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All Journal E-Jurnal Medika Udayana Berkala Ilmu Kesehatan Kulit dan Kelamin Jurnal Antropologi: Isu-Isu Sosial budaya ISM (Intisari Sains Medis) : Jurnal Kedokteran Jurnal Biomedika dan Kesehatan Bioscientia Medicina : Journal of Biomedicine and Translational Research Review of Primary Care Practice and Education (Kajian Praktik dan Pendidikan Layanan Primer) Bali Dermatology and Venereology Journal Indonesian Journal of Global Health research JOURNAL LA MEDIHEALTICO Bioscientia Medicina : Journal of Biomedicine and Translational Research Gema Kesehatan Bali Dermatology Venereology and Aesthetic Journal

Ni Luh Putu Ratih Vibriyanti Karna

Departemen Dermatologi Dan Venereologi, Fakultas Kedokteran, Universitas Udayana, Rumah Sakit Umum Pusat Sanglah, Denpasar, Bali, Indonesia

Author-ID : 1283218

Arts Humanities Biochemistry, Genetics & Molecular Biology Education Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary

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Interaction between leprosy and HIV infection Prima Sudarsa; Ratih Vibriyanti Karna; Luh Mas Rusyati
Bali Dermatology and Venereology Journal Vol. 1 No. 1 (2018)
Publisher : DiscoverSys Inc

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15562/bdv.v1i1.4

Introduction: Leprosy and Human Immunodeficiency Virus (HIV) infections still count as major health issues worldwide. Starting with the HIV pandemic back in the eighties, leprosy was feared to re-emerge as the HIV cases arose. Co-infections between leprosy and HIV were worried to cause an increase in leprosy cases, with worse clinical manifestation, predominantly toward the lepromatous spectrum, decrease in therapy response, and prolonged therapy period. Unlike its interaction with tuberculosis, HIV infection was turned out to not increasing nor deteriorating the manifestation of leprosy infection. All clinical spectrum of leprosy was found in HIV infection patients without predomination of lepromatous type. Responses to leprosy Multi-Drug Therapy (MDT) regimen were also found similar between leprosy patients with or without HIV.Conclusion: It is recommended to treat co-infective patients both with leprosy MDT and antiretroviral therapy. Manifestation of leprosy as a part of immune reconstitution syndrome need more attention and investigation.Keywords: HIV infection, leprosy, interaction

Systematic review of melasma treatments: advantages and disadvantages Sang Ayu Arta Suryantari; Ni Putu Tamara Bidari Sweta; Elvina Veronica; I Gusti Ngurah Bagus Rai Mulya Hartawan; Ni Luh Putu Ratih Vibriyanti Karna
Bali Dermatology and Venereology Journal Vol. 3 No. 2 (2020)
Publisher : DiscoverSys Inc

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15562/bdv.v3i2.41

Background: Melasma is an acquired chronic hyperpigmentation mostly affecting women. The pathogenesis of melasma is uncertain but it predominant related to ultraviolet (UV) exposure. Due to chronic and relapsing nature, melasma is challenging to treat. The current available treatment often has undesirable side effects and suboptimal results. The principal of treatment includes protect from UV radiation, inhibit melanin synthesize and increase pathway to remove melanin. Objectives: To define available treatments for melasma and determine advantages and disadvantages including topical, oral and procedural. Method: Medline, Cochrane library and PubMed database were searched for articles from January 2011 to June 2020. Only RCTs, comparative, prospective, retrospective and systematic reviews focusing on melasma treatments were extracted, analyzed and discussed. Results: We found 197 studies that met the inclusion and exclusion criteria with 2314 participants included in this review. The treatments included topical, oral and procedural. In several studies, hydroquinone alone or combination remains the most effective treatment for melasma. Oral and topical tranexamic acid have been found to be a useful adjuvant treatment in refractory melasma with minimal adverse effects. Procedural treatment such as chemical peels, laser and light-based therapies, and microneedling have a mixed and unpredictable result. Overall, the side effects tend to be mild and affect few of the subject.Conclusions: The current state of the evidence suggests that some treatments with multiple modalities have their respective advantages and disadvantages. The choice of treatment modality must be adjusted according to the type of melasma such as its severity, extent and location. A better understanding of melasma through the further research may improve the therapy options with the least adverse effects.

