantasi sumsum tulang, merupakan modalitas terapi utama untuk gangguan hematologi dan keganasan yang memungkinkan pemulihan komponen seluler darah, termasuk monosit, limfosit, basofil, eosinofil, neutrofil, eritrosit, dan trombosit. Stem cell yang dapat digunakan pada keganasan hematologi adalah kombinasi hematopoietic stem cell (HSC) dan mesenchymal stem cells (MSC) untuk transplantasi sumsum tulang dan pemulihan kekebalan untuk gangguan hematologi. Penggunaan HSC dengan ko-terapi MSC dapat memfasilitasi kelangsungan hidup cangkok dari transplantasi HSC. Kata kunci: keganasan, hematologi, stem cell.   Stem Cell Transplantation for Hematology Malignancy Abstract The incidence of hematological malignancies continues to increase and has a high rate of morbidity and mortality. Hematological malignancies are conditions of hematological cells such as erythrocytes, leukocytes, and platelets, growing uncontrollably and not dying so that they dominate the population and cannot work normally. Stem cell therapy in hematological malignancies, also known as bone marrow transplantation therapy, is the main therapeutic modality for hematological disorders and malignancies that supports the restoration of cellular components of blood, including monocytes, lymphocytes, basophils, eosinophils, neutrophils, erythrocytes, and platelets. Stem cells that can be used in hematological malignancies are a combination of hematopoietic stem cells (HSC) and mesenchymal stem cells (MSC) for bone marrow transplantation and immune restoration for hematological disorders. The use of HSCs with MSC co-therapy can help revive grafts from HSC transplants. Key words: malignancy, hematology, stem cell.
IDENTIFICATION OF -2849 IL-10 GENE PROMOTER POLYMORPHISM IN LEPROSY PATIENT Desi Oktariana; Arina P Jatmiko; Mutiara Budi Azhar
JURNAL KEDOKTERAN DAN KESEHATAN Vol 9, No 3 (2022)
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/JKK.V9I3.18894

Abstract

Leprosy is a chronic granulomatous disease. Leprosy is caused by M. leprae. However, not all exposure to M. leprae causes the disease. The condition of the host immune system determines the pathogenesis of leprosy. Interleukin-10 work as a pro- and anti-inflammatory cytokine. Polymorphism in the IL-10 gene promoter affects the amount of IL-10 secretion. The amount of IL-10 secretion determines the body’s response to M. leprae. The purpose of this study was to determine the distribution of -2849 IL-10 gene promoter polymorphism in leprosy patient at RSUP dr. Mohammad Hoesin Palembang. This research is an observational descriptive study with cross sectional design. Polymorphism identification was performed using PCR-RFLP. A total of 50 samples were identified. Most of the leprosy patients at RSUP dr. Mohammad Hoesin for the period January – February were < 50 years old (73.47%), male (66%), MB leprosy (92%), and came from Malay-South Sumatra ethnicity (53.06%). The genotype frequency distribution was GG 93.88%, AG 6.12%, and AA 0%. The frequency of allele G was 96.94% and allele A 3.06%. The majority of leprosy patients at RSUP dr. Mohammad Hoesin had wild-type genotypes.
Diagnosis of Osteogenesis Imperfecta in 23 Years Old Man: A Case Report Partan, Radiyati Umi; Hafizzanovian; Desi Oktariana
Jurnal RSMH Palembang Vol. 3 No. 1 (2022): Jurnal RSMH Palembang
Publisher : RSUP Dr Moh Hoesin Palembang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/jrp.v3i2.34

