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All Journal Indonesian Journal of Pharmaceutical Science and Technology JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Ensiklopedia of Journal Jurnal Riset Kefarmasian Indonesia Edukasi Masyarakat Sehat Sejahtera (EMaSS) Medical Sains : Jurnal Ilmiah Kefarmasian
Sutiswa, Shandra Isasi
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Arts Humanities Chemistry Computer Science & IT Dentistry Education Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Nursing Public Health Social Sciences Other

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Effectiveness Test of Spray Gel Hand Sanitizer with Carbomer 940 as a Preventive Product in Emergency Conditions Sutiswa, Shandra Isasi; Aji, Nur; Yulia, Nunung
Indonesian Journal of Pharmaceutical Science and Technology Vol 12, No 2 (2025)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v12i2.45186

Abstract

Hand sanitizer is known for its ability to kill germs quickly due to its alcohol content, making it more effective than washing hands with soap and water. However, excessive use of alcoholbased sanitizers can cause skin irritation and dryness. Alcohol is polar and volatile, leading to rapid skin dryness and reduced effectiveness. To address this, gelling agents like Carbomer 940 are added to spray gel formulations. Carbomer 940 offers high stability and low toxicity, thereby enhancing the gel’s antibacterial properties. This study aims to develop an innovative spray gel hand sanitizer using Carbomer 940. The research method used was a pure experiment, evaluating the % inhibition of microbial growth on agar media. Results showed that the spray gel with 0.05% Carbomer 940 had superior effectiveness, with 60.77% inhibition, compared to the control group using the WHO formula, which achieved 33.11%. Additionally, the spray gel had a pH of 6.5 ± 0.2, a viscosity of 135.10, and an average spray weight of 0.027 ± 0.000 g, demonstrating optimal physical quality. In conclusion, the spray gel hand sanitizer with 0.05% Carbomer 940 was more effective at inhibiting microbial growth than the WHO standard formula.
Formulation and Characterization of Instant Powder Combination of Ginger, Bangle, and Lemon Extract as an Antioxidant Aji, Nur; Sutiswa, Shandra Isasi
JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Vol. 10 No. 3 (2023): JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jfiki.v10i32023.331-346

Abstract

Background: Degenerative disease is a  decreasing organ function; clinical manifestations can affect the whole body, which is caused by oxidative stress. Ginger, bangle, and lemon have antioxidant properties. The combination of the three is expected to increase antioxidant activity. Objective: This study aimed to determine the potential antioxidant activity of the mixture of the three samples formulated as instant powder. Methods: This research is an experimental laboratory. This study will examine the effect of variations in extract concentration and PEG-40 HCO concentration on instant powder's characteristics and antioxidant activity. Results: Individually, ginger extract has extreme antioxidant activity (IC50 = 23.57 ± 0.13 µg/mL) and bangle strong (IC50 = 64.89 ± 0.15 µg/mL), while lemon has weak antioxidant activity (IC50 >500 µg/mL). Combining ginger, bangle, and lemon with a simplex axial method obtained the combination of ginger: bangle: lemon with the ratio of 4/6: 1/6: 1/6. Adding a mixture of extracts affects the solubility and antioxidant activity of the extracts. The greater the amount of extract, the lower the solubility, and the antioxidant activity did not increase with addition. The addition of PEG-40 HCO increases the solubility of the extract in the instant powder. Antioxidant activity increased to the "medium” category (121.90 µg/mL) after adding PEG-40 HCO at a concentration of 2.70%. The unfavourable impact of PEG-40 HCO addition on instant powders is the angle of repose, flow time, and compressibility. Conclusion:  The ginger, bangle, and lemon can be combined and made into instant powder with potential antioxidant activity in the moderate category.
Co-Authors Aji, Nur Anwar, Seniwaty Apidianti, Sari Pratiwi Arniawan, Arniawan Asep Kuswandi Askur, Askur Diky Mudhakir ernita, ernita Fauzi, Ahmad Zil Gama Bagus Kuntoadi Gustini, Gustini Mohammad Ali Noorma, Nilam Nunung Yulia Nuri Handayani Ohorella, Arfan Primasari, Yefta Putra, Ryryn Suryaman Prana Raden Bagus Edy Santoso Riana Dewi Sety, La Ode Muhamad Siddiq, Muhammad Nuzul Azhim Ash Suryani, Maria Eka YEYET CAHYATI Yoyoh, Imas Yulia, Nunung Yulianita, Yulianita