Case report: a child with type 1 neurofibromatosis and intellectual disability Elice Wijaya; Ni Luh Putu Ratih Vibriyanti Karna; Ida Ayu Uttari Priyadarshini
Bali Dermatology and Venereology Journal Vol. 4 No. 2 (2021)
Publisher : DiscoverSys Inc

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15562/bdv.v4i2.55

Background: Neurofibromatosis is a genetic disorder which manifests as a tumor that surrounds the nerves and several other pathologic presentations.Case: Female, 11 years old, according to history, physical examination and supporting investigation was consistent with the diagnostic criteria of type 1 neurofibromatosis (NF-1). Patient also has intellectual disability. On the patient, a tumor on the foot region that was functionally disabling was found and a surgical treatment was performed.Discussion: Cognitive disorder is the most common neurological complication in individuals with NF-1 and usually present with low intelligence quotient (IQ). There is no specific treatment to prevent the development of NF-1. However, early treatment can minimize and prevent further complication. Treatment for the patient involve multiple clinical discipline.Conclusion: A neurofibromatosis case can be diagnosed clinically alone, however, since there are many other systemic involvements that require multi-disciplinary approach.

Profil pioderma pada anak usia 0-14 tahun di Rumah Sakit Umum Pusat (RSUP) Sanglah, Denpasar periode Juni 2015-2016 Dewa Ayu Agung Dwita Arthaningsih; Ni Luh Putu Ratih Vibriyanti Karna
Intisari Sains Medis Vol. 11 No. 1 (2020): (Available online: 1 April 2020)
Publisher : DiscoverSys Inc.

Background: Pyoderma is a skin infection caused by bacteria Staphylococcus, Streptococcus, or both of it. Pyoderma often experienced by children which caused he skin resistance against the invasion of pathogenic germs, which not perfect as ts. Pyoderma morbidity in pediatric patients still occurs, especially in developing countries with tropical climates. This study aims to determine the pyoderma profile among children 0-14 years old at Sanglah General Hospital, Denpasar, in June 2015-2016 period.Methods: A cross-sectional descriptive design using a retrospective approach was conducted in this study. Samples were determined using total sampling technique and this sample using pediatric patients aged 0-14 years in Sanglah General Hospital periods June 201 5to June 2016 who had pyoderma. The data obtained in this study were analyzed descriptively using SPSS version 17 for Windows.Results: The results founded that there were 347 admissions, 53 patients suffering from pyoderma in Sanglah General Hospital. The majority of patients aged â‰¤ 4 years were 31 patients (58.5%), followed by the sex of the male as many as 34 patients (64.2%), diagnosis of bullous impetigo 27 patients (50.9%) and the location of lesions on the head of 32 patients (60.4%). Positive results of gram-positive coccus examination were 28 patients (52.8%) followed by the majority of patients getting a combination of topical and systemic antibiotics were 42 patients (79.2%).Conclusion: According to the data analysis and discussion, it can be concluded that the incidence of pyoderma in children is still quite a lot happening in Sanglah General Hospital during June 2015-2016 period.Â Latar Belakang: Pioderma merupakan infeksi kulit yang disebabkan oleh kuman staphylococcus, streptococcus, atau oleh keduanya. Pioderma sering dialami anak-anak, karena daya tahan kulit terhadap invasi kuman pathogen belum sesempurna orang dewasa. Angka morbiditas pioderma pada pasien anak masih cukup terjadi terutama di negara berkembang dengan iklim tropis. Tujuan dari penelitian ini adalah ntuk mengetahui profil pioderma pada anak usia 0-14 tahun di Rrumah Sakit Umum Pusat Sanglah Denpasar periode Juni 2015- Juni 2016.Metode: Penelitian ini menggunakan studi potong lintang deskriptif dengan desain penelitian retrospektif. Sampel ditentukan dengan menggunakan teknik total sampling, dalam sampel ini yang digunakan adalah pasien anak yang berusia 0-14 tahun di Rumah Sakit Umum Pusat Sanglah Denpasar periode Juni 2015- Juni 2016 yang mengalami pioderma. Data yang diperoleh dalam penelitian ini dianalisis secara deskriptif menggunakan SPSS versi 17 untuk Windows.Hasil: Hasil penelitian secara deskriptif menunjukan bahwa dari 347 kunjungan, 53 pasien yang menderita pioderma di Rumah Sakit Umum Pusat Sanglah Denpasar. Sebagian besar pasien berusia â‰¤ 4 tahun sebanyak 31 pasien (58.5%), diikuti dengan jenis kelaminl laki-laki sebanyak 34 pasien (64.2%), diagnosis impetigo bulosa 27 pasien (50.9%) dan lokasi lesi pada kepala yaitu 32 pasien (60.4%). Hasil positif pemeriksaan kokus gram positif sebanyak 28 pasien (52.8%) diikuti dengan sebagian besar pasien mendapatkan kombinasi topikal dan antibiotik sistemik adalah 42 pasien (79.2%).Kesimpulan: Berdasarakan hasil analisis data dan pembahasan, maka dapat disimpulkan bahwa insidens pioderma pada anak masih cukup banyak terjadi di Rumah Sakit Umum Pusat Sanglah periode Juni 2015-2016.

