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All Journal BIOTROPIA - The Southeast Asian Journal of Tropical Biology Jurnal Sains dan Teknologi Pharmaciana: Jurnal Kefarmasian Farmasains : Jurnal Ilmiah Ilmu Kefarmasian JPSCR : Journal of Pharmaceutical Science and Clinical Research Jurnal Riset Kesehatan Nasional Jurnal Ilmiah Medicamento Jurnal Penelitian Agama Hindu Jurnal Kesehatan Primer JRKN Usadha Borneo Journal of Pharmacy Jurnal Kesehatan Primer

Dwi Arymbhi Sanjaya

Universitas Mahasaraswati Denpasar

Author-ID : 1288600

Religion Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Computer Science & IT Dentistry Education Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Veterinary

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Studi Retrospektif Penggunaan Antibiotik pada Pasien Covid-19 dengan Pneumonia di Rumah Sakit “X” Provinsi Bali, Indonesia Siada, Nyoman Budiartha; Juanita, Rr Asih; Sanjaya, Dwi Arymbhi; Meriyani, Herleeyana
Jurnal Ilmiah Medicamento Vol 10 No 1 (2024): Jurnal Ilmiah Medicamento
Publisher : Fakultas Farmasi Universitas Mahasaraswati Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36733/medicamento.v10i1.7637

COVID-19 with bacterial pneumonia co-infection is a condition with bacteria present in COVID-19 patients. The prevalence of bacterial co-infection in COVID-19 patients ranges from 12.4%–50%. This study aims to determine the relationship between the appropriate use of antibiotics and the severity of inpatients with COVID-19 and pneumonia co-infection at Hospital "X" Bali Province, Indonesia. This research is an observational study with a cross-sectional approach. Data collection was carried out retrospectively on medical record data of COVID-19 inpatients with pneumonia co-infection at Hospital "X" Bali Province, Indonesia for the period January - December 2021. The sampling technique used total sampling according to inclusion and exclusion criteria. Appropriate use of antibiotics antibiotic was analyzed using Pharmaceutical Care Network Europe (PCNE) version 9.1. The patient severity index was an assessment based on the Pneumonia Severity Index (PSI) score. The relationship between the appropriate use of antibiotics and the severity of inpatients with COVID-19 and pneumonia co-infection was analyzed using Fisher's test. Of the 80 COVID-19 inpatients with pneumonia co-infection, 90% experienced inappropriate use of antibiotics. Fisher's test results showed that there was no significant relationship between the appropriate use of antibiotics and the severity of inpatients with COVID-19 and pneumonia co-infection at Hospital "X" Bali Province, Indonesia (p > 0.05).

Eribulin Effectiveness and Safety in Metastatic Triple-Negative Breast Cancer: A Narrative Review Meriyani, Herleeyana; Sanjaya, Dwi Arymbhi; Juanita, Rr. Asih; Siada, Nyoman Budiartha; Chusna, Nurul; Ketupapa, Florentina Gabriela
Borneo Journal of Pharmacy Vol. 8 No. 1 (2025): Borneo Journal of Pharmacy
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjop.v8i1.7913

Triple-negative breast cancer is an aggressive and poor prognosis subtype of breast cancer. Eribulin has shown promise in the treatment of metastatic triple-negative breast cancer (mTNBC). This review aimed to provide a specific description, evidence, and discussion of the efficacy and safety of eribulin both as monotherapy and in combination with another agent in patients with mTNBC. The search was conducted in five databases (PubMed, ScienceDirect, PLoS One, Wiley Online Library, and Cochrane Library) towards published articles during the 2013-2023 period. A total of 237 articles were identified. After removing 69 duplicates, 168 articles underwent the screening process and 10 articles met the research criteria. Eribulin monotherapy effectiveness profile includes: overall survival (10.8-17.6 months), progression-free survival (2.8-3.2 months), partial response (21.0%-58.7%), progressive disease (15.5% -47.0%), and stable disease (28.8%-32%). However, there were no cases of complete response. Combination of eribulin with other agents' effectiveness profiles includes: overall survival (8.3-14.5 months), PFS (2.6-8.1 months), partial response (31.8-76.0%), complete response (2.4-8%), progressive disease (8.0-28%), and stable disease (8.0-52.3%). Eribulin monotherapy's safety profile is similar to that of combination therapy. No grade 5 adverse event was reported during monotherapy or in combination with other agents. The grade 4 adverse events reported are neutropenia, leukopenia, thrombocytopenia, anemia, peripheral neuropathy, fatigue, diarrhea, vomiting, dyspnea, back pain, arthralgia, febrile neutropenia, dyspnea, constipation, general physical health deterioration, alopecia. The all-grade adverse events with a percentage above 50% are neutropenia, leukopenia, thrombocytopenia, asthenia, alopecia, elevated AST, elevated ALT, hand-foot syndrome, fatigue, anemia, peripheral neuropathy, oral mucositis, and nausea.

