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All Journal Indonesian Journal of Pharmaceutical Science and Technology JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Ensiklopedia of Journal Jurnal Riset Kefarmasian Indonesia Edukasi Masyarakat Sehat Sejahtera (EMaSS) Medical Sains : Jurnal Ilmiah Kefarmasian
Sutiswa, Shandra Isasi
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PENINGKATAN DISOLUSI ROSUVASTATIN CALSIUM DARI SEDIAAN TABLET DENGAN TEKNIK LIQUISOLID DAN PEMBENTUKAN KOMPLEKS INKLUSI Sutiswa, Shandra Isasi; Cahyati, Yeyet; Mudhakir, Diky
Jurnal Riset Kefarmasian Indonesia Vol 1 No 2 (2019): Jurnal Riset Kefarmasian Indonesia
Publisher : APDFI (Asosiasi Pendidikan Diploma Farmasi Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (678.776 KB) | DOI: 10.33759/jrki.v1i2.21

Abstract

Rosuvastatin calcium is a salt form of rosuvastatin with antilipidemia activity. Rosuvastatin Calcium classified in class two of Biopharmaceutics Clasification System (BCS) has low solubility in water (17.96 mg / L) and high permeability. Based on this, rosuvastatin calcium needs to be formulated appropriately in order to produce high bioavailability and maximum therapeutic effect. The bioavailability of BCS 2 drug is determined by the dissolution rate of the drug in gastrointestinal fluid so that a technique is needed in formulating the drug. This study aims to develop a formulation technique for rosuvastatin calcium tablets through liquisolid technique and formation of inclusion complexes with β-cyclodextrin in order to increase the rate of dissolution. Tablet formulation with liquisolid technique was made with a concentration of 10% rosuvastatin calcium in propylene glycol, with a ratio of US2® (carrier) and Aerosil 200 (coating) made with a ratio of 10: 1 and 20: 1. In addition to the formulation with liquisolid technique, formulations were also carried out with the complex inclusion technique of rosuvastatin calcium-β-cyclodextrin using kneading method and freeze drying method with a mol ratio of 1: 1 and 1: 2. The liquisolid system and inclusion complexes formed were characterized using FTIR and SEM. Characterization results indicated changes in the form of polymorphous rosuvastatin calcium. Tablet formulations were made by direct compression using a liquisolid system and an inclusion complex equivalent to 10 mg of rosuvastatin calcium. Based on the results of the ANOVA statistical test and further LSD tests showed that calcium rosuvastatin tablets made with liquisolid and inclusion complexes can increase the dissolution rate compared to pure rosuvastatin calcium tablets and inovator rosuvastatin calcium tablets. The highest dissolution rate was produced by liquisolid R20: 1 tablet at 60 minutes at 85.53 ± 1.02% in an enzyme-free simulated gastric fluid dissolution medium and 110.02 ± 1.71% in an enzyme-free simulated intestinal fluid dissolution medium.
HUBUNGAN BREEDING PLACE, KEBERADAAN RESTING PLACE DAN PRAKTIK 3M PLUS DENGAN KEJADIAN PENYAKIT DEMAM BERDARAH DENGUE (DBD) Sety, La Ode Muhamad; Sutiswa, Shandra Isasi; Dewi, Riana; Ohorella, Arfan; Yoyoh, Imas
Ensiklopedia of Journal Vol 6, No 4 (2024): Vol. 6 No. 4 Edisi 3 Juli 2024
Publisher : Lembaga Penelitian dan Penerbitan Hasil Penelitian Ensiklopedia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33559/eoj.v6i4.2437

