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All Journal Indonesian Journal of Cancer Chemoprevention Jurnal Kesehatan Andalas Dentino: Jurnal Kedokteran Gigi Jurnal Analis Kesehatan Jurnal Ilmu Kedokteran dan Kesehatan Jurnal Medika Malahayati Jurnal Kebidanan Mutiara Mahakam Jurnal Kesehatan Pasak Bumi Kalimantan Jurnal Kedokteran Mulawarman Jurnal Medika: Karya Ilmiah Kesehatan Mulawarman Dental Journal Journal of Tropical Pharmacy and Chemistry Jurnal Sains dan Kesehatan
Irawiraman, Hadi
Universitas Mulawarman
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health

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PROFIL PENDERITA KANKER PAYUDARA USIA DIATAS 50 TAHUN DI LABORATORIUM PATOLOGI ANATOMI TAHUN 2020-2022 RSUD ABDUL WAHAB SJAHRANIE SAMARINDA. Anggraini, Githa Dwi; Irawiraman, Hadi; Saputri, Maulida Julia
Jurnal Analis Kesehatan Vol. 13 No. 2 (2024): JURNAL ANALIS KESEHATAN
Publisher : Department of Health Analyst, Politeknik Kesehatan, Kementerian Kesehatan Tanjungkarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26630/jak.v13i2.4560

Abstract

Kanker payudara menempati urutan tertinggi dalam jumlah kasus kanker sekaligus menjadi penyebab kematian terbesar akibat kanker di dunia setiap tahunnya. Data Globocan tahun 2020, jumlah kasus baru kanker payudara mencapai 68.858 kasus (16.6%) dari total 396.914 kasus baru kanker di Indonesia. penderita kanker payudara lebih dominan di usia 40 - 60 tahun. Pada penelitian ini bertujuan Untuk mengidentifikasi profil penderita kanker payudara berdasarkan paritas, Gambaran Histopatologi, dan Stadium Klinis Profil penderita kanker payudara usia diatas 50 tahun dilaboratorium patologi anatomi tahun 2020-2022 RSUD Abdul Wahab Sjahranie. Penelitian ini menggunakan desain Cross Sectional, observasional analitik. Besar Sampel 49 penderita kanker payudara, teknik pengambilan Purposive sampling. Penelitian ini dilaksankan di Rekam Medik dan Laboratorim Patologi Anatomi RSUD Abdul Wahab Sjahranie Samarinda. Hasil penelitian menggunkan Analisis Univariat. Dari penelitian ini menunjukkan persentase terbanyak pada penderita kanker payudara kelompok Paritas Multipara 31 orang (64%), Gambaran Histopatologi pada karsinoma duktal infiltrasi 41 orang (94%), dan Stadium Klinis tipe IIB 17 orang (35%). Sebaran kanker payudara terbanyak pada Paritas Multipara, Gambaran histopatologi terbanyak karsinoma duktal infiltrasi, dan Stadium klinis terbanyak pada tipe IIB.
Uji Efektifitas Ekstrak Etanol Bawang Tiwai (Eleutherine americana Merr) Terhadap Keadaan Klinis Tikus Periodontitis Yang Diinduksi Porphyromonas gingivalis Ibrahim, Jamilah; Yani, Sinar; Irawiraman, Hadi
Mulawarman Dental Journal Vol 1, No 2 (2021): MOLAR September 2021
Publisher : Fakultas Kedokteran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30872/MOLAR.v1i2.5040

Abstract

Background: Periodontitis is inflammation and infection that occurs in the periodontal tissue and alveolar bone supporting the teeth. Periodontal tissue examination should be performed to determine the severity of a periodontal disease. There are various kinds of examinations such as gingival index measurement, probing depth measurement, & bleeding on probing examination. Tiwai onions (Eleutherine americana Merr) have anti-inflammatory effects through the content of flavonoids and phenolic compounds. Objective: This study aims to determine the anti-inflammatory effectiveness of the ethanol extract of tiwai onion (Eleutherine americana Merr) against the clinical condition of post Porphyromonas gingivalis induced periodontitis rats.Method: The study was a true experimental method with the Posttest Only and Control Group Design method. The bacteria used was Porphyromonas gingivalis ATCC® 33277. This study consisted of 5 treatment groups using ethanol extracts of tiwai onions leaves with a concentration 140 mg/kg BW, 280 mg/kg BW, 560 mg/kg BW, sodium diclofenac 9 mg/kg BW and CMC. Data obtained by measuring the diameter of the gingival edema. Statistical analysis by using One Way Anova.Results: The ethanol extract of tiwai onion has an effect at a dose of 560 mg / kgBW on the clinical condition of the periodontal tissue by measuring the gingival index, periodontal depth and bleeding on probing in periodontitis rats.Conclusion: The ethanol extract of tiwai dose has an effect on the clinical condition of periodontal tissue by measuring the gingival index, periodontal depth and bleeding on probing in preventing periodontitis in male white wistar rats after Porphyromonas gingivalis induction at a dose of 560 mg / kg BW. Keywords: Eleutherine Americana Merr, Porphyromonas gingivalis, Periodontitis, gingival index, periodontal depth, bleeding on probing
Efektivitas Ekstrak Daun Sirih Tanah (Piper sarmentosum Roxb.ex Hunter) Terhadap Jumlah Makrofag Pasca Pencabutan Gigi Tikus Wistar Tofarisa, Dzulhiyana Laili; Purnamasari, Cicih Bhakti; Yani, Sinar; Irawiraman, Hadi
Mulawarman Dental Journal Vol 1, No 2 (2021): MOLAR September 2021
Publisher : Fakultas Kedokteran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30872/MOLAR.v1i2.5587

