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All Journal E-Jurnal Medika Udayana Berkala Ilmu Kesehatan Kulit dan Kelamin Jurnal Antropologi: Isu-Isu Sosial budaya ISM (Intisari Sains Medis) : Jurnal Kedokteran Jurnal Biomedika dan Kesehatan Review of Primary Care Practice and Education (Kajian Praktik dan Pendidikan Layanan Primer) Bali Dermatology and Venereology Journal Indonesian Journal of Global Health research JOURNAL LA MEDIHEALTICO Bioscientia Medicina : Journal of Biomedicine and Translational Research Gema Kesehatan Bali Dermatology Venereology and Aesthetic Journal
Ni Luh Putu Ratih Vibriyanti Karna
Departemen Dermatologi Dan Venereologi, Fakultas Kedokteran, Universitas Udayana, Rumah Sakit Umum Pusat Sanglah, Denpasar, Bali, Indonesia
Arts Humanities Biochemistry, Genetics & Molecular Biology Education Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary

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Systematic review of melasma treatments: advantages and disadvantages Sang Ayu Arta Suryantari; Ni Putu Tamara Bidari Sweta; Elvina Veronica; I Gusti Ngurah Bagus Rai Mulya Hartawan; Ni Luh Putu Ratih Vibriyanti Karna
Bali Dermatology Venereology and Aesthetic Journal BDVJ - Vol. 3 No. 2 (December 2020)
Publisher : Explorer Front

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51559/dy28rh70

Abstract

Background: Melasma is acquired chronic hyperpigmentation mainly affecting women. The pathogenesis of melasma is uncertain, but it is predominantly related to ultraviolet (UV) exposure. Due to its chronic and relapsing nature, melasma is challenging to treat. The currently available treatment often has undesirable side effects and suboptimal results. The treatment principle includes protecting from UV radiation, inhibiting melanin synthesis, and increasing the pathway to remove melanin. Objectives: To define available treatments for melasma and determine advantages and disadvantages, including topical, oral and procedural. Method: Medline, Cochrane library and PubMed databases were searched for articles from January 2011 to June 2020. Only RCTs, comparative, prospective, retrospective and systematic reviews focusing on melasma treatments were extracted, analyzed and discussed. Results: We found 197 studies that met the inclusion and exclusion criteria, with 2314 participants included in this review. The treatments included topical, oral and procedural. In several studies, hydroquinone alone or combination remains the most effective treatment for melasma. Oral and topical tranexamic acid is a beneficial adjuvant treatment in refractory melasma with minimal adverse effects. Procedural treatments such as chemical peels, laser and light-based therapies, and microneedling have mixed and unpredictable results. Overall, the side effects tend to be mild and affect a few of the subjects. Conclusions: The current state of the evidence suggests that some treatments with multiple modalities have their respective advantages and disadvantages. The choice of treatment modality must be adjusted according to the type of melasma, such as its severity, extent and location. A better understanding of melasma through further research may improve the therapy options with the least adverse effects.
Case report: a child with type 1 neurofibromatosis and intellectual disability Elice Wijaya; Ni Luh Putu Ratih Vibriyanti Karna; Ida Ayu Uttari Priyadarshini
Bali Dermatology Venereology and Aesthetic Journal BDVJ - Vol. 4 No. 2 (December 2021)
Publisher : Explorer Front

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51559/fz3cvm46

Abstract

Background: Neurofibromatosis is a genetic disorder that manifests as a tumor surrounding the nerves and several other pathologic presentations. Case: Female, 11 years old, according to history, physical examination and supporting the investigation, was consistent with the diagnostic criteria of type 1 neurofibromatosis (NF-1). The patient also has an intellectual disability. A tumor on the foot region that was functionally disabling was found on the patient, and surgical treatment was performed. Cognitive disorder is the most common neurological complication in individuals with NF-1 and usually presents with a low intelligence quotient (IQ). There is no specific treatment to prevent the development of NF-1. However, early treatment can minimize and prevent further complications. Treatment for the patient involves multiple clinical disciplines. Conclusion: A neurofibromatosis case can be diagnosed clinically alone, since many other systemic involvements require a multi-disciplinary approach.
The role of anti-phenolic glycolipid-1 serological test in leprosy Ni Luh Putu Ratih Vibriyanti Karna; Anak Agung Indah Jayanthi; Desak Nyoman Trisepti Utami
Bali Dermatology Venereology and Aesthetic Journal BDVJ - Vol. 5 No. 1 (June 2022)
Publisher : Explorer Front