Cross-resistance to antibiotics of Escherichia coli in the inpatient installation of general regional hospital “X” Bali, Indonesia Mahaputra, I Putu Yudistira; Sanjaya, Dwi Arymbhi; Meriyani, Herleeyana; Juanita, Rr Asih; Siada, Nyoman Budiartha; Kamalia, Made Gek Adisti; Adrianta, Ketut Agus; Noviani, Lusy
Pharmaciana Vol. 15 No. 1 (2025): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/pharmaciana.v15i1.29209

Escherichia coli (E. coli) is a critical-priority group of MDR bacteria and its spread can occur in hospital inpatient settings. Several studies showed that antibiotics consumption for inpatients can cause E. coli resistance to other antibiotics called cross-resistance. The aim of this study to determine the cross-resistance in E. coli to antibiotics in the inpatient installation of the regional general hospital "X" in Bali, Indonesia by analyzing the relationship between the antibiotic consumption and the percentage of antibiotic resistance of E. coli. This research is an ecological study with the independent variable is the antibiotics consumption defined as defined daily doses/100 bed-days and the dependent variable is the percentage of E. coli resistance during 2017-2020. The correlation between the level of antibiotic consumption and the percentage of E. coli resistance to antibiotics was analyzed using the Pearson correlation tests. The results showed that the consumption of tetracycline had a significant correlation with increased resistance of E. coli to meropenem and piperacillin-tazobactam (r=0.8-1.0; p<0.05). This showed that there is cross-resistance in E. coli. This incident is associated with selective pressure, horizontal and vertical gene transfer in E. coli. The consumption of tetracycline, apart from inducing the production of the tet gene which is the cause of resistance to tetracycline, can also induce the production of resistance genes to broad-spectrum beta-lactam antibiotics such as piperacillin-tazobactam and meropenem.

Efektivitas dan Efek Samping pada Terapi Multi-Drug-Resistant Tuberculosis (MDR-TB): Kajian Literatur Sanjaya, Dwi Arymbhi; Meriyani, Herleeyana; Juanita, Rr. Asih; Siada, Nyoman Budiartha; Noviani, Lusy
Jurnal Ilmiah Medicamento Vol 11 No 1 (2025): Jurnal Ilmiah Medicamento
Publisher : Fakultas Farmasi Universitas Mahasaraswati Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36733/medicamento.v11i1.9685

Multi-drug-resistant tuberculosis (MDR-TB) leads to a reduced cure rate for tuberculosis treatment. The global number of MDR-TB cases remained relatively stable between 2015 and 2020 but increased in 2021. In 2020, the World Health Organization (WHO) estimated 437,000 MDR-TB cases worldwide, which rose to 450,000 cases in 2021. Various treatment regimens recommended by the WHO require a review of the literature on the efficacy and side effects of drug use in MDR-TB. This review aims to provide updated information that can be used as a reference for the early identification and management of side effects. The article was a narrative review that collected and analyzed information from various international articles on databases such as PubMed, PlosOne, and ScienceDirect from January 2014 to June 2024. A total of six relevant articles were synthesized from 609 articles. The effectiveness of MDR-TB therapy with WHO-recommended drugs has shown a high cure rate (cured>50%). The incidence of side effects in MDR-TB therapy is smaller compared to the effectiveness of treatment. However, a study conducted at Wuhan Jinyintan Hospital in China from July 2019 to December 2020 showed that all study subjects experienced side effects. This included nausea and vomiting from protionamide, gatifloxacin, and ethambutol; hyperuricemia from pyrazinamide, and hyperpigmentation from clofazimine. It is recommended that a therapy regimen be selected based on culture test results, patient conditions, and drug availability in each country.

