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All Journal Farmaka International Journal of Integrated Health Sciences Jurnal Farmasi Klinik Indonesia Global Medical and Health Communication JURNAL PENDIDIKAN KEPERAWATAN INDONESIA Jurnal Kebidanan Jurnal Kesehatan Bakti Tunas Husada JURNAL PENDIDIKAN JASMANI DAN OLAHRAGA NurseLine Journal Jurnal Keperawatan Padjadjaran Jurnal Kesehatan Manarang Majalah Kedokteran Andalas Journal of the Indonesian Medical Association : Majalah Kedokteran Indonesia Journal of Applied Nursing and Health JKKI : Jurnal Kedokteran dan Kesehatan Indonesia Jurnal Kesehatan Bakti Tunas Husada Media Penelitian dan Pengembangan Kesehatan Indonesian Journal of Electronics, Electromedical Engineering, and Medical Informatics
Shelly Iskandar
Departemen Ilmu Kedokteran Jiwa, Fakultas Kedokteran, Universitas Padjadjaran/ RSUP Dr. Hasan Sadikin Bandung
Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Control & Systems Engineering Decision Sciences, Operations Research & Management Dentistry Education Electrical & Electronics Engineering Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Public Health Veterinary

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Acute effects of methadone on neural oscillations: an EEG study of theta, alpha, beta power, and frontal alpha asymmetry in opioid rehabilitation patients Nadiya, Ulfah; Simbolon, Artha Ivonita; Kusumandari, Dwi Esti; Rahmawati, Annida; Amri, M Faizal; Wibowo, Jony Winaryo; Danasasmita, Febrianti Santiardi; Sobana, Siti Aminah; Iskandar, Shelly; Turnip, Arjon
Indonesian Journal of Electronics, Electromedical Engineering, and Medical Informatics Vol. 7 No. 2 (2025): May
Publisher : Jurusan Teknik Elektromedik, Politeknik Kesehatan Kemenkes Surabaya, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35882/ijeeemi.v7i2.64

Abstract

Methadone is a synthetic opioid that commonly employed in opioid substitution therapy (OST) to reduce withdrawal symptoms and suppress cravings in individuals with opioid use disorder. While its pharmacological effects are well-documented, the neurophysiological changes it induces especially during acute administration remain underexplored. This study aims to address that gap by investigating methadone-induced alterations in brain oscillatory activity through electroencephalography (EEG). Specifically, it examines changes in theta (4–8 Hz), alpha (8–12 Hz), and beta (12–30 Hz) frequency bands, along with frontal alpha asymmetry (FAA) for F4-F3 and F8-F7, a biomarker associated with emotional and cognitive processing. EEG data were collected from patients enrolled in opioid rehabilitation programs both prior to and one hour following oral methadone intake. The results revealed a significant global decrease in theta power, notably within the frontal, temporal, and occipital cortices. This reduction may reflect changes in executive functioning, emotional regulation, and increased sedation. In contrast, alpha power showed a marked increase, particularly in the central, parietal, and occipital regions, suggesting reduced sensory processing and heightened sedation or attentional disengagement. Meanwhile, beta power was consistently reduced across cortical regions, pointing toward decreased cortical arousal and cognitive alertness. FAA analysis revealed high variability among participants, indicating that methadone's influence on emotional valence and approach-avoidance behavior may differ significantly across individuals. These findings underscore methadone’s sedative and stabilizing effects on neural activity and support its clinical role in managing opioid dependence. Further research into inter-individual differences in EEG responses may inform more personalized and effective OST protocols.
Analisis Efektivitas Biaya Penggunaan Antipsikotik Tipikal (Haloperidol) dan Atipikal (Risperidon) pada Pasien Skizofrenia di RSUP Dr. Hasan Sadikin Bandung Syahrina, Nadira Alvi; Barliana, Melisa Intan; Zakiyah, Neily; Iskandar, Shelly
Indonesian Journal of Clinical Pharmacy Vol 13, No 2 (2024)
Publisher : Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15416/ijcp.2024.13.2.61455

