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Damayanti, Ria
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Pengaruh Pemberian Propolis terhadap Ekspresi INOS dan Kadar MDA pada Otak Tikus Model Cedera Otak Traumatik Damayanti, Ria; Fitri, Loeki Enggar; Dalhar, Mochamad
Jurnal Kedokteran Brawijaya Vol 29, No. 2 (2016)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jkb.2016.029.02.3

Abstract

Propolis memiliki aktivitas antioksidan dan antiinflamasi yang kuat, dengan menetralisir berbagai radikal bebas dalam tubuh seperti seperti ROS dan reactive nitrogen species (RNS) dan menurunkan ekspresi dari nitric oxide synthase (NOS) dan mencegah kerusakan DNA, sehingga propolis memiliki potensi sebagai alternatif terapi dalam menurunkan ekspresi iNOS dan menurunkan radikal bebas yang diukur melalui kadar MDA pada cedera otak traumatik. Penelitian ini bertujuan untuk menguji pengaruh pemberian propolis dalam berbagai dosis pada ekspresi iNOS dan MDA di otak tikus Rattus norvegicus model traumatik. Sampel dibagi menjadi 5 kelompok, yaitu: kontrol negatif, kontrol positif, kelompok model trauma dan diberi perlakuan propolis masing-masing dosis 50mg, 100mg, dan 200mg per kgBB/hari. Pada akhir penelitian, tikus dikorbankan dan dibuat preparat otak untuk menilai ekspresi iNOS dan kadar MDA. Berdasarkan hasil analisa statistik, didapatkan hubungan yang signifikan antara ekspresi iNOS dan kadar MDA otak tikus model traumatik dengan berbagai dosis propolis (secara berurutan, Kruskal Wallis p=0,001; ANOVA p=0,000 (p<0,05)). Penelitian ini membuktikan bahwa propolis berpengaruh dalam penurunan ekspresi iNOS dan kadar MDA di otak tikus model traumatik.Kata Kunci: Cedera otak traumatik, iNOS, MDA, propolis
PATTERN OF ANTI EPILEPTIC DRUG ADVERSE EFFECT IN TERTIARY REFERRAL HOSPITAL Damayanti, Ria; Husna, Machlusil; Mondiani, Yeni Quinta; Kurniawan, Shahdevi Nandar
MNJ (Malang Neurology Journal) Vol. 6 No. 2 (2020): July
Publisher : PERDOSSI (Perhimpunan Dokter Spesialis Saraf Indonesia Cabang Malang) - Indonesian Neurological Association Branch of Malang cooperated with Neurology Residency Program, Faculty of Medicine Brawijaya University, Malang, Indonesia

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Abstract

Background: Epilepsy is a major chronic neurological problem in the world. The goal of epilepsy therapy is seizure-free and without side effects. The emergence of side effects in patients with epilepsy will be its limitations that can cause the failure of epilepsy therapy. Therefore, it is necessary to do a simple descriptive study, which illustrates the pattern of side effects of anti-epileptic drugs that occur in people with epilepsy, so that later clinicians are more alert and can take preventative measures.Objective: Knowing the pattern of side effects of antiepileptic drugs at the Neurology Outpatient Clinic dr. Saiful Anwar hospital.Methods: This research is an observational descriptive study. Samples were taken by filling the questionnaire at the Neurology Outpatient Clinic dr. Saiful Anwar hospital. Demographic data in this study will be presented in the frequency distribution table. Chi Square test is used to determine the relationship of demographic data, also the pattern of therapy with the side effects that arise.Results: 93 epilepsy patients were involved in the study. More than 40% of patients experience side effects. The most common side effects appear in idiopathic epilepsy (30.1%). Based on the duration of epilepsy, the most side effects appear in epilepsy duration> 10 years (17.2%). However, from the results of the influence test using chi square, there was no significant difference between the duration of epilepsy with the appearance of side effects, even the type of epilepsy (p-value> 0.05). 28 patients who experience side effects, appear after the duration of use of AED 1 - 5 years. It was found that the duration of AED uses affected the emergence of side effects (p-value <0.05).Conclusion: Side effects occur in patients taking anti-epileptic drugs, and are related to the duration of drug use. This data can be used to increase the awareness of clinicians related to the emergence of side effects in patients who consume AED.
THE EFFECT OF DURATION OF ACETYLCHOLINE-ESTERASE INHIBITOR ON MMSE, CDT AND BARTHEL INDEX SCORING ON PATIENTS WITH VASCULAR DEMENSIA Rianawati, Sri Budhi; Damayanti, Ria; Al Rasyid, Harun; Megayasa, Nyoman Artha
MNJ (Malang Neurology Journal) Vol. 7 No. 2 (2021): July
Publisher : PERDOSSI (Perhimpunan Dokter Spesialis Saraf Indonesia Cabang Malang) - Indonesian Neurological Association Branch of Malang cooperated with Neurology Residency Program, Faculty of Medicine Brawijaya University, Malang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.mnj.2021.007.02.4

