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All Journal Jurnal Riset Kefarmasian Indonesia JPK: Jurnal Proteksi Kesehatan Indonesia Berdaya Science And Education Journal (SNEJ) Medical-Surgical Journal of Nursing Research Jurnal Farmasi Ma Chung: Sains, Teknologi, dan Klinis Komunitas Pharmacon: Jurnal Farmasi Indonesia Jurnal Ilmiah Manuntung: Sains Farmasi dan Kesehatan
Mardhiyani, Dini
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Religion Arts Humanities Biochemistry, Genetics & Molecular Biology Chemistry Economics, Econometrics & Finance Education Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Mathematics Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary Other

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EVALUASI SEDIAAN MASKER GEL PEEL-OFF KOMBINASI EKSTRAK DAUN MANGGA BACANG (Mangifera foetida)DAN DAUN SALAM (Syzygium polyanthum) Putriani, Kony; Mardhiyani, Dini; Anggraini, Lovera
Jurnal Riset Kefarmasian Indonesia Vol 4 No 1 (2022): Jurnal Riset Kefarmasian Indonesia
Publisher : APDFI (Asosiasi Pendidikan Diploma Farmasi Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33759/jrki.v4i1.218

Abstract

Mango Bacang leaves and bay leaves are plants that can be used as ingredients in traditional medicine as natural antibacterials which are believed to help get rid of acne. Several previous studies also reported that Bacang mango leaves and bay leaves have activity against Staphylococcus aureus, Escherichia coli and Salmonella typhi bacteria. This study aims to determine the evaluation results of peel-off gel mask preparations that meet the requirements. The test methods include organoleptic test, pH test, viscosity, homogeneity test and dispersion test. The test results showed that F1 and F2 were the best formulas with the characteristics of a green-black gel, a characteristic odor of mango Bacang and bay leaves, a viscosity of 1129 cPs and 1135 cPs, pH 4.4 and 4.5. The dispersion test was 5.1 cm and 5.7 cm and the homogeneity test on the peel off gel mask was homogeneous, there were no fibers, lumps or differences in color when applied to a transparent slide.
Aktivitas Antibakteri Ekstrak Etanol Daun Iler (Plectranthus scutellarioides (L.) R. Br.) Terhadap Bakteri Salmonella typhi : Antibakteri Ekstrak Daun Iler (Plectranthus scutellarioides (L.) R. Br.) Mardhiyani, Dini; Irma, Dinda Aulia; Pratiwi, Denia
Science and Education Journal Vol 2 No 2 (2024): Science and Education Journal (SNEJ)
Publisher : Yayasan Pendidikan Cahaya Budaya Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.64626/snej.v2i2.202

Abstract

Salah satu tanaman yang berkhasiat sebagai obat yaitu tanaman iler darah (Plectranthus scutellarioides (L.) R. Br.). Secara empiris rebusan daun iler darah bermanfaat sebagai obat antibakteri atau antiradang, demam, diare, obat bisul, dan sebagainya. Daun iler darah mengandung senyawa seperti senyawa alkaloid, saponin, tanin, dan flavonoid yang merupakan metabolit sekunder tumbuhan yang memiliki khasiat sebagai obat penyakit infeksi yang disebabkan oleh bakteri. Penelitian ini dilakukan dengan tujuan untuk mengetahui aktivitas antibakteri ekstrak etanol daun iler darah terhadap bakteri Salmonella typhi. Sampel dalam penelitian ini adalah ekstrak etanol daun iler darah dengan menggunakan tiga konsentrasi yaitu konsentrasi 30%, 20%, dan 10%. Pada penelitian ini digunakan kloramfenikol sebagai kontrol positif dan DMSO sebagai kontrol negatif dengan masa inkubasi selama 24 jam pada suhu 37°C menggunakan metode difusi cakram kertas. Hasil penelitian yang telah dilakukan dapat diketahui bahwa ekstrak etanol daun iler darah memiliki aktivitas sebagai antibakteri terhadap Salmonella typhi baik pada konsentrasi 30% (15,01 mm), 20% (10,08 mm) maupun pada konsentrasi 10% (7,52 mm).
Formulation and Characterization of Nanoemulsion Turmeric oil Hendrika, Yan; Aulia, Zulikho; Mardhiyani, Dini
JURNAL PROTEKSI KESEHATAN Vol 12 No 2 (2023): JPK: Jurnal Proteksi Kesehatan
Publisher : Poltekkes Kemenkes Riau