Penggunaan Antibiotik dan Resistensi Escherichia coli and Klebsiella pneumoniae: Studi Ekologikal Lima Tahun di Sebuah Rumah Sakit Umum Daerah Sanjaya, Dwi Arymbhi; Meriyani, Herleeyana; Juanita, Rr. Asih; Siada, Nyoman Budiartha; Mahaputra, Yudistira; Kamalia, Made Gek Adisti
Jurnal Ilmiah Medicamento Vol 11 No 2 (2025): Jurnal Ilmiah Medicamento
Publisher : Fakultas Farmasi Universitas Mahasaraswati Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36733/medicamento.v11i2.11156

Antibiotic resistance is a growing global health threat, partly driven by high antibiotic consumption. The World Health Organization (WHO) has identified critical-priority bacteria, including Escherichia coli and Klebsiella pneumoniae, due to their increasing resistance to multiple antibiotics. This study aimed to evaluate the correlation between antibiotic consumption and resistance rates in Escherichia coli and Klebsiella pneumoniae. This ecological study was conducted at a Regional Hospital in Indonesia based on retrospective inpatient data from January 2019 to December 2023. The population in this study is all data on systemic antibiotic consumption based on the J01 category of the Anatomical Therapeutic Chemical/Defined Daily Dose (ATC/DDD) classification system and antibiogram from inpatient databases. Pearson and Spearman’s rank correlation analyses were performed to examine the associations between systemic antibiotic consumption levels and the percentage of Escherichia coli and Klebsiella pneumoniae resistance to other antibiotics. The most frequently used antibiotics were cefixime (305.664 DDD/100 bed-days), levofloxacin (139.552 DDD/100 bed-days), and ceftriaxone (109.805 DDD/100 bed-days). A strong and statistically significant correlation was observed between doxycycline consumption and Escherichia coli resistance to meropenem (r=0.894; p=0.041). Moreover, consumption levels of cefazolin, ceftazidime, cefepime, and ciprofloxacin were correlated with Escherichia coli resistance to ceftriaxone (p<0.05), while cefoperazone use demonstrated a very strong and statistically significant correlation with Escherichia coli resistance to ampicillin-sulbactam (r=0.952; p=0.012). Conversely, no significant correlation was found between antibiotic consumption and resistance in Klebsiella pneumoniae, suggesting that alternative factors such as intrinsic resistance mechanisms, mobile genetic elements, and environmental reservoirs may influence resistance development.

Karakteristik Fisik Dan Uji Mikrobiologi Serta Skrining Fitokimia Loloh Kombinasi Daun Jempiring, Daun Pegagan, Daun Katuk, Dan Air Kelapa Puspawati, Made; Sanjaya, Dwi Arymbhi; Mendra, Ni Nyoman Yudianti
Usadha Vol 4 No 2 (2025): Usadha : Jurnal Integrasi Obat Tradisional
Publisher : Fakultas Farmasi Universitas Mahasaraswati Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36733/usadha.v4i02.7362

Loloh is a traditional herbal beverage specifically produced by the Balinese community to prevent and treat various ailments. One example of loloh used for health maintenance can be formulated from a mixture of jempiring leaves (Gardenia jasminoides), pegagan leaves (Centella asiatica), katuk leaves (Breynia androgyna), and coconut water (Cocos nucifera). A major challenge in loloh production is the risk of microbial contamination. This study aims to examine the physical characteristics, bioactive compound profile, and microbiological quality of loloh formulated from a combination of jempiring leaves (G. jasminoides), pegagan leaves (C. asiatica), katuk leaves (B. androgyna), and coconut water (C. nucifera). The research employed an experimental design with a descriptive approach. Observed variables included organoleptic characteristics (color, form, odor), pH, microbiological parameters (total plate count [TPC] and yeast and mold count [YMC]), and phytochemical screening of the loloh preparation. The samples used in this study were loloh packaged in 250 ml bottles. A total of six bottles were used, with five allocated for microbiological testing and one for phytochemical screening. The resulting loloh exhibited a brown color, a distinctive odor, and a pH of 6. All five microbiological samples showed microbial contamination exceeding the permissible limits, with TPC values surpassing 10⁶ CFU/g and YMC values exceeding 10⁴ CFU/g. Phytochemical screening revealed the presence of alkaloids, flavonoids, saponins, tannins, and steroids. It can be concluded that loloh is rich in bioactive compounds; however, hygienic practices and microbiological safety must be carefully considered, particularly during production and packaging processes.