Abstract

Background: Vascular dementia is a cognitive decline with functional deterioration caused by cerebrovascular disease. It is the second leading cause of dementia. A number of screening questionnaires and models have been developed to help in assessing cognitive function and activity daily living (ADL) in patients with dementia. Mini Mental State Examination (MMSE), Clock Drawing Test (CDT) and Barthel Index are instruments to evaluate cognitive function and ADL of vascular dementia patients. Objective: To determine the role of achetylcholine-esterase inhibitor therapy on cognitive function and ADL in patients with vascular dementia in Saiful Anwar General Hospital.Methods: This study is an analytical study assessing the improvement of cognitive function and ADL of patients with vascular dementia after administration of acethylcholine-esterase inhibitor by assessing the MMSE, CDT and Barthel Index scoring in 1, 3, 6 and 12 month period consecutively.Results: From 15 study subjects, individuals who have been given treatment for 12 months consecutively have the highest increase in MMSE and CDT whilst for Barthel Index has shown highest improvement in one month period.Conclusion: The administration of acetylcholine-esterase inhibitor drugs has the potential to improve and maintain cognitive function and improve ADL. The limited number of study subjects and the many confounding factors that we did not evaluate were the drawbacks of this study. The results of this study cannot be generalized to all patients with vascular dementia and only apply to 15 patients who were the subjects of this study.
Penerapan Pembelajaran Berdiferensiasi Dengan Metode Inkuiri Terbimbing Terhadap Keaktifan Dan Hasil Belajar Damayanti, Ria; Dewi, Asih Fitriana
BIOMA: Jurnal Biologi dan Pembelajarannya Vol 6 No 1 (2024): BIOMA: Jurnal Biologi dan Pembelajarannya
Publisher : Universitas Sulawesi Barat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31605/bioma.v6i1.3516

Abstract

Kurangnya keaktifan peserta didik dapat menyebabkan rendahnya hasil belajar yang diperoleh peserta didik. Tujuan penelitian ini yaitu untuk meningkatkan keaktifan dan hasil belajar peserta didik kelas 11 Biologi 4 SMA Negeri 6 Metro dengan menerapkan pembelajaran berdiferensiasi serta metode inkuiri terbimbing khususnya pada materi sistem peredaran darah. Penelitian ini menggunakan penelitian tindakan kelas (PTK) yang berlangsung selama 2 siklus. Setelah menganalisis data, peneliti memperoleh hasil bahwa keaktifan klasikal peserta didik pada siklus I mencapai 59% dan pada siklus II mencapai 75%. Begitu pula pada hasil belajar peserta didik, persentase ketuntasan klasikal pada saat dilaksanakan pretest adalah 17%, kemudian pada siklus I terjadi peningkatan menjadi 41% dan pada siklus II ketuntasannya mencapai 83% atau mengalami peningkatan sebanyak 42% dari siklus I. Berdasarkan data hasil tersebut, dapat disimpulkan bahwa penerapan model pembelajaran berdiferensiasi dengan metode inkuri terbimbing dapat meningkatkan keaktifan dan hasil belajar peserta didik.
THE RELATIONSHIP BETWEEN IRON TABLET CONSUMPTION AND ANEMIA IN PREGNANT WOMEN IN SINTANG REGENCY, WEST KALIMANTAN Juliansyah, Elvi; Haryanti, Yunida; Masan, Lea; Damayanti, Ria
Multidisciplinary Indonesian Center Journal (MICJO) Vol. 2 No. 3 (2025): Vol. 2 No. 3 Edisi Juli 2025
Publisher : PT. Jurnal Center Indonesia Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62567/micjo.v2i3.929

