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All Journal JURNAL ILMIAH KESEHATAN KEPERAWATAN Pharmacon JFL : Jurnal Farmasi Lampung Indonesian Journal of Global Health research Jurnal Ilmiah Medicamento Jurnal EMPATI (Edukasi Masyarakat, Pengabdian dan Bakti) Jurnal Farmasi Komunitas Journal Borneo Pharmaqueous Prosiding University Research Colloquium Jurnal Farmasi Klinik dan Sains Serulingmas Health Journal (SHJ) Usadha Journal of Pharmacy
Widiastuti, Tri Cahyani
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Humanities Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Dentistry Education Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health Other

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Journal : Jurnal Ilmiah Medicamento

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Aktivitas Antidiabetes Kombinasi Ekstrak Daun Jambu Biji dan Daun Rambutan pada Tikus Putih Jantan Galur Wistar (Rattus norvegicus) yang Diinduksi Streptozotocin Pradani, Lintang Oktavian; Widiastuti, Tri Cahyani; Khuluq, Muhammad Husnulq
Jurnal Ilmiah Medicamento Vol 11 No 2 (2025): Jurnal Ilmiah Medicamento (In progress)
Publisher : Fakultas Farmasi Universitas Mahasaraswati Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36733/medicamento.v11i2.9887

Abstract

Diabetes mellitus is a metabolic disorder characterized by elevated blood glucose levels due to insulin deficiency or resistance. Long-term use of oral antidiabetic drugs can lead to adverse effects and high costs, making safer alternatives necessary. Herbal medicines derived from natural sources offer a promising option with relatively fewer side effects. Guava (Psidium guajava) and rambutan (Nephelium lappaceum) leaves are known to contain bioactive compounds with potential antihyperglycemic properties. This study aimed to determine the optimal dose combination of guava and rambutan leaf extracts for controlling blood glucose levels in streptozotocin-induced Wistar rats (Rattus norvegicus). The extracts were prepared using maceration, standardized, and analyzed by Thin Layer Chromatography (TLC) to identify active compounds. Thirty-two rats were divided into eight groups: healthy control, negative control (CMC-Na 0.5%), positive control (glimepiride 0.036 mg/kg BW), single extract of guava leaves (50 mg/kg BW), single extract of rambutan leaves (70 mg/kg BW), and three combinations of extracts (50%:50%, 75%:25%, and 25%:75%). Diabetes was induced intraperitoneally using streptozotocin. Blood glucose levels were measured every seven days for 21 days using a glucometer. Data were analyzed using One-Way ANOVA followed by Games-Howell post hoc test. The extracts met standardization requirements and contained flavonoids. The highest glucose reduction (72%) was observed in the 25%:75% combination (guava:rambutan), showing a significant difference compared to the negative control. These findings suggest that the combination of guava and rambutan leaf extracts has strong potential as a natural antidiabetic agent.
Co-Authors Adi Pratama, Faiz Surya agung setiawan Agustina, Eli Dwi Ainni, Ayu Nissa Amalia, Tika Anggraeni, Riski Anwar Sodik Awalia, Lukluatul Chondrosuro Miyarso Desi Kurniawati Dyah, Rafita Endang Yuniarti Ery purwanti Fitriyati, Laeli Fitriyati, Laely Hamdi, Lazuardi Fatahillah Handaningrum, Karunia Nining Handayani, Eka Wuri Indra Kurniawan Intiyani, Rafila isma yuniar Istiqomah, Hanisah Khuluq, Husnul Khuluq, Khusnul Khuluq, Muh Husnul Khuluq, Muh. Husnul Khuluq, Muhammad Husnul Khuluq, Muhammad Husnulq Kiromah, Naelaz Zukhruf Wakhidatul Krisdiyanti, Yayu Kurniasih Kurniasih Ledianasari, L Malihah, Umi Maulida, Risqina Mawwadah, Nazilatul Miyarso, Condro Suro Mulyani, Ayu Achiriyah Nabilah, Zukhrufina Muthiah Nurhalisah, Alvina Dwi Nurhasanah, Lutfia Okti, Eriska Kumala Harmilia Pamungkas, Royan Abdi Pradani, Lintang Oktavian Putri, Ananda Rafena Hanin Rahayu, Kukuh Puji Sarwono Sarwono Supriyanto, Sugeng Utami, Rafika Wahyu Eka Sakti Wahyuningsih, Riska Winarno, Tunjung Wukirsari, Laras Sinta Yusuf Kurniawan Zubaidah, Siti Nur