Abstract

Abstract: Dengue fever is a disease caused by the dengue virus and transmitted by the Aedes aegypti mosquito. From 2020 to 2022, both the number of cases and mortality rates have decreased, but dengue fever is still spread across all 20 Puskesmas in Jambi City. During the last three years, Rawasari Health Center has the highest prevalence of dengue fever cases at 0.031%. The purpose of the study was to determine the relationship between breeding places, the presence of resting places and the practice of 3M plus with the incidence of dengue hemorrhagic fever (DHF). The type of research is quantitative with a case control approach. The research was conducted at the Rawasari Health Center. The population is the number of DHF patients in the working area of the Rawasari Health Center in 2022 as many as 16 cases. The sample in this study taken was 16 respondents. Where in this study using a ratio of 1: 2 between case and control, so that the case sample is 16 cases and 32 controls, it is known that the total number of samples is 48 samples. The sampling technique used total sampling. Data analysis was carried out univariate and bivariate. The results showed that there was a relationship between breeding places (p value: 0.001) and 3M plus practices (p value: 0.000) to the incidence of DHF. It is suggested that the community can utilize and recycle used goods around the house so as to minimize the opportunity for mosquitoes to breed in used goods and increase the practice of 3M plus.Keywords: Breeding Place, DBD, Praktik 3M Plus
KORELASI FAKTOR IBU TERHADAP KEJADIAN STUNTING PADA ANAK USIA 0-59 BULAN Anwar, Seniwaty; Sutiswa, Shandra Isasi; Primasari, Yefta; Siddiq, Muhammad Nuzul Azhim Ash; Apidianti, Sari Pratiwi
Ensiklopedia of Journal Vol 6, No 4 (2024): Vol. 6 No. 4 Edisi 3 Juli 2024
Publisher : Lembaga Penelitian dan Penerbitan Hasil Penelitian Ensiklopedia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33559/eoj.v6i4.1512

Abstract

Abstract: Stunting, or short stature, is a common nutritional problem among children in many countries. Stunting refers to chronic malnutrition that results in a child's height not being appropriate for their age. The Geragai area is the area with the highest incidence of stunting in Jambi City, namely 262 children aged 0-59 months who are stunted with a prevalence of 24.58%. The purpose of the study was to determine the correlation of maternal factors with the incidence of stunting in children aged 0-59 months. This type of research is quantitative with a cross sectional approach. The sample amounted to 73 people. The sampling technique used Stratified Proportional Sampling. The results showed that there was a relationship between maternal knowledge (p value: 0.000) and the incidence of stunting. It is expected that the Puskesmas can increase public knowledge through preventive actions and health promotion to the community and conduct counseling to cadres in each village, then increase breastfeeding counseling to pregnant women, adolescents, or prospective brides.Keywords: Toddlers, Maternal Knowledge, Stunting
PENINGKATAN PENGETAHUAN WARGA KECAMATAN MANONJAYA TENTANG TANAMAN OBAT YANG DAPAT DIMANFAATKAN SEBAGAI ANTI INFLAMASI Sutiswa, Shandra Isasi; Aji, Nur; Handayani, Nuri
Edukasi Masyarakat Sehat Sejahtera (EMaSS) : Jurnal Pengabdian kepada Masyarakat Vol. 6 No. 1 (2024): Januari
Publisher : Poltekkes Kemenkes Tasikmalaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37160/emass.v6i1.307

Abstract

Inflammation is the body's defense reaction against various kinds of stimuli. The visible signs of inflammation are redness, heat, swelling, pain, and loss of function. Anti-inflammatory drugs are generally the NSIAD group which causes side effects of stomach ulcers, nausea and vomiting. Currently, people tend to choose traditional medicine using medicinal plants that are rich in benefits. There are several medicinal plants that can be used as anti-inflammatories that are not widely known by the public. Manonjaya District has plantation land and yards that can be used to grow medicinal plants. Manonjaya District has a large millennial population who do a lot of physical activity which can trigger inflammation. The Tasikmalaya Ministry of Health Polytechnic, which is part of the City of Tasikmalaya, through its role in the Tri Dharma of Higher Education, especially in the community service program, aims to improve the health status of the community. The methods used in this activity were counseling about medicinal plants that can be used as anti-inflammatory agents and distributing pocket books on anti-inflammatory medicinal plants to 20 youth organizations. Evaluation of the results of activities to increase knowledge is carried out through pre-tests and post-tests. The pre-test and post-test scores were analyzed statistically using t-Test data analysis: Paired Two Samples for Means with a significance value of 0.05. The evaluation results show that the significance value is <0.05, meaning there is an increase in participants' knowledge about medicinal plants which can be used as anti-inflammatory agents.
FORMULATION AND CHARACTERIZATION OF INSTANT POWDER COMBINATION OF MILK, YOLK AND TEMULAWAK (Curcuma xanthorriza Roxb) TO PREVENT STUNTING Sutiswa, Shandra Isasi; Aji, Nur
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 9 No 4 (2024)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v9i4.1234