Antidepressant-Like Activity and Physicochemical Analysis of Essential Oils from Michelia alba and Plumeria alba Flowers Nayaka, Ni Made Dwi Mara Widyani; Swari, Ni Luh Putu; Widnyani, Dewa Ayu Sri Bintang; Sukmayanti, Ni Kadek; Yuda, Putu Era Sandhi Kusuma; Wardani, I Gusti Ayu Agung Kusuma; Sanjaya, Dwi Arymbhi
JST (Jurnal Sains dan Teknologi) Vol. 11 No. 2 (2022)
Publisher : Universitas Pendidikan Ganesha

Depression is a mental disorder with an increased prevalence. Other than conventional antidepressants, essential oils have been used in aromatherapy as a complementary and alternative medicine to reduce depression. In the current study, the antidepressant-like activity of the inhalation of essential oils from Michelia alba (MAEO) and Plumeria alba (PAEO) flowers was analyzed using the forced swim test. The immobility time of mice from tested groups was evaluated statistically by the non-parametric Kruskal Wallis test, followed by the Mann Whitney post hoc test. Also, the characterization of both essential oils was determined by refractive index, solubility, and Gas Chromatography-Mass Spectrophotometry (GC-MS) analysis. PAEO showed stronger antidepressant-like activity than MAEO (p<0.05) and it was equal to the positive control (essential oil of Lavandula angustifolia) (p>0.05). The GC-MS analysis revealed some calming agents in MAEO and PAEO such as linalool, linalyl acetate, phenylethyl alcohol, and methyl anthranilate.

Antibiotic consumption and resistance: a 3-years ecological study for four critical groups of bacteria in a general regional hospital Sanjaya, Dwi Arymbhi; Siada, Nyoman Budiartha; Juanita, Rr Asih; Mahaputra, I Putu Yudistira; Kamalia, Made Gek Adisti; Meriyani, Herleeyana
Pharmaciana Vol. 14 No. 1 (2024): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/pharmaciana.v14i1.27321

Pseudomonas aeruginosa, Acinetobacter baumannii, Escherichia coli, and Klebsiella pneumoniae are the most critical groups of multi-drug resistant (MDR) bacteria that cause a threat in hospitals. This study identified the trend of antibiotic consumption, antibiotic resistance pattern, and the relationship between antibiotic consumption and antibiotic resistance in a critical group of bacteria in a general regional hospital. This ecological study was based on retrospective data from inpatient databases in a general regional hospital over three years (2017-2019). The trend for annual antibiotic consumption over 2017-2019 was defined as defined daily doses/100 bed-days. The relationship between total antibiotic consumption and the percentage of antibiotic resistance among four isolated critical bacteria was explored in time series analysis and linear regression. The most frequently used antibiotic was ampicillin (220.33 DDD/100 bed-days), ciprofloxacin (126.86 DDD/100 bed-days), and ampicillin-sulbactam (126.34 DDD/100 bed-days). There was a significant relationship between antibiotic consumption (ampicillin, ampicillin-sulbactam, ceftazidime, gentamicin, amikacin, and ciprofloxacin) in DDD/100 bed-days and antibiotic resistance in E. coli, K. pneumoniae, and P. aeruginosa (p<0.05) but not statically significant in A. baumannii (p=0.062). The annual usage fluctuated or remained stable, with no statistically significant trends change. The relationship between antibiotic consumption and antibiotic resistance was significant in three out of four critical groups of bacteria.

Procedure for Using Crystalloid and Colloid Fluids in Blood Pressure in Sectio Caesaria Patients Using Spinal Anesthesia Technique Sanjaya, Dwi Arymbhi; Agustini, Ni Luh Putu Inca Buntari; Putra, I Gede Agus Shuarsedana; Lewar, Emanuel Ileatan
JURNAL KESEHATAN PRIMER Vol 3 No 2 (2018): JKP (Jurnal Kesehatan Primer)
Publisher : Poltekkes Kemenkes Kupang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.5281/jkp.v3i2.255

