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All Journal Majalah Kedokteran Nusantara The Journal Of Medical School Indonesian Journal of Cardiology ACI (Acta Cardiologia Indonesiana) Sumatera Medical Journal Contagion: Scientific Periodical Journal of Public Health and Coastal Health Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML) Heart Science Journal Narra J Journal of Endocrinology, Tropical Medicine, and Infectious Disease (JETROMI) Jurnal Al Ulum: LPPM Universitas Al Washliyah Medan The Journal of Society Medicine (JSOCMED) Jurnal Penyakit Dalam Indonesia
Hasan, Refli
Division Of Cardiology Of Department Of Internal Medicine, Faculty Of Medicine, Universitas Sumatera Utara
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Economics, Econometrics & Finance Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Mechanical Engineering Medicine & Pharmacology Neuroscience Public Health

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Journal : Narra J

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Proprotein convertase subtilisin/kexin type 9 (PCSK9) as a marker of coronary lesion severity in stable coronary artery disease (CAD) patients Andra, Cut A.; Rambe, Aldy S.; Hasan, Refli; Sembiring, Rosita; Firman, Doni; Eyanoer, Putri C.; Mukhtar, Zulfikri; Sungkar, Taufik; Rusda, Muhammad; Amin, Mustafa M.
Narra J Vol. 3 No. 3 (2023): December 2023
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v3i3.409

Abstract

Coronary artery disease (CAD) remains a significant global health concern with considerable high morbidity and mortality and its development is influenced by various genetic and environmental factors. Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a vital regulator of low-density lipoprotein receptor (LDLR) metabolism, directly impacting serum cholesterol levels. However, its role in development of CAD is not fully understood. The aim of this study was to assess the association between the level of PCSK9 and coronary lesion severity in patients with CAD. A case-control study using consecutive sampling was conducted among CAD patients at H. Adam Malik General Hospital and Murni Teguh Memorial Hospital, Medan, Indonesia. A total of 200 CAD patients were divided into two groups based on the SYNTAX score: control (score ≤22, n=100) and case (score >22, n=100). Plasma PCSK9 levels were measured from venous blood using quantitative sandwich enzyme immunoassay. The Chi-squared test was used to analyze the data. Our data suggested that PCSK9 level was associated with coronary lesion severity (p<0.001) of which high PCSK9 level was associated with severe coronary lesion. We also found that hypertension (p<0.001), smoking (p=0.072), diabetes (p<0.001), dyslipidemia (p<0.001), obesity (p=0.023), and family history (p=0.001) were associated with lesion severity. Using the receiver operating characteristic (ROC) curve analysis, the cut-off 70.35 ng/mL of PCSK9 had sensitivity 75% and specificity 78% to predict severe coronary lesion. This study highlights that PCSK9 level has moderate sensitivity and specificity to predict the coronary lesion severity among CAD patients.
Co-Authors -, Maulinda Putri A. Afif Siregar A. Afif Siregar Abdul Halim Raynaldo Ahmad, Herwindo Akbar, Nizam Zikri Aldino Satria Adhitya Ali Nafiah Nasution Ali Nafiah Nasution Amin, Mustafa M. Andra, Cut A. Andra, Cut Aryfa Andra, Cut Aryfa Angelina, Marcellia Anggia C Lubis Ardini, Tengku Winda Ashrinda, Dika Assania, Rizka Farahin Baginda Yusuf Siregar Bertha Gabriella Napitupulu Cut Aryla Andra Dalimunthe, Naomi Niari Daulay, Elvita Rahmi Doni Firman Dudut Tanjung Effendy, Elmeid Eyanoer, Putri C. Harris Hasan Harris Hasan Harris Hasan Hasan, Harris Hasan, Harris Hasan, Harris Herman William Parlindungan Hutapea, Mery Natalia Ilyas, Kamal Kharrazi Karo, Kartika br Kesumawardani, Enggar Sari Ketaren, Andre Pasha Ketaren, Andre Pasha Khairul, Andi Khairunnisah, Dina Lubis, Anggia Chairuddin Mardianto Masrul Lubis Muhtar, Zulfikri Mukhtar, Zulfikri Muttaqien, Chairiza Nasution, Ali Nafiah Nizam Akbar Nizam Akbar Nizam Zikri Akbar Nurwijayanti Opim Salim Sitompul Permatasari, Ranti Pratiwi, Harvinda Arya Purba, Antonius Leonardo Purba, Joy Wulansari Putra, Muhammad Hafiz Mahruzza Rahmad Isnanta Rahmad Isnanta, Rahmad Rambe, Aldy S. Ramzi, Defriyan Ratna Akbari Ganie, Ratna Akbari Raynaldo, Abdul Halim Realsyah, T Reynaldo, Abdul Halim Rusda, Muhammad Safri, Zainal Sarastri, Yuke Sembiring, Rosita Sheila Dhiene Putri Siahaan, Basten Jeremiah Siallagan, Delpiana Sinaga, Akbar Siregar, Abdullah Afif Siregar, Jelita Siregar, Muhammad Harmen Reza Sitepu, Andika Sumbayak, Novra Christy Grace Tamba, Ratna Mariana Tanjung, Yulisa Astari Taufik Sungkar, Taufik Taufik, Yasdika Imam Teti Hariani Pane Teuku Bob Haykal Yusrina Saragih Zainal Safri Zainal Safri Zulfikri Mukhtar Zulfikri Mukhtar