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Adini, Syilvi
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OPTIMASI RASIO VOLUME PELARUT DAN WAKTU EKSTRAKSI TERHADAP RENDEMEN EKSTRAK BATANG KECOMBRANG (Etlingera eltior) SERTA PROFIL METABOLIT SEKUNDER MENGGUNAKAN LC-MS/MS: EFFECT OF SOLVENT VOLUME RATIO AND TIME OF EXTRACTION ON THE YIELD EXTRACT OF KECOMBRANG STEM (Etlingera elatior) AND SECONDARY METABOLITE PROFILING USING LC-MS/MS Syilvi Adini; Shirly Kumala; Siswa Setyahadi; Sofi Nurmay Stiani; Yusransyah
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 8 No 1 (2023)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v8i1.713

Abstract

Kecombrang (Etlingera elatior) merupakan salah satu tanaman asli Indonesia yang digunakan sebagai obat. Walaupun semua bagian tanaman ini dapat dimanfatkan, bagian batang merupakan yang paling banyak digunakan sebagai obat.  Metabolit sekunder yang terkandung dalam batang kecombrang memiliki banyak aktivitas farmakologi. Proses ekstraksi metabolit sekunder dipengaruhi oleh beberapa faktor, diantaranya adalah volume pelarut dan waktu ekstraksi. Penelitian ini bertujuan untuk mengetahui rasio volume pelarut dan waktu ekstraksi optimal pada proses ekstraksi batang kecombrang yang memberikan rendemen tertinggi dan untuk mengetahui profil metabolit sekunder yang terkandung di dalamnya. Batang kecombrang dimaserasi dengan metode maserasi kinetik menggunakan pelarut metanol dengan rasio volume pelarut 1:10, 1:20 dan 1:30 selama 60 menit. Kemudian hasil rendemen tertinggi dari variasi volume pelarut dioptimasi lebih lanjut menggunakan variasi waktu ekstraksi 15, 30, 60, 90, 120 dan 180 menit. Pengujian profil metabolit sekunder dilakukan menggunakan LC-MS/MS. Hasil optimasi menunjukan bahwa volume pelarut dengan rendemen tertinggi terdapat pada rasio 1:30 dan variasi waktu pada menit ke 120 menit. Esktrak metanol batang kecombrang menunjukkan adanya senyawa biondinin A, methyl kushenol C, trichosanic acid dan malvalic acid. Hal ini menunjukkan bahwa kondisi optimal ekstraksi batang kecombrang adalah pada rasio volume pelarut 1:30 selama 120 menit dan profil metabolit sekundernya biondinin A, methyl kushenol C, asam punisik dan asam malvalic. Kata kunci: Batang kecombrang, optimasi, rendemen, LC-MS/MS
OPTIMASI RASIO VOLUME PELARUT DAN WAKTU EKSTRAKSI TERHADAP RENDEMEN EKSTRAK BATANG KECOMBRANG (Etlingera eltior) SERTA PROFIL METABOLIT SEKUNDER MENGGUNAKAN LC-MS/MS: EFFECT OF SOLVENT VOLUME RATIO AND TIME OF EXTRACTION ON THE YIELD EXTRACT OF KECOMBRANG STEM (Etlingera elatior) AND SECONDARY METABOLITE PROFILING USING LC-MS/MS Syilvi Adini; Shirly Kumala; Siswa Setyahadi; Sofi Nurmay Stiani; Yusransyah
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 8 No 1 (2023)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v8i1.713