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36929/jpk.v12i2.733

Abstract

Turmeric oil is an essential oil derived from turmeric (Curcuma domestica). Turmeric oil is known to have antiinflammatory, antibacterial, antifungal and antioxidant activities. Nanoemulsions have the advantage of improving drug absorption and bioavailability. The purpose of the formulation of this nanoemulsion is to know the characteristics of turmeric oil nanomulsions. The formula consists of F1 (5%), F2 (10%), and F3 (15%). The preparation assessment covers organoleptic, pH, viscosity, stability, particle size, and zeta potential. The nanoemulsion preparation is produced in a thick yellow, typical odor of turmeric oil, with a pH of 6.8-7, a viskosity of 23-29 Cps, transmission values of 43.3-74.6%, droplet sizes at F1, F2, F3 of 23.2 nm, 203.8 nm, and 298.7 nm and zeta values potentials F1, F2 - 18.5mV, F 2 - 13.4mv, and F3 -8,5mV, all of the formulas well physically stable by the cracking, sedimentation and tubidity.
Antioxidant Activity Assay of Black Turmeric (C. Caesia) Water and Ethanol Extracted Using DPPH Kartini, Sri; Susanti, Pratiwi; Marshanda, Isty Maulia; Pratiwi, Denia; Mardhiyani, Dini; Hendrika, Yan
JURNAL PROTEKSI KESEHATAN Vol 12 No 2 (2023): JPK: Jurnal Proteksi Kesehatan
Publisher : Poltekkes Kemenkes Riau

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36929/jpk.v12i2.790

Abstract

Antioxidants are compounds that provide electrons; they function by donating an electron to oxidizing compounds, thereby inhibiting the activity of these oxidants. The objective of this study is to ascertain the presence of secondary metabolites and evaluate the antioxidant properties of water and methanol extracts obtained from black turmeric (C. caesia). The determination of antioxidant activity was conducted using the DPPH method with a microplate reader at a wavelength of 520 nm, by calculating the IC50 value. The research findings indicate that both water and methanol extracts contain flavonoids, saponins, and tannins. The antioxidant activity of the water extract measured at 392.47 ± 46.38 ppm (weaker), the methanol extract displayed a higher activity at 69.66 ± 2.91 ppm (strong), and Vitamin C exhibited very strong activity at 3.98 ± 0.26 ppm.
IMPACT OF EXTRACTION SOLVENTS AND FRACTIONATION TECHNIQUES ON PHENOLIC CONTENT AND ANTIOXIDANT POTENCY IN TURMERIC (CURCUMA DOMESTICA) Pratiwi, Denia; Wardaniati, Isna; Nasution, Azlaini Yus; Islami, Deri; Mardhiyani, Dini
Medical-Surgical Journal of Nursing Research Vol. 3 No. 2 (2024): Medical-Surgical Journal of Nursing Research
Publisher : Himpunan Perawat Medikal Bedah Indonesia (HIPMEBI) Regional Jawa Barat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70331/jpkmb.v3i1.45

Abstract

Turmeric is known to have many properties, one of which is as an antioxidant, the active substance which is considered to play a role in this activity is curcuminoid. Curcuminoids are part of the secondary metabolites of flavonoids and more specifically are phenolic. The purpose of this study was to examine the effect of the type of solvent on total phenolic levels with antioxidant activity in turmeric.  The method of the research is experimental laboratory has been carried out at the FMIPA UNRI laboratory in 2019. The turmeric rhizome which has been made as a simplicial is extracted using ethanol and graded fractionated using n-butanol and ethyl acetate solvents. Determination of total phenolic levels with Follin Ciocalteau reagents using a Microplate reader and gallic acid comparison while the value of antioxidant activity using the DPPH method. The result will be analyzed descriptively. Based on the results of the study it was found that there is a solvent effect on total phenolic content and antioxidant activity seen from IC50 values and different total phenolics, namely in determining the total phenolic content of turmeric (Curcuma domestica) successively ethanol extract, water fraction, ethyl acetate fraction, fraction n-butanol of 90.1364; 22,0303; 45,2397; 20,9697 mg / g (GAE) and on the measurement of antioxidant activity the IC50 value was 65.7506 µg / mL; 384,2774 µg / mL; 64,6012 µg / mL; 834,3335 µg / mL with smaller activity compared to the antioxidant activity of vitamin C which is 7.27624 µg / mL.
Upaya peningkatan pengetahuan masyarakat tentang asam urat dan pemeriksaan kesehatan di Kelurahan Lembah Sari, Rumbai Timur Wati, Huda Marlina; Mursyida, Eliya; Susanti, Lasiah; Surya, Alfin; Mardhiyani, Dini
Indonesia Berdaya Vol 5, No 4 (2024)
Publisher : UKInstitute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47679/ib.2024848

