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All Journal BIOTROPIA - The Southeast Asian Journal of Tropical Biology Jurnal Sains dan Teknologi Pharmaciana: Jurnal Kefarmasian Farmasains : Jurnal Ilmiah Ilmu Kefarmasian Jurnal Riset Kesehatan Nasional Jurnal Ilmiah Medicamento Jurnal Penelitian Agama Hindu Jurnal Kesehatan Primer JRKN Usadha Borneo Journal of Pharmacy Jurnal Kesehatan Primer
Dwi Arymbhi Sanjaya
Universitas Mahasaraswati Denpasar
Religion Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Computer Science & IT Dentistry Education Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Veterinary

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Efektifitas Bilateral Packing Pada Pemasangan Laryngeal Mask Airway Klasik Pada Pasien Dengan General Anesthesia Inhalasi Lewar, Emanuel Ileatan; Suyasa, Agus Baratha; Sanjaya, Dwi Arymbhi
JURNAL KESEHATAN PRIMER Vol 5 No 1 (2020): JKP (Jurnal Kesehatan Primer)
Publisher : Poltekkes Kemenkes Kupang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31965/jkp.v5i1.456

Abstract

Introduction: The anesthesiologist found the problem in classic LMA and they modified with bilateral packing, but there is no study to see the risk factor for failure in classic LMA and LMA with bilateral packing. The purpose of this study was to identify the effectiveness of bilateral packing on classic LMA use in patients with general inhalation anesthesia at Kasih Ibu Hospital Denpasar. Method: this research is a case control with a retrospective approach which is an analytical survey study with a purposive sampling technique. The variable observed in this study was the risk of leakage, biting, regardless of classic LMA installation compared to classic LMA with bilateral packing. The data used in this study are secondary data based on observations in as many as 46 cases of patients with classic LMA with bilateral packing and classic LMA listed in the medical record. Data analysis was performed with a comparative test of group data fitted with bilateral packing and the classic LMA group with the Mann-Whitney test. Results: of the analysis showed that bilateral packing was significantly effective because there was no leakage, biting, regardless event compared to the use of classic LMA (p <0.005). Conclusion: This researcher stated that the installation of LMA with bilateral packing method is very effective to prevent failures, such as leakage, biting, regardless. Pendahuluan: Hingga saat ini masih ditemukan adanya masalah dalam pemasangan LMA klasik sehingga dilakukan modifikasi yaitu dengan pemasangan bilateral packing, namun belum dilakukan kajian yang lebih mendalam untuk melihat faktor resiko kegagalan. Tujuan penelitian ini untuk mengidetifikasi efektivitas pemasangan bilateral packing pada penggunaan LMA klasik pada pasien dengan general anesthesia inhalasi di rumah sakit Kasih Ibu Denpasar. Metode: penelitian ini yaitu case control dengan pendekatan retrospektif yang merupakan suatu penelitian survei analitik dengan teknik purposive sampling. Variabel yang diamati dalam penelitian ini yaitu resiko kebocoran, tergigit, terlepas pada pemasangan LMA klasik dibandingkan dengan LMA klasik dengan bilateral packing. Data yang digunakan dalam penelitian ini merupakan data sekunder berdasarkan hasil pengamatan pada sebanyak masing-masing 46 kasus pasien dengan pemasangan LMA klasik dengan bilateral packing dan LMA klasik yang tertera pada rekam medis. Analisa data dilakukan dengan uji komparatif terhadap data kelompok yang dipasang bilateral packing dan kelompok LMA klasik dengan uji Mann-Whitney. Hasil: analisis menunjukkan bahwa pemasangan bilateral packing secara signifikan lebih efektif karena tidak ada kejadian kebocoran, tergigit, dan terlepas (p<0,005) dibandingkan dengan penggunaan LMA Klasik. Kesimpulan: Peneliti ini bahwa pemasangan LMA dengan metode bilateral packing sangat efektif yang dilakukan untuk mencegah kegagalan antara lain terlepas, bocor dan tergigit.
ETHNOBOTANICAL STUDY OF MEDICINAL PLANT USAGE DURING COVID-19 PANDEMIC: A COMMUNITY-BASED SURVEY IN INDONESIA Nayaka, Ni Made Dwi Mara Widyani; Yuda, Putu Era Sandhi Kusuma; Sanjaya, Dwi Arymbhi; Ernawati, Desak Ketut; Cahyaningsih, Erna; Dewi, Ni Luh Kade Arman Anita; Sasadara, Maria Malida Vernandes
BIOTROPIA Vol. 30 No. 2 (2023): BIOTROPIA Vol. 30 No. 2 August 2023
Publisher : SEAMEO BIOTROP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11598/btb.2023.30.2.1784

