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Syafruddin Ilyas
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Investigation of 3% Binahong (Anredera cordifolia) Leaf Extract Nanogel on the Alveolar Bone Healing: BMP-2 Modulation in Rat Models Bernard, Bernard; Syafruddin Ilyas; Olivia Avriyanti Hanafiah
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 8 No. 7 (2024): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v8i7.1020

Abstract

Background: Alveolar bone healing relies on osteoblasts activity and differentiation, with bone morphogenetic protein-2 (BMP-2) playing a crucial regulatory role. Binahong leaf extract (BLE) has demonstrated efficacy in bone healing due to its rich phytochemical composition. Nanogel offers enhanced bioavailability and targeted release to effectively deliver therapeutic agents. This study aims to assess the impact of 3% BLE nanogel on BMP-2 expression in tooth extraction socket healing. Methods: Thirty male Wistar rat underwent anaesthesia for the extraction of their lower incisors to induce alveolar bone healing. Subjects were randomly assigned into treatment (BLE nanogel) and control (base nanogel) group. Five rats from each group were respectively sacrificed at 7, 14, and 28 days after procedures. BMP-2 expression was assessed by performing immunohistochemistry analysis using BMP antibody reagent. Data were analysed using chi-square. Results: The analysis of BMP-2 expression showed no significant difference between treatment and control groups on days 7, 14, and 28 (p>0,05). However, a subtle increase was observed in the treatment group throughout observation period. Conclusion: Application of 3% BLE nanogel may enhance the expression of BMP-2, even though it was not significantly increase. The findings underscore the complex interplay between Binahong leaf extract, nanogel and BMP-2 expression.
The Effect of Snakehead Fish (Channa striata) Extract on Dry Socket Wound Healing: TGF-β1 Expression in Rats Model HG, Afifah Ayuni; Syafruddin Ilyas; Olivia Avriyanti Hanafiah
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 8 No. 7 (2024): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v8i7.1035

Abstract

Background: Dry socket or alveolar osteitis is a condition characterized by the breakdown of blood clots due to excessive fibrinolysis activity, which disrupts the wound healing process. Consumption of nutrition-rich foods such as snakehead fish (Channa striata) rich in albumin, omega-3 fatty acids, vitamins, minerals, and striatin may accelerate delayed wound healing. This study aimed to analyze the role of snakehead fish extract on the expression of TGF-β1 in the healing of dry socket wounds after tooth extraction in Wistar rats. Methods: This study was an in vivo study with a posttest-only control group design. Forty-five Wistar rats were divided into five groups: snakehead fish extract groups with doses of 1/2, 1, 2, 4 times human dose, and a negative control. The lower left incisor teeth of the rats were extracted, then dry socket was induced with adrenaline using a paper point. On days 3, 7, and 14, TGF-β1 expression was assessed using immunohistochemical staining. Results: This study showed significant difference in TGF-β1 expression on days 3, 7, and 14. TGF-β1 expression was higher in the treatment groups than the control (p<0.05). Conclusion: Administration of snakehead fish extract increased TGF-β1 expression. These findings underline the complex interaction between snakehead fish extract and TGF-β1 expression.
THE EFFECT OF CELERY LEAF EXTRACT (APIUM GRAVEOLENS L.) ON TNF-Α, IL-6 AND MDA LEVELS IN HYPERPIGMENTED WISTAR RATS (RATTUS NOVERGIUS SP.) Dina R. Purba; Jekson M. Siahaan; Endy Juli Anto; Syafruddin Ilyas
Multidiciplinary Output Research For Actual and International Issue (MORFAI) Vol. 6 No. 3 (2026): Multidiciplinary Output Research For Actual and International Issue
Publisher : RADJA PUBLIKA

