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All Journal Global Medical and Health Communication Biomedical Journal of Indonesia SRIWIJAYA JOURNAL OF MEDICINE Jurnal Respirasi (JR) Indonesian Journal of Global Health research Jurnal Pengabdian Masyarakat: Humanity and Medicine Jurnal RSMH Palembang
Ahmad, Zen
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Biochemistry, Genetics & Molecular Biology Dentistry Education Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Medicine & Pharmacology Neuroscience Nursing Public Health

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Association Between LENT Score and Survival in Patients with Malignant Pleural Effusion at Dr. Mohammad Hoesin General Hospital, Palembang Rizkyani Sariza, Fania; Ahmad, Zen; Kurniati, Nova; Yusri, Muhammad; Irfannudin; Sudarto; Andriani, Raden Ayu Linda; Pasaribu, Rouly Pola; Rachman, Alif Fathur
Sriwijaya Journal of Medicine Vol. 8 No. 2 (2025): Vol 8, No 2, 2025
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/sjm.v8i2.352

Abstract

The presence of a malignant pleural effusion (MPE) indicates advanced stage of malignancy, which severely compromises in a poor prognosis. LENT score has been developed as a prognostic tool for MPE, yet its association with survival has not been thoroughly evaluated in Indonesia. This study aims to examine the association between LENT score and 3-month survival in patients with MPE at Dr. Mohammad Hoesin General Hospital, Palembang. This prospective cohort study included 35 patients with MPE. Survival analysis using Kaplan-Meier curves. In this study cohort, the most frequent primary malignancy observed was lung cancer (62,8%). Kaplan-Meier analysis showed a median survival of 22 days for the high-risk LENT scores and 85 days for the moderate-risk group (p < 0,001). LENT score is significantly associated with three-month mortality in EPG patients. LENT score remains a robust tool for risk stratification in MPE management.
Identification of Mitochondrial DNA Polymorphism on Linezolid-induced Toxic Optic Neuropathy Patients Setyorini, Dwi Indira; Ahmad, Zen; Amalia, Ella; Subandrate, Subandrate; Hutabarat, Yosafat Beltsazar
Global Medical & Health Communication (GMHC) Vol 13, No 1 (2025)
Publisher : Universitas Islam Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/gmhc.v13i1.14142

Abstract

Drug-resistant tuberculosis (DR-TB) is difficult to eradicate due to several factors, including insufficient treatment and medication side effects. Linezolid is among the medications with serious adverse effects. Linezolid toxicity is suspected to be related to the drug's binding to mitochondrial 16s rRNA. Some studies indicate that polymorphisms in patients' mtDNA may increase vulnerability to the development of toxic optic neuropathy. This study aims to identify a genetic influence on the vulnerability to the occurrence of toxic optic neuropathy side effects in drug-resistant tuberculosis patients receiving linezolid treatment. This research was conducted at the Faculty of Medicine, Universitas Sriwijaya, Palembang, from September to October 2023. Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was undertaken to detect mutations in the G3010A mtDNA of the patients. Two patients experiencing toxic optic neuropathy side effects during drug-resistant tuberculosis treatment underwent blood sample collection. Blood samples were examined for mutations in the G3010A and A2706G genes using the PCR-RFLP method. The PCR-RFLP examination results indicated the presence of mutations in G3010A. In conclusion, polymorphism of G3010A mtDNA may contribute to the vulnerability to toxic optic neuropathy side effects in drug-resistant tuberculosis patients receiving linezolid. Further research with a larger population is needed to prove the involvement of mtDNA polymorphisms in the vulnerability to toxic optic neuropathy.
Giant Pleural Hydatid Cyst: A Case Report Sudarto, Sudarto; Belinda, Selli; Fathurrachman, Alif; Andriani, Linda; Pasaribu, Rouly; Rasyid, Ahmad; Ahmad, Zen; Setiawan, Tommy
Jurnal Respirasi Vol. 9 No. 1 (2023): January 2023
Publisher : Faculty of Medicine Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jr.v9-I.1.2023.49-55

Abstract

Introduction: Echinococcosis is a zoonotic disease caused by the larva stage of a Taeniidae parasite of Echinococcus. Echinococcus granulosus (E. granulosus) causes cystic echinococcus (CE) and is the most common species causing disease in humans. A pleural hydatid cyst should be considered initially with a corresponding chest radiograph. It can develop into fatal complications, including secondary infection, severe bleeding, bronchial rupture and pleural or pericardial cavities. This case report shows a rare case of a pleural hydatid cyst. Case: We reported a 59-year-old woman with shortness of breath and a productive cough for three months. The chest radiography and computed tomography (CT) scan revealed a cystic lesion measuring 14.2 x 18.5 cm with edge calcification thick around 3 mm. The pleural histopathology revealed that the cyst wall was made of fibrocollagen with a red oval echinococcus. The patient received oral albendazole/ABZ (400mg BID) for three months, paracetamol (500mg TID), and n-acetylcysteine (200mg TID). After three months, the patient had no complaints, only shortness of breath with heavy activity. Conclusion: It is important to be aware of this condition to avoid inappropriate and potentially dangerous underdiagnoses and treatment, which could endanger the patient.
Co-Authors Ahmad Rasyid ahmad rasyid, ahmad Alif Fathurrachman Andriani, Linda Andriani, Raden Ayu Linda Belinda, Selli Dwi Indira Ella Amalia, Ella Elzan Zulqad Maulana Fathurrachman, Alif Hu, Owen Hutabarat, Yosafat Beltsazar Iche Andriyani Liberty, Iche Andriyani Indira, Dwi Irfannudin kurniati, nova Linda Andriani Lubis, Fadhyl Zuhry Muhammad Irsan Saleh Muhammad Novran Chalik Muhammad Yusri Pasaribu, Rouly Pasaribu, Rouly Pola Rachman, Alif Fathur Raden Mohamad Herdian Bhakti Rizkyani Sariza, Fania Rouly Pasaribu Salutondok, Welly Setiawan, Tommy Setyorini, Dwi Indira Setyorini, Dwi Indira  Subandrate Sudarto Sudarto Sudarto Syafriani, Diah Wirdah, Aisyah Zen Hafy Zulfadli, Nadia Karimah Amalia