Garuda - Garba Rujukan Digital

Effects of topical hyaluronic acid on nasal mucosa wound healing Sabig, Lidya; Dewi, Anna Mailasari Kusuma; Hariyati, Riece; Karlowee, Vega; Septarina, Faiza Rizky Aryani
Oto Rhino Laryngologica Indonesiana Vol. 54 No. 2 (2024): VOLUME 54, NO. 2 JULY - DECEMBER 2024
Publisher : PERHATI-KL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32637/orli.v54i2.544

Background: Chronic rhinosinusitis (CRS) is a chronic inflammatory disease of the nasal and paranasal sinuses mucosa that takes place for more than 3 months. The treatment paradigm nowadays depends on Functional Endoscopic Sinus Surgery (FESS) in the hope to repair the damaged mucosa, restoring it to its physiological condition. Hyaluronic Acid (HA) could restore the natural barrier of the mucosa and stop the inflammatory cascade. Purpose: To understand the difference in the number of inflammatory cells in the post-FESS nasal mucosa in CRS patients that had been treated with HA. Method: This was pre and post-test, double-blinded, randomized control group study design of 22 CRS patients (range 18 to 55 years) in Dr. Kariadi General Hospital, Semarang from May to August 2019. All subjects had undergone biopsies of the inferior turbinate at the time of surgery and 4 weeks after surgery. The number of pre and post-test neutrophil, eosinophil and lymphocyte counts were compared between control and treatment groups. The neutrophil-to-lymphocyte ratio (NLR) and eosinophil-to- lymphocyte ratio (ELR) levels were also compared between the two groups. Data analysis was done using the Wilcoxon test. Result: When the pre and post-test treatment group and the control group were compared, no statistically significant difference was found between two groups except for ELR in the treatment group (p=0.028). Conclusion: ELR was decreased significantly in the treatment group. NLR level was also decreased but not significant. This study had shown that topical HA could positively modulate the inflammatory response. Keywords: chronic rhinosinusitis, FESS, histopathology, neutrophil, eosinophil, lymphocyte ABSTRAK Latar belakang: Rinosinusitis kronis (RSK) merupakan penyakit inflamasi kronik pada mukosa hidung dan sinus paranasal yang berlangsung lebih dari 12 minggu. Bedah Sinus Endoskopi Fungsional (BSEF) pada RSK bertujuan untuk memperbaiki mukosa yang rusak dan mengembalikannya ke kondisi fisiologis. Asam hyaluronat (AH) dapat mengembalikan penghalang alami mukosa dan menghentikan proses inflamasi. Tujuan: Untuk mengetahui perbedaan jumlah sel inflamasi pada mukosa hidung pasca BSEF pada pasien RSK yang diberikan terapi tambahan AH. Metode: Penelitian ini merupakan penelitian pre dan post-test, tersamar ganda, desain penelitian kelompok kontrol acak terhadap 22 pasien RSK (berusia 18 hingga 55 tahun) di RS Dr. Kariadi, Semarang dari bulan Mei hingga Agustus 2019. Semua subjek dilakukan biopsi konka inferior pada saat operasi dan 4 minggu setelah operasi. Jumlah neutrofil, eosinofil, dan limfosit sebelum dan sesudah terapi dibandingkan antara kelompok kontrol dan kelompok perlakuan. Rasio neutrofil terhadap limfosit (NLR) dan rasio eosinofil terhadap limfosit (ELR) juga dibandingkan antara kedua kelompok. Analisis data dilakukan dengan menggunakan uji Wilcoxon. Hasil: Hasil perbandingan kelompok perlakuan dan kelompok kontrol sebelum dan sesudah terapi, menunjukkan tidak ada perbedaan yang signifikan secara statistik antara kedua kelompok kecuali ELR pada kelompok perlakuan (p=0,028). Kesimpulan: ELR menurun secara signifikan pada kelompok perlakuan. Tingkat NLR juga menurun tetapi tidak signifikan. Penelitian ini menunjukkan bahwa AH topikal dapat secara positif memodulasi respon inflamasi. Kata kunci: rinosinusitis kronis, BSEF, histopatologi, neutrofil, eosinofil, limfosit

