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Journal : Jurnal Borneo Cendekia

UJI EFEKTIVITAS EKSTRAK ETANOL DAUN KALAKAI (Stenochlaena palustris (Burm.F) Bedd) TERHADAP PENURUNAN KADAR GLUKOSA DARAH PADA TIKUS PUTIH JANTAN YANG DIINDUKSI GLUKOSA Fakhruddin, Fakhruddin; Billi, Joseph; Dwiannur, Febriandi Ramadhan; A'yun, Qurrotul; Hatimah, Naimi Amalia; Rahimamullah, M Arsyad
Jurnal Borneo Cendekia Vol 8 No 2 (2024): Jurnal Borneo Cendekia
Publisher : STIKES Borneo Cendekia Medika

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54411/jbc.v8i2.591

Abstract

Diabetes Mellitus is characterized by elevated blood glucose levels. Kalakai leaf is one of the plants formulated as a traditional remedy to address Diabetes Mellitus. One of the compounds found in Kalakai leaf extract is flavonoids, which act as antioxidants and help reduce blood glucose levels. The aim of this study is to investigate the effect of ethanol extract of Kalakai leaf on blood glucose reduction in male white rats induced by glucose. This experimental study employed a pre-test and post-test control group design. Kalakai leaf was used as the sample, and 15 male white rats were divided into 5 groups, each consisting of 3 rats. Group 1 was given a treatment of CMC suspension, Group 2 received glibenclamide suspension, Group 3 was treated with 50 mg/kgBB of Kalakai leaf ethanol extract, Group 4 received 100 mg/kgBB of Kalakai leaf ethanol extract, and Group 5 was given 150 mg/kgBB of Kalakai leaf ethanol extract. The results of this study showed that Kalakai leaf ethanol extract had an effect on lowering blood glucose levels. However, the extract at a dose of 150 mg/kgBB was more effective in significantly reducing blood glucose levels compared to the 50 mg/kgBB and 100 mg/kgBB doses. This study concludes that Kalakai leaf ethanol extract has the potential to lower blood glucose levels in male white rats induced by glucose.
Uji Aktivitas Antikanker Ekstrak Tanaman Rumput Bambu (Lophatherum Gracile B.) Metode Ultrasonik Terhadap Sel Kanker Payudara T47D A'yun, Qurrotul; Romaidha, Iqlila; Makani, Mawaqit; ., Sarinah
Jurnal Borneo Cendekia Vol 9 No 1 (2025): Jurnal Borneo Cendekia
Publisher : STIKES Borneo Cendekia Medika

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54411/jbc.v9i1.629

Abstract

Bamboo grass (Lophatherum gracile B.) is a type of weed that can be utilized as a medicinal plant. Almost all parts of this plant contain secondary metabolites with potential as herbal medicine. This study was conducted to evaluate the breast cancer (T47D) anticancer activity of bamboo grass using an ultrasonic extraction method. The solvents used in this study were 80% ethanol, n-hexane, and chloroform. All extract samples were tested for their breast cancer (T47D) anticancer activity using the MTT assay. The IC50 values of the 80% ethanol, n-hexane, and chloroform extracts were 218.081; 292.412; and 395.144 ?g/mL, respectively. The TLC separation of tannin compounds from the 80% ethanol extract was identified using FTIR. The identification results showed key absorption peaks of tannin compounds, including O-H alcohol, C-O secondary alcohol, aliphatic C-H, C=C alkene, and ortho-substituted aromatic ring, with corresponding wavenumbers of 3455; 1094; 2963; 2929; 1650; and 780 cm?ยน.