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Journal : Indonesian Health Journal

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The Effectiveness of Red Ginger Extract (Zingiber Officinale Var. Rubrum) on Decreased Blood Glucose Levels in Mice (Mus Musculus) khafyah, Nur; TR Dewi, Sisilia; Jumain, Jumain
Indonesian Health Journal Vol. 2 No. 1 (2023): Indonesian Health Journal
Publisher : Riviera Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58344/ihj.v2i1.23

Abstract

Diabetes mellitus is a group of metabolic diseases characterized by hyperglycemia conditions (increased blood glucose) caused by abnormalities in insulin secretion, abnormalities in the action of insulin or perhaps both. Red Ginger (Zingiber officinale var. rubrum) contains alkaloids, flavanoids, tannins, saponins, gingerol and shagol which have blood glucose-lowering, anti-inflammatory, anticancer and antitumor effects. This study aims to determine the effectiveness of Red Ginger extract against decreasing blood glucose levels in mice (Mus musculus). This research is a type of experimental study conducted to determine the effectiveness of red ginger extract against decreasing blood glucose levels in mice. This study was conducted using alloxane as a diabetes inducer, Na CMC 1% as a negative control, glibenclamide as a positive control, extract dose 2 %, 5 % and 7 % orally for 7 days in 5 groups of test animals. The results of the study obtained 1% Na-CMC results showed a percentage decrease, namely -16.32% and -103.03%. In the group of mice given Red Ginger extract 2% showed a percentage decrease, namely 105.57% and 102.04%. The group of mice given Red Ginger extract 5% showed a percentage decrease of 105.83% and 86.84%. The group of mice given 7% Red Ginger extract showed a percentage decrease, namely 67.34% and 97.45%. The group of mice suspended by glibenclamide showed a percentage decrease of 73.05% and 66.66%. It can be concluded that the administration of Red Ginger extract has been shown to reduce blood glucose levels in aloxane-induced mice at concentrations of 2%,5% and 7% with significant values (p < 0.05) indicating a difference and obtained the most effective concentration in lowering blood glucose levels in mice (Mus musculus) is a concentration of 7%.
Formulation and Stability Test of Physical Quality of Lotion Preparations from Moringa Oleifera L. Leaf Extract with Various Concentrations of Emulsifier TEA Selvi Mutia, Andi; Jumain, Jumain; Arisanty, Arisanty
Indonesian Health Journal Vol. 2 No. 1 (2023): Indonesian Health Journal
Publisher : Riviera Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58344/ihj.v2i1.24

Abstract

The tendency to use herbal ingredients has entered the world of beauty leading to increased research on cosmetic and plant formulations used to be cosmetic active substances. There are many plants that can be used, one of which is the Moringa plant which is considered sacred because it has many benefits. This study aims to determine whether Moringa leaf extract with variations in TEA concentrations of 2.5%, 3%, and 3.5% is formulated into lotions to produce an effective, stable, and safe cream. This type of research is experimental; physical quality testing is carried out before and after the storage conditions are accelerated (Freeze-thaw), including organoleptic tests, homogeneity tests, viscosity tests, pH tests, dispersion tests, and emulsion type tests. Moringa Leaf Extract can be formulated into lotion preparations with variations in TEA concentrations of 2.5%, 3%, and 3.5%. The results of the physical quality test show that all formulas meet the requirements of physical qualification. Third, the dosage formulation of Moringa leaf extract lotion (Moringa oleifera L.) with variations in TEA emulsifying concentrations of 2.5%, 3%, and 3.5% based on physical quality stability tests all meet the requirements.
Effectiveness of Fig Leaf Extract (Ficus Carica L.) in Lowering Blood Glucose in Mice (Mus Musculus) Aisyah, Nur; TR Dewi, Sisilia; Jumain, Jumain
Indonesian Health Journal Vol. 2 No. 1 (2023): Indonesian Health Journal
Publisher : Riviera Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58344/ihj.v2i1.26