Abstract

Anemia is a medical condition where the number of red blood cells or hemoglobin levels in the blood is below normal, which is a protein in red blood cells that functions to carry oxygen from the lungs to the entire body. The prevalence of anemia in pregnant women in Sintang Regency showed that in 2017 there were 116 cases, in 2018 there were 121 cases, and in 2019 there were 164 cases. This research method uses a quantitative analytical approach with a cross-sectional design in Sintang Regency. The population is all pregnant women registered as many as 369 respondents within the scope of the Health Center services in Sintang Regency during the data collection period. The simple random sampling technique was used to select respondents, with a sample size of 192 pregnant women after calculating the population size. The results showed that there was a relationship between knowledge with a p value = 0.000 and OR = 6.900, parity with a p value = 0.000 and OR = 5.040, consumption of iron tablets with a p value = 0.000 and OR = 5.271 with the incidence of anemia in pregnant women in Sintang Regency. The most dominant multivariate test result is knowledge with OR = 7.25 followed by consumption of iron tablets with OR = 4.61 and parity with OR = 4.26. The conclusion related to the incidence of anemia in pregnant women is knowledge, parity, and consuming iron tablets and the most dominant is knowledge and followed by consumption of iron tablets, and parity. It is recommended that pregnant women can improve their knowledge, multi and grandi para pregnant women to comply with consuming iron tablets routinely.   
Analisis Pelaksanaan Peran, Fungsi dan Wewenang Governing Body, dan Direktur di Rumah Sakit Dalam Upaya Peningkatan Manajemen Mutu Rudiansyah, Rudiansyah; Herman, Joni; Wagiran, Wagiran; Sardi, Aditiya; Rudi, Abil; Hasan, Akhmad; Nisa, Nurul Khoirun; Damayanti, Ria; Sohibun, Sohibun
SENTRI: Jurnal Riset Ilmiah Vol. 4 No. 7 (2025): SENTRI : Jurnal Riset Ilmiah, Juli 2025
Publisher : LPPM Institut Pendidikan Nusantara Global

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55681/sentri.v4i7.4198

Abstract

Healthcare services in hospitals involve a high level of complexity, making them prone to conflicts both within and outside the institution. The implementation of quality management still faces numerous obstacles, as evidenced by the lack of staff awareness regarding quality management, frequent conflicts, and unclear coordination, communication, and information pathways. This study aims to analyze the implementation of the roles, functions, and authorities of the governing body and the hospital director in quality management practices. The research design uses a descriptive method with a qualitative approach. The main informants are the governing body and the hospital director, while the triangulation informants include attending physicians, nurses, and the quality team leader. Data were collected through in-depth interviews and analyzed using content analysis. The results show that while the roles and functions of the governing body have been implemented, its authority has not been fully optimized. Likewise, the roles and authority of the director have been carried out, but the functions have not been optimally implemented. The study recommends allocating a budget for off-site training, creating guidelines for documentation and reporting, developing performance evaluation manuals, preparing evaluation checklists, and establishing internal satisfaction assessments.
Determinants Of The Incident Of Hypertension In The Working Area Of The New City Puskesmas, Melawi District, 2023 Damayanti, Ria; Dwi Saroso Libra Putra; Sohibun, Sohibun; Rika Yuanita Pratama; Sunarti, Sunarti
Jurnal EduHealth Vol. 14 No. 04 (2023): Jurnal eduHealt, 2023, December
Publisher : Sean Institute

