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All Journal SAINS MEDIKA : JURNAL KEDOKTERAN DAN KESEHATAN Jurnal Kesehatan Masyarakat Journal of Health Education Indonesian Journal of Medicine Oto Rhino Laryngologica Indonesiana Medica Hospitalia Diponegoro International Medical Journal (DIMJ) Indonesian Journal of Cancer
Dewi, Anna Mailasari Kusuma
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Biochemistry, Genetics & Molecular Biology Dentistry Education Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health

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Case Series : Orbital Complications In Pediatric Rhinosinusitis Dewi, Anna Mailasari Kusuma; Iriani, Desy
Medica Hospitalia : Journal of Clinical Medicine Vol. 11 No. 1 (2024): Med Hosp
Publisher : RSUP Dr. Kariadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36408/mhjcm.v11i1.1073

Abstract

Introduction: Acute bacterial rhinosinusitis in children can cause orbital complications, either directly through fissures or indirectly through veins. Proper treatment can reduce morbidity due to orbital complications. Case: Two cases of orbital complications in pediatric acute bacterial rhinosinusitis caused by adenoid hypertrophy and dental infection. The first case of acute bacterial rhinosinusitis with periorbital cellulitis and left premaxillary abscess accompanied by adenoid hypertrophy and multiple pulp gangrene. The second case of acute bacterial rhinosinusitis with subperiosteal abscess accompanied by adenoid hypertrophy and multiple dental caries. Functional endoscopic sinus surgery (FESS), abscess drainage, adenoidectomy and odontectomy were performed. The culture results of the first patient were Streptococcus anginosus, and it was resistant to tetracycline. Meanwhile, the culture results of the second patient, Staphylococcus epidermidis, were resistant to amoxiclav, ampicillin, cefoxitin, oxacillin, penicillin G, and tetracyclin. Conclusion: Acute rhinosinusitis with orbital complications can caused by adenoid hypertrophy and dental infection. Medical treatment with adequate antibiotic followed by FESS, abscess drainage, adenoidectomy and odontectomy give an optimal result.
The Effect of Coenzym Q10 on Doxorubicin-induced Cardiotoxicity in Non Hodgkin's Lymphoma Patients Dewi, Julita Melisa; Antono, Dwi; Nugroho, Nur Iman; Yusmawan, Willy; Dewi, Anna Mailasari Kusuma
Medica Hospitalia : Journal of Clinical Medicine Vol. 11 No. 2 (2024): Med Hosp
Publisher : RSUP Dr. Kariadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36408/mhjcm.v11i2.1089

Abstract

BACKGROUND : Non-Hodgkin's Lymphoma is a primary malignancy in the Lymph Nodes and lymphoid tissue originating from B lymphocytes, T lymphocytes and Natural Killer (NK) cells. Therapy for Non-Hodgkin's Lymphoma chemotherapy can be given alone or combined with radioactive therapy. Doxorubicin is a chemotherapy drug used for lymphoma with side effects, one of which is cardiotoxic effects. AIMS :  To prove that coenzyme Q10 can reduce the cardiotoxic effect of doxorubicin chemotherapy in non-Hodgkin's lymphoma patients METHOD : Intervention study with a randomized pre and post test double blind control group design with 34 NHL patients undergoing chemotherapy. The treatment group received additional therapy with coenzyme Q10 300mg/day for 12 weeks while the controls received placebo. The cardiotoxic effects examined were assessed based on the results of Electrocardiography and Echocardiography. RESULT :  The treatment group with coenzyme Q10 supplementation after the 4th chemotherapy showed a decrease in echocardiography results in 3 patients (18%) and in the control group 17 patients (100%). There was a significant difference in the echocardiography results of the treatment and control groups (p=0.001). There were no drug side effects in both groups CONCLUSION : Coenzyme Q10 supplementation provides an improvement in the cardiotoxic effects of doxorubicin in non-Hodgkin's lymphoma patients, on echocardiography, but not on Electrocardiography.
The Association between Obstructive Sleep Apnea and Glycated Haemoglobin A1c (Hba1c) Level in Diabetes Mellitus Type II Patient Dewi, Anna Mailasari Kusuma; Handayani, Peny; Rachma, Devi Elvina; Limijadi, Edward Kurnia Setiawan
Diponegoro International Medical Journal Vol 3, No 2 (2022): December 2022
Publisher : Faculty of Medicine, Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dimj.v3i2.15191