Abstract

Before the availability of a vaccine, Indonesian population relied on traditional medicines to prevent COVID-19. Any species used by indigenous people could lead to further investigations in modern pharmacology, to preserve ancient knowledge, and to plan for plants’ conservation. The study aimed to discover and record species, methods of preparation, route of administration, and motivation in using medicinal plants by the Indonesian population during the COVID-19 pandemic. Participants of survey were selected from the people who live in Java and Bali for responding to an online structured questionnaire. Relative Frequency of Citation (RFC) was employed in the quantitative analysis of the collected data. The pharmacological relevance of the five plants with the highest RFC was further reviewed. The results showed that respondents used 59 plants from 28 families. Five species with the highest RFC were Curcuma longa (0.707), Zingiber officinale (0.674), Cymbopogon citratus (0.269), Kaempferia galanga (0.174), and Curcuma zanthorrhiza (0.165). Most plants were prepared by boiling (77.97%) and administered orally as a single ingredient or mixed with other herbals. Respondents believed that the plants were beneficial as immune-booster (71.26%), maintain good health (24.85%) and stamina (12.28%), and prevent viral infection, including COVID-19 (5.39%). The most commonly used plants might be scientifically based to boost immunity. However, their usage against COVID-19 and the medicinal value of herbal mixtures should be further investigated.
Aktivitas Analgesik Ekstrak Daun Liligundi (Vitex trifolia L.) Pada Mencit Putu Era Sandhi Kusuma Yuda; Ni Made Wiwik Setiawati; Ni Luh Kade Arman Anita Dewi; Dwi Arymbhi Sanjaya; Erna Cahyaningsih
Farmasains : Jurnal Ilmiah Ilmu Kefarmasian Vol. 6 No. 2 (2019)
Publisher : Universitas Muhammadiyah Prof. DR. HAMKA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22236/farmasains.v6i2.5135

Abstract

Penggunaan obat antiinflamasi non steroid (AINS) pada nyeri kronis dalam jangka waktu panjang dapat menimbulkan efek samping terutama gangguan pada saluran pencernaan sehingga diperlukan agen alternatif yang lebih aman terutama dari herbal. Dalam Usada Bali, salah satu tanaman yang digunakan untuk mengurangi nyeri adalah Liligundi (Vitex trifolia L.) famili Lamiaceae. Penelitian ini bertujuan untuk membuktikan aktivitas analgesik ekstrak daun Liligundi pada mencit. Daun Liligundi diekstraksi menggunakan pelarut alkohol 70% dilanjutkan dengan skrining fitokimia dan uji aktivitas analgesik menggunakan metode induksi panas (hot plate) suhu 55°C pada 20 ekor mencit yang terbagi menjadi empat kelompok, yaitu kelompok kontrol negatif diberikan Tween 80, kelompok kontrol positif diberikan Ibuprofen 52 mg/kg BB, dan perlakuan Ekstrak Daun Liligundi (EDL) dosis 250 mg/kg BB dan 500 mg/kg BB. Waktu respon nyeri pada mencit diukur pada menit ke-30 ditandai dengan gerakan melompat ataupun menjilat kaki setelah diletakkan diatas hot plate. Data dianalisis secaraOne Way ANOVA dilanjutkan dengan uji Tukey.Dari hasil penelitian diperoleh bahwa EDL mengandung alkaloid, flavonoid, saponin, tanin dan terpenoid. EDL dosis 250 mg/kgBB dan 500 mg/kgBB mampu memperpanjang respon nyeri secara bermakna dibandingkan kontrol negatif dan menghasilkan waktu respon nyeri yang lebih panjang secara bermakna dibandingkan Ibuprofen (p<0.05).
The Association between Resistance of Sepsis-Inducing Bacteria to First-Line Antibiotics and Sepsis Outcome: A Retrospective Cross-Sectional Study Herleeyana Meriyani; Dwi Arymbhi Sanjaya; Rr. Asih Juanita; Nyoman Budiartha Siada; I Wayan Maysa Yudiartha; Kadek Suryawan
Jurnal Ilmiah Medicamento Vol 12 No 1 (2026): Jurnal Ilmiah Medicamento (In progress)
Publisher : Fakultas Farmasi Universitas Mahasaraswati Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36733/medicamento.v12i1.13597