Profil dermatitis kontak akibat kerja pada pekerja garmen di Kota Denpasar Made Wardhana; Made Martina Windari; I Gusti Ayu Agung Dwi Karmila; Ni Luh Putu Ratih Vibriyanti Karna; Ni Made Dwi Puspawati; I Gusti Ayu Agung Praharsisni; Luh Made Mas Rusyati; Nyoman Suryawati
Intisari Sains Medis Vol. 11 No. 2 (2020): (Available online: 1 August 2020)
Publisher : DiscoverSys Inc.

Background: The development of the garment industry in Bali is increasing as a tourism supporting industry. As a consequence the number of garment and textile companies is growing in quantity and quality. According to data in the Denpasar City, there were around 125 large garment companies employing at least 100 workers. A small garment company as a home industry is almost five hundred. The impact of the development of the garment industry requires a lot of human resources by recruiting, opening jobs both for trained and untrained workers, most of whom are casual workers, without getting attention in terms of health. This research was conducted to collect data about the pattern of skin lesions (work-related contact dermatitis) in garment workers in Denpasar City because they do not have complete and accurate data.Methods: The method used in this study was a survey on three large garment companies in Denpasar with interviews and examinations of their skin disease patterns.Results: Total 288 workers included in this study consisted of 105 (36.5%) men and 183 (63.5%) women. From 288 respondents, 74 workers (25.7%) suffer from skin disorders related to their work. The occupational category that suffered the most was colouring workers of 30 people.Conclusion: The pattern of skin disease in garment workers by 25.7% suffering from DKAK. Disease categories are often workers who come into contact with colour materials.Â Latar Belakang: Perkembangan industri garment di Bali semakin meningkat sebagai salah satu industri penunjang pariwisata. Sebagai konsekuensi jumlah perusahan garmen dan tekstil semakin banyak secara kuantitas dan kualitas. Menurut data di kodya Denpasar, tercatat sekitar 125 perusahan garmen yang besar dengan memperkerjakan sedikitnya 100 orang pekerja. Perusahan garmen yang kecil sebagai industri rumah tangga hampir sebanyak lima rastusan. Dampak dari perkembangan industri garment membutuhkan banyak tenaga kerja dengan merekrut, membuka lapangan pekerjaan baik itu untuk pekerja yang terlatih maupun yang tidak terlatih, kebanyakan merupakan pekerja lepas, tanpa mendapat perhatian dari segi kesehatan. Penelitian ini dilakukan untuk mengumpulkan data tentang pola kelainaan kulit pada(DKAK) pekerja garmentÂ di Kodya Denpasar, karena belum memiliki data yang lengkap dan akurat.Metode: Metode yang digunakan pda penelitian ini adalah survelanse, pada 3 perusahan garment yang besar di Denpasar dengan wawancara dan pemeriksaan terhadap pola penyakit kulitnya.Hasil: Dari 288 pekerja yang di ikut sertakan dalam penelitian ini terdiri dari 105 (36,5%) laki-laki dan 183 (63,5%) perempuan. Dari 288 responden, sebanyak 74 pekerja (25,7%) yang menderita kelainan kulit yang berhubungan dengan pekerjaannya. Katagori pekerjaan yang paling banyak menderita adalah pada pekerja pencelupan (coloring) sebesar 30 orang.Simpulan: Pola penyakit kulit pada pekerja garment sebesar 25,7% menderita DKAK. Katagori penyakit sering adalah pekerja yang berhubungan kontak dengan bahan warna.

