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All Journal Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Berkala Kedokteran Jurnal Berkala Kesehatan Jurnal Profesi Medika: Jurnal Kedokteran dan Kesehatan Dinamisia: Jurnal Pengabdian Kepada Masyarakat Jurnal Sinergitas PkM & CSR MAGNA MEDICA: Berkala Ilmiah Kedokteran dan Kesehatan Prosiding Konferensi Nasional PKM-CSR Homeostasis: Jurnal Mahasiswa Pendidikan Dokter
Siti Kaidah
Universitas Lambung Mangkurat
Humanities Biochemistry, Genetics & Molecular Biology Control & Systems Engineering Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Other

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Journal : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

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The effects of regular exercise on hippocampal estradiol levels and spatial memory of ovariectomized Sprague Dawley rats Sri Kadarsih Soejono, Siti Kaidah Ginus Partadiredja
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 45, No 02 (2013)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (71.551 KB)

Abstract

The decrease of estrogen levels leads to dysfunction of hippocampus, including spatial learning and memory. Previous studies have shown that physical exercise improved spatial memory of ovariectomized rats. Physical exercise was observed to be associated with increased extragonadal aromatization and neurotrophin synthesis. This study aimed to evaluate the effect of regular exercise on serum and hippocampal estrogens levels and the spatial memory of ovariectomized rats. The present study used 10 ovariectomized Sprague Dawley rats aged 12 weeks. The rats were randomly assigned into two groups with five rats in each group. Group I was exercise group and Group II was control group without exercise. During the exercise period, the rats were required to keep running constantly on the treadmill at a speed of 18 m/min and at the slope of 5% for a total duration of 60 minutes per day. The exercise was performed five times per week for 12 weeks. The spatial memory of rats was measured using Morris water maze. After the exercise program was completed, the blood and hippocampus samples were collected to determine the estrogen levels. This study revealed that the mean levels of hippocampal estrogen of exercise group (33.794 ± 4.760 pg/mL/100mg tissue weight) were significantly higher than that ofcontrol group (20.552 ± 2.057 pg/mL/100 mg tissue weight) (p<0.05). However, there was no significant difference in serum estrogen levels between the exercise group (26.070 ± 4.064 pg/mL/100mg tissue weight) and control group (24.530 ± 8.661 pg/mL/100mg tissue weight) (p>0.05). In the Morris water maze tests, there was no difference in the spatial learning between both groups (p>0.05). The spatial memory retention of the exercise group was significantly better than control group (p<0.05). In conclusion, regular exercise increases hippocampal estrogen levels and improves spatial memory of ovariectomized rats. Keywords: exercise - hippocampus - spatial memory - estrogen - ERβ
Moderate-intensity interval exercise but not high-intensity interval exercise improves the spatial memory of ovariectomized rats Kaidah, Siti; Rauf, Saidah; Soesatyo, Marsetyawan HNE; Agustiningsih, Denny; Partadiredja, Ginus
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 50, No 3 (2018)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (518.401 KB) | DOI: 10.19106/JMedScie/005003201804

Abstract

Physical exercise exerts beneficial effects on the spatial learning and memory. High-intensity interval exercise (HIIE) has been proposed as a time-efficient physical exercise regimen. On the other hand, there were evidences that HIIE increased oxidative stress biomarkers and reduced antioxidant capacity, which resulted in oxidative damage. The present study aimed to investigate the effects of high-intensity interval exercise and moderate-intensity interval exercise on oxidative stress biomarkers and oxidative enzymes activity in the hippocampus and the spatial memory of ovariectomized rats. A total of 16 female Sprague Dawley rats aged 12 weeks were randomly assigned into 4 groups, i.e. the sham-operated (SO), ovariectomized without exercise (O), ovariectomized with high-intensity interval exercise (HIIE), and ovariectomized with moderate-intensity interval exercise (MIIE) groups. Rats of the exercise groups (HIIE & MIIE groups) performed 6 sessions of interval exercise per week for 6 weeks. The spatial memory of rats was measured using the Morris water maze procedure. The malondialdehyde (MDA) levels and activity of catalase (Cat) as well as glutathione peroxidase (GPx) in hippocampus were determined using spectrophotometry method. The spatial learning and memory retention of the moderate-intensity interval exercise group was significantly better than that of the high-intensity interval exercise group. The GPx activity of MIIE group was higher than any other groups. The SO group had the lowest hippocampal MDA level and highest Cat activity among groups. Moderate-intensity interval exercise reduces the ovariectomy induced-oxidative stress in the hippocampus and improves spatial learning and memory retention of ovariectomized rats.
Co-Authors Achmad Rofi’i Adira Zahwa Ramadhina Alfi Yasmina Alfi Yasmina Alfyonika Oktaviani Br Bukit Alievia Febriyantiningrum F. Putri Alya Nabilahsaffa Maulidinna Amalia Rahman Asnawati Asnawati Asnawati Asnawati Azhari, Nazla Puteri Azma Rozida Azzahra, Wikha Budiarman, Andi Azizah Maulidia Cibro, Impana Darwis, Yulizar Denny Agustiningsih Dewi Indah Noviana Pratiwi Didik Dwi Sanyoto Dina Ananda Wulandari Dona Marisa Dona Marisa, Dona Dona Masrisa Effiyana, Arika Eka Yudha Rahman Erida Widyamala Farida Heriyani Fauzan Muttaqien Febriyanti, Annisa Putri Finna Rahmiati Firdaus, Muhammad Reyhan FX Hendriyono Ginus Partadiredja Gunma, San Haryati Haryati Hendriyono Hendriyono, Hendriyono Hendriyono, F X Heru Prasetya Huldani Huldani Huldani Huldani Huldani Huldani Husnul Khatimah Ida Yuliana Ihsanti, Shofia Hilwa Islami, Shafira Aulia Juhairina Juhairina Kanessha Winola Sunata Khan, Muhammad Fawwaz Khatimah, Husnul Lena Rosida Lena Rosida Lia Yulia Budiarti Lia Yulia Budiarti Marsetyawan HNE Soesatyo Mawarni, Khairida Muhammad Bari NurQaedi Muhammad Bayu Fernanda Muhammad Hasan Ridhoni Muhammad Hasbi Muhammad Marwan Muthmainah, Noor Nadya Salsabila Nasywa, Nabila Nazla Puteri Azhari Nazmyatus Sa’idah Noor Muthmainah Noor Rizka Yulia Rahmani Noorsyifa Safitri Tahir Nur Qamariah Nur Qamariah Nur Ramadhanti Cindy Levissa Oski Illiandri Oski Illiandri Putri Putri, Putri Rahmiati Rahmiati Raida Namira Rizky Nabila Febriani Rofi’i, Achmad Roselina Panghiyangani Rudiansyah, Syafina Dwiayu Ardelia Saidah Rauf Santrino, Syifa Nurafifah Sanyoto, Didik Dwi Septerini, Ditha Detiana Shelin Amanda Pusparesa Triana Norwidianti Wathan , Nashrul Zhasifa Khoirunnisa Suwanto