Abstract

Fig leaves (Ficus carica L.) is a plant that has antidiabetic properties, because fig leaves contain alkaloid compounds, flavonoids, tannins, polyphenols, saponins, terpenoids, and steroids. This study aims to determine the extract of fig leaves (Ficus carica L.) in lowering blood glucose in mice (Mus musculus). Extraction is carried out by maceration with 96% ethanol solvent, then evaporated using Rotavapor. This study used alloxane as a diabetes inducer, the dose of fig leaf extract tested was 5%, 10% and 15% given orally. Observations were made on day 3 and day 7. As a positive control used Glibenclamide and Na. CMC 1% w/v as a negative control. The results showed an average percent reduction in blood glucose levels for negative controls by 18.6%, for 5% extracts by 29.1%, for 10% extracts by 46.6%, for 15% extracts by 83.9% and for positive controls by 45.8%. The results of research have been obtained that the administration of Fig Leaf extract (Ficus carica L.) is proven to reduce blood glucose levels in mice (Mus musculus) induced by alloxane at concentrations of 5%, 10%, 15%. In the One-way ANOVA test, it shows a significant value (p < 0.05) showing a significant difference in each contract. It can be concluded that fig leaves can be a potential alternative treatment for diabetes mellitus with the right concentration can be an effective and natural treatment option.
Formulation of Herbal Toothpaste Combination of Anna Apple Peel and Kaffir Lime Peel with Variation of Sodium Lauryl Sulfate Concentration Nila Sastrawati, Andi; Jumain, Jumain; Arisanty, Arisanty
Indonesian Health Journal Vol. 2 No. 1 (2023): Indonesian Health Journal
Publisher : Riviera Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58344/ihj.v2i1.27

Abstract

Toothpaste is a preparation whose use aims to clean the mucous membranes of the mouth. Anna's apple is a fruit that contains malic acid which has the ability to whiten teeth. Kaffir lime contains essential oils that have effects as antibacterial, antifungal and refreshing. This study aims to formulate herbal toothpaste preparations a combination of Anna Apple Skin extract (Malus domestica) and Purut Orange Peel extract (Citrus hystrix) and determine the physical quality of the preparation made. This type of research is experimental research using maceration methods with physical quality stability testing, namely organoleptic observations, homogeneity, pH, foam height, viscosity, and dispersion. In this study, two herbal toothpaste formulations were made with variations in the concentration of Sodium Lauryl Sulfate as a foaming agent in toothpaste. From the results of the study, it was obtained that the combination of the two extracts can be formulated into herbal toothpaste preparations and based on the results of physical quality tests, both formulations with variations in the concentration of Sodium Lauryl Sulfate 1.5% and 2.5% meet the requirements of the established standards.
Co-Authors @Mustaffa, Madiawati Mamat Abdullah Joni Guci, Ammar Adwiat, Nur Rabiatul Andi Saparia Anwar Anwar Arisanty, Arisanty Assa, Anggri Alfira Yunita Azizatuz Zahro Beba, Nova Natalia Budi Budi Dwi Listyorini Fahmi, Agria Fahrul, Muhammad Faisal, Eka Oktaviani Faradiba, Deajeng Azura Gunawan Gunawan HS, Mutmainnah. Humaedi Ikhwan Abduh Jamaluddin Jamaluddin Kamarudin Kamarudin khafyah, Nur Khotiah, Titik Lestari, Nunik Martin Madude, Meilin Anggreyni Mua, Estelle Lilian Mustayah ., Mustayah Nila Sastrawati, Andi Nur Aisyah Nur Halifah, Nur Rahmawati, Dyah Restawan, I Gede Ribka, Juliana Neng Sabarulin, Sabarulin Salasa, Alfrida Monica Satriana Satriana Selvi Mutia, Andi Sepang, Janice Sri Purwaningsih Susanto, Denny Syamsuddin Mallala Syifa, Hariani TR Dewi, Sisilia Tri Widyasari Untu, Zainuddin Usba, Muhammad Yanuangga Galahartlambang