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FORMULASI HAIR TONIC KOMBINASI EKSTRAK BUNGA SEPATU (Hibiscus rossa sinensis L.) DAN DAUN SELEDRI (Apium graveolens L.) SEBAGAI PERANGSANG PERTUMBUHAN RAMBUT PADA KELINCI (New Zealand White) Qurrota'Ain, Rusyda; Wicahyo, Septian Maulid; Fitriawati, Anna
Jurnal Buana Farma Vol. 5 No. 3 (2025): Jurnal Buana Farma : Jurnal Ilmiah Farmasi
Publisher : Fakultas Farmasi Universitas Buana Perjuangan Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36805/jbf.v5i3.1515

Hair plays an essential role not only as protection for the scalp but also as an aesthetic element that influences appearance. One way to maintain hair health is through the use of hair tonic, a liquid cosmetic preparation formulated to care for and stimulate hair growth. This study aimed to formulate and evaluate the effectiveness of a hair tonic combining hibiscus (Hibiscus rosa-sinensis L.) and celery (Apium graveolens L.) extracts, both of which are traditionally recognized for their bioactive compounds that promote hair growth. The extracts were obtained by maceration using 96% ethanol and formulated into three concentration variations: F1 (2.5%:7.5%), F2 (5%:5%), and F3 (7.5%:2.5%). The experiment was conducted using male New Zealand White rabbits, with hair growth observed for 28 days, while physical quality parameters such as organoleptic properties, homogeneity, pH, and viscosity were also evaluated. The results showed that all formulas met the physical quality requirements of hair tonic, but differences in effectiveness were observed between formulas. Formula II (5%:5%) produced the most optimal effect, with an average hair length of 16.86 mm, outperforming Formula I (15.39 mm) and Formula III (13.39 mm), and approaching the positive control (17.89 mm). These findings highlight that the balanced combination of hibiscus and celery extracts provides a synergistic effect on hair growth. In conclusion, the formulated hair tonic not only demonstrated stability and compliance with physical standards but also offers novelty as a natural alternative that may be safer than synthetic minoxidil-based products.

Antioxidant Activity of Nipa Palm (Nypa fruticans Wurmb) Leaf Ethanol Extract: Analysis Based on DPPH Radical Scavenging and FRAP Reducing Power Assays Permata, Bangkit Riska; Wicahyo, Septian Maulid; Raharjo, Danang
Proceeding of the International Conference Health, Science And Technology (ICOHETECH) 2025: Proceeding of the 6th International Conference Health, Science And Technology (ICOHETECH)
Publisher : LPPM Universitas Duta Bangsa Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47701/gwn3sv88

Background: The search for natural antioxidants as alternatives to synthetic ones is crucial due to safety concerns. Nipa palm (Nypa fruticans Wurmb) leaf, an abundant mangrove waste product in Indonesia, is a potential source of natural antioxidants but remains understudied, particularly regarding its reducing power capacity. Objective: This study aimed to evaluate the antioxidant activity of nipa palm leaf ethanol extract through two mechanisms: free radical scavenging activity (DPPH method) and ferric reducing antioxidant power (FRAP method).Methods: Dried nipa leaf powder was macerated with 70% ethanol. The antioxidant activity was determined by the DPPH method to obtain the IC?? value and by the FRAP method to measure the reducing power expressed as µM Fe(II) equivalent per gram of extract. Vitamin C and Quercetin were used as standards for the DPPH and FRAP assays, respectively.Results: The extraction yield was 15%. The nipa leaf extract exhibited very strong antioxidant activity with an IC?? value of 42.08 µg/mL in the DPPH assay. Furthermore, the FRAP assay confirmed its potent reducing capacity, with a value of 2850.50 µM Fe(II)/g extract.Conclusion: The ethanol extract of nipa palm leaves demonstrates potent antioxidant activity through both free radical scavenging and reducing power mechanisms. These findings suggest that nipa leaf, currently an underutilized waste product, is a promising source of natural antioxidants for potential applications in the food, cosmetic, and pharmaceutical industries.

