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All Journal Indonesian Journal of Urology Journal of Islamic Medicine Acta Biochimica Indonesiana Cendana Medical Journal Vision Science and Eye Health Journal Brawijaya Journal of Urology
Arley Sadra Telussa
Universitas Nusa Cendana
Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Public Health

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Perbandingan Efektivitas Ekstrak Daun Chromolaena Odorata Dan Povidone Iodine 10% Terhadap Kepadatan Kolagen Pada Luka Insisi Tikus Putih (Spraguedawley) Binsasi, Richarda Anggraini; Telussa, Arley Sadra; Damanik, Efrisca M
Cendana Medical Journal Vol 11 No 2 (2023): Cendana Medical Journal
Publisher : Universitas Nusa Cendana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35508/cmj.v11i2.13056

Abstract

Background: Wound is a discontinuity or damage in part of human tissue. The uses of traditional medicine for the treatment of wound were still commonly found in especially indonesia. One of the tradisional medicine is Cromolaena Odorata. Chromolaena odonarata may promote wound healing and also increases collagen expression. Povidone iodine was currently the standard treatment for wound and has an antiseptic effect. Aim: To understand the comparison of the effectivity of Chromolaena odonarata and Povione iodine 10% to collagen density in incision wound in white mice (Sprague dawley). Method: This is an experimental study with 4 groups which were the control group (P1) which was treated with Povidone iodine 10% and comparison group (P1,P2,P3) which was treated chromolaena odorata 10%,15% dan 20%. Collagen density was measured under the microscope using Nagaoka criteria. Data was analyzed using Kruskall Wallis analysis. Result: The result of this study was p value of p=0.609 (>0.05). Conclusion: The use of Chromolaena odonarata leaf extract and povidone iodine 10% did not showed any significant difference of effectivity in prior to collagen density in incision wound in white mice from Sprague dawley strain.
Perbandingan Efektivitas Ekstrak Daunn Kirinyuh (Chromolaena odorata) dan Povidone Iodine 10% Terhadap Angiogenesis Pada Luka Insisi Kulit Tikus Putih (Sprague dawley) Panjaitan, Yolanda Indah Wirijayanti; Telussa, Arley Sadra; Sihotang, Jojor Sadra
Cendana Medical Journal Vol 11 No 2 (2023): Cendana Medical Journal
Publisher : Universitas Nusa Cendana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35508/cmj.v11i2.13938

Abstract

Abstract Background: Wound is an injury or damage in the body tissue. The use of herb as traditional medicine for the treatment of wound was still commonly found. The siam weed leaf (Chromolaena odorata) is one of the herbs found in Indonesia which was still used as a traditional medicine for wound recovery. Siam weed leaf (Chromolaena odorata) has an effect in wound recovery and may increase angiogenesis. Povidone iodine 10% was currently the standard treatment for wound and has an antiseptic effect. Method: This is an experimental study. The mice was divided into 4 groups which were control group (P1) which was treated with Povidone iodine 10%, treatment group I (P2) which was treated with siam weed leaf (Chromolaena odorata) extract 10%, treatment group II (P3) which was treated with siam weed leaf (Chromolaena odorata) extract 15% and treatment group III (P4) which was treated with siam weed leaf (Chromolaena odorata) extract 20%. Angiogenesis was examined under microscope for angiogenesis count. Data was analyzed using the Kruskall Wallis test. Result: The result of this study showed the p value of p=0.294 (>0.05). Conclusion: Siam weed (Chromolaena odorata) leaf extract and Povidone iodine did not show any significant difference in effectivity to the angiogenesis in incision wound in Sprague dawley white mice.
A study on the hepatoprotective effect of turmeric (Curcuma longa) extract on the liver histopathology of albino rats induced by sodium diclofenac Hibur, Grasia Intan Praskawati; Amat, Anita Lidesna Shinta; Riwu, Magdarita; Telussa, Arley Sadra
Acta Biochimica Indonesiana Vol. 8 No. 1 (2025): Acta Biochimica Indonesiana
Publisher : Indonesian Society for Biochemistry and Molecular Biology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32889/actabioina.209

Abstract

Background: Diclofenac sodium, a widely used nonsteroidal anti-inflammatory drug (NSAID), causes significant hepatotoxicity through oxidative stress mechanisms. Turmeric (Curcuma longa L.), rich in curcuminoid antioxidants, may offer hepatoprotection. Objective: To evaluate the hepatoprotective effects of turmeric extract against diclofenac sodium-induced liver injury in rats. Methods: Twenty-eight male Sprague Dawley rats were randomly divided into four groups (n=7): normal control, negative control (diclofenac sodium 10 mg/kg BW for 7 days), and two treatment groups receiving diclofenac sodium followed by turmeric extract at 100 or 200 mg/kg BW for 14 days. Liver histopathology was assessed using hematoxylin-eosin staining. Data were analyzed descriptively. Results: Turmeric extract attenuated hepatocellular damage in a dose-dependent manner. The 200 mg/kg BW dose completely prevented necrosis, demonstrating superior hepatoprotection compared to 100 mg/kg BW. Conclusion: Turmeric extract exerts hepatoprotective effects against diclofenac-induced liver injury through attenuation of histopathological damage.
Percutaneous Nephrolithotomy For Staghorn Stones: A Minimally Invasive Approach In A Region With Elevated Kidney Stone Risk Putera, Dewa Gede Agung Sasmara; Ariandy, Zaky; Telussa, Arley Sadra
Cendana Medical Journal Vol 13 No 2 (2025): Cendana Medical Journal
Publisher : Universitas Nusa Cendana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35508/cmj.v13i2.22406