Risk Factors for Nasal Symptoms, Olfactory Disorders and Mucociliary Transport in Factory Workers Dewi, Anna Mailasari Kusuma; Kristyanto, Jarod Wahyu
Indonesian Journal of Medicine Vol. 10 No. 1 (2025)
Publisher : Masters Program in Public Health, Sebelas Maret University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26911/theijmed.2025.10.1.800

Background: Occupational exposure to a variety of individual chemicals has been associated with olfactory dysfunction, which is important for many occupational groups that rely on intact olfactory function to perform their jobs and for their safety. We aim to determine the risk factors for nasal symptoms, olfactory disorders and mucociliary transport in spice factory workers in Semarang. Subjects and Method: This was a cross-sectional study. A sample of 600 factory workers filled out the NOSE Scale and QOD-NS questionnaires, having their ears, nose, and throat examined, and calculated the time in which the participants tasted sweetness after being given saccharin to the inferior turbinate. The analysis used were univariate, bivariate and multivariate analysis. Results: Of 600 respondents, 52.2% were women, 87.8% had reported no nassal symptoms, 81.5% had normal NOSE scale, and 83.3% had normal mucociliary transport. Risk factors for nasal disorders, smell disorders, and mucociliary transport disorders were age ≥40 years old, male, smoking, longer exposure time, obesity, and PPE use. Conclusion: There is a significant association between occupational risk factors and nasal symptoms, olfactory disorders and mucociliary transport disorders. The most influential factor is discipline in using PPE to prevent nasal disorders, olfactory disorders and mucociliary transport disorders.

Fibrous Dysplasia in the Maxillary Bone: The Early Diagnosis of Progressive Pain with Facial Asymmetry Liemiyah, Rikha; Dewi, Anna Mailasari Kusuma; Antono, Dwi; Nugroho, Nur Iman; Muyassaroh, Muyassaroh; Kusumaningrum, Lely; Arsita, Cynthia
Indonesian Journal of Cancer Vol 19, No 1 (2025): March
Publisher : http://dharmais.co.id/

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33371/ijoc.v19i1.1316

Introduction: Fibrous dysplasia (FD) is a genetic, non-familial skeletal disorder, where in medullary bone is replaced by fibro-osseus tissue. Ninety percent of FD instances involve the craniofacial region, which usually involves one or more bones. The ethmoid, sphenoid, frontal, maxillary, and temporal bones are the most affected, but the maxilla is most affected. Misdiagnosis and inappropriate diversity in investigations and therapies are frequently caused by the disease’s rarity and varying presentation to other specialties. This study aims to analyze the signs, symptoms, and laboratory-radiology examinations of suspected FD patients at Dr. Kariadi General Hospital Semarang so that it can increase the sensitivity of medical personnel in establishing this diagnosis based on the symptoms and signs complained of by the patient.Case Presentation: A case series study assessing three patients diagnosed with FD of the maxillae between January and December 2021 at Dr. Kariadi General Hospital, Semarang. The study found 3 patients diagnosed with FD of the maxillae consisting of 2 males and 1 female. The initial complaints reported in all patients were progressive facial pain, thick sensation in the cheek area, and asymmetrical facial shape due to abnormal protrusions. Physical examination found an increase in facial volume with a hard consistency. CT scan evaluation obtained a sclerotic image with ground glass opacity in two patients and hyperostosis in one patient. Surgery with the Weber Ferguson technique was undergone by two patients, while one patient underwent the Weber Ferguson Technique + Zoledronic Acid for 6 cycles. Both patients who underwent Weber Ferguson technique surgery experienced recurrence related to symptoms in the form of pain and increased volume in the facial area within 2–4 weeks after surgery.Conclusions: Patients with complaints of progressive pain and asymmetrical shape in the facial area and physical examination found an increase in facial volume with hard consistency should be able to increase the suspicion of medical personnel regarding the diagnosis of FD. Further radiological examination with tissue histopathology should be performed to rule out or confirm the diagnosis of FD.

