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All Journal Media Teknologi Hasil Perikanan Jurnal MIPA PHARMACON JURNAL BIOMEDIK CHEMISTRY PROGRESS Briliant: Jurnal Riset dan Konseptual Jurnal Farmasi Medica (Pharmacy Medical Journal) PMJ Jurnal Abdi Insani Vivabio : Jurnal Pengabdian Multidisiplin Malacca Pharmaceutics Grimsa Journal of Science Engineering and Technology Journal of Community Empowerment Jurnal Lentera Farma
Antasionasti, Irma
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Earth & Planetary Sciences Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Mathematics Medicine & Pharmacology Physics Public Health Social Sciences

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Journal : CHEMISTRY PROGRESS

 1 
KARAKTERISASI NANOPARTIKEL EKSTRAK ETANOL KAYU MANIS (Cinnamomum burmanii) DENGAN KITOSAN SODIUM TRIPOLIFOSFAT SEBAGAI KANDIDAT ANTIOKSIDAN Antasionasti, Irma; Jayanto, Imam; Abdullah, Surya Sumantri; Siampa, Jainer Pasca
CHEMISTRY PROGRESS Vol 13, No 2 (2020)
Publisher : Sam Ratulangi University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/cp.13.2.2020.31392

Abstract

Ekstrak etanol kayu manis memiliki kandungan fenol yang tinggi yang berpotensi sebagai antioksidan tetapi memiliki bioavailabilitas yang rendah pada kondisi ukuran partikel yang besar. Oleh karena itu, dilakukan analisis karakteristik nanopartikel ekstrak etanol kayu manis. Tujuan penelitian untuk membuat dan mengevaluasi karakteristik nanopartikel ekstrak kayu manis sebagai kandidat antioksidan secara in vitro. Preparasi nanopartikel ekstrak etanol kayu manis dengan metode gelasi ionik. Nanopartikel ekstrak etanol kayu manis memiliki ukuran partikel sebesar 400,3 nm dengan potential zeta +6,60 mV. Spektra Fourier Transform Infrared (FTIR) menunjukkan adanya gugus hidroksil dan gugus amida dari kitosan dan gugus fosfat dari STPP. Studi aktivitas antioksidan secara in vitro dengan metode 2,2-diphenyl-1-picrylhydrazyl (DPPH), 2,2'-azino-bis (3-ethylbenzothiazoline-6-sulfonic acid (ABTS) dan reduksi besi III menunjukkan bahwa nanopartikel ekstrak etanol kayu manis memiliki aktivitas antioksidan yang lebih kecil dibandingkan ekstrak tetapi masih dalam kategori sangat kuat. Aktivitas antioksidan yang diberikan dipengaruhi oleh kandungan total fenolik dan total flavonoid secara berturut-turut sebesar 75,685 ± 1,408 % EAG dan 60,546 ± 0,670 % EK untuk ekstrak etanol kayu manis serta 61,845 ± 0,529 % EAG dan 57,939 ± 0,446 % EK untuk nanopartikel ekstrak etanol kayu manis. Penerapan teknologi nanopartikel pada ekstrak etanol kayu manis melalui ikat silang antara kitosan-TPP dapat mempertahankan aktivitas antioksidannya.ABSTRACT Ethanol extract of cinnamon has a high phenol content which is potential as an antioxidant but has a low bioavailability under conditions of large particle size. Therefore, nanoparticles were prepared for the ethanol extract of cinnamon. The aim of this research was to make and evaluate the characteristics of cinnamon nanoparticles as antioxidant candidates in vitro. The cinnamon nanoparticles were prepared using the ionic gelation method. Cinnamon nanoparticles has a particle size of 400,3 nm with a zeta potential of +6,60 mV. Fourier Transform Infrared (FTIR) spectra showed the presence of a hydroxyl and amida group from chitosan and a phosphate group from STPP. In vitro antioxidant activity studies with the 2,2-diphenyl-1-picrylhydrazyl (DPPH), 2,2'-azino-bis (3-ethylbenzothiazoline-6-sulfonic acid (ABTS) method and ferric reducing activity power showed that cinnamon nanoparticle has smaller antioxidant activity than the extract but is still in the very strong category. The antioxidant activity given is influenced by the total phenolic and total flavonoids content 75.685 ± 1.408% EAG and 60.546 ± 0.670% EK for cinnamon ethanol extract. and 61.845 ± 0.529% EAG and 57.939 ± 0.446% EK for cinnamon ethanol extract nanoparticles, respectively The application of nanoparticle technology to the ethanol extract of cinnamon through chitosan-TPP cross-linking can maintain its antioxidant activity.
ANALISIS SIFAT FISIKOKIMIA, FARMAKOKINETIK DAN TOKSIKOLOGI PADA PERICARPIUM PALA (Myristica fragransa) SECARA ARTIFICIAL INTELLIGENCE Abdullah, Surya Sumantri; Putra, Purnawan Pontana; Antasionasti, Irma; Rundengan, Gerald; Suoth, Elly Juliana; Abdullah, Rezky Putri Indarwati; Abdullah, Fatamorgana
CHEMISTRY PROGRESS Vol 14, No 2 (2021)
Publisher : Sam Ratulangi University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/cp.14.2.2021.37112