Abstract

Osteogenesis imperfecta is a disorder of the formation of collagen tissue that functions as connective tissue and is caused by a gene mutation that causes disturbances in the formation of type 1 collagen. This study aimed to describe the diagnosis of osteogenesis imperfecta. A 23-year-old man came to the rheumatology polyclinic of Dr. Mohammad Hoesin General Hospital Palembang with a complaint of recurrent fractures since ± 17 years ago. The patient also complained that the hearing in the left ear was slowly decreasing. The patient's right thigh was still pinned 2 years ago, but after being controlled by orthopedics, it was said that the bones were still not fused. Then the patient was referred to the rheumatology polyclinic for further examination and management. On examination, the patient was 145 cm tall and weighed 40 kg. He had blue-gray sclera, triangular facial appearance, right leg length 86 cm, left leg length 78 cm, blue sclera, and scoliosis, while secondary sex growth was within normal limits. From the examinations of bone survey and bone age, it was found osteoporotic bone structure, scoliosis, plate-screw in the middle 1/3 of the right femur, fracture union of the femur, bowing of the left femur, BMD Z-Score -3.0 means very low compared to the same age and gender. Management is more focused on supportive therapy with the aim of minimizing the occurrence of fractures, minimizing disability, and helping people with osteogenesis imperfecta to be independent and maintain overall health. The goal of orthopedic management is to treat osteogenesis imperfecta with fractures and prevent or correct bone deformity. In conclusion, osteogenesis imperfecta is a complex hereditary disease characterized by striking clinical variability necessitating a logical classification system. Disease management requires multidisciplinary experts and further research on therapeutic approaches such as bisphosphonates.
Potensi Growth Factor dalam Platelet Rich Plasma (PRP) sebagai Pengobatan Regeneratif: Tinjauan Pustaka Wulandari, Septi; Oktariana, Desi
JPP JURNAL KESEHATAN POLTEKKES PALEMBANG Vol 19 No 1 (2024): (JPP) Jurnal Kesehatan Poltekkes Palembang
Publisher : Poltekkes Kemenkes Palembang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36086/jpp.v19i1.2195

Abstract

Latar Belakang: Platelet Rich Plasma (PRP) merupakan suatu bagian plasma dari darah yang diambil dari pasien itu sendiri (autologous) dengan kandungan konsentrasi platelet atau trombosit yang cukup tinggi yakni 3 sampai 5 kali lebih besar dari konsentrasi trombosit dalam darah. PRP memiliki kandungan Growth Factor (GF) yang melimpah, di antaranya Platelet Derived Growth Factor (PDGF), Transforming Growth Factor (TGF), Vascular Endothelial Growth Factor (VEGF), Epithelial Growth Factor (EGF) dan Insulin-Like Growth Factor (IGF) yang berfungsi mempercepat regenerasi endothelial, epitel, dan epidermal, merangsang angiogenesis, meningkatkan sintesis kolagen, penyembuhan jaringan, mengurangi jaringan parut pada kulit, dan meningkatkan respon hemostatik terhadap cedera. Berbagai studi baik in vitro maupun uji klinis menunjukkan bahwa pemberian PRP berpengaruh signifikan dalam penyembuhan cedera, perbaikan jaringan dan angiogenesis. Terapi PRP telah digunakan dalam dunia kesehatan sebagai pengobatan dalam berbagai penyakit yang berkaitan dengan pertumbuhan sel Kata kunci : Plasma kaya trombosit, faktor pertumbuhan, pengobatan regeneratif
Antibodi Monoklonal Anti-CD38 (Daratumumab) dalam Terapi Kanker Mieloma Multipel Afifah, Salwa Nur Nur; Oktariana, Desi
JPP JURNAL KESEHATAN POLTEKKES PALEMBANG Vol 19 No 1 (2024): (JPP) Jurnal Kesehatan Poltekkes Palembang
Publisher : Poltekkes Kemenkes Palembang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36086/jpp.v19i1.2196

Abstract

Mieloma multipel (MM) merupakan jenis keganasan hematologi yang belum dapat dibudidayakan dan prevalensinya terus meningkat secara global, termasuk di Indonesia. Antibodi monoklonal Anti-CD38, khususnya daratumumab, telah membuktikan efektivitasnya dalam pengobatan MM dengan memicu berbagai mekanisme anti tumor.
Skrining dan Penyuluhan Status Gizi dan Hemoglobin Remaja Putri di MTsN 1 Palembang Kurniati, Ardesy Melizah; Athiah, Medina; Oktariana, Desi; Agustine, Vania
Abdimas Galuh Vol 6, No 2 (2024): September 2024
Publisher : Universitas Galuh