Abstract

Skizofrenia merupakan gangguan mental kronis yang membutuhkan terapi jangka panjang serta melibatkan biaya perawatan kesehatan yang besar. Penelitian ini bertujuan untuk menganalisis efektivitas biaya antara penggunaan risperidon dibandingkan dengan haloperidol pada terapi skizofrenia, serta menganalisis faktor utama yang memengaruhi nilai efektivitas biaya pada rawat inap di RSUP Dr. Hasan Sadikin Bandung (RSHS) pada 2017–2018. Data dikumpulkan secara retrospektif dari perspektif penyedia layanan kesehatan, mencakup total biaya medis langsung baik yang ditanggung rumah sakit maupun oleh Badan Penyelenggara Jaminan Sosial (BPJS). Nilai efektivitas diukur dalam penurunan penurunan skor PANSS. Hasil menunjukkan bahwa nilai average cost-effectiveness ratio (ACER) risperidon adalah Rp527.002 per satuan penurunan PANSS, sedangkan haloperidol Rp357.374. Berdasarkan perhitungan incremental cost-effectiveness ratio (ICER), haloperidol menunjukkan nilai Rp486.809 per satuan penurunan PANSS dibandingkan risperidon. Meskipun ICER haloperidol lebih tinggi dari risperidon, hasil tersebut masih berada dalam ambang batas willingness to pay yang ditetapkan di Indonesia (berdasarkan 1–3 kali PDB per kapita), sehingga terapi haloperidol dapat dikategorikan sebagai cost-effective. Dari sisi efisiensi biaya, haloperidol menghasilkan penghematan sekitar Rp378.737 dibandingkan risperidon. Dengan demikian, terapi haloperidol lebih dominan secara ekonomi dan layak dipertimbangkan sebagai pilihan pengobatan yang lebih efisien bagi pasien skizofrenia rawat inap di RSHS Bandung.
Hatha Yoga vs Prenatal gymnastic: The Perfect Choice to Reduce Stress and Improve Health for Primigravid Fernandez, Veronica; Lesmana, Ronny; Krisnadi, Sofie Riyani; Susiarno, Hadi; Tarawan, Vita Murniati; Iskandar, Shelly
JURNAL KEBIDANAN Vol. 15 No. 1 (2025): April 2025
Publisher : Politeknik Kesehatan Kementerian Kesehatan Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31983/jkb.v15i1.12677

Abstract

Abstract: Pregnancy is a critical period involving significant physiological and psychological changes, particularly in primigravida women who are more susceptible to anxiety and stress. Elevated stress levels during pregnancy may increase the risk of complications like high blood pressure, preeclampsia, and premature delivery. Non-pharmacological interventions like Hatha Yoga and gymnastic prenatalhave been widely recommended to improve maternal well-being. The purpose of this research was to evaluate and compare the impacts of two different interventions on maternal psychological and physiological health through a Systematic Literature Review (SLR) conducted in accordance with PRISMA guidelines. Relevant literature was retrieved from databases including Pubmed, Scopus, ScinceDirect, Google Scholar, focusing on research published between 2014 and 2024. The findings indicate that Hatha Yoga is more effective in reducing anxiety, cortisol levels, and systolic blood pressure, while prenatal gymnastic better supported diastolic blood pressure regulation and physical endurance for labor. Both interventions contribute to better cardiovascular function, increased oxygen saturation, and a smoother labor process. Additionally, yoga is associated with improved neonatal outcomes, while studies on prenatal exercise’s effects on newborn health remain limited. Future research should explore the long-term effects and key differences between these interventions to determine the most effective approach for maternal and neonatal health. These findings support integrating yoga and gymnastic prenatalinto antenatal care programs to enhance pregnancy outcomes.
The Comparative Effects of Hatha Yoga and Prenatal Exercise on Physiological and Psychological Outcomes in Primigravid Women: A Randomized Controlled Trial Fernandez, Veronica; Lesmana, Ronny; Krisnadi, Sofie R.; Susiarno, Hadi; Iskandar, Shelly; Tarawan, Vita Muniarti
Journal of Applied Nursing and Health Vol. 7 No. 3 (2025): Journal of Applied Nursing and Health
Publisher : Chakra Brahmanda Lentera Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55018/janh.v7i3.445