The prevalence between stress and acne vulgaris among medical students at Universitas Udayana in the 2019 period Somia Sri Subramaniam; Anak Agung Gde Putra Wiraguna; Ni Luh Putu Ratih Vibriyanti Karna
Intisari Sains Medis Vol. 12 No. 1 (2021): (Available online : 1 April 2021)
Publisher : DiscoverSys Inc.

Background: Acne vulgaris is a common disease in medical students. One of the causes of acne vulgaris is stress. Acne vulgaris can affect the quality of life associated with one's self-confidence. But often, this disease is ignored and not treated properly. This study aims to know if acne vulgaris occurs in students at the Faculty of Medicine, Universitas Udayana, Bali, Indonesia, related to the stress that affects acne vulgaris.Methods: This research is a descriptive cross-sectional study. Data is collected using a data retrieval form. The inclusion criteria in this study were: 1) Participants selected must be from English class from semester 7 and aged 20 or above; 2) Participants can be from both genders; and 3) Participants that join the study willingly. Besides, the exclusion criteria were respondents who did not approve as a research sample and did not fill out informed consent. Data were analyzed using SPSS version 17 for Windows.Results: About 62 of 93 study participants were diagnosed with acne vulgaris in students at the Faculty of Medicine, Universitas Udayana. There were 31 of 62 study participants who were diagnosed with acne vulgaris due to stress. Women had more acne vulgaris than men and the number of students that had acne vulgaris the most are at the age of 21. The most common type of lesion is comedonal with a mild classification level. Most of the subject's cause of acne due to stress is before block exam. Most of the participants feel embarrassed due to acne. About 24.2% of the subjects had a habit of scratching/squeezing acne vulgaris.Conclusion: Most of the subjects diagnosed with acne were female and age 21 years old. Besides, comedones were the predominant type of lesion, followed by a mild degree of acne severity.

Satu Kasus Langka: Harlequin Ichthyosis I Gusti Ayu Sattwika Pramita; Ni Luh Putu Ratih Vibriyanti Karna
Intisari Sains Medis Vol. 12 No. 3 (2021): (Available online: 1 December 2021)
Publisher : DiscoverSys Inc.

Introduction: Harlequin ichthyosis is a genetic skin disease due to mutations in the ABCA12 gene inherited in an autosomal recessive manner. It is a severe form of ichthyosis characterized by a distinct clinical appearance of a thick stratum corneum. Harlequin ichthyosis is rarely found, and patients generally die a few days after birth.Case description: We reported a baby girl aged one day with thick and cracked skin since birth. Physical examination revealed eclabium, ectropion, microtia, hyperflexion of the arms and legs, and hypoplasia of the fingers and toes. Dermatological examination showed thick yellowish-white scales separated by deep and erythematous fissures. The patient was placed in an incubator and was given supportive care, including nutrition and fluid through an orogastric tube, oleum olivarum as a moisturizer, gentamicin cream 0.1%, and gentamicin eye ointment 0.3%. The patient died after 21 days of treatment.Conclusion: Harlequin ichthyosis has a poor prognosis and a high mortality rate due to impaired skin barrier functions that lead to dehydration, impaired thermoregulation, respiratory problems, and infections. Management of harlequin ichthyosis needs a multidisciplinary team and supportive care, consisting of fluid, electrolyte, and nutrition management, maintaining skin hydration, eye care, and preventing respiratory failure or sepsis. Pendahuluan: Harlequin ichthyosis adalah penyakit kulit genetik yang diturunkan secara resesif autosomal dan merupakan bentuk berat dari iktiosis akibat adanya mutasi pada gen ABCA12. Penyakit ini ditandai dengan adanya gambaran klinis yang khas berupa penebalan stratum korneum. Harlequin ichthyosis jarang ditemukan dan umumnya pasien meninggal beberapa hari setelah kelahiran.Kasus: Dilaporkan seorang bayi perempuan berumur 1 hari dengan keluhan kulit tebal dan pecah-pecah sejak lahir. Pada pemeriksaan fisik ditemukan eklabium, ektropion, mikrotia, hiperfleksi lengan dan kaki, serta hipoplasia jari-jari tangan dan kaki. Berdasarkan pemeriksaan status dermatologikus didapatkan skuama tebal berwarna putih kekuningan yang dipisahkan fisura. Pasien diberikan perawatan suportif berupa perawatan dalam inkubator, pemberian nutrisi melalui OGT, pelembab topikal oleum olivarum, antibiotik topikal gentamisin krim 0,1 %, dan salep mata gentamisin 0,3%. Pasien meninggal setelah perawatan selama 21 hari. Simpulan: Harlequin ichthyosis memiliki prognosis yang buruk dan angka kematian yang tinggi akibat gangguan dari barier kulit yang menyebabkan dehidrasi, gangguan termoregulasi, gangguan nafas dan infeksi. Penatalaksanaan pasien harlequin ichthyosis adalah multidisiplin dan bersifat suportif, terdiri atas manajemen cairan dan elektrolit, perawatan secara intensif dalam inkubator, pemberian nutrisi, menjaga hidrasi kulit, perawatan mata, dan pencegahan terjadinya gangguan napas, atau sepsis.