Abstract

Through its health transformation program, the Ministry of Health has replaced giving biscuits as additional food to toddlers and pregnant women to prevent stunting with animal protein made from local food. Milk and eggs are local food sources of animal proteins that can be processed into nutraceuticals. Another cause of stunting is lack of appetite, nausea, and vomiting in children during pregnancy. Temulawak is a traditional medicine that can improve appetite. A combination of milk, yolk, and temulawak can be formulated for nutraceutical preparation. This study aimed to develop and test the characteristics of instant powder combinations of milk, yolk, and temulawak to prevent stunted growth. The laboratory experimental method was used in this study. The formula was prepared by mixing temulawak extract granules with powder obtained from the freeze-drying process of milk and yolk. There were 3 variations of the combination concentration with a ratio of milk : yolk : temulawak, F1 (40:2:3), F2 (50:3:2), and F3 (60:4:1). The results of the research showed that all formulas had physical characteristics in the form of light yellow powder with a typical ginger aroma, particle size between 119.66–120.39µm, angle of repose between 36.40–44.46°, flow rate between 1.32–1 .34g/sec, specific gravity between 0.44-0.47g/mL, tap density between 0.62–0.68g/mL, compressibility between 13.00-13.33%, pH between 6.45–6, 48, dispersibility time between 02.14 – 02.17 minutes and water content between 3.48 – 4.93% according to SNI-01-2970-2006 instant milk powder ...
HUBUNGAN KUALITAS TIDUR DENGAN GLUKOSA DARAH PADA PASIEN DIABETES MELLITUS TIPE II Sutiswa, Shandra Isasi; Gustini, Gustini; Yoyoh, Imas; Ali, Mohammad
Ensiklopedia of Journal Vol 7, No 1 (2024): Vol. 7 No. 1 Edisi 3 Oktober 2024
Publisher : Lembaga Penelitian dan Penerbitan Hasil Penelitian Ensiklopedia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33559/eoj.v7i1.2764

Abstract

Abstract: Diabetes mellitus has become an increasingly serious health problem, with the incidence rate continuing to increase significantly. The results of a preliminary study conducted by researchers in May 2023 on 10 patients with type II diabetes mellitus (DM type II) who were undergoing treatment at Prima Hospital showed significant findings. Of the 10 patients involved in the study, 8 reported frequent difficulty sleeping at night and feeling tired during the day. The purpose of the study was to determine the relationship between sleep quality and blood glucose in patients with type II diabetes mellitus. The research design used in this study was cross sectional. The research was conducted in July 2023 at Prima Hospital. The population was all type II DM patients who were recorded as many as 31 people from July to August 2023, with details of the number of type II DM patients who visited the poly in July to August 2023, totaling 31 people as well as the research sample.  The sampling technique used total sampling. The research instrument used a research questionnaire. Data analysis was performed univariate and bivariate. The results showed there was a relationship between sleep quality (p value: 0.003) with blood glucose levels. It is recommended that the hospital can improve services, especially in the field of nursing care for type II DM patients.Keywords: Diabetes, Blood Glucose Levels, Sleep Quality.
HUBUNGAN KARAKTERISTIK INDIVIDU DAN PENYAKIT PENYERTA DENGAN KUALITAS HIDUP PENDERITA DIABETES MELLITUS Santoso, Raden Bagus Edy; Ernita, Ernita; Sutiswa, Shandra Isasi; Yulianita, Yulianita; Noorma, Nilam
Ensiklopedia of Journal Vol 7, No 1 (2024): Vol. 7 No. 1 Edisi 3 Oktober 2024
Publisher : Lembaga Penelitian dan Penerbitan Hasil Penelitian Ensiklopedia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33559/eoj.v7i1.1834