Effects of topical hyaluronic acid on nasal mucosa wound healing Sabig, Lidya; Dewi, Anna Mailasari Kusuma; Hariyati, Riece; Karlowee, Vega; Septarina, Faiza Rizky Aryani
Oto Rhino Laryngologica Indonesiana Vol. 54 No. 2 (2024): VOLUME 54, NO. 2 JULY - DECEMBER 2024
Publisher : PERHATI-KL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32637/orli.v54i2.544

Background: Chronic rhinosinusitis (CRS) is a chronic inflammatory disease of the nasal and paranasal sinuses mucosa that takes place for more than 3 months. The treatment paradigm nowadays depends on Functional Endoscopic Sinus Surgery (FESS) in the hope to repair the damaged mucosa, restoring it to its physiological condition. Hyaluronic Acid (HA) could restore the natural barrier of the mucosa and stop the inflammatory cascade. Purpose: To understand the difference in the number of inflammatory cells in the post-FESS nasal mucosa in CRS patients that had been treated with HA. Method: This was pre and post-test, double-blinded, randomized control group study design of 22 CRS patients (range 18 to 55 years) in Dr. Kariadi General Hospital, Semarang from May to August 2019. All subjects had undergone biopsies of the inferior turbinate at the time of surgery and 4 weeks after surgery. The number of pre and post-test neutrophil, eosinophil and lymphocyte counts were compared between control and treatment groups. The neutrophil-to-lymphocyte ratio (NLR) and eosinophil-to- lymphocyte ratio (ELR) levels were also compared between the two groups. Data analysis was done using the Wilcoxon test. Result: When the pre and post-test treatment group and the control group were compared, no statistically significant difference was found between two groups except for ELR in the treatment group (p=0.028). Conclusion: ELR was decreased significantly in the treatment group. NLR level was also decreased but not significant. This study had shown that topical HA could positively modulate the inflammatory response. Keywords: chronic rhinosinusitis, FESS, histopathology, neutrophil, eosinophil, lymphocyte ABSTRAK Latar belakang: Rinosinusitis kronis (RSK) merupakan penyakit inflamasi kronik pada mukosa hidung dan sinus paranasal yang berlangsung lebih dari 12 minggu. Bedah Sinus Endoskopi Fungsional (BSEF) pada RSK bertujuan untuk memperbaiki mukosa yang rusak dan mengembalikannya ke kondisi fisiologis. Asam hyaluronat (AH) dapat mengembalikan penghalang alami mukosa dan menghentikan proses inflamasi. Tujuan: Untuk mengetahui perbedaan jumlah sel inflamasi pada mukosa hidung pasca BSEF pada pasien RSK yang diberikan terapi tambahan AH. Metode: Penelitian ini merupakan penelitian pre dan post-test, tersamar ganda, desain penelitian kelompok kontrol acak terhadap 22 pasien RSK (berusia 18 hingga 55 tahun) di RS Dr. Kariadi, Semarang dari bulan Mei hingga Agustus 2019. Semua subjek dilakukan biopsi konka inferior pada saat operasi dan 4 minggu setelah operasi. Jumlah neutrofil, eosinofil, dan limfosit sebelum dan sesudah terapi dibandingkan antara kelompok kontrol dan kelompok perlakuan. Rasio neutrofil terhadap limfosit (NLR) dan rasio eosinofil terhadap limfosit (ELR) juga dibandingkan antara kedua kelompok. Analisis data dilakukan dengan menggunakan uji Wilcoxon. Hasil: Hasil perbandingan kelompok perlakuan dan kelompok kontrol sebelum dan sesudah terapi, menunjukkan tidak ada perbedaan yang signifikan secara statistik antara kedua kelompok kecuali ELR pada kelompok perlakuan (p=0,028). Kesimpulan: ELR menurun secara signifikan pada kelompok perlakuan. Tingkat NLR juga menurun tetapi tidak signifikan. Penelitian ini menunjukkan bahwa AH topikal dapat secara positif memodulasi respon inflamasi. Kata kunci: rinosinusitis kronis, BSEF, histopatologi, neutrofil, eosinofil, limfosit

Title

Found 14 Documents
Search

Abstract

Abstract

Abstract

Abstract

Title Search

Found 14 Documents Search

Abstract

Abstract

Abstract

Abstract

Title

Found 14 Documents
Search