Abstract

Background: Sepsis is a significant infectious disease linked to high mortality rates. Several bacterial pathogens that cause sepsis have shown resistance to first-line antibiotics. This resistance in sepsis-causing bacteria to initial antibiotic agents threatens treatment success, elevating mortality risk, healthcare costs, and prolonged hospital stays.Objective: This study aimed to investigate the relationship between the resistance of sepsis-causing bacteria to first-line antibiotics and sepsis treatment outcomes.Methods: This cross-sectional study was a single-center retrospective study. Data were collected from sepsis patients admitted to the intensive care unit of a general hospital in Bali between 2022 and 2023. The patients included in this study were those with a positive bacterial infection, as provided in the culture result. Therapy outcomes were evaluated based on discharge status: improved or unimproved (deceased). The resistance of sepsis-causing bacteria to first-line antibiotics, including fluoroquinolones, third- and fourth-generation cephalosporins, piperacillin-tazobactam, and vancomycin, was assessed through blood cultures. The relationship between antibiotic resistance and therapy outcomes was analyzed using the Gamma correlation coefficient. This study included 57 of 108 sepsis patients, primarily male (57.89%) and older than 60 years (57.89%).Results: A strong, significant positive correlation was observed between the resistance of sepsis-causing bacteria to third-generation cephalosporins and therapy outcomes (p=0.001; r=0.637). In contrast, resistance to fluoroquinolones (p=0.108; r=0.387), fourth-generation cephalosporins (p=0.377; r=-0.199), piperacillin-tazobactam (p=0.816; r=-0.060), and vancomycin (p=0.911; r=0.030) did not significantly impact therapy outcomes. The outcome of sepsis therapy is associated with resistance of sepsis-causing bacteria to third-generation cephalosporins but not to fluoroquinolones, fourth-generation cephalosporins, piperacillin-tazobactam, or vancomycin. This study uses a relatively small sample size, which precludes subgroup analyses.Conclusion: Non-significant findings for some antibiotics may reflect insufficient power; further study is needed to assess the correlation between resistance of sepsis-causing bacteria to fluoroquinolones, fourth-generation cephalosporins, piperacillin-tazobactam, and vancomycin.
Co-Authors AA Istri Mas Padmiswari Agus Baratha Suyasa Asthadi Mahendra Bhandesa, Asthadi Mahendra Desak Ketut Ernawati Emanuel Ileatan Lewar Erna Cahyaningsih Fitria Megawati Herleeyana Meriyani I Gede Agus Shuarsedana Putra I Putu Yudistira Mahaputra I Wayan Maysa Yudiartha Ida Ayu Manik Damayanti Kadek Suryawan Kamalia, Made Gek Adisti Ketupapa, Florentina Gabriela Ketut Agus Adrianta LEWAR, EMANUEL ILEATAN Luh Risma Putri Rahayu Lusy Noviani Made Agus Deny Mahendra Putra Made Gek Adisti Kamalia Mahaputra, I Putu Yudistira Mahaputra, Yudistira Mendra, Ni Nyoman Yudianti Ni Kadek Sukertiasih Ni Luh Kade Arman Anita Dewi Ni Luh Putu Inca Buntari Agustini Ni Made Dwi Mara Widyani Nayaka Ni Made Wiwik Setiawati Ni Wayan Sukma Antari Nurul Chusna Nyoman Budiartha Siada Puspawati, Made Putra, I Gede Agus Shuarsedana Putu Era Sandhi Kusuma Yuda Putu Sukma Purnamasari RR. Asih Juanita Sasadara, Maria Malida Vernandes Sukmayanti, Ni Kadek Suyasa, Agus Baratha Swari, Ni Luh Putu Triska Ananda Rahayu Wardani, I Gusti Ayu Agung Kusuma Widnyani, Dewa Ayu Sri Bintang