Abstract

Kecombrang (Etlingera elatior) merupakan salah satu tanaman asli Indonesia yang digunakan sebagai obat. Walaupun semua bagian tanaman ini dapat dimanfatkan, bagian batang merupakan yang paling banyak digunakan sebagai obat.  Metabolit sekunder yang terkandung dalam batang kecombrang memiliki banyak aktivitas farmakologi. Proses ekstraksi metabolit sekunder dipengaruhi oleh beberapa faktor, diantaranya adalah volume pelarut dan waktu ekstraksi. Penelitian ini bertujuan untuk mengetahui rasio volume pelarut dan waktu ekstraksi optimal pada proses ekstraksi batang kecombrang yang memberikan rendemen tertinggi dan untuk mengetahui profil metabolit sekunder yang terkandung di dalamnya. Batang kecombrang dimaserasi dengan metode maserasi kinetik menggunakan pelarut metanol dengan rasio volume pelarut 1:10, 1:20 dan 1:30 selama 60 menit. Kemudian hasil rendemen tertinggi dari variasi volume pelarut dioptimasi lebih lanjut menggunakan variasi waktu ekstraksi 15, 30, 60, 90, 120 dan 180 menit. Pengujian profil metabolit sekunder dilakukan menggunakan LC-MS/MS. Hasil optimasi menunjukan bahwa volume pelarut dengan rendemen tertinggi terdapat pada rasio 1:30 dan variasi waktu pada menit ke 120 menit. Esktrak metanol batang kecombrang menunjukkan adanya senyawa biondinin A, methyl kushenol C, trichosanic acid dan malvalic acid. Hal ini menunjukkan bahwa kondisi optimal ekstraksi batang kecombrang adalah pada rasio volume pelarut 1:30 selama 120 menit dan profil metabolit sekundernya biondinin A, methyl kushenol C, asam punisik dan asam malvalic. Kata kunci: Batang kecombrang, optimasi, rendemen, LC-MS/MS
Edukasi Penggunaan Kosmetik yang Aman dan Halal pada Masyarakat di Desa Kemanisan Curug Serang Nabillah, Deya Adiby; Stiani, Sofi Nurmay; Yusransyah, Yusransyah; Ismiyati, Renditya; Adini, Syilvi; Seira, Trisya
Jurnal Pengabdian Pada Masyarakat Vol 9 No 3 (2024): Jurnal Pengabdian Pada Masyarakat
Publisher : Universitas Mathla'ul Anwar Banten

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30653/jppm.v9i3.908

Abstract

Kosmetik yang beredar di pasaran harus dijamin keamanan dan kehalalannya oleh instansi terkait, untuk memberikan rasa aman kepada setiap konsumen. Tujuan dari pengabdian ini adalah untuk meningkatkan pemahaman tentang pentingnya penggunaan kosmetik yang aman dan halal kepada Masyarakat desa Kemanisan, Kota Serang. Kegiatan pengabdian kepada masyarakat ini berupa edukasi masyarakat melalui penyuluhan dengan mengukur tingkat pengetahuan menggunakan kuesioner. Hasil pengabdian menunjukkan bahwa tingkat pengetahuan responden sebelum penyuluhan adalah baik (42%), Cukup (46%), dan Kurang (12%). Tingkat pengetahuan responden setelah konseling baik (56%), Cukup (38%) dan Kurang (6%). Berdasarkan hasil pengabdian ini dapat disimpulkan bahwa tingkat pengetahuan responden sebelum dan sesudah penyuluhan dilakukan terjadi peningkatan. Kegiatan pengabdian kepada masyarakat melalui metode penyuluhan mampu meningkatkan pengetahuan responden mengenai penggunaan kosmetik yang aman dan halal. Cosmetics circulating on the market must be guaranteed safety and halal by the relevant agencies, to provide a sense of security to every consumer. The aim of this service is to increase understanding of the importance of using safe and halal cosmetics among the people of Kemanisan village, Serang City. This community service activity takes the form of public education through counseling by measuring the level of knowledge using a questionnaire. The results of the service showed that the level of knowledge of respondents before counseling was good (42%), sufficient (46%), and poor (12%). The level of knowledge of respondents after counseling was good (56%), sufficient (38%) and poor (6%). Based on the results of this service, it can be concluded that the level of knowledge of respondents before and after the counseling was carried out increased. Community service activities through outreach methods are able to increase respondents' knowledge about the use of safe and halal cosmetics.
Edukasi Penggunaan Obat Antidiabetes saat Berpuasa Ramadhan di Panti Asuhan Hasanudin Pandeglang Stiani, Sofi Nurmay; Yusransyah, Yusransyah; Chairani, Farahdina; Adini, Syilvi; Noviyanto, Fajrin; Ernawati, Eneng Elda; US, Sumarlin; Udin, Baha; Pratiwi, Linda Rani
Jurnal Pengabdian Pada Masyarakat Vol 9 No 4 (2024): Jurnal Pengabdian Pada Masyarakat
Publisher : Universitas Mathla'ul Anwar Banten