Abstract

Abstract: Diabetes mellitus (DM) is a non-communicable disease that occurs due to very high blood sugar levels. Based on data search, it is known that Pulomerak Health Center is the health center with the highest DM cases in Cilegon City with 920 cases. The purpose of the study was to determine the relationship between individual characteristics and comorbidities with the quality of life of patients with diabetes mellitus. The type of research is quantitative research with a cross sectional design. The research was conducted in May 2023 at Pulomerak Health Center. The sample amounted to 163 people. The sampling technique used probability sampling with simple random sampling technique. The research instrument used a research questionnaire. Data analysis was carried out univariate and bivariate. The results showed that there was a relationship between individual characteristics, namely age (p value: 0.009) and comorbidities (p value: 0.000) on the quality of life of patients with diabetes mellitus. It is recommended for diabetics to not only carry out examinations related to DM disease but comorbidities suffered also really need to be checked to monitor their health conditions so as to prevent complications and not interfere with daily activities which will then have a positive impact on their quality of life and for Puskesmas to improve health services to DM sufferers not only in DM treatment but also can pay attention to the quality of life.Keywords: Diabetes Mellitus, Comorbidities, Age.
ANALISIS KEPUASAN PASIEN BPJS DALAM PELAYANAN KESEHATAN Sutiswa, Shandra Isasi; Arniawan, Arniawan; Kuntoadi, Gama Bagus; Putra, Ryryn Suryaman Prana
Ensiklopedia of Journal Vol 7, No 2 (2025): Vol. 7 No. 2 Edisi 3 Januari 2025
Publisher : Lembaga Penelitian dan Penerbitan Hasil Penelitian Ensiklopedia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33559/eoj.v7i2.2863

Abstract

Abstract: Patient satisfaction is a customer response to fulfilling needs and expectations. The Rambah Samo I Puskesmas is one of the Puskesmas in Rokan Hulu Regency which has experienced a decrease in the number of patient visits utilizing services. The purpose of the study was to determine the relationship of several factors with patient satisfaction with primary health services. Quantitative research type with cross sectional design. The research was conducted in 2023 with a sample of 99 people. The research instrument used a research questionnaire. Data analysis was carried out univariate and bivariate. The results showed that there was a relationship between reliability (p value 0.043), responsiveness (p value 0.040, POR 2.751). It is recommended to the Puskesmas to be able to improve the quality of health services consisting of administrative officers, health worker services, and pharmacy services in order to provide friendly and attentive service to patients and provide clear information to patients.Keywords: Reliability, Patient, Health Center
EDUKASI PENCEGAHAN STUNTING DAN WASTING DENGAN PEMANFAATAN SUSU, KUNING TELUR DAN TEMULAWAK SEBAGAI NUTRACEUTIKAL PADA KADER POSYANDU DI WILAYAH KERJA PUSKESMAS PANGANDARAN Sutiswa, Shandra Isasi; Nunung Yulia; Asep Kuswandi
Edukasi Masyarakat Sehat Sejahtera (EMaSS) : Jurnal Pengabdian kepada Masyarakat Vol. 7 No. 1 (2025): Januari
Publisher : Poltekkes Kemenkes Tasikmalaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37160/emass.v7i1.576