Abstract

Asam urat merupakan salah satu radang sendi yang terjadi karena adanya penumpukan kristal asam urat di jari kaki, pergelangan kaki, lutut, dan paling sering di jempol kaki. Kadar asam urat antara pria dan wanita berbeda, dimana asam urat yang normal pada pria berkisar antara 2,5-7mg/dL dan pada wanita berkisar antara 1,5-6mg/dL. Asam urat yang tinggi dapat diobati dengan obat antiinflamasi non steroid seperti ibuprofen, dan sebagainya. Namun dapat juga dicegah dengan menerapkan pola makan sehat dan pola hidup yang sehat. Pengetahuan masyarakat RT 02 RW 06 Lembah Sari masih minim terhadap asam urat. Pengabdian bertujuan untuk mengedukasi dan mendeteksi dini asam urat. Pengabdian ini dilakukan di RT 02 RW 06 Lembah Sari dengan cara pengisian kuesioner pretest, penyampaian materi secara langsung, dilanjutkan dengan sesi tanya-jawab, dan pengisian kuesioner posttest. Hasil pretest dan posttest terkait pengetahuan asam urat didapatkan adanya peningkatan pengetahuan peserta menjadi baik sebesar 46,2%. Pada pemeriksaan dari 4 orang prempuan didapatkan 50% peserta memiliki kadar asam urat yang tinggi, 1 peserta (25%) rendah, dan 1 peserta (25%) normal.
AKTIVITAS ANTIJAMUR KOMBINASI EKSTRAK ETANOL DAUN MANGGA BACANG (MANGIFERA FOETIDA L.) DAN DAUN BIDARA (ZIZIPHUS MAURITIANA L.) TERHADAP CANDIDA ALBICANS Mardhiyani, Dini; Putriani, Kony
Jurnal Ilmiah Manuntung Vol 7 No 2 (2021): Jurnal Ilmiah Manuntung: Sains Farmasi Dan Kesehatan
Publisher : Sekolah Tinggi Ilmu Kesehatan Samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51352/jim.v7i2.501

Abstract

Along with increasing life expectancy, the community tries to find solutions to health problems. One of the health problems that occur in humans is caused by fungi. Candida albicans is one of the fungi that can be found in humans. Candida albicans are normal flora in the vagina, digestive tract, and oral cavity. Nevertheless, it can change into a pathogen and cause changes in the host. Based on compound contained in leaf of mango bacang and leaf of bidara, they have antifungal effect. This study aims to determine the antifungal activity of single ethanol extract of mango bacang leaves and bidara leaves with a combination of bidara leaves ethanol extract and ethanol extract of mango bacang leaves against Candida albicans. The method of this study begins with collecting mango bacang leaves and bidara leaves then extracted maceration with ethanol solvents. The antifungal activity is tested with the disk diffusion method using potato dextrose media. Based on the results of the hypothesis test obtained a significance value of 0.010 <0.05, there was a difference in the diameter of the inhibition zone against the growth of Candida albicans due to a single giving and variations in the combination of ethanol mango bacang leaves and bidara leaves ethanol extract. Extract single antifungal activity after combined experienced a minimum increase of 1.2%. The conclusion of this study shows that the combination of ethanol extract of bacang mango leaves with bidara leaves ethanol extract has a larger inhibiting zone than a single extract and shows the synergy effect. The use of bacang mango leaves as anti-fungal is recommended in combination with bidara leaves.
Evaluasi Penyimpanan Obat di Gudang Puskesmas Rawat Inap Kota Pekanbaru Fitri Andriani; Mardhiyani, Dini
Jurnal Farmasi Ma Chung: Sains, Teknologi, dan Klinis Komunitas Vol. 3 No. 1 (2025): Jurnal Farmasi Ma Chung: Sains, Teknologi, dan Klinis Komunitas
Publisher : Program Studi Farmasi, Universitas Ma Chung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33479/jfmc.v3i1.60