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30653/jppm.v9i4.934

Abstract

Umat muslim diwajibkan untuk berpuasa di bulan Ramadhan, temasuk penderita Diabetes Melitus sehingga terdapat perubahan waktu makan dan menyebabkan terjadinya perubahan pola waktu penggunaan obat yang tidak tepat pada saat berpuasa dan dapat menimbulkan efek yang tidak diinginkan sehingga tidak tercapainya target terapi obat. Kesalahan penggunaan obat diabetes dapat dicegah dengan memberikan edukasi terkait penggunaan obat pada saat berpuasa. Oleh karena itu, pemberian edukasi pada pengabdian masyarakat ini menjadi salah satu rangkaian kegiatan utama dengan tujuan untuk meningkatkan pengetahuan masyarakat terkait penggunaan obat diabetes pada saat berpuasa sehingga dapat meningkatan ketepatan dalam mencapai target terapi. Kegiatan ini menggunakan metode ceramah yang dilanjutkan dengan diskusi tanya jawab. Tolak ukur keberhasilan edukasi ini adalah jawaban kuesioner sebelum dan sesudah pelaksanaan edukasi. Total peserta pada kegiatan ini sebanyak 50 orang dengan mayoritas laki-laki berusia 28-33 tahun. Hasil kegiatan ini menunjukan peningkatan pengetahuan penggunaan obat di bulan Ramadhan tanpa harus membatalkan puasa. Hal tersebut ditunjukkan pada peningkatan persentase peserta dengan kategori baik (10%) dan cukup (2%). Selain itu, hasil uji statistik menunjukkan terdapat perbedaan signifikan antara jawaban benar saat sebelum dan setelah edukas. Hal ini membuktikan bahwa pelaksanaan edukasi sangat penting untuk meningkatkan pengetahuan masyarakat terutama terkait penggunaan obat di bulan Ramadhan. Muslims are required to fast in the month of Ramadan, including people with Diabetes Mellitus so that there are changes in meal times and cause changes in the pattern of inappropriate drug use during fasting and can cause unwanted effects so as not to achieve the target of drug therapy. Errors in the use of diabetes drugs can be prevented by providing education related to the use of drugs during fasting. Therefore, providing education in this community service is one of the main series of activities with the aim of increasing public knowledge related to the use of diabetes drugs during fasting so as to increase accuracy in achieving therapeutic targets. This activity uses a lecture method followed by a question and answer discussion. The benchmark for the success of this education is the answer to the questionnaire before and after the implementation of education. The total number of participants in this activity was 50 people with the majority of men aged 28-33 years. The results of this activity showed an increase in knowledge of the use of drugs in the month of Ramadan without having to break the fast. This is shown in the increase in the percentage of participants in the good (10%) and fair (2%) categories. In addition, the statistical test results showed a significant difference between the correct answers before and after education. This proves that the implementation of education is very important to improve public knowledge, especially regarding the use of drugs in the month of Ramadan.
Socialization on the use of medicinal plants to raise public awareness of herbal medicine Kelutur, Faruk Jayanto; Adini, Syilvi; Amoretti, Riffa Sephillda; Rohmah, Siti Laila; Hasana, Indah Ayu Nur; Harpan, Andri; Hadi, Agriyaningsih Oktaviana
Abdimas: Jurnal Pengabdian Masyarakat Universitas Merdeka Malang Vol. 10 No. 1 (2025): February 2025
Publisher : University of Merdeka Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26905/abdimas.v10i1.14805