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51559/3zcf9307

Abstract

The number of new leprosy cases in the world is surprisingly high, Indonesia is still at the third rank in the term of new leprosy cases over the world. Leprosy control strategies can be successful if early diagnosis and appropriate therapy are carried out. Currently, several serological tests have been developed which can help detecting subclinical leprosy, making the diagnosis,and monitoring therapy. One such serological tests is the anti-Phenolic Glycolipid-1 (PGL-1) serological test. The antibody response to PGl-1 is mainly IgM, the amount of this antibody is correlated to the number of bacteria; so, the titer is higher in lepromatous type compared with tuberculoid type, this causes serological tests still have limitation in diagnosing leprosy, especially in paucibacillary type leprosy.
the Correlation Between Erythrocyte Index Levels with The Anemia Morphology in Leprosy Patients Before Therapy: A Secondary Data Research Marrietta Sugiarti Sadeli; Luh Made Mas Rusyati; Ni Luh Putu Ratih Vibriyanti Karna
Indonesian Journal of Global Health Research Vol 6 No 6 (2024): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/ijghr.v6i6.5826

Abstract

Leprosy is a chronic inflammatory disease caused by Mycobacterium leprae. Chronic infection can cause anemia of chronic disease which is characterized by normochromic normocytic morphology. This study was conducted to assess the relationship between erythrocyte index levels (MCV, MCH, and MCHC) with the morphology of anemia that occurs in leprosy patients before treatment. A cross-sectional study using secondary data from medical records and management information system applications at Sanglah Hospital. The variables of this study were age, sex, hemoglobin levels, and erythrocyte index levels (MCV, MCH, and MCHC). Data were collected after permission was granted and ethical clearance was completed. Of the 156 study samples, 106 patients were diagnosed with leprosy who had not received therapy and 50 patients were not leprosy. The mean age of the patients was 39.15 ± 12.218 years and male patients were more common than female patients. There was a positive correlation between anemia, normal erythrocyte index levels, and the leprosy group. Following are the p-values, prevalence ratios, and confidence intervals; anemia [p= 0.017; PR(95% CI)= 1,458(1.034-2.056)], MCV, MCH, and MCHC [p= 0.020; PR(95% CI)= 1,268(1.010-1.591); p= 0.015; PR(95% CI)= 1,293(1,021-1,639); p= 0.009; PR(95% CI)= 1,297(1,036-1,624)]. The results of the analysis were statistically significant and clinically important. Leprosy patients had anemia before therapy with normochromic normocytic anemia morphology in accordance with anemia of chronic disease.
Co-Authors A.A.G.P. Wiraguna Anak Agung Gde Putra Wiraguna Anak Agung Indah Jayanthi Andrew Wicaksono Aurelia Stephanie Aurelia Stephanie Bharata, Putu Evindya Vipascitadewi Nandanaya Darmaputra, I Gusti Nyoman Desak Nyoman Trisepti Utami Dewa Ayu Agung Dwita Arthaningsih Dewa Ayu Agung Dwita Arthaningsih Dewi Gotama Dewi Gotama Duarsa, Putu Laksmi Anggari Putri Elice Wijaya Elice Wijaya Elvina Veronica Elvina Veronica Gotama, Dewi Hartawan, I Gusti Ngurah Bagus Rai Mulya Herman Saputra Herman Saputra I Gusti Ayu Agung Dwi Karmila I Gusti Ayu Agung Elis Indira I Gusti Ayu Agung Praharsini I Gusti Ayu Agung Praharsisni I Gusti Ayu Sattwika Pramita I Gusti Ngurah Bagus Rai Mulya Hartawan I Gusti Ngurah Bagus Rai Mulya Hartawan Ida Ayu Ide Nanda Divyani Ida Ayu Uttari Priyadarshini Ida Ayu Uttari Priyadarshini Juliari, Gusti Ayu Made Karina Chandra Ketut Kwartantaya Winaya Ketut Wida Komalasari Komang Saputra Yadnya Luh Made Mas Rusyati Luh Putu Sustiana Kartika Sari Made Hermina Laksmi Made Hermina Laksmi Made Martina Windari Made Wardhana Mario Korwa Marrietta Sugiarti Sadeli Nandya Dwizella Nevristia Pratama Ni Made Ari Purwaningrum Ni Made Dwi Puspawati Ni Putu Ayu Riska Yunita Sari Ni Putu Tamara Bidari Sweta Ni Putu Tamara Bidari Sweta Nyoman Suryawati Prima Saraswati Sanjiwani Sudarsa Prima Sudarsa Primasari, Putu Yunita Priyadarshini, Ida Ayu Uttari Putu Gde Hari Wangsa Putu Gde Hariwangsa Roslina Horo Sissy Sissy Sissy Sissy, Sissy Somia Sri Subramaniam Sudarsa, Prima Sweta, Ni Putu Tamara Bidari Triatmakusuma, Yogi Veronica, Elvina Winaya, Ketut Kwartantaya