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All Journal Pharmaciana: Jurnal Kefarmasian Majalah Obat Tradisional Abditani : Jurnal Pengabdian Masyarakat Jurnal Karinov JUNCTO: Jurnal Ilmiah Hukum Budapest International Research and Critics Institute-Journal (BIRCI-Journal): Humanities and Social Sciences Jurnal Ilmiah Medicamento COMSERVA: Jurnal Penelitian dan Pengabdian Masyarakat Jurnal Locus Penelitian dan Pengabdian Usadha
Putra, I Made Agus Sunadi
Program Studi S1Fakultas Farmasi Universitas Mahasaraswati Denpasar
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Journal : Usadha

 1 
Formulasi Sediaan Shampo Kombinasi Ekstrak Daun Pandan Wangi (Pandanus amaryllifolius Roxb) dan Daun Seledri (Apium graveolens L.) sebagai Antiketombe terhadap Jamur Candida albicans Danayasa, I Kadek; Yudianti Mendra, Ni Nyoman; Sunadi Putra, I Made Agus
Usadha Vol 2 No 3 (2023): Usadha: Jurnal Integrasi Obat Tradisional
Publisher : Fakultas Farmasi Universitas Mahasaraswati Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36733/usadha.v2i3.7382

Abstract

Dandruff is a scalp condition characterized by an anomaly, often caused by the fungus of Candida albicans. The development of safe and effective anti-dandruff shampoo is imperative. Notably, traditional medicine employs pandan wangi and celery leaves, rich in polyphenols, flavonoids, saponins, tannins and alkaloids as potential anti-dandruff agents. The aims of this study was to formulate and evaluate the antifungal activity of a combination shampoo containing extracts form pandan wangi and celery leaves. Antifungal testing was carried out using the diffusion method using paper discs. Three formulations were prepared FI (without extract), FII (10% pandan leaf extract, 20% celery leaf), FIII (20% pandan leaf extract, 10% celery leaf). Antifungal test was evaluated using the paper disc diffusion method, with 2% ketoconazole shampoo as the positive control. Physical quality test demonstrated favorable attributes for pandan wangi and celery leaf extract shampoo, with FII and FIII exhibiting dark green colors whit distinct odors, while FI remained colorless and odorless. Furthermore, all formulations were in semi-solid dosage forms and met pH requirement for scalps (pH 6,) and produced satisfactory foam yields (6,8-8,9 cm). The antifungal activity test revealed FI as the negative control with a 7 mm and 2% ketoconazole shampoo with a 24 mm inhibition zone, while FII and FIII showed no inhibition zone. The combination of pandan wangi and celery leaf extract in shampoo preparation showed no synergic activity to inhibit the growth of Candida albicans fungus. Further investigations and clinical trials are warranted to validate its effectiveness and safety for practical application.
Uji Aktivitas Sediaan Hand Sanitizer Ekstrak Etanol Daun Euphorbia milli Terhadap Bakteri Staphylococcus epidermidis Sri Budiasih, Putu Eka; Sunadi Putra, I Made Agus; Santoso, Puguh
Usadha Vol 3 No 2 (2024): Usadha: Jurnal Integrasi Obat Tradisional
Publisher : Fakultas Farmasi Universitas Mahasaraswati Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36733/usadha.v3i2.7435

Abstract

  Euphorbia milli is a plant that has medicinal properties, one of which is that Euphorbia milli leaves contain peroxidase, saponins, calcium oxalate, peptic substances, and starch. Meanwhile, the sap contains euphorbol, euphol, and cyoartenol. The leaves are widely used as a remedy for boils (furuncle), purulent inflammation of the skin (piodermi), scalds, and burns. Euphorbia milli folia leaves contain saponins, which have potential as antibacterials. This study aims to determine the antibacterial activity of the ethanol extract of the giwang fern cactus leaves on the growth of Staphylococcus epidermidis by making a hand sanitizer gel from the giwang fern cactus leaf extract using three variations of extract concentrations: 5%, 10%, and 15%. The plant extracts were obtained using the maceration method using 70% ethanol with three replications. This research method is laboratory-experimental research. The results showed that the hand sanitizer gel had an inhibitory effect on the growth of the Staphylococcus epidermidis bacteria.
Formulasi Dan Uji Mutu Fisik Ekstrak Etanol Rimpang Kunyit Putih (Curcuma Zedoaria) Pada Sediaan Tablet Dengan Variasi Bahan Polivinil Pirolidon Dan Starch 1500 Rika, Putu; Juliadi, Debby; Putra, I Made Agus Sunadi
Usadha Vol 2 No 2 (2023): Usadha: Jurnal Integrasi Obat Tradisional
Publisher : Fakultas Farmasi Universitas Mahasaraswati Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36733/usadha.v2i2.7363