Abstract

Kualitas penyimpanan obat di fasilitas pelayanan kesehatan dasar seperti Puskesmas sangat menentukan mutu terapi dan keselamatan pasien. Penyimpanan yang tidak sesuai standar dapat menyebabkan penurunan stabilitas, efektivitas, dan keamanan obat. Penelitian ini bertujuan untuk mengevaluasi kesesuaian penyimpanan obat di gudang Puskesmas rawat inap di Kota Pekanbaru berdasarkan Petunjuk Teknis Standar Pelayanan Kefarmasian tahun 2019. Penelitian dilakukan dengan metode deskriptif observasional pada lima Puskesmas rawat inap selama Mei hingga Juli 2023. Data dikumpulkan melalui observasi langsung menggunakan checklist dan wawancara terhadap petugas gudang. Hasil penelitian menunjukkan bahwa rata-rata kesesuaian penyimpanan obat di lima Puskesmas adalah 78,25%, yang masuk kategori baik. Puskesmas Sidomulyo mencatat nilai tertinggi sebesar 95,65%, sementara Puskesmas Karya Wanita paling rendah dengan 65,21%. Aspek yang sesuai meliputi penggunaan rak dan lemari penyimpanan, pelabelan obat, serta penerapan metode FIFO dan FEFO. Namun demikian, beberapa indikator masih belum memenuhi standar, seperti pencatatan suhu harian (20%), pemantauan suhu (40%), serta penandaan obat High Alert dan LASA (masing-masing 40%). Kesimpulan dari penelitian ini adalah bahwa penyimpanan obat di gudang Puskesmas di Kota Pekanbaru secara umum telah sesuai standar, namun diperlukan perbaikan pada aspek monitoring suhu dan penandaan obat berisiko tinggi untuk menjamin kualitas dan keamanan obat secara optimal.
The Potential UV-B Filter of Gel Preparation Containing Ethanol Extract of Bidara Arab Leaf (Ziziphus spina-christi) Cultivated in Indonesia Mardhiyani, Dini; Aswatul Ulya; Eni Yanti Wulan Desri; Gendis Purno Yudanti; Muslim Suardi; Vonny Kurnia Utama; Kony Putriani; Isna Wardaniati
Pharmacon: Jurnal Farmasi Indonesia Volume 22, No 1 (2025)
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/pharmacon.v22i1.7487

Abstract

Bidara arab leaf (Ziziphus spina-christi) contains flavonoids, saponins, triterpenoids, alkaloids, steroids, and lipids that may act synergistically as natural UV filters. Flavonoids are highlighted for their ability to absorb UVA and UVB light, while other compounds may enhance photoprotection. Previous studies reported that its ethanol extract contains 1.53% flavonoids and exhibits strong antioxidant activity (LC₅₀ = 90.96 ppm). To formulate gel preparations containing Bidara Arab leaf ethanol extract and evaluate their physicochemical properties, sun protection factor (SPF), and photoprotective efficacy against UV-B–induced erythema. The extract was incorporated into gel at concentrations of 2.5% (F1), 5% (F2), and 10% (F3). Physicochemical tests included organoleptic assessment, pH, viscosity, and spreadability. In vitro SPF was determined using UV-Vis spectrophotometry. In vivo testing involved UV-B–irradiated mice, and erythema was scored to assess protection. All gels met standard parameters (pH 5.34–6.51; viscosity 10.352–15.459 cP; spreadability 5.2–5.8 cm). SPF values were 19.26 (F1), 20.22 (F2), and 20.50 (F3), indicating medium UV-B protection. Erythema scores in all extract-treated groups were 0, with erythema areas of 0.50 mm², 0.38 mm², and 0.19 mm², respectively—significantly lower than in the blank gel (3.96 mm²) and untreated control (7.51 mm²) (p<0.01). Bidara arab leaf extract gel (2.5–10%) shows medium SPF protection and effectively prevents UV-B–induced erythema in mice. These findings support its potential as a natural sunscreen agent.
Co-Authors Alfin Surya Anggraini, Lovera Aswatul Ulya Aulia, Zulikho Eni Yanti Wulan Desri Fitri Andriani Gendis Purno Yudanti Hendrika, Yan Irma, Dinda Aulia Islami, Deri Isna Wardaniati Kony Putriani Marshanda, Isty Maulia Mursyida, Eliya Muslim Suardi Nasution, Azlaini Yus Pratiwi, Denia Putriani, Kony Sri Kartini, Sri Susanti, Lasiah Susanti, Pratiwi vonny kurnia utama Wardaniati, Isna Wati, Huda Marlina