Incontinentia pigmenti in neonate: a case report Putu Gde Hari Wangsa; Luh Made Mas Rusyati; I Gusti Ayu Agung Dwi Karmila; Ni Luh Putu Ratih Vibriyanti Karna; Ketut Wida Komalasari; Made Hermina Laksmi
Intisari Sains Medis Vol. 13 No. 1 (2022): (Available Online : 1 April 2022)
Publisher : DiscoverSys Inc.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15562/ism.v13i1.1227

Background: Incontinentia pigmenti (IP) is a rare X-linked dominant inherited genodermatosis that occurs almost in females and is usually accompanied by other ectodermal tissue diseases such as the central nervous system, eyes, hair, nails, teeth and skeletal system. This case report aims to enhance understanding of incontinentia pigmenti and provide appropriate treatment to patients and proper education to families. Case report: A 3-days-od baby girl was consulted by the Pediatric department with complaints of blisters and erythematous rashes on almost her entire body with the Blaschko line distribution. The nails on the right and left big toes appeared inward. No history of fever and seizure. No family had similar complaints. There were no eye and nerve abnormalities involved. She treated with hydrocortisone 1% cream every 12 hours on erythematous papules and vesicles, open compresses with 0.9% NaCl every 8 hours for 10-15 minutes on lesions with yellowish crusts. Thus, the patient diagnosed with incontinentia pigmenti. Conclusion: The diagnosis of incontinentia pigmenti is based on history and physical examination. This case is very rare, so the family needs to understand the course of this disease. Appropriate management and education can prevent secondary infection.

Kasus kromoblastomikosis yang awalnya diduga furunkel pada seorang perempuan Roslina Horo; Ni Luh Putu Ratih Vibriyanti Karna; Ni Putu Ayu Riska Yunita Sari
Intisari Sains Medis Vol. 13 No. 1 (2022): (Available Online : 1 April 2022)
Publisher : DiscoverSys Inc.