Background: In Indonesia, the study about effectivity and side effect of colloid and crystalloid fluid have been completed, but the study about standard operating procedures (SOP) never have been done. The aim of this research was to describe and evaluate the SOP for the use of crystalloid and colloid fluids on blood pressure in sectio caesarea by using spinal anesthesia techniques. Method: The research employed a descriptive quantitative method by using a questionnaire. The basic features of crystalloid and colloid fluid selection were analyzed by multiple response tests. This research was conducted in type A hospitals in the Denpasar area by involving 30 anesthesiologist as a respondent. Result: The results indicated that 76.7% of respondents stated that there was no SOP for crystalloid and colloid fluids to prevent maternal hypotension in sectio caesarea by using spinal anesthesia techniques. In the multiple response tests, the effectiveness and side effects (21.3%) were the factors that had to be considered in the crystalloid and colloids fluid selection to prevent maternal hypotension in sectio caesarea by using spinal anesthesia techniques. The National Guideline of Medical Services for Anesthesiology and Incentive Therapy have been followed in determining the use of crystalloid and colloid fluids at section Caesarea. However, the guideline did not explain the basis for selecting crystalloid and colloid fluids to prevent maternal hypotension in sectio caesarea by using spinal anesthesia techniques in more detail, therefore the factors of effectiveness and risk of side effects are the main consideration.

Criteria for Patients using Crystalloid and Colloid Fluids in Sectio Caesaria Lewar, Emanuel Ileatan; Sanjaya, Dwi Arymbhi; Putra, I Gede Agus Shuarsedana
JURNAL KESEHATAN PRIMER Vol 3 No 2 (2018): JKP (Jurnal Kesehatan Primer)
Publisher : Poltekkes Kemenkes Kupang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.5281/jkp.v3i2.260

Background: In Indonesia, the study about effectivity and side effect of colloid and crystalloid fluid have been completed, but the sample on the study was varied. The aim of this research was to describe the criteria of patient which used of crystalloid and colloid fluids on blood pressure in sectio caesarea by using spinal anesthesia techniques. Method: The research employed a descriptive quantitative method by using a questionnaire. The basic features of crystalloid and colloid fluid selection were analyzed by multiple response tests. This research was conducted in type A hospitals in the Denpasar area by involving 30 anesthesiologist as a respondent. Result: The results indicated that 100% of respondents stated that they used crystalloid for patient with allergic and they used coloid for patient with high risk edema. The result has been reviewed with The National Guideline of Medical Services for Anesthesiology and Incentive Therapy have been followed in determining the use of crystalloid and colloid fluids at section Caesarea. However, the guideline did not explain the basis for selecting crystalloid and colloid fluids to prevent maternal hypotension in sectio caesarea by using spinal anesthesia techniques, therefore the factors of effectiveness and risk of side effects are the main consideration.

Co-Authors AA Istri Mas Padmiswari Agus Baratha Suyasa Ambara Damayanti, Made Elvenia Asthadi Mahendra Bhandesa, Asthadi Mahendra Chusna, Nurul Desak Ketut Ernawati Emanuel Ileatan Lewar Erna Cahyaningsih Fitria Megawati Herleeyana Meriyani I Gede Agus Shuarsedana Putra I Putu Yudistira Mahaputra Ida Ayu Manik Damayanti Kamalia, Made Gek Adisti Ketupapa, Florentina Gabriela Ketut Agus Adrianta LEWAR, EMANUEL ILEATAN Luh Risma Putri Rahayu Made Agus Deny Mahendra Putra Made Gek Adisti Kamalia Mahaputra, I Putu Yudistira Mahaputra, Yudistira Mendra, Ni Nyoman Yudianti Meriyani, Herleeyana Ni Kadek Sukertiasih Ni Luh Kade Arman Anita Dewi Ni Luh Putu Inca Buntari Agustini Ni Made Dwi Mara Widyani Nayaka Ni Made Wiwik Setiawati Ni Wayan Sukma Antari Noviani, Lusy Nyoman Budiartha Siada Prascitasari, Nyoman Ayu Puspawati, Made Putra, I Gede Agus Shuarsedana Putu Era Sandhi Kusuma Yuda Putu Sukma Purnamasari RR. Asih Juanita Sasadara, Maria Malida Vernandes Setiawati, Ni Made Wiwik Sukmayanti, Ni Kadek Suryawan, Kadek Suyasa, Agus Baratha Swari, Ni Luh Putu Triska Ananda Rahayu Wardani, I Gusti Ayu Agung Kusuma Widnyani, Dewa Ayu Sri Bintang Wulandari, Ni Putu Nadya Kirana Yudiartha, I Wayan Maysa

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