Abstract

Pencabutan gigi merupakan salah satu pelayanan kesehatan gigi yang sering dijumpai. Setelah tindakan pencabutan gigi, akan terbentuk soket gigi dan luka pada jaringan lunak di sekitarnya. Luka adalah hilang atau rusaknya sebagian jaringan tubuh. Penyembuhan luka dikatakan baik apabila luka pada soket sudah menutup sempurna. Penelitian ini bertujuan untuk mengetahui efektifitas ektsrak daun sirih tanah (Piper sarmentosum Roxb ex. Hunter) dalam penyembuhan luka dan penurunan jumlah makrofag pasca pencabutan gigi tikus wistar. Jenis penelitian ini merupakan penelitian ekperimental dengan desain penelitian post test only control group design. Terdapat kelompok perlakuan dengan dosis EDST 20%,30% dan 40%, kontrol positif dan kontrol negatif. Pengulangan dilakukan sebanyak 2 kali. Analisis statistik yang digunakan yaitu Komolgrov Sminorv Test, Levenes Test , Annova dan LSD Test. Hasil penelitian menunjukkan terdapat efektivitas ekstrak daun sirih tanah 20%, 30% dan 40% terhadap penurunan jumlah makrofag pasca pencabutan gigi tikus Wistar. Ekstrak daun sirih tanah (Piper sarmentosum Roxb.ex Hunter) dengan dosis 40% memiliki efektivitas paling baik dalam menurunkan jumlah makrofag pada soket pasca pencabutan gigi tikus wistar dibandingkan dengan dosis ekstrak 20% dan 30%.Kata kunci: Pencabutan gigi, ekstrak daun sirih tanah, Piper sarmentosum Roxb.ex Hunter,  makrofag
Distribution of Mandibular Fractures Based on Age, Gender, Etiology, and Fracture Region at Abdoel Wahab Sjahranie Hospital Samarinda from 2019 to 2023 Gayatri, Amanda Putri; Pramasari, Cristiani Nadya; Cahya, Wahyuni Dwi; Anitasari, Silvia; Irawiraman, Hadi
Jurnal Sains dan Kesehatan Vol. 7 No. 1 (2025): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v7i1.2367

Abstract

Mandibular fracture is one of the fractures in the facial area and is most often caused by trauma. A hard impact to the face can result in a fracture of the mandible. This research aims to investigate the distribution of mandibular fracture based on age, gender, etiology, and fracture region at Abdoel Wahab Sjahranie Hospital Samarinda from 2019 to 2023. This research is quantitative research using descriptive observational research design. The results of this research showed that adolescent age from 12 to 25 years old was the age group in which mandibular fracture cases were found the most, with 34 cases (54%) in this research were from that age group. In terms of gender, mandibular fracture cases were found more in male samples, with 52 cases (82.5%) were male. Traffic accident was the most common etiology of mandibular fractures found, comprising of 47 cases (74.6%) from the total number of cases in this research. The most common fracture region found in this research was the parasymphysis region, with 13 cases (20.6%) in this research had parasymphyseal fracture.   Keywords:          Distribution, Mandibular Fracture, Mandibular Fracture Region
Profil Penderita Kanker Di RSUD Aji Muhammad Parikesit Tenggarong Kalimantan Timur Anggada, Satria Pria; Irawiraman, Hadi; Hasanah, Nurul
Jurnal Ilmu Kedokteran dan Kesehatan Vol 12, No 2 (2025): Volume 12 Nomor 2
Publisher : Prodi Kedokteran Fakultas Kedokteran Universitas Malahayati