Abstract

A 41-year-old male with a 2-month history of left-sided abdominal pain and renal stones was treated at Prof. W. Z. Johannes Hospital, East Nusa Tenggara, Indonesia. The patients’ primary drinking water sources were rivers and refillable bottles, which elevated the risk of kidney stones. Plain radiography and MSCT imaging revealed a 5 cm x 3.5 cm staghorn stone in the left kidney. Percutaneous nephrolithotomy (PCNL) was performed in the supine position using the C-arm. A nephroscope was inserted through a small incision to visualize and extract the stone. Post-extraction, C-arm imaging assessed the kidney, and a nephrostomy tube was placed for drainage. Staghorn stones are large, branched stones that occupy much of the renal pelvis or calyces. The European Association of Urology (EAU) recommends PCNL as the first-line treatment for staghorn stones due to its high efficacy and low morbidity. PCNL, a minimally invasive approach, offers high stone-free rates, up to 95%, making it effective for stones over 20 mm. The patient's successful outcome highlights the efficacy of PCNL in managing staghorn stones, especially in areas with a high risk of kidney stones due to poor water quality. Early diagnosis and treatment avert severe complications such as recurrent infections and urosepsis.
In Vitro Antibacterial Activity Test of Ethanolic Extract of Kersen (Muntingia calabura L.) Leaves Against the Growth of Escherichia coli Angsar, Abigail Eugelia Veterine; Nurina, Rr Listyawati; Adang, Gottfrieda Patiencia Taeng-Ob; Telussa, Arley Sadra
Cendana Medical Journal Vol 13 No 2 (2025): Cendana Medical Journal
Publisher : Universitas Nusa Cendana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35508/cmj.v13i2.27195

Abstract

Background: Diarrhea is a global health problem that causes millions of deaths every year. Treating diarrhea often involves the use of antibiotics, but antibiotic resistance is a serious problem. Cherry plants (Muntingia calabura L.) has been used traditionally to treatt infections . This research can provide new insights regarding the potential of using cherry plants as an alternative for treating bacterial infections without relying only on antibiotics. Objective: To determine the antibacterial activity of ethanol extracts from the cherry leaves (Muntingia calabura L.) against the Escherichia coli growth. Methods: This research is using a true experimental method with a post-test only control group design. The bacteria used is Escherichia coli with 8 treatment groups, the positive control group using ciprofloxacin, the negative control group using sterile aquadest, and six concentrations of cherry leaf extract treatment groups. The data was analyse with One Way Anova test. Results and Discussion: Inhibition zones produced at the concentrations of 100%, 50%, 25%, 12.5%, 6.25%, 3.125% measuring 15.39 mm ; 14.02 mm; 11.82 mm; 10.82 mm; 9.64 mm; 8.32 mm , indicating strong to moderate antibacterial effects. Conclusion: Ethanol extracts of cherry leaves (Muntingia calabura L.) exhibit antibacterial activity against Escherichia coli in vitro. Keywords: Ethanol Extracts from Cherry Leaves, Antibacterial Activity, Escherichia coli, in vitro.
Co-Authors Adang, Gottfrieda Patiencia Taeng-Ob Angsar, Abigail Eugelia Veterine Anita Lidesna Shinta Amat Ariandy, Zaky Binsasi, Richarda Anggraini Bi’i, Gaudensia Rosa Mistika Bria Seran, Maria Jozilyn Cindy Marie Agnes Lorenza Aurelia Edon Damanik, Efrisca M Djungu, Epafroditus M.K Doddy M Soebadi Ephram Sanders Alfian Siadary Ephram Sanders Alfian Siadary Folamauk, Conrad Liab Hendricson Fransiska Roslinda Dua Neang Goller, Ardito Ario Willy Hibur, Grasia Intan Praskawati Hyasinta Arlette Nikita I Putu Fandy Artha Gunawan Kartini Lidia Kause, Eureka Y. Koamesah, Sangguana Marthen Jacobus Kresnawati Wahyu Setiono Lidia, Kartini Lukman Hakim Malelak, Elric Brahm Manek, Balthasar Kristoforus Maria Agnes Etty Dedy Mawikere, Stevanikov J.M. Nurina, Rr. Listyawati Paceli, Verena Panjaitan, Yolanda Indah Wirijayanti PRISCA DEVIANI PAKAN Purba, Julya Dasura Putera, Dewa Gede Agung Sasmara Riwu, Magdarita Sagabulang, Gilberth Umbu Kaledi Salsabila, Daffa Annora Setianingrum, Elisabeth Levina Setianingrum, Elisabeth Levina Sari Setiawan, I Made Buddy Sihotang, Jojor Sadra Sunarno, Martinus Ezra Wardana, I Gede Aprilian I Wea, Aulia Rahmah Wijaya, Adrianus Gupta Wora Wora, Marguerita Merpati Octaviani Wungouw, Herman Pieter L