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25157/ag.v6i2.15724

Abstract

Masa remaja merupakan masa transisi menuju dewasa. Terjadi peningkatan pertumbuhan dan perkembangan yang pesat, membutuhkan asupan gizi yang optimal. Kekurangan atau kelebihan asupan gizi dapat menyebabkan gangguan gizi. Prevalensi remaja putri di Indonesia yang mengalami berat badan kurus mencapai 5,4%, pendek atau stunting 24,9%, dan mengalami obesitas mencapai 16%. Pada remaja putri terdapat risiko mengalami anemia. Kasus anemia pada anak remaja tercatat mencapai 39,8 % pada tahun 2019. Skrining status gizi dan anemia pada remaja diperlukan agar masalah gizi dan anemia dapat ditatalaksanai. Pengabdian ini bertujuan untuk mengetahui status gizi dan kadar hemoglobin pada remaja putri di MTsN 1 Palembang. Kegiatan dimulai dengan penyuluhan, dilanjutkan dengan pengukuran tinggi badan dan berat badan. Pengambilan data kadar Hb dilakukan dengan metode Point of Care Testing (POCT). Pemeriksaan dilakukan kepada 148 subjek. Status gizi terbanyak terdapat pada kelompok gizi baik sebanyak 82 subjek (55,4%). Sebagian besar remaja mengalami anemia, yaitu sebanyak 82 subjek (55%). Kegiatan pengabdian ini diharapkan dapat meningkatkan pengetahuan peserta kegiatan, dan hasil skrining dilaporkan ke Puskesmas untuk ditindaklanjuti.
Comparative Analysis of Molecular Diagnostic Techniques for Pulmonary Tuberculosis: A Literature Review Rachmatunisa, Anita; Oktariana, Desi
Biomedical Journal of Indonesia Vol. 11 No. 1 (2025): Vol 11, No 1, 2025
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bji.v11i1.207

Abstract

Pulmonary tuberculosis is a global health problem that requires early and precise diagnosis for effective control. In this literature review, we compare several molecular diagnostic techniques used in the detection of pulmonary tuberculosis, such as Polymerase Chain Reaction (PCR), Whole Genome Sequencing (WGS), and Next Generation Sequencing (NGS), as well as Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)-based Diagnostic Techniques. Polymerase Chain Reaction stands out for its high sensitivity, although time-consuming and high operational costs. Meanwhile, whole genome sequencing and next generation sequencing have detailed tuberculosis (TB) strain identification capabilities but have high costs and limited availability. On the other hand, CRISPR-based diagnostic techniques offer speed and low cost but are still in the advanced stages of development. Challenges in implementing new techniques include technical barriers, logistics, and improving sensitivity and specificity. Suggestions for future research include the development of more effective, faster, and affordable techniques, especially in developing portable diagnostic tests for accessibility of pulmonary tuberculosis diagnosis in various regions.
Optimalisasi Pemanfaatan Tanaman Herbal Sebagai Obat Anti-Gout Arthritis Sebagai Upaya Pencegahan Penyakit Gagal Ginjal Evi Lusiana; Nia Savitri Tamzil; Desi Oktariana; Gita Dwi Prasasty; Bintang Fajarullah; Bella Puspita Aziatri
Faedah : Jurnal Hasil Kegiatan Pengabdian Masyarakat Indonesia Vol. 2 No. 1 (2024): Jurnal Hasil Kegiatan Pengabdian Masyarakat Indonesia
Publisher : FKIP, Universitas Palangka Raya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59024/faedah.v2i1.725

Abstract

Health education about the benefits of herbal plants as anti-gout arthritis drugs needs to be done to help people increase their knowledge so that they can apply wise actions and attitudes that can improve their quality of life. The purpose of community service activities is to find out the effect of health socialization on the use of herbal plants on gout by assessing the increase in knowledge, attitudes, actions of participants and assistance in making ginger tea as a prevention of gout arthritis, as well as conducting gout screening tests. Methods of community service activities in the form of counseling, outreach, and education as well as assistance in making ginger medang which will then be evaluated with pre and post counseling questionnaires. The number of participants 30 people are people who live in the work area of the Palembang Kertapati Health Center. An indicator of the success of counseling is an increase in the knowledge, attitudes and actions of community service participants. In the results of the study, it was known that the level of knowledge before socialization and education was 36.7% and increased after socialization (86.7%); attitude of participants before socialization 80% after socialization increased to 100%; action before socialization 63.3% after socialization 100%. It is known that there is an influence from education and outreach in the form of increasing knowledge, attitudes and actions of the community at the Kertapati Health Center, Palembang City, South Sumatra so that a follow-up program is needed in the form of intensive counseling for health center cadres as the spearhead of information on a wider range of people.
Cycle Threshold Value as A Death Predictor of COVID-19 Patients Oktariana, Desi; Saleh, Irsan; Banun, Syahri; Rahadiyanto, Kemas Ya’kub; Liana, Phey; Rahmawati, Eny; Hafizzanovian, Hafizzanovian; Lusiana, Evi; Tamzil, Nia Savitri; Prasasty, Gita Dwi; Aseptianova, Aseptianova
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol. 31 No. 3 (2025)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v31i3.2390