Abstract

The white turmeric plant (Curcuma zedoaria) is a species from the Zingiberaceae family which is very important in traditional medicine and the medicinal industry. Apart from being used as a food or beverage ingredient, white turmeric is also used as a traditional medicine, such as stomach ache medicine, stomach booster, fever reducer and can treat skin diseases. This study aims to determine the effect of the concentration of polyvinyl pyrrolidone binder and starch 1500 disintegrating agent on the physical properties of tablets and to obtain a white turmeric rhizome ethanol extract tablet formula which has the best physical quality test. The method used in the manufacture of tablets is the wet granulation method, because this method can improve flow properties and increase compressibility. The results of this study on the physical quality testing of FI and FIII tablets have fulfilled the physical quality test requirements for tablets, but FII has not fulfilled the physical quality test requirements for tablet preparations because FII does not meet the disintegration time test requirements, this is influenced by the concentration of polyvinyl pyrrolidone binder (PVP) was higher than Starch 1500 disintegrant. In this study, FIII had the best physical quality test, where FIII was a physical quality test and had the fastest tablet disintegration time, which was 10 minutes. This is influenced by the higher concentration of Starch 1500 disintegrant, which is 8% compared to the polyvinyl pyrrolidone (PVP) binder, which is 5%.
Uji Aktivitas Antibakteri Sediaan Gel Hand Sanitizer Ekstrak Etanol Daun Kaktus Pakis Giwang (Euphorbia milli) Terhadap Bakteri Pseudomonas aeruginosa Putra, I Made Agus Sunadi; Putri, Ni Putu Devi Nirmala; Santoso, Puguh
Usadha Vol 4 No 2 (2025): Usadha : Jurnal Integrasi Obat Tradisional
Publisher : Fakultas Farmasi Universitas Mahasaraswati Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36733/usadha.v4i02.7434

Abstract

The Covid-19 pandemic has heightened public awareness of hand hygiene thus creating a demand for safe and effective natural-based hand sanitizers. This study aimed to determine the antibacterial activity of hand sanitizer gel containing ethanol extract of Euphorbia milli leaves against Pseudomonas aeruginosa. The extract was obtained through maceration of 500 g of powdered leaves in 70% ethanol and formulated into gels with concentrations of 5%, 10%, and 15% using CMC-Na, glycerin, propylene glycol, and methyl paraben as base ingredients. Physical quality tests included organoleptic properties, homogeneity, pH, and spreadability, while antibacterial activity was assessed using the disc diffusion method on Mueller Hinton Agar. All formulations showed brown colour, homogeneous texture, and pH averaging 5.5, meeting standard requirements. The spreadability ranged between 5.0–6.0 cm, indicating good application consistency. Inhibition zone diameters against P. aeruginosa increased with extract concentration: 6.52 ± 0.26 mm (5%), 7.51 ± 0.30 mm (10%), and 8.39 ± 0.35 mm (15%), whereas the positive control (Ciprofloxacin 5 µg) produced 29.92 ± 1.06 mm and the negative control showed 0 mm. Based on inhibition zone classification, all formulations exhibited moderate antibacterial activity. In conclusion, the ethanol extract of Euphorbia milli leaves demonstrates antibacterial potential against Pseudomonas aeruginosa, with effectiveness increasing proportionally to concentration, suggesting its potential as a natural active ingredient for hand sanitizer formulations
Co-Authors Agung Nur Cahyanta Agustini, Ni Putu Dewi Danayasa, I Kadek Debby Juliadi Eko Mugiyanto Erna Cahyaningsih I Gusti Ayu Putri Kartika, I Gusti Ayu I Gusti Ngurah Parikesit Widiatedja I Putu Tangkas Suwantara Ika Widi Astuti, Ika Widi Ketut Agus Adrianta Ketut Agus Adrianta Megawati, Fitria Meriyani, Herleeyana Nggaba, Ellenoire Rambu Kabeba Hammu Ni Luh Kade Arman Anita Dewi Ni Made Dwi Mara Widyani Nayaka Ni Nyoman Wahyu Udayani Ni Putu Leona Yorita Dewi Ni Putu Udayana Antari Partomuan Simanjuntak Puguh Santoso puguh santoso, puguh Putra Hilmi Prayitno Putri, Ni Putu Devi Nirmala Putu Era Sandhi Kusuma Yuda Riastini, Ni Wayan Rika, Putu SARTIKAWATI, NI KADEK AYU Sasadara, Maria Malida Vernandes Siswa Setyahadi Sri Budiasih, Putu Eka Wardani, I Gusti Agung Ayu Kusuma Yudianti Mendra, Ni Nyoman Yuwono, Moch.