Background: Chromoblastomycosis is a chronic profound fungal infection caused by dematiaceous from the surrounding environment. Trauma was the site of fungal implantation. The prevalence is mainly in agriculture workers. The clinical picture varies. Diagnosis is made when muriform cells are found. Early diagnosis is very important because it affects the prognosis. Case Description: A woman, 24 years old, Balinese, went to The Skin and Genital Polyclinic of Sanglah General Hospital with the main complaint of boils in the area below the left knee six months ago. It starts from red papules and then becomes a painless lump. The lump breaks and contains yellowish pus. Patients have a history of gardening. Physical examination within normal limits. Dermatological status on left cruris, there are solitary erythema nodules, firm borders, round shape, a diameter of 2.5 cm, smooth and shiny surface, and fluctuations containing yellowish pus. From sabouraud dextrose agar culture (SDA) obtained the growth of Cladophialophora carrionii. The diagnosis was chromoblastomycosis. Patients were given a pulse dose of itraconazole 400 mg every 24 hours intraorally. There was a clinical improvement. Conclusion: There have been reported cases of chromoblastomycosis that were initially suspected to be furuncle in a 24-year-old woman. Diagnosis is made based on anamnesis, physical examination, and laboratory examination. Patients were given a pulse dose of itraconazole. There was a clinical improvement. The prognosis is dubius ad bonam. Extended observations still need to monitor the clinical and mycological healing, medication side effects and complications of the disease. Latar belakang: Kromoblastomikosis adalah infeksi jamur profunda kronik yang disebabkan oleh dematiaceous yang berasal dari lingkungan sekitar. Penyakit ini biasanya diawali oleh trauma sebagai situs implantasi jamur. Prevalensi penyakit ini terutama pada individu yang bekerja di bidang agrikultural. Gambaran klinis kromoblastomikosis bervariasi. Penegakan diagnosis bila ditemukan sel muriform pada jaringan. Diagnosis dini pada lesi awal sangat penting karena mempengaruhi prognosis penyakit. Deskripsi kasus: Seorang perempuan, 24 tahun, suku Bali, berobat ke Poliklinik Kulit dan Kelamin RSUP Sanglah Denpasar dengan keluhan utama bisul pada area bawah lutut kiri sejak 6 bulan yang lalu. Awalnya berupa bintil kemerahan lalu menjadi benjolan yang tidak nyeri. Benjolan pecah dan mengeluarkan nanah. Pasien memiliki hobi berkebun. Pemeriksaan fisik dalam batas normal. Status dermatologi pada regio kruris sinistra terdapat nodul eritema soliter, batas tegas, bentuk bulat, diameter 2,5 cm, permukaan halus dan mengkilap, tampak fluktuasi berupa pus kekuningan. Pemeriksaan kultur sabouraud dextrose agar (SDA) didapatkan pertumbuhan Cladophialophora carrionii. Diagnosis kerja adalah kromoblastomikosis. Pasien diterapi dengan itrakonazol 400 mg setiap 24 jam intraoral dosis denyut dan terdapat perbaikan klinis pada lesi. Simpulan: Telah dilaporkan kasus kromoblastomikosis yang awalnya diduga furunkel pada seorang perempuan usia 24 tahun. Diagnosis ditegakkan berdasarkan anamnesis, pemeriksaan fisik, dan pemeriksaan penunjang. Pasien diberikan terapi itrakonazol dosis denyut dan tampak perbaikan klinis yang signifikan pada lesi. Prognosis pada pasien dubius ad bonam. Pengamatan lanjutan masih perlu dilakukan untuk mengamati kesembuhan secara klinis maupun mikologi, efek samping terapi, dan komplikasi penyakit.

Kadar feritin yang rendah merupakan faktor risiko melasma pada wanita Aurelia Stephanie; Luh Made Mas Rusyati; Ni Luh Putu Ratih Vibriyanti Karna; Ketut Kwartantaya Winaya; Nyoman Suryawati; I Gusti Ayu Agung Dwi Karmila
Intisari Sains Medis Vol. 13 No. 2 (2022): (In Press : 1 August 2022)
Publisher : DiscoverSys Inc.