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Abstract

Hypertension occurs when systolic and diastolic blood pressure is too high. Hypertension is a condition when measured on two different days, the systolic blood pressure reading on both days is ≥140 mmHg and/or the diastolic blood pressure reading on both days is ≥90 mmHg (WHO, 2019). Objective: To determine the determinants of hypertension in the work area of the Kota Baru Health Center, Melawi Regency. Method: This research was carried out using quantitative methods with a cross sectional design, a population of 15,872, and using the Stanley Lemeshow formula, 100 samples were obtained using the Portional Random Sampling sampling technique. The instrument used was a closed questionnaire by means of an interview. Data analysis was carried out using the Chi-Square test. Results: There is a relationship between Knowledge (p-value = 0.008, OR = 3.378 95%), Attitude (p-value = 0.016, OR = 3.114), Smoking Habits (p-value = 0.012, OR = 3.194) and Diet (p -value = 0.036, OR = 2.768) with the incidence of hypertension in the working area of the Kota Baru Health Center, Melawi Regency. Conclusion: There is a relationship between knowledge, attitudes, smoking habits and patterns with the incidence of hypertension in the work area of the Kota Baru Health Center, Melawi Regency. Suggestion: The community health center health promotion program can be more active in providing education to the people of Tanah Pinoh sub-district, especially to people with hypertension. Providing information regarding the need for counseling on the prevention of hypertension and programs related to health education in the adult population so that it can prevent an increase in the prevalence rate of hypertension.
Analisis Strategi Komunikasi Pemasaran Digital dalam Kegiatan Pemasaran Klub Olahraga Damayanti, Ria; Sari, Yunita; Prasetya, Hendri
Jurnal Dinamika Ilmu Komunikasi Vol 11, No 2 (2025)
Publisher : Universitas Prof. Dr. Moestopo (Beragama)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32509/dinamika.v11i2.6046

Abstract

XYZ is a sports club specializing in swimming and water polo training, primarily focusing on developing young athletes. In the digital era, the club utilizes social media as its main platform to promote services and enhance brand visibility among the public. This study aims to analyze the digital marketing communication strategies implemented by XYZ Sports Club and explore ways to optimize their effectiveness. The research adopts a post-positivist paradigm with a qualitative descriptive approach using a case study method. Data were collected through in-depth interviews with club managers, coaches, and members, as well as observation of digital activities across social media platforms. The findings reveal that XYZ has applied an integrated marketing communication framework encompassing five strategic principles: identification, individualization, interaction, integration, and integrity. However, the effectiveness of these strategies remains limited due to the absence of a structured customer feedback system and insufficient use of digital analytics. The study recommends strengthening data-driven evaluation mechanisms to enhance message personalization and improve the overall effectiveness of digital marketing communication in community sports organizations.
Co-Authors Asih Fitriana Dewi, Asih Fitriana Dalhar, Mochamad Dwi Saroso Libra Putra Elvi Juliansyah Harun Al Rasyid Haryanti, Yunida Hasan, Akhmad Herman, Joni Loeki Enggar Fitri Machlusil Husna, Machlusil Masan, Lea Mondiani, Yeni Quinta Nurul Khoirun Nisa Nyoman Artha Megayasa, Nyoman Artha Prasetya, Hendri Rika Yuanita Pratama Rudi, Abil Rudiansyah Sardi, Aditiya Shahdevi Nandar Kurniawan, Shahdevi Nandar Sohibun -, Sohibun Sri Budhi Rianawati, Sri Budhi Sunarti Wagiran Wagiran Yunita Sari