Abstract

Over time, advancements in the medical field have led to a decline in public trust in herbal medicine due to the fast-acting effects of chemical drugs. However, herbal medicines generally have fewer side effects. Public awareness of health remains low, particularly in Kamanisan Village, largely due to limited knowledge. A comprehensive strategy is needed to enhance public awareness and understanding of medicinal plants. This program aims to increase public knowledge and awareness of the use of medicinal plants. The activity took place in RT.07/RW.13 Kamanisan, Curug District, involving 30 participants. It included a pre-test questionnaire, material presentation, Q&A session, and post-test. The results showed an increase in participant knowledge from 86.76 percent to 90 percent. The number of participants who strongly agreed with the use of medicinal plants (in Indonesia: TOGA) rose from 12 to 22 people. The Chi-Square test indicated a significant impact on knowledge and attitudes before and after the session. Additionally, the paired sample t-test confirmed differences in pre- and post-knowledge, pre- and post-attitude, and knowledge-to-attitude shifts. The success of this activity strengthens public awareness of TOGA as a complementary and alternative treatment for various diseases.
Effectiveness of TB-Reminder Application in Improving Medication Adherence and Quality of Life of Lung Tuberculosis Patients in Indonesia Yusransyah, Yusransyah; Stiani, Sofi Nurmay; Chairani, Farahdina; Adini, Syilvi; Subchan, Mohamad; Ferdiyansyah, Ferdiyansyah; Putri, Nabila Septiani; Pratiwi, Rossi; Udin, Baha
Sciences of Pharmacy Volume 4 Issue 3
Publisher : ETFLIN Publishing House

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58920/sciphar0403358

Abstract

Poor adherence to anti-tuberculosis (TB) treatment continues to hinder therapeutic success and patient quality of life. This study aimed to evaluate the effectiveness of the TB-R mobile application in improving medication adherence and quality of life among pulmonary TB patients at Pandeglang Regional Hospital. Eighty-six patients were randomized into intervention (n = 43) and control (n = 43) groups. Adherence and quality of life were measured using the Medication Adherence Rating Scale (MARS) and EQ-5D-5L, respectively. After one month, the intervention group demonstrated significantly higher adherence (97.7% vs. 79.0%, p < 0.001) and improvement in mean MARS scores (24.7 vs. 22.7, p < 0.001). Although quality of life gains were not statistically significant overall, notable improvements were observed in anxiety/depression and self-care domains. Demographic factors influenced outcomes: patients aged 29–39 and those living with others showed better adherence, while patients aged 40–50 experienced greater quality of life gains. Women aged 51–60 living alone had decreased adherence despite quality of life improvements. These results suggest that mHealth tools like TB-R can enhance adherence, especially when supported by favorable social and demographic conditions. Tailored digital interventions may optimize treatment outcomes in TB care. Future mHealth app development should consider these social and demographic factors to maximize effectiveness and user engagement.
Antibacterial Activity of Kecombrang (Etlingera elatior) Stems Against Skin Infection-Causing Bacteria Adini, Syilvi; Kumala, Shirly; Setyahadi, Siswa
Sciences of Pharmacy Volume 4 Issue 3
Publisher : ETFLIN Publishing House