Antioxidant Activity of Weeping Fig (Ficus benjamina L.) Leaf Extract: A Comparative Analysis Using ABTS and FRAP Assays Wicahyo, Septian Maulid; Raharjo, Danang; Permata, Bangkit Riska
Proceeding of the International Conference Health, Science And Technology (ICOHETECH) 2025: Proceeding of the 6th International Conference Health, Science And Technology (ICOHETECH)
Publisher : LPPM Universitas Duta Bangsa Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47701/4rwtq796

Ficus benjamina L. (weeping fig) has been traditionally used in folk medicine, but its antioxidant potential remains scientifically underexplored. This study aimed to comprehensively evaluate the in vitro antioxidant activity of a 70% ethanolic extract of F. benjamina leaves using two assays. The extract was prepared by maceration and subjected to phytochemical screening. Antioxidant activity was assessed through the ABTS radical scavenging assay, reported as IC?? and Trolox equivalents (TE), and the FRAP reducing power assay, reported as FeSO? equivalents (FE). Phytochemical analysis revealed abundant flavonoids, phenolics, and tannins. The extract demonstrated potent antioxidant activity, with an IC?? of 28.4 ?g/mL in the ABTS assay and a value of 412.3 mg TE/g. The FRAP assay confirmed strong reducing power, with a value of 1850.6 ?mol FE/g. A very strong positive correlation (r = 0.978) was found between the results of the two assays. While less potent than pure ascorbic acid, the extract's activity is significant for a plant extract. The 70% ethanolic extract of F. benjamina leaves possesses substantial in vitro antioxidant activity, attributed to its high phenolic and flavonoid content. The strong correlation between ABTS and FRAP results indicates complementary antioxidant mechanisms.

ANTIHYPERGLYCEMIC ACTIVITY, IMPROVING ENZIMATIC ANTIOXIDANT ACTIVITY OF ETHYL ACETATE FRACTION FROM KERSEN LEAVES (Muntingia calabura) ON INDUCED STREPTOZOTOSIN-NICOTINAMIDE RAT Wicahyo, Septian Maulid; Pratama, Kharisma Jayak
Duta Pharma Journal Vol. 4 No. 1 (2024): DUTA PHARMA JOURNAL
Publisher : Universitas Duta Bangsa Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47701/djp.v4i1.3811

Balance blood glucose concentration and antioxidant activity are keys to prevent Diabetes Melitus and its complications. Kersen leaves (Muntingia calabura) a plant that have empirical usage for reducing glucose blood that can do both. Purposes of this study were for observing ethyl acetate fraction from kersen leaves effects in reducing blood glucose, improving enzim antioxidant SOD and GPx activity, reducing MDA concentration and Î² cell regeneration. Forty two Wistar male white rats of 8 weeks with weight 150-250 g were made diabetes with streptozotosin-nicotinamide and randomly divided into 7 groups. Group I as normal rats, group II diabetic rats, group III diabetic with glibenclamid treatment, group IV and V diabetic rat treated by ethil acetate fraction 250 dan 350 mg/kg BW respectively. treatment had done orally once a day within 18 days. Blood glucose was measured on the 1st, 4th, 11th and 18th day. Ethyl acetate fractions significantly decreased blood glucose concentration, improved SOD and GPx activity, reduced MDA concentration and regenerated pancreatic Î²-cell also occured. In conclusion, ethyl acetate fraction have antihyperglycemic activity, ameliorates enzimatic antioxidant activity and can induce Î² cell regeneration.

FORMULASI SEDIAAN GEL EKSTRAK ETANOL DAUN KEMANGI (Ocimum sanctum L.) DENGAN AMYLUM MANIHOT SEBAGAI GELLING AGENT Wicahyo, Septian Maulid; Fauzi Rifqi Pramita
Duta Pharma Journal Vol. 4 No. 1 (2024): DUTA PHARMA JOURNAL
Publisher : Universitas Duta Bangsa Surakarta

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Basil leaves (Ocimum sanctum L.) contain bioactive compounds such as flavonoids, tannins, and saponins that have the potential as antibacterials and antioxidants. This study aims to formulate a gel preparation of basil leaf ethanol extract with manihot starch as a gel-forming agent, and to evaluate the physical characteristics and stability of the gel. The results showed that the formula with a concentration of 3% manihot starch gave optimal results in viscosity, pH, and gel spreadability. Stability tests showed that the gel remained stable during 28 days of storage at room temperature. This study proves the potential use of manihot starch as a natural alternative in gel formulation.