Abstract

Background: Primigravid women are prone to stress due to physical and psychological changes during pregnancy, which can lead to hypertension, preeclampsia, preterm birth, fetal growth restriction, and postpartum depression. While non-pharmacological interventions like hatha yoga and prenatal exercise are used to reduce stress, comparative evidence—especially on oxygen saturation (SpO₂)—is limited. This study analyzes the effects of hatha yoga and prenatal exercise on stress, blood pressure, and SpO₂ among primigravid women, and compares both interventions across these outcomes. Methods: This randomized controlled trial (RCT) followed the CONSORT 2010 guidelines. Forty-eight eligible primigravid women were selected using a probability sampling technique, specifically the simple random sampling method. Random numbers were generated using Microsoft Excel to determine participant selection from the maternal cohort register. Inclusion criteria were a normal singleton pregnancy at 24–28 weeks of gestation, maternal age 20–35 years, and normal Body Mass Index (BMI) (18.5–24.9 kg/m²). Exclusion criteria included regular exercise more than twice a week, abnormal fetal heart rate, and scheduled elective cesarean delivery. Participants were randomly assigned to either a hatha yoga group or a prenatal exercise group (24 each). Both interventions were conducted twice weekly for four weeks. Data were analyzed using the Wilcoxon and Mann–Whitney tests. Results: Data were analyzed using the Wilcoxon and Mann-Whitney tests. Median stress scores decreased from 22 to 12 in the hatha yoga group and from 22 to 17 in the prenatal exercise group (p < 0.001). Median SpO₂ increased from 96.88% to 98.38% and from 96.81% to 97.00%, respectively (p = 0.002). Median systolic pressure changed from 120.06 to 121.31 mmHg and 118.75 to 117.44 mmHg (p = 0.009), while diastolic pressure showed no significant difference (p = 0.076). Overall, hatha yoga showed greater improvements in stress, SpO₂, and blood pressure stability than prenatal exercise. Conclusion: Hatha yoga proved more effective than prenatal exercise in reducing stress, increasing SpO2, and stabilizing systolic blood pressure among primigravid women, although no significant difference was found in diastolic pressure. These findings strengthen the evidence supporting yoga as a safe, non-pharmacological approach to enhance maternal physiological and psychological well-being during pregnancy.
Co-Authors Achadiyani Adityana Sulistyo Agraini Agraini AJENG DIANTINI Ajeng Fitria Ambrosius Purba Ambrosius Purba Amri, M Faizal Antania Hanjani Irianti Arjon Turnip Bambang Eryanto Danasasmita, Febrianti Santiardi Dewi, Sumartini Dhanasari Vidiawati Dwi Agustian efri widianti Eka Puji Lestari Elda Nazriati Eldi Sauma Erwin Sumardi Fedri Rinawan Fernandez, Veronica Fidella Fidella Fitri N. Ramadhani Fitria, Nita Francisca Nungki Triandari Hardiyati Hardiyati Hertini, Reni Imas Rafiyah Irfan I Irianti, Antania Hanjani Johanes C. Mose Kartika Farahdilla Fitri Kevin Sulay Wijaya Khairiyatul Munawwarah Krisnadi, Sofie Riyani Kurnianingsih, Tuti Kusumandari, Dwi Esti Leonardo Lubis Leonardo Lubis Lydyana, Lynna Lynna Lidyana Lynna Lidyana Martin, Novia Melisa I. Barliana Melisa Intan Barliana, Melisa Intan Mohammad Ghozali Nadiya, Ulfah Nita Fitria Paramitha Kusuma Primal Sudjana Priskila Gracianita Rahmawati, Annida Reni Hertini Rio Dananjaya Ronny Lesmana Rudi Wisaksana Simbolon, Artha Ivonita Siti Aminah Sobana Sofie R. Krisnadi Sumartini Dewi Susiarno, Hadi Syahrina, Nadira Alvi Taty Hernawaty Taty Hernawaty Taty Hernawaty Taty Hernawaty Theresia Dewi Tuti Kurnianingsih Tuti Kurnianingsih Veranita Pandia Veranita Pandia Veranita Pandia Vita Muniarti Tarawan Vita Murniati Tarawan Wibowo, Jony Winaryo Winda Kurniati Zakiyah, Neily