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Abstract

The objective of this study was to evaluate the anti-inflammatory effects of Celery leaf extract (Apium graveolens L.) on hyperpigmented Wistar rats (Rattus norvegicus sp.) induced by Azidothymidine (AZT). Celery leaves are known to contain bioactive compounds which may serve as potent anti-inflammatory and antioxidant agents. About 30 male Wistar rats were divided into five groups, including a positive control, a negative control, and groups treated with various doses (1%, 3% and 5%) of celery leaf extract. The study examined inflammation indicators such as MDA, TNF-α, and IL-6. Celery leaf extract significantly (P<0.001) reduced MDA, TNF-α, and IL-6 levels in rats, demonstrating its capacity to attenuate inflammation and oxidative stress produced by AZT. With the increase in celery leaf extract concentration from 1% to 5%, MDA, IL-6 and TNF-α levels decreased from 42.083 ± 3.49 to 28.277 ± 10.27 nmol/ml, 14.588 ± 3.38 to 4.539 ± 1.40 nmol/ml and 667.614 ± 143.41 to 326.920 ± 62.72 nmol/ml respectively. Histopathological examinations demonstrated improvements in skin tissues damaged by inflammation. The results indicate that an ethanol extract of celery leaves has the potential to be an efficient anti-inflammatory drug, notably in lowering AZT-induced inflammation and hyperpigmentation. Further research is required to explore its clinical applicability in controlling inflammatory diseases in human.
ANTI-MELANOGENIC PROPERTIES OF CELERY LEAF EXTRACT IN HYPERPIGMENTATION INDUCED BY AZIDOTHYMIDINE Dearni Damanik; Jekson M. Siahaan; Endy Juli Anto; Syafruddin Ilyas; Hadyanto L
Multidiciplinary Output Research For Actual and International Issue (MORFAI) Vol. 6 No. 3 (2026): Multidiciplinary Output Research For Actual and International Issue
Publisher : RADJA PUBLIKA

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Abstract

The purpose of this study is to examine the impact of ethanolic extract form Celery leaves (Apium graveolens L.) on hyperpigmented Wistar rats (Rattus norvegicus sp.) induced by Azidothymidine (AZT). Celery leaves are known to contain bioactive compounds which may serve as potent anti-inflammatory and antioxidant agents. About 30 male Wistar rats were divided into five groups, including a positive control, a negative control, and groups treated with various doses (1%, 3% and 5%) of celery leaf extract. The study examined inflammation indicators such as MDA, TNF-α, and IL-6. Celery leaf extract significantly (P<0.001) reduced MDA, TNF-α, and IL-6 levels in rats, demonstrating its capacity to attenuate inflammation and oxidative stress produced by AZT. With the increase in celery leaf extract concentration from 1% to 5%, MDA, IL-6 and TNF-α levels decreased from 42.083 ± 3.49 to 28.277 ± 10.27 nmol/ml, 14.588 ± 3.38 to 4.539 ± 1.40 nmol/ml and 667.614 ± 143.41 to 326.920 ± 62.72 nmol/ml respectively. Histopathological examinations demonstrated improvements in skin tissues damaged by inflammation. The results indicate that an ethanol extract of celery leaves has the potential to be an efficient anti-inflammatory drug, notably in lowering AZT-induced inflammation and hyperpigmentation. Further research is required to explore its clinical applicability in controlling inflammatory diseases in human.
Co-Authors . Suryati Ahri Maulida Bernard Bernard, Bernard Dearni Damanik Delyuzar, Delyuzar Dina R. Purba Eka Prasetiawan Emita Sabri Endang Sjamsudin Endy Juli Anto Erlintan Sinaga Hadyanto L Harry Agusnar Herti Folarida Hutajulu HG, Afifah Ayuni Hot Setiado Ibezaro Zega It Jamilah Jekson M. Siahaan Jernih Nurani Hulu Kesuma Wardani Nanin Triana Nursal Nurul Amalia Sofyan Olivia Avriyanti Hanafiah Panal Sitorus Riza, Ahyar Ronald Pasaribu Rosmayati Rosmayati Saharman Gea Salomo Hutahaean Sri Wardani Ummi Kalsum Yasmeini Yazir Yetty Machrina Zulfiani Zulfi