Abstract

Abstract Background: Obstructive sleep apnea (OSA) is a chronic condition characterized by repetitive episodes of upper airway collapse, apnea, and arousal during sleep. OSA and type 2 diabetes mellitus (T2DM) are common comorbid conditions. Haemoglobin A1c (HbA1c) is an approximation of an individual’s average blood glucose level for the prior two to three months, and therefore is considered to be a major index for monitoring glycaemic control in diabetic patientsObjective: This study aimed to examine the association between OSA and HbA1c levels in T2DM patients.Methods: This was a cross-sectional study. The study assesses the association between OSA and HbA1c levels in 75 T2DM patients. OSA in the patient was asses with Epworth Sleepiness Scale (ESS) questionnaire. HbA1c values were obtained from the patient’s records. Data presented in mean ± SD, max, and min. Correlations analyses using Pearson correlation coefficient with p < 0.05 were considered statistically significant.Results: A total of 75 T2DM has a mean BMI were 25.26 ± 48.31 kg/m2 with mean HbA1c levels of about 7.1 ± 0.19%. The mean ESS score was 5 ± 0.429. The very weak correlation between OSA and BMI was statistically significant, r = 0.213; p = 0.047. Meanwhile, a very weak correlation between OSA and HbA1c levels was not statistically significant, r = 0.137; p = 0.242Conclusion: Among adults with T2DM, the correlation between OSA with HbA1c was not statistically significant
RISK FACTORS FOR SMELL AND TASTE DISORDER IN MILD AND MODERATE COVID-19 IN SEMARANG Dewi, Anna Mailasari Kusuma; Astika, Ismiar; Farokah, Farokah; yunika, kanti; Marliyawati, Dwi
Diponegoro International Medical Journal Vol 4, No 2 (2023): December 2023
Publisher : Faculty of Medicine, Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dimj.v4i2.17892

Abstract

ABSTRACK Background: COVID-19 can make smell and taste disorder due to Angitensin Converting Enzyme 2 (ACE2) binding to olfactory tractus and taste bud that affected by gender, age, comorbid and COVID-19 severerity.Aim: To analyze age, gender, comorbid and COVID-19 severity as risk factor for smell and or taste disorder in mild and moderate Covid -19 patient in SemarangMethods: Observational research used cross section design. Sample is COVID-19 patients age >10 years old with severity mild and moderate nonhospitalize that record on Health Center of Semarang City June – July 2021. Sampling metode using purposive sampling with secondary data. Association between variable analyze using Chi square or Fisher exact test, multivariate analyze with logistic regression.Results: Research on 4337 people, 2.0% smell disorder and 0.5% taste disorder. Prevalence COVID-19 mostly on women 50.5% and adult (20-60 years old) 82.5%. Risk factor gender, age and COVID-19 severity is not associated with smell and taste disorder on COVID-19 patients (p<0.05). Chronic liver disease as a risk factor only for smell disorder on COVID-19 patients (p 0.04, CI 3.029-786.993, RP 48.828). Conclusion: Chronic liver disease is a comorbid as a risk factor for smell disorder ini COVID-19 patients at Semarang. age, gender and other comorbid not as a risk factor for smell and or taste disorder. 
Effects of topical hyaluronic acid on nasal mucosa wound healing Sabig, Lidya; Dewi, Anna Mailasari Kusuma; Hariyati, Riece; Karlowee, Vega; Septarina, Faiza Rizky Aryani
Oto Rhino Laryngologica Indonesiana Vol. 54 No. 2 (2024): VOLUME 54, NO. 2 JULY - DECEMBER 2024
Publisher : PERHATI-KL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32637/orli.v54i2.544