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/jikk.v12i2.17734

Abstract

Kanker merupakan penyakit yang disebabkan oleh proliferasi sel tubuh yang tak terkendali dan dapat menyebar ke bagian tubuh lain. Hingga saat ini, kanker masih menjadi salah satu masalah kesehatan utama di dunia. Penelitian ini bertujuan untuk mengetahui profil penderita kanker di RSUD Aji Muhammad Parikesit Tenggarong tahun 2020-2023. Variabel yang diteliti meliputi usia, jenis kelamin, lokasi kanker, stadium kanker dan domisili. Penelitian ini merupakan penelitian deskriptif retrospektif dengan menggunakan metode total sampling. Hasil penelitian menunjukkan bahwa terdapat total 535 penderita kanker. Usia penderita kanker terbanyak berada pada rentang usia 41-50 tahun (29,7%), 51-60 tahun (25,6%), 61-70 tahun (15,3%), 31-40 tahun (15,1%), dan 71-80 tahun (5,4%). Penderita kanker berjenis kelamin laki-laki sebanyak 35,3% dan 64,7% lainnya adalah perempuan. Lokasi kanker terbanyak adalah di payudara (28,6%), serviks (11,6%), kelenjar getah bening (8,0%), nasofaring (7,7%), dan kolorektal (6,9%). Penderita kanker yang berdomisili di Kabupaten Kutai Kartanegara sebanyak 93,1%, dengan 31,0% di antaranya berdomisili di Kecamatan Tenggarong. Sementara itu, 5,4% penderita kanker berdomisili di luar Kabupaten Kutai Kartanegara, dan 1,5% tidak memiliki keterangan domisili. Disimpulkan bahwa penderita kanker sebagian besar berusia di atas 40 tahun, didominasi oleh perempuan, lokasi kanker terbanyak adalah di payudara, dan sebagian besar berdomisili di Kecamatan Tenggarong, Kabupaten Kutai Kartanegara.
Hubungan antara Rasio Neutrofil Terhadap Limfosit Preterapi dengan Angka Harapan Hidup Pasien Karsinoma Nasofaring di RSUD Abdoel Wahab Sjahranie Tahun 2018 Aulia, Nabiella Hasti; Irawiraman, Hadi; Susanti, Eva
Jurnal Kesehatan Andalas Vol. 12 No. 1 (2023): Online March 2023
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jka.v12i1.2155

Abstract

Nasopharyngeal carcinoma is a malignancy that originates from the epithelial tissues lining the nasopharynx and is considered one of the most common malignant cancers which cause mortality in Indonesia. Neutrophils and lymphocytes are the first lines to provide body immunity against foreign substances. Neutrophil-to-Lymphocyte Ratio (NLR) is a prognostic factor in various malignancies. Objective: To investigated the correlation between pre-therapy Neutrophil-to-Lymphocyte Ratio (NLR) and survival rate among patients with nasopharyngeal carcinoma at Abdoel Wahab Sjahranie Regional Public Hospital in 2018. Methods: The Neutrophil-to-Lymphocyte Ratio (NLR) data were obtained from outpatient medical records at Abdoel Wahab Sjahranie Regional Public Hospital in 2018. In addition, the data on mortality status were collected based on the information after directly contacting the patients. A purposive sampling technique was used to collect the data. Thirty-three data of patient medical records were obtained and analyzed using Kaplan-Meier survival analysis with a significant p-value of <0.05. Results: The analysis result showed p-value of 0.495. Conclusion: There is no correlation between pre-therapy Neutrophil-to-Lymphocyte Ratio (NLR) and survival rate among patients with nasopharyngeal carcinoma.Keywords:  nasopharyngeal carcinoma, neutrophil-to-lymphocyte ratio, survival rate
Hubungan Usia dan Kadar Prostate Specific Antigen (PSA) dengan Derajat Histopatologi Adenokarsinoma Prostat di RSUD Abdoel Wahab Sjahranie Samarinda Pratiwi, Novita Eka Tyas; Riastiti, Yudanti; Irawiraman, Hadi; Danial, Danial
Jurnal Kesehatan Andalas Vol. 12 No. 2 (2023): Online July 2023
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jka.v12i2.2176