Abstract

For several years, COVID-19 has been a major problem in human health and also caused a global socio-economic crisis. However, the impact of viral load on patient mortality has not been thoroughly investigated. This study analyzes the association between CT value and the mortality of COVID-19 patients in inpatients at Mohammad Hoesin Hospital. This study used observational analysis with a longitudinal retrospective design. This study had 280 subjects. Fifty-four of the 280 patients died (19.3%) 33% had a CT <22.93; 16.7% had a CT 22.93-29.93; 31.5% had a CT 29.94-34.9, 18.5% had a CT >35 with p-value >0.05 for patient mortality. Analysis of age, comorbidities, and clinical severity of patient mortality showed a p-value <0.05. Meanwhile, gender analysis of patient mortality showed a p-value >0.05. These results indicate that the CT value cannot predict patient mortality. Patients with older age, comorbidities, and admission with severe clinical severity have a higher risk of death.
Pengendalian skabies dan pedikulosis melalui pengobatan dan penyuluhan perilaku hidup bersih dan sehat (PHBS) Prasasty, Gita Dwi; Handayani, Dwi; Dalilah, Dalilah; Susilawati, Susilawati; Oktariana, Desi; Kristalia, Mareska Reggina; Khairani, Attina
Jurnal Pengabdian Masyarakat: Humanity and Medicine Vol 6 No 1 (2025): Jurnal Pengabdian Masyarakat: Humanity and Medicine
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/Hummed.V6I1.149

Abstract

Neglected tropical diseases, including scabies and pediculosis, are diseases that are still a health problem in Indonesia. Islamic boarding schools are risky locations with a high prevalence of scabies and pediculosis because they have dense housing, lack of environmental sanitation and personal hygiene. This service activity aimed to increase knowledge about preventing and treating scabies and pediculosis in Pondok Pesantren X, South Sumatra. A total of 46 students with complaints of itching on the skin and head were present as participants in the activity which has been carried out in November 2023. The implementation of service consists of examination, counseling, as well as pretest and posttest. The scabies examination method was carried out clinically according to IACS 2020 criteria, while pediculosis examination was carried out with a serit combs. Counseling activities on the topic of clean and healthy living behavior was began and ended with the pretest and posttest. From the examination activities, it was found that 95% (44) students suffered scabies and 36% (17) students suffered pediculosis. Participants were quite enthusiastic in participating in counseling activities, as evidenced by the number of questions related to clean and healthy living behavior in daily activities at Islamic boarding schools. The counseling activity was quite successful, which can be seen from the increase in the correct value and significance (p < 0.05) of the pretest and posttest results.
Co-Authors Adil, Mahvira Chow Liana Herman Afifah, Salwa Nur Nur Agustine, Vania Andriani, R.A. Linda Ardesy Melizah Kurniati Arina P Jatmiko Aseptianova Aseptianova Athiah, Medina Az Zahra, Zaviera Banun, Syahri Bella Puspita Aziatri Bintang Fajarullah Dalilah Dalilah Debby Handayati Harahap Dwi Handayani Eny Rahmawati, Eny Eskalatin, Khaira Evi Lusiana Fifa Argentina Gita D. Prasasty Gita Dwi Prasasty Hafizzanovian Hafizzanovian Hafizzanovian Hafizzanovian Hafizzanovian Hafizzanovian, Hafizzanovian Indri Seta Septadina Jayawarsa, A.A. Ketut Kemas Y. Rahadiyanto Khairani, Attina Kristalia, Mareska Reggina Legiran Legiran Lorenza, Geofanny Lusia Hayati Luthfiah, Qonita Mahvira Chow Liana Herman Adil Maria Sidabutar, Carolina Mastiar Endang Frida Siahaan Muhammad Ali Apriansyah Muhammad Irsan Saleh Muhammad Reagan Mutiara Budi Azhar Nia S. Tamzil Nita Parisa Nopriyati Nopriyati, Nopriyati Phey Liana Rachmatunisa, Anita Radiyati Umi Partan, Radiyati Umi Rahadiyanto, Kemas Ya’kub Rahardiyanto, Kemas Ya’kub Rahma Yunita, Rahma SEPTI WULANDARI Smaradhna, Safira Sudarto Sudarto Theodorus Theodorus Vena Sabputri Sutrisno Yuli Kurniawati Yuli Kurniawati, Yuli Yuniza Yuniza