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58920/sciphar0403322

Abstract

Skin infections caused by Staphylococcus aureus, Staphylococcus epidermidis, and Propionibacterium acnes often exhibit resistance to conventional treatments. This issue has led to the exploration of medical plants, such as kecombrang stems (Etlingera elatior), which are known for their antibacterial properties. This study aimed to evaluate the antibacterial activity of kecombrang stem and to identify its active compounds. The methanolic extract of kecombrang stems was tested against the three bacteria using the disc diffusion method at concentrations of 80%, 40%, and 20%. The Minimum Inhibitory Concentration (MIC) was determined using the microdilution method and an ELISA reader. TLC-Bioautography was employed to identify the antibacterial compounds present in the extract. The methanol extract of kecombrang stems exhibited antibacterial activity against S. aureus, S. epidermidis, and P. acnes, with an inhibition zone diameter ranging from 9.23 ± 0.472 to 25.53 ± 0.378 mm. The MIC results showed that the minimum concentration of 78.12 ppm could inhibit the growth of S. aureus by 33.74%, S. epidermidis by 14.45%, and P. acnes by 3.5%. The results of TLC Bioautography analysis indicate that flavonoids exhibit antibacterial properties. The kecombrang stem has the potential to serve as an antibacterial agent against bacteria that cause skin infections.
Uji Anti Inflamasi Kombinasi Ekstrak Rimpang Kencur (Kaempferia Galanga L.) dan Daun Salam (Syzygium Polyanthum) pada Tikus Putih Galur Sprague Dawley yang Diinduksi Karagenan Elis Wildayani; Deya Adiby Nabillah; Syilvi Adini
Al-Hayat: Natural Sciences, Health & Environment Journal Vol. 3 No. 1 (2025): Al-Hayat: Natural Sciences, Health & Environment Journal 
Publisher : Institut Agama Islam Nasional Laa Roiba Bogor

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47467/alhayat.v3i1.9282

Abstract

Inflammation is the body's response to tissue injury, which is usually caused by physical trauma, harmful chemicals, or microorganisms. Kencur rhizomes and bay leaves have been proven effective as anti-inflammatories. The purpose of this study is to determine the anti-inflammatory effect of a combination of kencur rhizome extract and bay leaves in reducing the volume of 1% carrageenan-induced rat foot edema. The research method is a laboratory experiment using 24 Wistar Sprague dawley male white rats with 1% carrageenan induction. The test materials used were KNR (1% carrageenan), KNT (CMC-Na 0,5%), KD1 (50 : 50 mg/kg BB), KD2 (150 : 250 mg/kg BB), KD3 (250 : 75 mg/kg BB), and KPT (diclofenac sodium) ( mg/kg BB). The test materials were administered orally one hour before induction with 0.2 mL of 1% carrageenan. Foot volume measurements were taken every hour for six hours after carrageenan induction. The results showed that the 150 : 250 mg/kg dose combination group could inhibit the onset of inflammation by 89%; the 250 : 75 mg/kg dose combination group could inhibit it by 75%; and the 50 : 50 mg/kg dose combination group could inhibit it by 56%. In the positive control group (diclofenac sodium), the percentage of inflammation inhibition was 60%. Therefore, it can be concluded that the higher the concentration of kencur rhizome extract and bay leaves, the greater the decrease in anti-inflammatory activity. The combination of kencur rhizome extract and bay leaves at a dose of 150 : 250 mg/kgBB is an effective dose for inhibiting edema, as evidenced by the results of this study.
MEASUREMENT OF QUALITY PARAMETERS OF SIMPLICIA AND EKSTRACT OF KECOMBRANG STEM (Etlingera elatior) Adini, Syilvi; Shobah, Afifah Nur; Chandra, Pra Panca Bayu
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 10 No 3 (2025)
Publisher : Universitas Muhammadiyah Ahmad Dahlan Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v10i3.1752