Abstract

Adenocarcinoma prostate generally occurs in older adults and maybe because of increase in prostate-specific antigen (PSA) levels.  It is essential to know the relationship between age and PSA levels with histopathological grade to determine the appropriate management in cases of prostate adenocarcinoma. Objective: To determined  the relationship between age and  PSA levels with the histopathological grade of prostate adenocarcinoma patients at Abdoel Wahab Sjahranie General Hospital, Samarinda. Methods: The research design was analytic observational with a cross-sectional study approach. The data was taken from the medical records of prostate adenocarcinoma patients at Abdoel Wahab Sjahranie Hospital Samarinda from 2018 until 2022 using the total sampling method. 52 patients met the inclusion criteria. Bivariate analysis using the Chi-square test. Results:This study showed that there was no relationship between age (p=0.433) and PSA levels (p=0.347) with the histopathological grade of prostate adenocarcinoma patients at Abdoel Wahab Sjahranie General Hospital, Samarinda. Conclusion: There was no significant relationship between age and PSA levels with the histopathological grade of prostate adenocarcinoma at Abdoel Wahab Sjahranie Hospital, Samarinda.Keywords: adenocarcinoma prostate, age,  histopathological degree, PSA levels
Ethanol Extract of Artocarpus odoratissimus (Tarap) Bark Inhibit Migration of MDA-MB-231 Triple Negative Breast Cancer Cells Rachmi, Eva; Hasanah, Nurul; Irawiraman, Hadi; Nuratifah, Annisa Puteri; Nahusuly, Fritz
Indonesian Journal of Cancer Chemoprevention Vol 14, No 2 (2023)
Publisher : Indonesian Society for Cancer Chemoprevention

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14499/indonesianjcanchemoprev14iss2pp83-93

Abstract

Breast cancer is the most diagnosed cancer in the world, with triple negative breast cancer (TNBC) being one of its subtypes that exhibits an aggressive clinical course, a tendency for early metastasis, and a poor prognosis. Tarap (Artocarpus odoratissimus Blanco) is an endemic plant of East Kalimantan, which possesses anticancer potential. This study aimed to explore the ability of ethanol extract of Tarap bark (EETB) in reducing cell viability, inducing apoptosis and inhibiting migration of MDA-MB-231 cells. Cell viability was observed by 3-(4.5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. EETB -induced apoptosis was analyzed by double staining allophycocyanin (APC) Annexin V with PI kit through flow cytometry. Cell migration was determined through scratch assay. EETB was found to decrease cell viability with an IC50 value of 1607.302 μg/ml (R=0.369). EETB’s ability to induce total apoptosis did not show significant differences across various concentrations. EETB was able to inhibit cell migration, especially at concentrations of 800 mg/ml, both at 24-h and 48-h observations. This finding demonstrates that EETB has a weak effect on reducing the viability and inducing the apoptosis of MDA-MB-231 cells. EETB induced morphological cells type change in to globular type and significantly inhibits two-dimensional migration of MDA-MB-231 cells.Keywords: Tarap, Artocarpus odoratissimus, triple negative breast cancer.
Co-Authors Abdillah Iskandar Anggada, Satria Pria Anggraini, Githa Dwi anggrayni, Yuni Annisa Salsabila Aulia, Nabiella Hasti Azis, Sepriani indriati Cahya, Wahyuni Dwi Carta A. Gunawan Danial - Danial Danial Dipo Try Harto Nusantara Eko Nugroho Emil Bachtiar Moerad Emil Bachtiar Moerad Endang Sawitri Enggarita Widyahapsari Eva Rachmi Eva Susanti Eva Susanti Fauziah Putri Chatamy Gayatri, Amanda Putri Hasyimi, Ryadh Kamil Huljannah, Mifta Hutahaean, Yetty Octavia Ibrahim, Jamilah Ihza Firdaus, Ajril Ilham Akbar Choirul Umam Kesuma, Suryanata Khairunnida Rahma Krispinus Duma Moriko Pratiningrum Muhammad Imaduddin Nur Ichsan Muhammad Rizky Ramadhan Muthi’ah, Nisa Nabiella Hasti Aulia Nahusuly, Fritz Nirapambudi Devianto Nova, Dewa Made Rama Novita Eka Tyas Pratiwi Nuratifah, Annisa Puteri Nurul Hasanah Nurul Hasanah Nurul Hikmah Ompusunggu, P.M.T. Mangalindung Pramasari, Cristiani Nadya Pratiningrum, Moriko Pratiwi, Novita Eka Tyas Prinadira, Sarah Purnamasari, Cicih Bhakti Rahmat Bakhtiar Retnaningrum, Yuliana Rahmah Saputri, Maulida Julia Silvia Anitasari, Silvia Sulistiani, Dewi Arsih Swandari Paramita Tofarisa, Dzulhiyana Laili Widia Rahmadhani Yani, Sinar Yudanti Riastiti Yudanti Riastiti Yudanti Riastiti Yulianto, Ade Yusuf