Abstract

Pala (Myristica fragransa) mengandung senyawa metabolit sekunder yang menunjukkan aktivitas farmakologi. Namun, bagian perikarpium terutama bagian nonvolatil belum banyak dilaporkan. Tujuan dari penelitian ini sebagai screening awal dengan melihat potensi dari senyawa yang dihasilkan perikarpium pala.Dua belas senyawa digambar dua dimensi, dianalisis menggunakan software dan server prediktor. Software yang digunakan adalah Marvin Sketch, ChembioDraw kemudian dianalisis sifat fisikokimia senyawa tersebut. Selanjutnya, server predictor untuk melihat karakteristik farmakokinetika dan toksisitasnya. Berdasarkan analisis sifat fisikokimia senyawa terbaik yaitu licarin (titik didih, titik kritis temperature dan refraksi molar), guaiacin (titik leleh), dan virolane (titik kritis tekanan). Hasil analisis Lipinski menunjukkan senyawa stigmasterol dan b-sitosterol tidak memenuhi kriteria Lipinski.. Selain itu data farmakokinetika menunjukkan stigmasterol, b-sitosterol, asetoneoglinan memiliki kelarutan dalam air yang rendah. Nilai permeabilitas CaCO-2 dan intestinal absorption semuanya memenuhi. Licarin termasuk substrat P-glikoprotein. Volume Distribusi menunjukkan semua senyawa terikat protein serum. b-sitosterol permeabilitas terhadap sawar darah-otak yang paling baik dan erythro-(7S,8R)-∆8’-7-acetoxy-3,4,3’,5’-tetramethoxy-8-O-4’-neolignan permeabilitasnya buruk. Surinamensin menunjukkan permeabilitas terhadap sistem saraf pusat yang tidak dapat berpenerasi. Elemicin dan surinamensin tidak dimetabolisme oleh enzim sitokrom CYP3A4. B-sitosterol memiliki klirens paling tinggi. Semua senyawa menunjukkan tingkat toksisitas yang rendah untuk penggunaan kulit (kecuali elemicin) dan tidak toksik bagi hati.ABSTRACT Nutmeg (Myristica fragransa) contains secondary metabolites that exhibit pharmacological activity. However, the pericarpium, especially the nonvolatile part, has not been widely reported. The purpose of this study was as an initial screening by looking at the potential compounds produced by the nutmeg pericarp. Twelve compounds were drawn in two dimensions, analyzed using software and predictor servers. The software used is Marvin Sketch, ChembioDraw and then the physicochemical properties of these compounds are analyzed. Furthermore, the predictor server to see the pharmacokinetic characteristics and toxicity. Based on the analysis of the physicochemical properties of the best compounds, compound licarin (boiling point, critical point of temperature and molar refractivity), guaiacin (melting point), and virolane (critical point of pressure). The results of Lipinski's analysis showed that stigmasterol and b-sitosterol compounds did not meet Lipinski's rule. In addition, pharmacokinetic data showed that stigmasterol, b-sitosterol, acetoneoglinan had low solubility in the water. The values of CaCO-2 permeability and intestinal absorption were all satisfactory. Licarin is a P-glycoprotein substrate. The Volume Distribution shows all the compositions of the serum proteins. B-sitosterol with the best permeability to the blood-brain barrier and erythro-(7S,8R)-∆8'-7-acetoxy-3,4,3',5'-tetramethoxy-8-O-4'-neolignan bad permeability. Surinamensin exhibits permeability to the non-permeable central nervous system. Elemicin and surinamensin are not metabolized by the cytochrome enzyme CYP3A4. B-sitosterol has the highest clearance. All compounds show a low level of toxicity for skin use (except elemicin) and are not toxic to the liver. 
Co-Authors AA Sudharmawan, AA Abdulgani, Nayla Inayah Abdullah, Fatamorgana Abdullah, Rezky Putri Indarwati Abdullah, Surya Sumantri Adithya Yudistira Bawole, Avinda Shania Wiane Dadiani, Ni Made Damanis, Frelinsia V.M. Defny S. Wewengkang, Defny S. Dolongtelide, Jeclin Inebel Dzaki, Najwan Nafis Edwin de Queljoe Elly Suoth Ering, Mariando N. Fatimawali . GONI, BRIGITA CHRISTANIA AURORA Hariyanto, Yuanita Amalia Hebber, Tri Herny E.I. Simbala Jayanto, Imam Julianri Sari Lebang, Julianri Sari Kalalo, Marko Jeremia LAPIAN, ALDA JULISTY GABRIELA Lasut, Misella R. C. Lasut, Misella Regina Lestari, Utami Sasmita Ma'ruf, Nurul Qalbiyyah Mahendra Kusuma Nugraha Maringka, Pingkan C. Meilani Jayanti Muhammad Setiawan Nurhamidin, Anastasia P.R. Nurmiati Nurmiati PANI, PUTRI MARGARETHA GLAUDY Paulina yamlean Prayoga, Deshanda Kurniawan Rahmawati, Dian Wahyu Ratte, Titah Amelia Rumagit, Tjandra A. RUMALUTUR, CHRISTHALIA IEWANDA Rundengan, Gerald Rundengan, Gerald Edward Samiun, Asriyani Siampa, Jainer Pasca Sri Sudewi, Sri Sukmaningrum, Krisnawati Sumantri Abdullah, Surya Sutrisna, Agung Takawaian, Agrita Feisilia Tasiam, Ezrani TRINA EKAWATI TALLEI Trina Tallei Widya Astuty Lolo, Widya Astuty Wiyono, Weny I. Wiyono, Weny Indayany