Abstract

Stunting dan Wasting merupakan masalah kesehatan yang disebabkan karena kekurangan asupan nutrisi dalam waktu lama, sehingga mengakibatkan gangguan pertumbuhan pada anak. Puskesmas Pangandaran merupakan Puskesmas dengan kasus wasting sebanyak 23 kasus dan kasus stunting sebanyak 20 kasus. Tujuan kegiatan ini adalah meningkatkan pengetahuan kader posyandu tentang stanting dan wasting baik penyebab, cara pencegahan dan dampak dari kasus tersebut. Kegiatan edukasi bertema “Cegah Stunting dan Wasting Dengan Pemberian Makanan Tambahan (PMT) Nutraceutical Lokal” diberikan pada 5 orang perwakilan kader dari masing desa serta ibu hamil dan ibu balita. Metode yang akan dilakukan dalam kegiatan ini yaitu dengan kegiatan penyuluhan mengenai penyebab wasting dan stunting, cara pencegahan wasting dan stunting melalui asupan nutrisi yang tepat bersumber dari bahan local, serta dampak dari kasus stunting dan wasting. Kegiatan ini yaitu penyuluhan tentang dilakukan pada 20 orang kader. Evaluasi hasil kegiatan untuk meningkatkan pengetahuan dilakukan melalui pre test dan post test. Nilai pre test dan post test dianalisis secara statistik menggunakan analisis data t-Test: Paired Two Sample for Means dengan nilai signifikansinya 0,05. Hasil evaluasi menunjukkan bahwa nilai signifikansinya < 0,05 artinya terdapat peningkatan pengetahuan peserta tentang penyebab wasting dan stunting, cara pencegahan wasting dan stunting melalui asupan nutrisi yang tepat bersumber dari bahan local, serta dampak dari kasus stunting dan wasting.
ANALISIS FAKTOR YANG MEMPENGARUHI TINGKAT KEPATUHAN TERHADAP PENGOBATAN TUBERKULOSIS Sutiswa, Shandra Isasi; Fauzi, Ahmad Zil; Askur, Askur; Suryani, Maria Eka
Ensiklopedia of Journal Vol 7, No 3 (2025): Vol. 7 No. 3 Edisi 3 April 2025
Publisher : Lembaga Penelitian dan Penerbitan Hasil Penelitian Ensiklopedia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33559/eoj.v7i3.3106

Abstract

Abstract: Based on preliminary studies conducted at the Pacar Keling Health Center from January to June 2023, 37 patients suffered from TB. The results of interviews with 5 respondents found that 3 people were compliant with treatment and 2 people were not compliant with treatment. The phenomenon obtained at the Pacar Keling Health Center is that there are still patients who are not compliant with TB treatment, including patients who drop out (incomplete treatment), repeat treatment, feel bored with long treatment. The purpose of the study was to analyze the factors that influence the level of adherence to tuberculosis treatment. The research design used in this study was cross sectional. The study was conducted in the working area of Pacar Keling Health Center. The study was conducted in August 2024. The study population was all patients registered at Pacar Keling Health Center as well as the research sample which amounted to 34 respondents. The sampling technique used total sampling. Data analysis was carried out univariate and bivariate. The results showed a relationship between motivation (p value: 0.004) and family support (p value: 0.000) to the level of compliance with tuberculosis treatment. It is recommended for the patient's family to always provide support and motivation to patients with tuberculosis in the treatment process and for the health center to provide counseling in the form of health promotion about TB disease that can be used by patients.Keywords: Adherence, Motivation, Tuberculosis
Co-Authors Aji, Nur Anwar, Seniwaty Apidianti, Sari Pratiwi Arniawan, Arniawan Asep Kuswandi Askur, Askur Diky Mudhakir ernita, ernita Fauzi, Ahmad Zil Gama Bagus Kuntoadi Gustini, Gustini Mohammad Ali Noorma, Nilam Nunung Yulia Nuri Handayani Ohorella, Arfan Primasari, Yefta Putra, Ryryn Suryaman Prana Raden Bagus Edy Santoso Riana Dewi Sety, La Ode Muhamad Siddiq, Muhammad Nuzul Azhim Ash Suryani, Maria Eka YEYET CAHYATI Yoyoh, Imas Yulia, Nunung Yulianita, Yulianita