Abstract

Background: Chronic rhinosinusitis (CRS) is a chronic inflammatory disease of the nasal and paranasal sinuses mucosa that takes place for more than 3 months. The treatment paradigm nowadays depends on Functional Endoscopic Sinus Surgery (FESS) in the hope to repair the damaged mucosa, restoring it to its physiological condition. Hyaluronic Acid (HA) could restore the natural barrier of the mucosa and stop the inflammatory cascade. Purpose: To understand the difference in the number of inflammatory cells in the post-FESS nasal mucosa in CRS patients that had been treated with HA. Method: This was pre and post-test, double-blinded, randomized control group study design of 22 CRS patients (range 18 to 55 years) in Dr. Kariadi General Hospital, Semarang from May to August 2019. All subjects had undergone biopsies of the inferior turbinate at the time of surgery and 4 weeks after surgery. The number of pre and post-test neutrophil, eosinophil and lymphocyte counts were compared between control and treatment groups. The neutrophil-to-lymphocyte ratio (NLR) and eosinophil-to- lymphocyte ratio (ELR) levels were also compared between the two groups. Data analysis was done using the Wilcoxon test. Result: When the pre and post-test treatment group and the control group were compared, no statistically significant difference was found between two groups except for ELR in the treatment group (p=0.028). Conclusion: ELR was decreased significantly in the treatment group. NLR level was also decreased but not significant. This study had shown that topical HA could positively modulate the inflammatory response. Keywords: chronic rhinosinusitis, FESS, histopathology, neutrophil, eosinophil, lymphocyte ABSTRAK Latar belakang: Rinosinusitis kronis (RSK) merupakan penyakit inflamasi kronik pada mukosa hidung dan sinus paranasal yang berlangsung lebih dari 12 minggu. Bedah Sinus Endoskopi Fungsional (BSEF) pada RSK bertujuan untuk memperbaiki mukosa yang rusak dan mengembalikannya ke kondisi fisiologis. Asam hyaluronat (AH) dapat mengembalikan penghalang alami mukosa dan menghentikan proses inflamasi. Tujuan: Untuk mengetahui perbedaan jumlah sel inflamasi pada mukosa hidung pasca BSEF pada pasien RSK yang diberikan terapi tambahan AH. Metode: Penelitian ini merupakan penelitian pre dan post-test, tersamar ganda, desain penelitian kelompok kontrol acak terhadap 22 pasien RSK (berusia 18 hingga 55 tahun) di RS Dr. Kariadi, Semarang dari bulan Mei hingga Agustus 2019. Semua subjek dilakukan biopsi konka inferior pada saat operasi dan 4 minggu setelah operasi. Jumlah neutrofil, eosinofil, dan limfosit sebelum dan sesudah terapi dibandingkan antara kelompok kontrol dan kelompok perlakuan. Rasio neutrofil terhadap limfosit (NLR) dan rasio eosinofil terhadap limfosit (ELR) juga dibandingkan antara kedua kelompok. Analisis data dilakukan dengan menggunakan uji Wilcoxon. Hasil: Hasil perbandingan kelompok perlakuan dan kelompok kontrol sebelum dan sesudah terapi, menunjukkan tidak ada perbedaan yang signifikan secara statistik antara kedua kelompok kecuali ELR pada kelompok perlakuan (p=0,028). Kesimpulan: ELR menurun secara signifikan pada kelompok perlakuan. Tingkat NLR juga menurun tetapi tidak signifikan. Penelitian ini menunjukkan bahwa AH topikal dapat secara positif memodulasi respon inflamasi. Kata kunci: rinosinusitis kronis, BSEF, histopatologi, neutrofil, eosinofil, limfosit
Risk Factors for Nasal Symptoms, Olfactory Disorders and Mucociliary Transport in Factory Workers Dewi, Anna Mailasari Kusuma; Kristyanto, Jarod Wahyu
Indonesian Journal of Medicine Vol. 10 No. 1 (2025)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26911/theijmed.2025.10.1.800