Formulasi Sediaan Lotion Tabir Surya Daun Pucuk Merah (Syzygium Oleana) dan Penentuan Nilai SPF dengan Spekrofotometri UV-VIS Nadzifah, Ifah; Wicahyo, Septian Maulid; Apriliawan, Hidayah
Jurnal Pendidikan Tambusai Vol. 9 No. 3 (2025): Desember
Publisher : LPPM Universitas Pahlawan Tuanku Tambusai, Riau, Indonesia

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Lotion tabir surya merupakan sediaan kosmetik yang berfungsi untuk melindungi kulit dari paparan sinar ultraviolet (UV). Daun pucuk merah (Syzygium oleana) diketahui berpotensi sebagai antioksidan alami dan memiliki kemampuan menyerap sinar UV. Penelitian ini bertujuan mengetahui aktivitas antioksidan ekstrak daun pucuk merah, dengan metode DPPH, mengetahui sifat fisik sediaan lotion (organoleptik, homogenitas, pH, daya sebar, daya lekat, dan tipe emulsi), serta menentukan nilai Sun Protection Factor (SPF) dari lotion yang diformulasikan dengan variasi konsentrasi ekstrak sebesar 1 %, 3 %, 5 %. Ekstraksi dilakukan secara maserasi menggunakan pelarut etanol 70%. Penilaian aktivitas antioksidan dilakukan dengan metode DPPH dan nilai SPF dianalisis secara in vitro menggunakan spektrofotometer UV-Vis pada panjang gelombang 290–320 nm termasuk kategori UV-B. Hasil menunjukkan bahwa ekstrak daun pucuk merah memiliki aktivitas antioksidan yang termasuk dalam kategori kuat Aktivitas antioksidan sediaan lotion tabir surya Formula 0, I, II, dan III menunjukkan nilai aktivitas antioksidan dengan nilai IC50 yaitu 105,06 ppm (sedang), 72,50 ppm (kuat), 66,99 ppm (kuat) dan 64,77 ppm (kuat) . Seluruh formula lotion menunjukkan sifat fisik yang memenuhi syarat mutu kosmetik. Nilai SPF lotion meningkat seiring peningkatan konsentrasi ekstrak, dengan kategori proteksi yang bervariasi lotion ekstrak daun pucuk merah pada Formula 0, I, II dan III yaitu 6,537 (sedang), 7,359 (ekstra), 22,99 (ultra) dan 30,00 (ultra). Kesimpulan dari penelitian ini adalah ekstrak daun pucuk merah dapat diformulasikan sebagai sediaan lotion yang kuat pada uji antioksidan dan memiliki nilai SPF yang ekstra dan ultra pada uji nilai SPF dengan spektrofotometer UV-Vis.

FORMULASI DAN UJI EFEKTIVITAS ANTIBAKTERI SEDIAAN MOUTHWASH DARI EKSTRAK DAUN KEMANGI (Ocimum x africanum L.) TERHADAP BAKTERI Staphylococcus aureus Voen-Na, Cut Dara; Wardani, Tatiana Siska; Wicahyo, Septian Maulid
JIFI (Jurnal Ilmiah Farmasi Imelda) Vol. 8 No. 2 (2025): JIFI (Jurnal Ilmiah Farmasi Imelda)
Publisher : Universitas Imelda Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52943/jifarmasi.v8i2.1856

The oral cavity is susceptible to bacterial infections because it has direct exposure to the outside environment, one of which is Staphylococcus aureus, which can cause oral health problems. The use of mouthwash as an additional treatment helps maintain optimal oral hygiene. Basil leaves (Ocimum x africanum L.) contain secondary metabolite compounds that have the potential to inhibit the growth of S. aureus. This study aims to determine the physical quality test of mouthwash of basil leaf extract and test its antibacterial effectiveness against S. aureus. This research method is laboratory experimental. Basil leaf simplicia powder (Ocimum x africanum L.) is macerated with 96% ethanol. Mouthwash formulations are made in concentrations of 4%, 6%, 8%, and 10%. Testing was carried out using the disc diffusion method to assess the antibacterial effectiveness against S. aureus ATCC 25923. Physical quality tests are also carried out on mouthwash preparations. The data from the antibacterial test results were analyzed using the One-Way ANOVA method. The results showed that the mouthwash preparation formula of basil leaf extract had good physical quality in terms of organoleptics, pH, specific gravity, viscosity, and clarity. The results of the statistical test showed a significant difference in the diameter of each group (P<0.05); mouthwash preparation at F4 (10%) had an inhibitory power against S. aureus bacteria of 8.46 mm with a bacterial inhibition zone of the medium category.