Abstract

Kecombrang (Etlingera elatior) is a type of plant known to the Indonesian people as a medicinal plant for a long time. Kecombrang stem is empirically used to treat coughs, reduce fever, act as an antiseptic, treat diarrhoea and stomach pain. Kecombrang stem has the potential to be used as a raw material for herbal medicines. Plants used as raw materials for herbal medicines must meet quality requirements in accordance with the requirements of both specific and non-specific parameters. This study aimed to determine the quality of the simplicia and 96% ethanol extract of kecombrang stem. Simplicia and 96% ethanol extract were tested for specific parameters, including organoleptic, microscopic, and phytochemical screening. Non-specific parameter testing includes the measurement of moisture content, residual solvents, and microbial contamination. Tests of specific parameters on organoleptic kecombrang stem simplicia are light brown, aromatic odor, and tasteless. Microscopically, kecombrang stem simplicia was identified with fragments consisting of transport bundles, ladder-type transport bundles, fibers, and parenchyma with secretory cells. Phytochemical screening of kecombrang stem simplicia revealed the presence of alkaloids, phenolics, flavonoids, steroids, tannins, and saponins. The results of non-specific parameter testing on 96% ethanol extract of kecombrang stem showed 1.09% moisture content, 0.48% solvent residue, 0 CFU/g bacterial contamination, and yeast/mould. Kecombrang stem is a raw material for herbal medicine that meets the quality requirements of specific and non-specific parameters. Keywords: Etlingera elatior, Non-specific parameters, Simplicia quality, Specific parameters.
PENGARUH PERBEDAAN JENIS PELARUT TERHADAP KADAR FLAVONOID TOTAL BATANG KECOMBRANG (Etlingera elatior) Adini, Syilvi; Syilvi Adini; Sofi Nurmay Stiani; Yusransyah
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 10 No 2 (2025): Jurnal Ilmiah Ibnu Sina
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jiis.v10i2.2546

Abstract

Kecombrang stem (Etlingera elatior) contains flavonoid compounds and can be used as a medicine, an antibacterial, and an antioxidant. Several factors influence the extraction compounds in plants, one of which is the type of solvent. This study aimed to determine the effect of different solvents on the total flavonoid content in kecombrang stems. Kecombrang stems were extracted using methanol, 70% ethanol, and 96% ethanol. Qualitative flavonoid analysis was carried out using color reagents and thin-layer chromatography (TLC), and quantitative analysis was carried out using a UV-Vis spectrophotometer. The results of the qualitative flavonoid test showed that all kecombrang stem extracts were positive for flavonoids, indicated by a color change to yellow-orange, and the TLC results showed that all extracts were positive for flavonoids, indicated by light blue fluorescence under UV light 366 nm, with an Rf value range of 0.62-0.66. The results of determining total flavonoid levels in methanol extract were 12.14 mgQE/g, 70% ethanol was 13.55 mgQE/g, and 96% ethanol was 21.77 mgQE/g. One-way ANOVA statistical analysis showed that differences in solvent types significantly affected the total flavonoid levels of kecombrang stems, with a p value <0.05. The highest flavonoid levels in kecombrang stems were found in 96% ethanol extract.
Co-Authors Amanda, Shalza Amoretti, Riffa Sephillda Ashari, Elva Febri Baha Udin Candra, Tifany Maulida Chairani, Farahdina Chandra, Pra Panca Bayu Deya Adiby Nabillah Elis Wildayani Ernawati, Eneng Elda Fajrin Noviyanto, Fajrin Ferdiyansyah, Ferdiyansyah Hadi, Agriyaningsih Oktaviana Harpan, Andri Hasana, Indah Ayu Nur Ismiyati, Renditya Kelutur, Faruk Jayanto Mursyid, Abdillah Nabillah, Deya Adiby Novita, Via Ofsah, Olin Najilah Perdi, Perdi Pratiwi, Linda Rani Pratiwi, Rossi Putri, Nabila Septiani Ristiani, Yuanisa Rohmah, Siti Laila Seira, Trisya Shirly Kumala Shobah, Afifah Nur Siswa Setyahadi Siswa Setyahadi Stiani, Sofi Nurmay Subchan, Mohamad Syilvi Adini US, Sumarlin Yulistina, Isti Yusransyah, Yusransyah