Abstract

Background: Occupational exposure to a variety of individual chemicals has been associated with olfactory dysfunction, which is important for many occupational groups that rely on intact olfactory function to perform their jobs and for their safety. We aim to determine the risk factors for nasal symptoms, olfactory disorders and mucociliary transport in spice factory workers in Semarang. Subjects and Method: This was a cross-sectional study. A sample of 600 factory workers filled out the NOSE Scale and QOD-NS questionnaires, having their ears, nose, and throat examined, and calculated the time in which the participants tasted sweetness after being given saccharin to the inferior turbinate. The analysis used were univariate, bivariate and multivariate analysis. Results: Of 600 respondents, 52.2% were women, 87.8% had reported no nassal symptoms, 81.5% had normal NOSE scale, and 83.3% had normal mucociliary transport. Risk factors for nasal disorders, smell disorders, and mucociliary transport disorders were age ≥40 years old, male, smoking, longer exposure time, obesity, and PPE use. Conclusion: There is a significant association between occupational risk factors and nasal symptoms, olfactory disorders and mucociliary transport disorders. The most influential factor is discipline in using PPE to prevent nasal disorders, olfactory disorders and mucociliary transport disorders.
Fibrous Dysplasia in the Maxillary Bone: The Early Diagnosis of Progressive Pain with Facial Asymmetry Liemiyah, Rikha; Dewi, Anna Mailasari Kusuma; Antono, Dwi; Nugroho, Nur Iman; Muyassaroh, Muyassaroh; Kusumaningrum, Lely; Arsita, Cynthia
Indonesian Journal of Cancer Vol 19, No 1 (2025): March
Publisher : http://dharmais.co.id/

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33371/ijoc.v19i1.1316

Abstract

Introduction: Fibrous dysplasia (FD) is a genetic, non-familial skeletal disorder, where in medullary bone is replaced by fibro-osseus tissue. Ninety percent of FD instances involve the craniofacial region, which usually involves one or more bones. The ethmoid, sphenoid, frontal, maxillary, and temporal bones are the most affected, but the maxilla is most affected. Misdiagnosis and inappropriate diversity in investigations and therapies are frequently caused by the disease’s rarity and varying presentation to other specialties. This study aims to analyze the signs, symptoms, and laboratory-radiology examinations of suspected FD patients at Dr. Kariadi General Hospital Semarang so that it can increase the sensitivity of medical personnel in establishing this diagnosis based on the symptoms and signs complained of by the patient.Case Presentation: A case series study assessing three patients diagnosed with FD of the maxillae between January and December 2021 at Dr. Kariadi General Hospital, Semarang. The study found 3 patients diagnosed with FD of the maxillae consisting of 2 males and 1 female. The initial complaints reported in all patients were progressive facial pain, thick sensation in the cheek area, and asymmetrical facial shape due to abnormal protrusions. Physical examination found an increase in facial volume with a hard consistency. CT scan evaluation obtained a sclerotic image with ground glass opacity in two patients and hyperostosis in one patient. Surgery with the Weber Ferguson technique was undergone by two patients, while one patient underwent the Weber Ferguson Technique + Zoledronic Acid for 6 cycles. Both patients who underwent Weber Ferguson technique surgery experienced recurrence related to symptoms in the form of pain and increased volume in the facial area within 2–4 weeks after surgery.Conclusions: Patients with complaints of progressive pain and asymmetrical shape in the facial area and physical examination found an increase in facial volume with hard consistency should be able to increase the suspicion of medical personnel regarding the diagnosis of FD. Further radiological examination with tissue histopathology should be performed to rule out or confirm the diagnosis of FD.
Co-Authors . Apriansyah Alamanda, Fathika Antono, Dwi Arsita, Cynthia Astika, Ismiar Budiarti, Rery Cahyani, Nastiti Dwi Dewi, Julita Melisa Edward Kurnia Setiawan Limijadi, Edward Kurnia Setiawan Farah Hendara Ningrum Farokah, Farokah Handayani, Peny Hariyati, Riece Iriani, Desy Israchmadi, Ardiga Kanti Yunika, Kanti Karlowee, Vega Kristyanto, Jarod Wahyu Kusumaningrum, Lely Liemiyah, Rikha Marliyawati, Dwi Muhammad Yusuf Muyassaroh Muyassaroh Nourma Wahyu Andriani Nugroho, Nur Iman Nurdopo Baskoro Priambada, Dody Pujo Widodo, Pujo Rachma, Devi Elvina Ruspita, Dian Ayu Sabig, Lidya sayuti, fajri imam Septarina, Faiza Rizky Aryani Widodo , Pujo Willy Yusmawan, Willy Yanuar Iman Santosa Yunika, Kanthi Zulfikar Naftali, Zulfikar