Pelatihan Pembuatan Reed Diffuser Berbasis Limbah Kulit Jeruk peras untuk Mendukung Ekonomi Sirkular di SMA Islam 1 Surakarta Bagas ardiyantoro; Triana Triana; Septian Maulid Wicahyo
Jurnal Pengabdian Bersama Masyarakat Indonesia Vol. 4 No. 3 (2026): Juli : : Jurnal Pengabdian Bersama Masyarakat Indonesia
Publisher : CV. Aksara Global Akademia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59031/jpbmi.v4i3.843

Limbah kulit Jeruk peras , yang sering dibuang dan menimbulkan masalah lingkungan, sebenarnya memiliki potensi besar untuk dimanfaatkan kembali. Kulit Jeruk peras mengandung minyak atsiri yang dapat diolah menjadi reed diffuser, pengharum ruangan alami yang ramah lingkungan. Namun, pengetahuan masyarakat tentang pemanfaatan kulit Jeruk peras masih terbatas. Siswa SMA, sebagai generasi muda yang sedang mempersiapkan diri untuk dunia kerja atau wirausaha, dapat memainkan peran penting dalam mengembangkan inovasi ini. Melalui pendidikan dan pelatihan, siswa SMA dapat mempelajari proses pembuatan reed diffuser dari kulit Jeruk peras , mulai dari ekstraksi minyak atsiri hingga pengemasan produk. Hal ini tidak hanya melatih keterampilan teknis dan kreativitas, tetapi juga membuka peluang kewirausahaan. Pemanfaatan kulit Jeruk peras untuk reed diffuser sejalan dengan prinsip ekonomi sirkular dan pembangunan berkelanjutan, yang menekankan pemanfaatan sumber daya secara efisien. Dengan menguasai keterampilan ini, siswa SMA dapat berkontribusi dalam mengurangi limbah organik sekaligus menciptakan produk bernilai ekonomi tinggi. Ini juga mendukung visi pendidikan SMA untuk menciptakan lulusan yang kompeten, kreatif, dan siap bersaing di dunia kerja. Pengabdian masyarakat kali ini dilaksanakan di SMA Islam 1 Surakarta, Kota Surakarta.

Pelatihan Pembuatan Reed Diffuser Berbasis Limbah Kulit Jeruk peras untuk Mendukung Ekonomi Sirkular di SMA Islam 1 Surakarta Bagas ardiyantoro; Triana Triana; Septian Maulid Wicahyo
Jurnal Pengabdian Bersama Masyarakat Indonesia Vol. 4 No. 3 (2026): Juli : : Jurnal Pengabdian Bersama Masyarakat Indonesia
Publisher : CV. Aksara Global Akademia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59031/jpbmi.v4i3.843

Limbah kulit Jeruk peras , yang sering dibuang dan menimbulkan masalah lingkungan, sebenarnya memiliki potensi besar untuk dimanfaatkan kembali. Kulit Jeruk peras mengandung minyak atsiri yang dapat diolah menjadi reed diffuser, pengharum ruangan alami yang ramah lingkungan. Namun, pengetahuan masyarakat tentang pemanfaatan kulit Jeruk peras masih terbatas. Siswa SMA, sebagai generasi muda yang sedang mempersiapkan diri untuk dunia kerja atau wirausaha, dapat memainkan peran penting dalam mengembangkan inovasi ini. Melalui pendidikan dan pelatihan, siswa SMA dapat mempelajari proses pembuatan reed diffuser dari kulit Jeruk peras , mulai dari ekstraksi minyak atsiri hingga pengemasan produk. Hal ini tidak hanya melatih keterampilan teknis dan kreativitas, tetapi juga membuka peluang kewirausahaan. Pemanfaatan kulit Jeruk peras untuk reed diffuser sejalan dengan prinsip ekonomi sirkular dan pembangunan berkelanjutan, yang menekankan pemanfaatan sumber daya secara efisien. Dengan menguasai keterampilan ini, siswa SMA dapat berkontribusi dalam mengurangi limbah organik sekaligus menciptakan produk bernilai ekonomi tinggi. Ini juga mendukung visi pendidikan SMA untuk menciptakan lulusan yang kompeten, kreatif, dan siap bersaing di dunia kerja. Pengabdian masyarakat kali ini dilaksanakan di SMA Islam 1 Surakarta, Kota Surakarta.

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