Introduction: Melasma is an acquired pigmentation disorder characterized by symmetrical hyperpigmented patches, most commonly seen on the face. Melasma and iron deficiency are most common in women of reproductive age. Iron deficiency causes a decrease in ferritin levels, which are iron stores in the body. The mechanism of iron deficiency causing melasma is thought to be due to cell hypoxia in the tissue involving mediators that increase melanogenesis. This study aims to prove that the mean ferritin level is lower in melasma than without melasma and that low ferritin levels are a risk factor for melasma in women. Methods: A case-control research included 28 participants with melasma and 28 without melasma who visited the dermatovenereology department of Prof. Dr. I.G.N.G Ngoerah Hospital, medical cosmetic division, in May-July 2022. The two groups will compare ferritin mean and ferritin risk factor analysis on the incidence of melasma. Data were tabulated and analyzed using SPSS 26. Results: The mean age in the melasma group was 40.64±3.39 years old, and the group without melasma was 37.64±3.50 years old (p=0.75). Of the 28 melasma subjects, there were more subjects with low ferritin levels (60.7%) than the group without melasma (32.1%). From the results of the Mann-Whitney test, the mean ferritin level in the melasma group (36.32±31.05) was significantly lower than in the non-melasma group (58.26±5.39); p=0.006. From the results of the Chi-Square test, it was found that low ferritin levels had a risk of 3.2 times the occurrence of melasma [OR (95% CI) = 3.2 (1.098-9.776), p=0.032]. Conclusion: The mean ferritin level in women with melasma is lower than in women without melasma, and low ferritin levels are a risk factor for melasma. Latar Belakang: Melasma merupakan kelainan pigmentasi didapat yang ditandai dengan adanya bercak hiperpigmentasi simetris, paling sering terlihat pada wajah. Melasma dan defisiensi besi paling sering dijumpai pada wanita usia reproduktif. Defisiensi besi menyebabkan turunnya kadar feritin yang merupakan cadangan besi dalam tubuh. Mekanisme defisiensi zat besi menyebabkan melasma diduga akibat hipoksia sel di dalam jaringan melibatkan mediator yang meningkatkan melanogenesis. Studi ini bertujuan untuk membuktikan rerata kadar feritin lebih rendah pada melasma dibandingkan tanpa melasma serta membuktikan kadar feritin yang rendah merupakan faktor risiko melasma pada wanita. Metode: Studi case-control yang melibatkan 28 subjek dengan melasma dan 28 subjek tanpa melasma yang berobat ke poliklinik kulit dan kelamin RSUP Prof. Dr. I.G.N.G Ngoerah divisi kosmetik medik periode Mei-Juli 2022. Kedua kelompok akan dibandingkan rerata feritin dan analisis faktor risiko feritin terhadap kejadian melasma. Data ditabulasi dan dianalisis dengan menggunakan SPSS 26. Hasil: Rerata usia pada kelompok melasma 40.64±3,39 tahun dan kelompok tanpa melasma 37,64±3,50 tahun (p=0,75). Dari 28 subjek melasma, didapatkan lebih banyak subjek dengan kadar feritin rendah (60,7%) dibandingkan kelompok tanpa melasma (32,1%). Dari hasil uji Mann-Whitney didapatkan rerata kadar feritin pada kelompok melasma (36,32±31,05) lebih rendah secara signifikan dibandingkan pada kelompok bukan melasma (58,26±5,39); p=0,006. Dari hasil uji Chi-Square didapatkan kadar feritin yang rendah memiliki risiko sebesar 3,2 kali terjadinya melasma [OR (IK 95%) =3,2 (1,098-9,776), p=0,032]. Simpulan: rerata kadar feritin pada wanita dengan melasma lebih rendah dibandingkan wanita tanpa melasma dan kadar feritin yang rendah merupakan faktor risiko melasma.

Co-Authors A.A.G.P. Wiraguna Anak Agung Gde Putra Wiraguna Anak Agung Indah Jayanthi Andrew Wicaksono Aurelia Stephanie Aurelia Stephanie Bharata, Putu Evindya Vipascitadewi Nandanaya Darmaputra, I Gusti Nyoman Desak Nyoman Trisepti Utami Dewa Ayu Agung Dwita Arthaningsih Dewa Ayu Agung Dwita Arthaningsih Dewi Gotama Dewi Gotama Duarsa, Putu Laksmi Anggari Putri Elice Wijaya Elice Wijaya Elvina Veronica Elvina Veronica Gotama, Dewi Hartawan, I Gusti Ngurah Bagus Rai Mulya Herman Saputra Herman Saputra I Gusti Ayu Agung Dwi Karmila I Gusti Ayu Agung Elis Indira I Gusti Ayu Agung Praharsini I Gusti Ayu Agung Praharsisni I Gusti Ayu Sattwika Pramita I Gusti Ngurah Bagus Rai Mulya Hartawan I Gusti Ngurah Bagus Rai Mulya Hartawan Ida Ayu Ide Nanda Divyani Ida Ayu Uttari Priyadarshini Ida Ayu Uttari Priyadarshini Juliari, Gusti Ayu Made Karina Chandra Ketut Kwartantaya Winaya Ketut Wida Komalasari Komang Saputra Yadnya Luh Made Mas Rusyati Luh Putu Sustiana Kartika Sari Made Hermina Laksmi Made Hermina Laksmi Made Martina Windari Made Wardhana Mario Korwa Nandya Dwizella Nevristia Pratama Ni Made Ari Purwaningrum Ni Made Dwi Puspawati Ni Putu Ayu Riska Yunita Sari Ni Putu Tamara Bidari Sweta Ni Putu Tamara Bidari Sweta Nyoman Suryawati Prima Saraswati Sanjiwani Sudarsa Prima Sudarsa Primasari, Putu Yunita Priyadarshini, Ida Ayu Uttari Putu Gde Hari Wangsa Putu Gde Hariwangsa Roslina Horo Sadeli, Marrietta Sugiarti Sissy Sissy Sissy Sissy, Sissy Somia Sri Subramaniam Sudarsa, Prima Sweta, Ni Putu Tamara Bidari Triatmakusuma, Yogi Veronica, Elvina Winaya, Ketut Kwartantaya

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